Preparation Bioactivity Evaluation And Quality Control Of Natural Products And Their Derivatives
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Preparation Bioactivity Evaluation And Quality Control Of Natural Products And Their Derivatives
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Author : Xi Zheng
language : en
Publisher: Frontiers Media SA
Release Date : 2025-02-27
Preparation Bioactivity Evaluation And Quality Control Of Natural Products And Their Derivatives written by Xi Zheng and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-02-27 with Science categories.
Natural products with biological activity are an important source of innovative drugs. Statistics show that over half of small molecule drugs come from natural products and their analogues. At the same time, the development of efficient synthesis methods and the evaluation of the functional activity of related active molecules, as necessary steps to obtain corresponding innovative drugs, have always been at the forefront of research for organic chemists and pharmaceutical chemists. In addition, the quality evaluation of natural products and their derivatives, including bioactive molecule, exogenous harmful substances and endogenous toxic components, will be guaranteed to ensure the safe and effective clinical treatment.
Quality Control And Evaluation Of Herbal Drugs
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Author : Pulok K. Mukherjee
language : en
Publisher: Elsevier
Release Date : 2019-05-30
Quality Control And Evaluation Of Herbal Drugs written by Pulok K. Mukherjee and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-30 with Science categories.
Quality Control and Evaluation of Herbal Drugs brings together current thinking and practices for evaluation of natural products and traditional medicines. The use of herbal medicine in therapeutics is on the rise in both developed and developing countries and this book facilitates the necessary development of quality standards for these medicines.This book elucidates on various challenges and opportunities for quality evaluation of herbal drugs with several integrated approaches including metabolomics, chemoprofiling, marker analysis, stability testing, good practices for manufacturing, clinical aspects, Ethnopharmacology and Ethnomedicine inspired drug development. Written by Prof. Pulok K Mukherjee, a leader in this field; the book highlights on various methods, techniques and approaches for evaluating the purity, quality, safety and efficacy of herbal drugs. Particular attention is paid to methods that assess these drugs' activity, the compounds responsible and their underlying mechanisms of action. The book describes the quality control parameters followed in India and other countries, including Japan, China, Bangladesh, and other Asian countries, as well as the regulatory profiles of the European Union and North America. This book will be useful in bio-prospecting of natural products and traditional medicine-inspired drug discovery and development. - Provides new information on the research and development of natural remedies - essential reading on the study and use of natural resources for preventative or healing purposes - Brings together current thinking and practices in quality control and standardization of herbal drugs highlighting several integrated approaches for metabolomics, chemo-profiling and marker analysis - Aids in developing knowledge of various techniques including macroscopy, microscopy, HPTLC, HPLC, LC-MS/MS, GC-MS etc. with the development of integrated methods for evaluation of botanicals used in traditional medicine - Assessment of herbal drugs through bio-analytical techniques, bioassay guided isolation, enzyme inhibition, pharmacological, microbiological, antiviral assays and safety related quality issues - References global organizations, such as the WHO, USFDA, CDSCO, AYUSH, TCM and others to serve as a comprehensive document for enforcement agencies, NGOs and regulatory authorities
Studies In Natural Products Chemistry
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Author : Atta-Ur Rahman
language : en
Publisher: Elsevier
Release Date : 2024-02-24
Studies In Natural Products Chemistry written by Atta-Ur Rahman and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-24 with Science categories.
Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry. Studies in Natural Products Chemistry covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products. - Focuses on the chemistry of bioactive natural products - Contains contributions by leading authorities in the field - Presents sources of new pharmacophores
Bioactive Natural Products In Drug Discovery
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Author : Joginder Singh
language : en
Publisher: Springer Nature
Release Date : 2020-04-30
Bioactive Natural Products In Drug Discovery written by Joginder Singh and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-30 with Medical categories.
This book highlights different natural products that are derived from the plants and microbes that have shown potential as the lead compounds against infectious diseases and cancer. Natural products represent an untapped source of strikingly diverse chemotypes with novel mechanisms of action and the potential to serve as anticancer and anti-infective agents. The book discusses a range of biotechnologically valuable bioactive compounds and secondary metabolites that have been derived from plant and microorganisms from various ecological niches. It also reviews the latest developments in the field of genomics, bioinformatics and industrial fermentation for harnessing the microbial products for commercial applications. In turn, the book’s closing section reviews important biotechnological applications of various natural products. Combining the expertise of specialists in this field, the book’s goal is to promote the further investigation of natural sources for the development of standardized, safe and effective therapies.
Novel Chemical Microbiological And Physical Approaches In Food Safety Control Volume Ii
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Author : Marco Iammarino
language : en
Publisher: Frontiers Media SA
Release Date : 2024-11-21
Novel Chemical Microbiological And Physical Approaches In Food Safety Control Volume Ii written by Marco Iammarino and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-21 with Medical categories.
