Preventive And Predictive Genetics Towards Personalised Medicine
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Preventive And Predictive Genetics Towards Personalised Medicine
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Author : Godfrey Grech
language : en
Publisher: Springer
Release Date : 2015-06-24
Preventive And Predictive Genetics Towards Personalised Medicine written by Godfrey Grech and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-06-24 with Science categories.
Pharmacogenomics supports personalized medicine by translating genome-based knowledge into clinical practice, offering enhanced benefit for patients and health-care systems at large. Current routine practice for diagnosing and treating patients is conducted by correlating parameters such as age, gender and weight with risks and expected treatment outcomes. In the new era of personalized medicine the healthcare provider is equipped with improved ability to prevent, diagnose, treat and predict outcomes on the basis of complex information sources, including genetic and genomic data. Targeted therapy and reliable prediction of expected outcomes offer patients access to better healthcare management, by way of identifying the therapies effective for the relevant patient group, avoiding prescription of unnecessary treatment and reducing the likelihood of developing adverse drug reactions.
Predictive Preventive And Personalised Medicine From Bench To Bedside
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Author : Halina Podbielska
language : en
Publisher: Springer Nature
Release Date : 2023-10-30
Predictive Preventive And Personalised Medicine From Bench To Bedside written by Halina Podbielska and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-30 with Medical categories.
This volume presents advanced bio/medical sciences with a particular value for translating research achievements into daily medical practice in the framework of Predictive, Preventive and Personalised Medicine (3PM/PPPM). First two decades of the 21st century are characterised by epidemics of non-communicable diseases such as many hundreds of millions of patients diagnosed with cardiovascular diseases and the type 2 diabetes mellitus, breast, lung, liver and prostate malignancies, neurological, sleep, mood and eye disorders, amongst others. Consequent socio-economic burden is tremendous. Unprecedented decrease in age of maladaptive individuals has been reported. The absolute majority of expanding non-communicable disorders carry a chronic character, over a couple of years progressing from reversible suboptimal health conditions to irreversible severe pathologies and cascading collateral complications. The paradigm change from reactive to predictive preventive and personalised medicine is essential to promote population health by application of individualised patient profiling, multi-parametric analysis leading to cost-effective targeted prevention. To this end, inadequate data for risk assessment on speed and urgency of COVID-19, combined with increased globalization of human society, led to the rapid spread of COVID-19. Despite an abundance of digital methods that could be used in slowing or stopping this virus and future pandemics, the world remains unprepared, and lessons have not been learned from previous cases of pandemics. The book presents PPPM strategies which might be of great clinical utility for future pandemics. In a long-term way, a significantly improved healthcare economy is one of the clear benefits of the proposed paradigm shift; a tight collaboration between all stakeholders including scientific community, healthcare providers, patient organisations, policy-makers and educators is analysed for the smooth implementation of the 3PM concepts. Further issues linked to big data management and medical ethics have to be carefully treated in the context of application of artificial intelligence in medicine.
Anticipation And Medicine
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Author : Mihai Nadin
language : en
Publisher: Springer
Release Date : 2016-10-22
Anticipation And Medicine written by Mihai Nadin and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-22 with Technology & Engineering categories.
In this book, practicing physicians and experts in anticipation present arguments for a new understanding of medicine. Their contributions make it clear that medicine is the decisive test for anticipation. The reader is presented with a provocative hypothesis: If medicine will align itself with the anticipatory condition of life, it can prompt the most important revolution in our time. To this end, all stakeholders—medical practitioners, patients, scientists, and technology developers—will have to engage in the conversation. The book makes the case for the transition from expensive, and only marginally effective, reactive treatment through “spare parts” (joint replacements, organ transplants) and reliance on pharmaceuticals (antibiotics, opiates) to anticipation-informed healthcare. Readers will understand why the current premise of treating various behavioral conditions (attention deficit disorder, hyperactivity, schizophrenia) through drugs has to be re-evaluated from the perspective of anticipation. In the manner practiced today, medicine generates dependence and long-lasting damage to those it is paid to help. As we better understand the nature of the living, the proactive view of healthcare, within which the science and art of healing fuse, becomes a social and political mandate.
Omics Technologies For Clinical Diagnosis And Gene Therapy Medical Applications In Human Genetics
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Author : Syeda Marriam Bakhtiar
language : en
Publisher: Bentham Science Publishers
Release Date : 2022-10-03
Omics Technologies For Clinical Diagnosis And Gene Therapy Medical Applications In Human Genetics written by Syeda Marriam Bakhtiar and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-03 with Medical categories.
