Principios Jur Dicos Impl Citos
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Translational Medicine
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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26
Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.
Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.
Italian Mathematics Between The Two World Wars
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Author : Angelo Guerraggio
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-01-20
Italian Mathematics Between The Two World Wars written by Angelo Guerraggio and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-01-20 with Mathematics categories.
This book describes Italian mathematics in the period between the two World Wars. It analyzes the development by focusing on both the interior and the external influences. Italian mathematics in that period was shaped by a colorful array of strong personalities who concentrated their efforts on a select number of fields and won international recognition and respect in an incredibly short time. Consequently, Italy was considered a third mathematical power after France and Germany.
Saracens
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Author : John Victor Tolan
language : en
Publisher: Columbia University Press
Release Date : 2002
Saracens written by John Victor Tolan and has been published by Columbia University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with History categories.
Medieval Christian writers distorted the teachings of Islam and caricatured its believers in a variety of ways. This book provides a comprehensive study of Christian polemical responses to Islam in the Middle Ages.
Reintroduction Biology
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Author : John G. Ewen
language : en
Publisher: John Wiley & Sons
Release Date : 2012-01-30
Reintroduction Biology written by John G. Ewen and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-30 with Science categories.
This book aims to further advance the field of reintroduction biology beyond the considerable progress made since the formation of the IUCN/SSC Re-introduction Specialist Group. Using an issue-based framework that purposely avoids a structure based on case studies the book's central theme is advocating a strategic approach to reintroduction where all actions are guided by explicit theoretical frameworks based on clearly defined objectives. Issues covered include husbandry and intensive management, monitoring, and genetic and health management. Although taxonomically neutral there is a recognised dominance of bird and mammal studies that reflects the published research in this field. The structure and content are designed for use by people wanting to bridge the research-management gap, such as conservation managers wanting to expand their thinking about reintroduction-related decisions, or researchers who seek to make useful applied contributions to reintroduction.
The Fortress Of Faith
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Author : Ana Echevarria
language : en
Publisher: BRILL
Release Date : 2023-08-21
The Fortress Of Faith written by Ana Echevarria and has been published by BRILL this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-08-21 with Architecture categories.
This study provides new fascinating testimonies about the development of a new image of Islam in Southern Europe in the fifteenth century and an approach to ways of acculturation in a mixed society.
Preclinical Safety Evaluation Of Biopharmaceuticals
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Author : Joy A. Cavagnaro
language : en
Publisher: John Wiley & Sons
Release Date : 2013-03-07
Preclinical Safety Evaluation Of Biopharmaceuticals written by Joy A. Cavagnaro and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-07 with Medical categories.
"The goal is to provide a comprehensive reference book for the preclinicaldiscovery and development scientist whose responsibilities span target identification, lead candidate selection, pharmacokinetics, pharmacology, and toxicology, and for regulatory scientists whose responsibilities include the evaluation of novel therapies." —From the Afterword by Anthony D. Dayan Proper preclinical safety evaluation can improve the predictive value, lessen the time and cost of launching new biopharmaceuticals, and speed potentially lifesaving drugs to market. This guide covers topics ranging from lead candidate selection to establishing proof of concept and toxicity testing to the selection of the first human doses. With chapters contributed by experts in their specific areas, Preclinical Safety Evaluation of Biopharmaceuticals: A Science-Based Approach to Facilitating Clinical Trials: Includes an overview of biopharmaceuticals with information on regulation and methods of production Discusses the principles of ICH S6 and their implementation in the U.S., Europe, and Japan Covers current practices in preclinical development and includes a comparison of safety assessments for small molecules with those for biopharmaceuticals Addresses all aspects of the preclinical evaluation process, including: the selection of relevant species; safety/toxicity endpoints; specific considerations based upon class; and practical considerations in the design, implementation, and analysis of biopharmaceuticals Covers transitioning from preclinical development to clinical trials This is a hands-on, straightforward reference for professionals involved in preclinical drug development, including scientists, toxicologists, project managers, consultants, and regulatory personnel.