One of the most important emerging aspects that requires further research in food safety is the simultaneous presence of different contaminants (both microbiological and chemical) in the same food, the so-called “cocktail effect”. Large amounts of data are needed for these evaluations, since the huge number of interactions among different contaminants, which maybe hypothesized, have to be statistically evaluated before confirming an effective risk. Moreover, the range of food to take into account within these studies is very wide. In order to obtain comprehensive datasets, new approaches are needed. These approaches, composed of new analytical procedures, microbiological protocols and chemical/physical determinations, should allow the quick and economic obtainment of many parameters, possibly respecting the environment, in the “green chemistry” perspective.
Bioactive Natural Products
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Author : Steven M. Colegate
language : en
Publisher: CRC Press
Release Date : 2007-12-14
Bioactive Natural Products written by Steven M. Colegate and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-12-14 with Medical categories.
Following the successful format of the original, this new edition presents applications of the most recent techniques for the detection, isolation, and structural determination of bioactive natural products. It features new case studies and illustrations that demonstrate applications of techniques covered in the book. Complementing as much as replacing the first edition, most of the contributors are new. The text includes updates on chemical extraction, and NMR-based structure determination, and new contributions on liquid chromatography linked with mass and NMR spectroscopy, dereplication approaches, assessment of source material for natural products and novel bioassay development.
Bioprospecting Of Tropical Medicinal Plants
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Author : Karuppusamy Arunachalam
language : en
Publisher: Springer Nature
Release Date : 2023-08-30
Bioprospecting Of Tropical Medicinal Plants written by Karuppusamy Arunachalam and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-08-30 with Science categories.
This book focuses on natural products, in particular medicinal plants and their derived products, as an indispensable source of bioactive molecules that serve as either drug candidates or lead compounds for drug design and discovery . There are several advantages for plant-derived therapeutics, including wide availability, diverse pharmacological actions, and a generally good profile of safety and tolerability. Over the recent years, there have been numerous reports from clinical studies testifying the efficacy and safety of medicinal plants and phytochemicals in treating human diseases. A plethora of basic studies has also unraveled molecular mechanisms underlying the health benefits of herbal medicines. Nevertheless, issues such as identification of bioactive ingredients, standardization of the products, and drug interactions remain to be systematically documented. Bioprospecting of Tropical Medicinal Plants represents a comprehensive analysis of natural products, mainly medicinal plants and phytochemicals. It includes detailed medicinal properties and pharmacological action from in vitro models to clinical trials. The goal is to present the readers a carefully curated collection of plant-derived natural products and their underlying molecular mechanisms.
Plants As Sources For Novel Medicines
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Author : Ameyatma Mahajan
language : en
Publisher: Educohack Press
Release Date : 2025-01-03
Plants As Sources For Novel Medicines written by Ameyatma Mahajan and has been published by Educohack Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-01-03 with Science categories.
"Plants as Sources for Novel Medicines" delves into the vital role plants play in providing essential resources for human well-being. Their unique metabolisms produce compounds beneficial to human health, making them indispensable in drug development. Many traditional methods of drug preparation use plant-derived compounds for their remarkable healing properties. Our book explores the various techniques used to produce drugs from plants, highlighting the advancements in recent methods while emphasizing the need to protect endangered plant species. We cover the different stages of drug preparation, discussing the properties of plants and their application in modern medicine. We also touch on the importance of botany and related fields in drug development, illustrating how sophisticated methods in plant-based drug preparation are transforming healthcare. This book is an invaluable resource for understanding how plants contribute to developing novel medicines and improving human health.
Evidence Based Validation Of Herbal Medicine
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Author : Pulok K. Mukherjee
language : en
Publisher: Elsevier
Release Date : 2022-07-12
Evidence Based Validation Of Herbal Medicine written by Pulok K. Mukherjee and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-12 with Medical categories.
Evidence-Based Validation of Herbal Medicines: Translational Research on Botanicals brings together current thinking and practice in the characterization and validation of natural products. The book describes different approaches and techniques for evaluating the quality, safety and efficacy of herbal medicine, particularly methods to assess their activity and understand compounds responsible and their probable underlying mechanisms of action. This book brings together the views, expertise and experiences of scientific experts in the field of medicinal plant research, hence it will be useful for researcher who want to know more about the natural lead with their validation and also useful to exploit traditional medicines. - Includes state-of-the-art methods for detecting, isolating and performing structure elucidation by degradation and spectroscopic techniques - Highlights the trends in validation and value addition of herbal medicine with different scientific approaches used in therapeutics - Contains several all-new chapters on topics such as traditional-medicine-inspired drug development to treat emerging viral diseases, medicinal plants in antimicrobial resistance, TLC bio profiling, botanicals as medicinal foods, bioprospecting and bioassay-guided isolation of medicinal plants, immunomodulators from medicinal plants, and more
Current Organic Chemistry
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Author :
language : en
Publisher:
Release Date : 2006
Current Organic Chemistry written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Asymmetric synthesis categories.
Provides in depth reviews on current progress in the fields of asymmetric synthesis, organometallic chemistry, bioorganic chemistry, heterocyclic chemistry, natural product chemistry, and analytical methods in organic chemistry. Each issue is edited by an appointed Executive Guest Editor.