Genetic disorders have been the focus of scientists for a long time. The emergence of next-generation sequencing techniques has ushered a new era in genetics and several developments have occurred in human genetics. The scientific perspective has also been widened with omics technologies that allow researchers to analyze genetic sequences and their expression products. An integrated approach is being used not only for diagnosis but also for disease management and therapeutic purposes. This book highlights emerging areas of omics technology and its application in the diagnosis and management of human genetic disorders. The book covers three areas of research and implementation: 1) Diagnosis (covering conventional strategies to next-generation platforms). This section focuses on the role of in silico analysis, databases and multi-omics of single-cell which will help in designing better management strategies. 2) Disease Management and therapeutic interventions. This section starts with genetic counselling and progresses to more specific techniques such as pharmacogenomics and personalized medicine, gene editing techniques and their applications in gene therapies and regenerative medicine. 3) Case studies. This section discusses the applications and success of all the above-mentioned strategies on selected human disorders. This book serves as a handy reference for students and academics studying advanced omics techniques in biochemistry and molecular genetics as part of courses in life sciences, pharmacology and medicine.
Healthcare Overview
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Author : Vincenzo Costigliola
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-11-06
Healthcare Overview written by Vincenzo Costigliola and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-06 with Medical categories.
In healthcare, the realisation of an optimistic prognosis against pessimistic ones depends on current innovations in diagnostic and cost-effective treatment approaches being widely adopted in clinical practice. Utilisation of advanced early and predictive diagnostics, targeted prevention and personalised medical approaches could enable the elderly subpopulation to reach the 100-year age limit in good physical and mental health, as actively contributing members of society. This task requires intelligent political regulations and creation of new guidelines to advance current healthcare systems. In this book, we will collect contributions from several geopolitical regions of Europe, Asia and USA that provide expert opinion on healthcare organisation and outlook as well as economical aspects of personalised medicine.
Law And Economics Of Personalized Medicine
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Author : Karin Bosshard
language : en
Publisher: Springer
Release Date : 2018-05-14
Law And Economics Of Personalized Medicine written by Karin Bosshard and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-14 with Law categories.
The book adds to the discussion about strategic approaches towards the translation of personalized medicine into clinical practice. It stresses the importance of non-science related, institutional barriers. A Law and Economics perspective is applied in order to examine the incentives induced by the barriers. An applied part identifies and evaluates policy levers to foster the translation of personalized medicine into Swiss clinical practice.
Anti Aging Drugs
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Author : Alexander M Vaiserman
language : en
Publisher: Royal Society of Chemistry
Release Date : 2017-02-01
Anti Aging Drugs written by Alexander M Vaiserman and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-02-01 with Health & Fitness categories.
Aging is a natural phenomenon that is peculiar to all living things. However, accumulating findings indicate that senescence could be postponed or prevented by certain approaches. Substantial evidence has emerged supporting the possibility of radical human health and lifespan extension, in particular through pharmacological modulation of aging. A number of natural dietary ingredients and synthetic drugs have been assumed to have geroprotective potential. In the development of anti-aging therapeutics, several cell, insect, and animal models may provide useful starting points prior to human studies. This book provides an overview of current research aimed to search for life-extending medications and describes pharmacological aspects of anti-aging medicine. Readers are introduced to the fascinating historical background of geroprotection in the first chapter. In-depth information on models for investigating geroprotective drugs precedes a section covering anti-aging properties of pharmaceutical compounds, such as calorie restriction mimetics, autophagy inducers, senolytics and mitochondrial antioxidants. Finally, strategies to translate discoveries from aging research into drugs and healthcare policy perspectives on anti-ageing medicine are provided to give a complete picture of the field. A timely and carefully edited collection of chapters by leading researchers in the field, this book will be a fascinating and useful resource for pharmacologists, gerontologists and any scientifically interested person wishing to know more about the current status of research into anti-aging remedies, challenges and opportunities.
Deploying Artificial Intelligence To Achieve The Un Sustainable Development Goals
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Author : Arthur Guseni Oliver Mutambara
language : en
Publisher: Springer Nature
Release Date : 2025-07-01
Deploying Artificial Intelligence To Achieve The Un Sustainable Development Goals written by Arthur Guseni Oliver Mutambara and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-07-01 with Technology & Engineering categories.
