Time Resolved Macromolecular Crystallography
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Time Resolved Macromolecular Crystallography
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Author : Royal Society (Great Britain)
language : en
Publisher: Oxford [England] ; New York : Oxford University Press
Release Date : 1992
Time Resolved Macromolecular Crystallography written by Royal Society (Great Britain) and has been published by Oxford [England] ; New York : Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Science categories.
The papers presented in this volume report the striking progress X-ray diffraction has facilitated in the study of structural molecular biology. Coupled with the revival of the Laue method, the advent of high-intensity synchrotron radiation sources has made possible the rapid collection of X-ray crystallography data, thereby allowing protein and virus crystallography to progress from studies of equilibrium structures to time-resolved studies of structures at reaction stages. The book also details the many recent technological developments in physics, chemistry and biochemistry that have been critical for the full exploitation of the synchrotron Laue method in the study of dynamic events in crystals. Necessary future developments are discussed.
Time Resolved Macromolecular Crystallography
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Author : D. W. Cruickshank
language : en
Publisher:
Release Date : 1992
Time Resolved Macromolecular Crystallography written by D. W. Cruickshank and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with categories.
Protein Crystallography
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Author : Alexander Wlodawer
language : en
Publisher: Humana Press
Release Date : 2017-06-02
Protein Crystallography written by Alexander Wlodawer and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-02 with Science categories.
This volume provides methods for modern macromolecular crystallography, including all steps leading to crystal structure determination and analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Protein Crystallography aims to ensure successful results in the further study of this vital field.
Time Resolved Diffraction
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Author : J. R Helliwell
language : en
Publisher: Oxford University Press
Release Date : 1997-12-18
Time Resolved Diffraction written by J. R Helliwell and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-12-18 with Science categories.
The acceleration of the technical capabilities of X-ray, electron and neutron diffraction techniques in recent years has been driven by developments in synchrotron and neutron sources, detectors and computers. These allow the rapid and repeated acquisition of diffraction data as a chemical and biological structural process proceeds, following its initiation. This opens up completely new studies from timescales ranging from the sub-picosecond, at the fastest, through all the time domains up to kiloseconds, for the slower molecular processes.
The Future Of Dynamic Structural Science
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Author : Judith A.K. Howard
language : en
Publisher: Springer
Release Date : 2014-07-08
The Future Of Dynamic Structural Science written by Judith A.K. Howard and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-08 with Science categories.
This work focuses on complementary crystallographic and spectroscopic areas of dynamic structural science, from papers presented at the 46th NATO sponsored course in Erice, Sicily 2013. These papers cover a range of material from background concepts to more advanced material and represent a fully inter-disciplinary collection of the latest ideas and results within the field. They will appeal to practising or novice crystallographers, both chemical and biological, who wish to learn more about modern spectroscopic methods and convergent advances and hence vice versa for experimental and computational spectroscopists. The chapters refer to the latest techniques, software and results and each chapter is fully referenced. The volume provides an excellent starting point for new comers in the emerging, multi-disciplinary area of time resolved science.
Macromolecular Crystallography With Synchrotron Radiation
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Author : John R. Helliwell
language : en
Publisher: Cambridge University Press
Release Date : 1992
Macromolecular Crystallography With Synchrotron Radiation written by John R. Helliwell and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Science categories.
This highly illustrated monograph provides a comprehensive treatment of the study of the structure and function of the molecules of life--proteins, nucleic acids, and viruses--using synchrotron radiation and crystallography. Beginning with chapters on the fundamentals of macromolecular crystallography and macromolecular structure, the book goes on to review the sources and properties of synchrotron radiation, instrumentation, and monochromatic data collection. There are also chapters on the Laue method, on diffuse X-ray scattering, and on variable wavelength anomalous dispersion methods. The book concludes with a description and survey of applications including studies at high resolution, the use of small crystals, the study of large unit cells, and time-resolved crystallography (particularly of enzymes). Appendices are provided that present essential information for the synchrotron user as well as information about synchrotron facilities currently available.
International Tables For Crystallography Volume F
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Author : Eddy Arnold
language : en
Publisher: John Wiley & Sons
Release Date : 2012-03-05
International Tables For Crystallography Volume F written by Eddy Arnold and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-03-05 with Science categories.
