Presystemic Drug Elimination
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Presystemic Drug Elimination
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Author : Charles F. George
language : en
Publisher: Elsevier
Release Date : 2013-10-22
Presystemic Drug Elimination written by Charles F. George and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Medical categories.
Butterworths International Medical Reviews, Clinical Pharmacology and Therapeutics 1: Presystemic Drug Elimination explores the principles of presystemic drug metabolism in human based on animal studies. This book is divided into four sections encompassing 10 chapters that specifically describe the extent of metabolism occurring in the gastrointestinal tract, liver, and lung. Section 1 focuses on presystemic elimination by the gastrointestinal tract. This section discusses the enzymatic biotransformation in the gastrointestinal mucosa and the ability of the microflora to metabolize drugs. Section 2 considers the contribution of the liver to presystemic drug elimination, with a particular emphasis on the physiological factors, which determine the rate of breakdown of drugs in vivo. This section also deals with the effects of hepatic cirrhosis on presystemic drug elimination. Section 3 presents first a brief outline of the knowledge of pulmonary structure and relevant physiology, followed by a discussion on “first-pass metabolism of endogenous substrates and drugs across the pulmonary circulation and of environmental chemicals after inhalation. This section also provides the methods for distinguishing between the contribution of the various sites to presystemic drug elimination and the problems associated with attempts to analyze available pharmacokinetic data. This work is an ideal source for clinical pharmacologists and researchers.
Presystemic Drug Elimination
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Author : Charles F. George
language : en
Publisher: Butterworth-Heinemann
Release Date : 1982-01-01
Presystemic Drug Elimination written by Charles F. George and has been published by Butterworth-Heinemann this book supported file pdf, txt, epub, kindle and other format this book has been release on 1982-01-01 with Drugs categories.
Medical Pharmacology And Therapeutics E Book
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Author : Derek G. Waller
language : en
Publisher: Elsevier Health Sciences
Release Date : 2013-08-07
Medical Pharmacology And Therapeutics E Book written by Derek G. Waller and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-08-07 with Medical categories.
This book covers all the pharmacology you need, from basic science pharmacology and pathophysiology, through to clinical pharmacology to therapeutics, in line with the integrated approach of new medical curricula. The first section covers the basic principles, and the rest is organised by body systems. The book ends with sections on toxicity and prescribing practice. Integrates basic science pharmacology, clinical pharmacology and therapeutics Brief review of pathophysiology of major diseases Case histories and multiple choice questions (and answers) Tabular presentation of all common drugs within each class Section on further reading Kinetics chapter simplified with more practical examples Includes more on genetic issues Drug tables made more concise to make information more accessible Fully updated to reflect current clinical practice
Oral Drug Absorption
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Author : Jennifer B. Dressman
language : en
Publisher: CRC Press
Release Date : 2016-04-19
Oral Drug Absorption written by Jennifer B. Dressman and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-19 with Medical categories.
Oral Drug Absorption, Second Edition thoroughly examines the special equipment and methods used to test whether drugs are released adequately when administered orally. The contributors discuss methods for accurately establishing and validating in vitro/in vivo correlations for both MR and IR formulations, as well as alternative approaches for MR an
Basic Knowledge Of Pharmacology
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Author : Roland Seifert
language : en
Publisher: Springer
Release Date : 2019-07-19
Basic Knowledge Of Pharmacology written by Roland Seifert and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-19 with Medical categories.
This is the perfect pharmacology textbook for medical and pharmacy students. The book was developed on the +30-year experience of the author as pharmacology professor in the United States and Germany. The book discusses the most important drugs (400) in the context of relevant diseases. Summary tables and schemes, MCQ exam questions, case studies and a list of drugs aid memorization of the material before an exam. All chapters are written in the same concise style and use a modern and precise pharmacological nomenclature. After reading of the book, the student will be able to critically assess the proper use of the most important drugs and advise patients properly. The didactic concept of the book has been developed on the author’s own pharmacology courses for which he has received numerous teaching awards. The book takes advantage of the learning spiral, in which material is presented repeatedly from various angles. This book is an adaptation for an international audience of the German textbook “Basiswissen Pharmakologie” (2018); ISBN: 978-3-662-56303-8.
Applied Biopharmaceutics And Pharmacokinetics
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Author : Leon Shargel
language : en
Publisher: McGraw-Hill/Appleton & Lange
Release Date : 1993
Applied Biopharmaceutics And Pharmacokinetics written by Leon Shargel and has been published by McGraw-Hill/Appleton & Lange this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Biopharmaceutics categories.
Drug Bioavailability
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Author : Han van de Waterbeemd
language : de
Publisher: John Wiley & Sons
Release Date : 2006-03-06
Drug Bioavailability written by Han van de Waterbeemd and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-03-06 with Science categories.
The peroral application (swallowing) of a medicine means that the body must first resorb the active substance before it can begin to take effect. The efficacy of drug uptake depends on the one hand on the chemical characteristics of the active substance, above all on its solubility and membrane permeability. On the other hand, it is determined by the organism's ability to absorb pharmaceuticals by way of specific transport proteins or to excrete them. Since many pharmacologically active substances are poorly suited for oral intake, a decisive criterion for the efficacy of a medicine is its so-called bioavailability. Written by an international team from academia and the pharmaceutical industry, this book covers all aspects of the oral bioavailability of medicines. The focus is placed on methods for determining the parameters relevant to bioavailability. These range from modern physicochemical techniques via biological studies in vitro and in vivo right up to computer-aided predictions. The authors specifically address possibilities for optimizing bioavailability during the early screening stage for the active substance. Its clear structure and comprehensive coverage make this book equally suitable for researchers and lecturers in industry and teaching.
Color Atlas Of Pharmacology
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Author : Heinz Lüllmann
language : en
Publisher: Thieme Medical Publishers
Release Date : 2005
Color Atlas Of Pharmacology written by Heinz Lüllmann and has been published by Thieme Medical Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Medical categories.
Updated with the most important new substances and scientific developments, the third edition of The Color Atlas of Pharmacology makes it easier than ever for students, nurses, and practicing physicians to keep up with the latest developments in this constantly changing field. Featuring a user-friendly layout, jargon-free language, and more than 160 spectacular color charts and illustrations, the atlas is divided in to four, color-coded sections: Part 1 - General pharmacology - includes descriptions of substance formulation, absorption, distribution, elimination, and molecular mechanisms of action Part 2 - Systems pharmacology - with special emphasis on the functional and therapeutic aspects of a wide range of medicinal agents Part 3 - Therapy of selected diseases - such as osteoporosis, acute myocardial infarction, migraine, asthma, tropical diseases, and many more Part 4 - Drug Index - helpfully listed by substance, generic, and brand names Concise, portable, and packed with information, the third edition of The Color Atlas of Pharmacology is the most practical first-stop reference for today's busy healthcare professional.
Veterinary Pharmacology And Toxicology
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Author : Yves Ruckebusch
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Veterinary Pharmacology And Toxicology written by Yves Ruckebusch and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Clinical Pharmacokinetics
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Author : Devarakonda Rama Krishna
language : en
Publisher: Berlin ; New York : Springer-Verlag
Release Date : 1990
Clinical Pharmacokinetics written by Devarakonda Rama Krishna and has been published by Berlin ; New York : Springer-Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with Medical categories.