This book provides research insights into how Artificial Intelligence (AI) can be used to achieve the UN’s Sustainable Development Goals (SDGs) – 17 interconnected goals designed to address the world’s most pressing challenges by 2030. It reviews the SDGs and discusses why progress has been mixed and uneven across different countries, regions and goals. The book posits that attaining the SDGs will depend on enhanced global cooperation, increased funding, improved infrastructure, public-private partnerships, regional/continental integration, addressing the climate crisis, inclusive economic transformation, and visionary leadership. More specifically, the publication advocates leveraging innovative and transformative technologies, particularly the deployment of AI. The research acknowledges the risks of digital imperialism, data colonialism and technological exclusion, especially in emerging and least industrialised economies. Hence, in deploying AI to achieve the SDGs, the book puts a premium on decoloniality in AI systems and democratising AI technology. Provides a critique of the current SDGs approach by reframing the goals as a comprehensive risk assessment of humanity’s most pressing threats in the 21st century; Features broad and holistic interventions to accelerate the attainment of the SDGs; Provides a comprehensive but accessible introduction to AI concepts and advanced innovations such as AlphaFold, ChatGPT-4, DeepSeek-R1, Grok 3, and autonomous vehicles (drones and driverless cars); Discusses the AI strategies of leading economies and assesses the impact of AI on geopolitics; Provides a comprehensive critique of global AI efforts by the UN and African Union, while proffering alternative paradigms and frameworks; Presents the enablers, drivers and strategic framework of AI deployment to achieve the SDGs; Develops and presents details of six distinct but related components of a novel Strategic Framework for developing and adopting AI – Vision, Strategy, Policy, Governance, Legislation/Regulations, and Implementation Matrix; Outlines specific ways that AI can be deployed to achieve each of the 17 SDGs and reviews seven countries’ experiences; Explores an innovative, forward-looking, and technology-driven framework for equitable global socio-economic transformation to succeed the SDGs post-2030.
Advances In Host Genetics And Microbiome In Colorectal Cancer Related Phenotypes
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Author :
language : en
Publisher: Elsevier
Release Date : 2024-10-11
Advances In Host Genetics And Microbiome In Colorectal Cancer Related Phenotypes written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-11 with Science categories.
Advances in Host Genetics and Microbiome in Colorectal Cancer-Related Phenotypes, Volume 112 in the Advances in Genetics series, highlights new advances in the field with this new volume presenting interesting chapters on topics such as What we need in colorectal cancer research, and why?, Host Genetics and Microbiota procedures in colorectal cancer research, Host Genetics-associated mechanisms in colorectal cancer, Microbiota-associated mechanisms in colorectal cancer, Inflammation regulation in colorectal cancer, Microbiota and detrimental protein metabolites in colorectal cancer, Microbiota and other detrimental metabolites in colorectal cancer, Microbiota and beneficial metabolites in colorectal cancer, and much more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Advances in Genetics series - Includes the latest information on new advancements in the study of genetics
Medical Ethics Prediction And Prognosis
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Author : Mariacarla Gadebusch Bondio
language : en
Publisher: Taylor & Francis
Release Date : 2017-04-21
Medical Ethics Prediction And Prognosis written by Mariacarla Gadebusch Bondio and has been published by Taylor & Francis this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-21 with Philosophy categories.
Recent scientific developments, in particular advances in pharmacogenetics and molecular genetics, have given rise to numerous predictive procedures for detecting predispositions to diseases in patients. This knowledge, however, does not necessarily promise benign results for either patients or health care professionals. The aim of this volume is to analyse issues related to prediction and prognosis as a burgeoning field of medicine, which is revolutionizing the way we understand and approach diagnosis and treatment. Combining epistemic and ethical reflection with medical expertise on contemporary practice and research, an interdisciplinary group of international experts critically examine anticipatory medicine from various perspectives, including history of medicine, bioethics, theories of science, and health economics. The highly complex issues involved in medical prediction call for a far-reaching debate on the value and scope of foreknowledge. For example, which responsibilities and burdens arise when still healthy people learn of their predisposition to diseases? How should health care insurance reflect risky life styles? Is the increasing medicalization of life connected with prevention ethically sustainable and financially possible in the developing world? These and other related issues are the subject of this timely and important book, which not only serves as an introduction to the area, but also proposes many feasible solutions to the problems outlined.