International Tables for Crystallography Volume F is an expert guide to macromolecular crystallography for the structural biologist. It was commissioned by the International Union of Crystallography in recognition of the extraordinary contributions that knowledge of macromolecular structure has made, and will make, to the analysis of biological systems, from enzyme catalysis to the workings of a whole cell. The volume covers all stages of a crystallographic analysis from the preparation of recombinant proteins, through crystallization, diffraction data collection, phase determination, structure validation and structure analysis. Although the volume is written for experienced scientists, it is recognized that the reader is more likely to be a biologist interested in structure than a classical crystallographer interested in biology. Thus, there are chapters on the fundamentals, history and current perspectives of macromolecular crystallography, as well as on useful programs and databases such as the Protein Data Bank. Each chapter is written by one or more internationally recognized experts. This second edition features 19 new articles and many articles from the first edition have been revised. The new articles cover topics such as standard definitions for quality indicators, expression of membrane proteins, protein engineering, high-throughput crystallography, radiation damage, merohedral twinning, low-resolution ab initio phasing, robotic crystal loading, whole-cell X-ray diffraction imaging and halogen interactions in biological crystal structures. There are also new articles on relevant software, including software for electron microscopy. These enhancements will ensure that Volume F continues to be a key reference for macromolecular crystallographers and structural biologists. More information on the series can be found at: http://it.iucr.org
Advanced Methods In Structural Biology
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Author : Ângela Sousa
language : en
Publisher: Springer Nature
Release Date : 2023-04-24
Advanced Methods In Structural Biology written by Ângela Sousa and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-24 with Science categories.
This volume explores the latest integrated bioprocesses and technologies used to study the production of the target recombinant protein of therapeutic or diagnostic interest; its isolation, purification, and stabilization; and the bio-interaction and structural analyses. The chapters in this book are organized into four parts. Part One covers production methods of soluble and membrane proteins in prokaryotic and eukaryotic expression systems, such as Lactococcus lactis and Escherichia coli. Part Two describes traditional and novel approaches for recombinant protein purification and stabilization, and buffers and additives. Part Three discusses automated methods in structural biology based on in silico approaches; and Part Four provides examples of advanced protein investigation methodologies to assess structural analysis such as high-throughput protein crystallization and time-resolved serial crystallography. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Advanced Methods in Structural Biology is a valuable resource to those in academia (i.e., graduate students and postdoctoral researchers) and researchers in the pharmaceutical industry who wish to learn more about this developing field. Chapter 5 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
21st Century Challenges In Chemical Crystallography I
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Author : D. Michael P. Mingos
language : en
Publisher: Springer Nature
Release Date : 2021-01-20
21st Century Challenges In Chemical Crystallography I written by D. Michael P. Mingos and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-20 with Science categories.
This volume summarises recent developments and possible future directions for small molecule X-ray crystallography. It reviews specific areas of crystallography which are rapidly developing and places them in a historical context. The interdisciplinary nature of the technique is emphasised throughout. It introduces and describes the chemical crystallographic and synchrotron facilities which have been at the cutting edge of the subject in recent decades. The introduction of new computer-based algorithms has proved to be very influential and stimulated and accelerated the growth of new areas of science. The challenges which will arise from the acquisition of ever larger databases are considered and the potential impact of artificial intelligence techniques stressed. Recent advances in the refinement and analysis of X-ray crystal structures are highlighted. In addition the recent developments in time resolved single crystal X-ray crystallography are discussed. Recent years have demonstrated how this technique has provided important mechanistic information on solid-state reactions and complements information from traditional spectroscopic measurements. The volume highlights how the prospect of being able to routinely “watch” chemical processes as they occur provides an exciting possibility for the future. Recent advances in X-ray sources and detectors that have also contributed to the possibility of dynamic single-crystal X-ray diffraction methods are presented. The coupling of crystallography and quantum chemical calculations provides detailed information about electron distributions in crystals and has resulted in a more detailed understanding of chemical bonding. The volume will be of interest to chemists and crystallographers with an interest in the synthesis, characterisation and physical and catalytic properties of solid-state materials. Postgraduate students entering the field will benefit from a historical introduction to the subject and a description of those techniques which are currently used. Since X-ray crystallography is used so widely in modern chemistry it will serve to alert senior chemists to those developments which will become routine in coming decades. It will also be of interest to the broad community of computational chemists who study chemical systems.
Integrated Structural Biology
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Author : Tatyana Polenova
language : en
Publisher: Royal Society of Chemistry
Release Date : 2023-12-08
Integrated Structural Biology written by Tatyana Polenova and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-08 with Science categories.
Modern research in biology increasingly relies on multiple techniques for describing structures and mechanisms. This book provides an overview of the contemporary integrated biology approaches for solving structures and understanding mechanisms of complex biological systems. It includes several methodology chapters discussing the current developments in the areas of cryo-electron microscopy (EM) and cryo-electron tomography (ET), computational biophysics, solution NMR spectroscopy, solid-state NMR spectroscopy and dynamic nuclear polarization (DNP), electron paramagnetic resonance (EPR), (photo-)chemically induced dynamic nuclear polarization (CIDNP), X-ray crystallography and small-angle X-ray and neutron scattering (SAXS/SANS). Several subsequent chapters demonstrate how these methods are used in synergy to address problems at the forefront of structural biology, with particular emphasis on examples where individual techniques are insufficient. Examples of biological systems include membrane proteins, viral protein assemblies, cytoskeleton protein assemblies, photosynthetic reaction centers, large enzyme complexes and whole cells. The book is targeted to both the current practitioners of structural biology and scientists who are interested in entering the fields of structural biology or biophysical chemistry.