Occupational Safety And Hygiene
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Author : Pedro Arezes
language : en
Publisher: CRC Press
Release Date : 2013-04-04
Occupational Safety And Hygiene written by Pedro Arezes and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-04 with Technology & Engineering categories.
Occupational Safety and Hygiene presents selected papers from the International Symposium on Occupational Safety and Hygiene – SHO2013 (Guimarães, Portugal, 14-15 February 2013), which was organized by the Portuguese Society for Occupational Safety and Hygiene (SPOSHO). The contributions from 15 different countries focus on: - Occupational safety - Risk assessment - Safety management - Ergonomics - Management systems - Environmental ergonomics - Physical environments - Construction safety - Human factors The papers included in the book are mainly based on research carried out at universities and other research institutions, but they are also based on practical studies developed by Occupational Health & Safety (OHS) practitioners within their companies. As a result, this book will be useful to get acquainted with the state-of-the-art of the research within the aforementioned domains, as well as with some practical tools and approaches that are currently used by OHS professionals worldwide.
Social Inclusion And Economic Development In Latin America
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Author : Mayra Buvinić
language : en
Publisher: IDB
Release Date : 2004
Social Inclusion And Economic Development In Latin America written by Mayra Buvinić and has been published by IDB this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Business & Economics categories.
Poverty and inequality in Latin America are easily recognizable in the faces of women, Afro-descendents, the indigenous, people with disabilities, victims of HIV/AIDS, and other groups outside the societal mainstream. Social Inclusion and Economic Development in Latin America reviews the common features of these excluded populations, including their invisibility in official statistics and the stigma, discrimination, and disadvantages they have long endured. But it also examines the region's inclusionary policies and programs that can improve access by these groups to the quality social services and economic and political resources these groups need to level the playing field. Case studies examine ethnic and racial political organization, gender quotas, and labor markets across the region, and social exclusion in Brazil, Honduras, Guatemala, Mexico, and Peru. Comparative studies summarize social inclusion policies of both the European Union and selected countries on the Continent.
The Social Dynamics Of Open Data
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Author : van Schalkwyk, Francois
language : en
Publisher: African Minds
Release Date : 2017-12-16
The Social Dynamics Of Open Data written by van Schalkwyk, Francois and has been published by African Minds this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-16 with Business & Economics categories.
The Social Dynamics of Open Data is a collection of peer reviewed papers presented at the 2nd Open Data Research Symposium (ODRS) held in Madrid, Spain, on 5 October 2016. Research is critical to developing a more rigorous and fine-combed analysis not only of why open data is valuable, but how it is valuable and under what specific conditions. The objective of the Open Data Research Symposium and the subsequent collection of chapters published here is to build such a stronger evidence base. This base is essential to understanding what open data’s impacts have been to date, and how positive impacts can be enabled and amplified. Consequently, common to the majority of chapters in this collection is the attempt by the authors to draw on existing scientific theories, and to apply them to open data to better explain the socially embedded dynamics that account for open data’s successes and failures in contributing to a more equitable and just society.
Ars Amatoria
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Author : Ovid
language : en
Publisher: Oxford University Press
Release Date : 1989
Ars Amatoria written by Ovid and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Literary Criticism categories.
Ovid's Ars Amatoria has met with astonishingly varied fortunes down the centuries. Ten years after publication the book became a reason, or more probably a pretext, for the author's banishment from Rome. It was removed from public libraries, and more recently the poem suffered a virtual embargo in schools and universities. This is the first detailed English commentary on any part of the poem. Examined afresh, it emerges as the wittiest of Ovid's love poems, turning upside down the attitudes and conventions of orthodox love elegy. The work is full of psychological insight and is richly embroidered with details of contemporary Roman social and political life. This new paperback edition intends to bring out the spirit of provocative frivolity which was undeniably meant to irritate Roman traditionalists. The text of Kenney's Oxford Classical Text is reproduced and supplemented with a full introduction to the style and historical background the poem, as well as with a full commentary and appendices.