Principles And Applications Of Asymmetric Synthesis
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Principles And Applications Of Asymmetric Synthesis
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Author : Guo-Qiang Lin
language : en
Publisher: John Wiley & Sons
Release Date : 2003-05-29
Principles And Applications Of Asymmetric Synthesis written by Guo-Qiang Lin and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-05-29 with Science categories.
Asymmetric synthesis remains a challenge to practicing scientistsas the need for enantiomerically pure or enriched compoundscontinues to increase. Over the last decade, a large amount ofliterature has been published in this field. Principles andApplications of Asymmetric Synthesis consolidates and evaluates themost useful methodologies into a one-volume resource for theconvenience of practicing scientists and students. Authored by internationally renowned scientists in the field, thisreliable reference covers more than 450 reactions and includesimportant stoichiometric as well as catalytic asymmetric reactions.The first chapter reviews the basic principles, commonnomenclature, and analytical methods, and the remainder of the bookis organized according to reaction type. The text examines suchtopics as: Carbon-carbon bond formations involving carbonyls, enamines,imines, and enolates Asymmetric C-O bond formations including epoxidation,dihydroxylation, and aminohydroxylation Asymmetric synthesis using the Diels-Alder reaction and othercyclizations Applications to the total synthesis of natural products Use of enzymes in asymmetric synthesis Practicing chemists in the pharmaceutical, fine chemical, andagricultural professions as well as graduate students will findthat Principles and Applications of Asymmetric Synthesis affordscomprehensive and current coverage.
Asymmetric Synthesis
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Author : Y. Vatsala
language : en
Publisher:
Release Date : 2015
Asymmetric Synthesis written by Y. Vatsala and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Asymmetric synthesis categories.
Deals with stereochemistry of specialised topics. This book provides a comprehensive account of concepts of Asymmetric Synthesis. It is based on three important principles: concepts and terminology used in asymmetric synthesis, the four types of asymmetric synthesis, and applications of asymmetric synthesis.
Principles Of Asymmetric Synthesis
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Author : R.E. Gawley
language : en
Publisher: Elsevier
Release Date : 1996-11-21
Principles Of Asymmetric Synthesis written by R.E. Gawley and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-11-21 with Science categories.
The world is chiral. Most of the molecules in it are chiral, and asymmetric synthesis is an important means by which enantiopure chiral molecules may be obtained for study and sale. Using examples from the literature of asymmetric synthesis (more than 1300 references), the aim of this book is to present a detailed analysis of the factors that govern stereoselectivity in organic reactions. It is important to note that the references were each individually checked by the authors to verify relevance to the topics under discussion. The study of stereoselectivity has evolved from issues of diastereoselectivity, through auxiliary-based methods for the synthesis of enantiomerically pure compounds (diastereoselectivity followed by separation and auxiliary cleavage), to asymmetric catalysis. In the latter instance, enantiomers (not diastereomers) are the products, and highly selective reactions and modern purification techniques allow preparation - in a single step - of chiral substances in 99% ee for many reaction types. After an explanation of the basic physical-organic principles of stereoselectivity, the authors provide a detailed, annotated glossary of stereochemical terms. A chapter on "Analytical Methods" provides a critical overview of the most common methods for analysis of stereoisomers. The authors then follow the 'tried-and-true' format of grouping the material by reaction type. Thus, there are four chapters on carbon-carbon bond forming reactions (enolate alkylations, organometal additions to carbonyls, aldol and Michael reactions, and cycloadditions and rearrangements), one chapter on reductions and hydroborations (carbon-hydrogen bond forming reactions), and one on oxidations (carbon-oxygen and carbon-nitrogen bond forming reactions). Leading references are provided to natural product synthesis that have been accomplished using a given reaction as a key step. In addition to tables of examples that show high selectivity, a transition state analysis is presented to explain - to the current level of understanding - the stereoselectivity of each reaction. In one case (Cram's rule) the evolution of the current theory is detailed from its first tentative (1952) postulate to the current Felkin-Anh-Heathcock formalism. For other reactions, only the currently accepted rationale is presented. Examination of these rationales also exposes the weaknesses of current theories, in that they cannot always explain the experimental observations. These shortcomings provide a challenge for future mechanistic investigations.
Principles Of Asymmetric Synthesis
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Author : Robert E. Gawley
language : en
Publisher: Elsevier
Release Date : 2012-07-16
Principles Of Asymmetric Synthesis written by Robert E. Gawley and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-07-16 with Science categories.
The world is chiral. Most of the molecules in it are chiral, and asymmetric synthesis is an important means by which enantiopure chiral molecules may be obtained for study and sale. The aim of this book is to present a detailed analysis of the factors that govern stereoselectivity in organic reactions.
Asymmetric Synthesis Of Natural Products
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Author : Ari M. P. Koskinen
language : en
Publisher: John Wiley & Sons
Release Date : 2022-11-30
Asymmetric Synthesis Of Natural Products written by Ari M. P. Koskinen and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-30 with Science categories.
Asymmetric Synthesis of Natural Products Fully updated learning resource covering the concept of using natural product chemistry for strategies in asymmetric synthesis The third edition of Asymmetric Synthesis of Natural Products introduces students to the rapidly growing field of natural products in organic chemistry, discussing the practical, mainly pharmacological, importance of selected compounds and emphasizing the target-oriented approach of organic synthesis which is key in industrial strategies. To aid in reader comprehension, the text includes key references and an Index of Compounds. The textbook is based on two lecture courses (Asymmetric Synthesis & Asymmetric Synthesis of Natural Products), which the author has delivered more than 50 times over the past 20 years in Finland, the UK, Italy, and Greece. This third edition is fully updated from the earlier versions (published by Wiley in 1993 and 2012). The importance of natural products as truly renewable raw materials in sustainable chemistry and circular economy is illustrated through applications of e.g. organocatalysis, organometallic catalysis, and biocatalysis. The contents consist of traditional text supplemented with illustrations (such as chemical drawings and structural formulae). Three dimensional aspects are also discussed with the use of 3D renderings of structures for both reaction mechanisms (molecular modeling) and crystallographic data. Sample topics covered in the textbook include: The foundations of asymmetric synthesis, including the theory and applications of individual asymmetric reactions Sustainable development, the circular economy, and use of renewable raw materials that have become prominent in many fields of science and technology Various natural product classes, including carbohydrates, amino acids, peptides, proteins, nucleosides, nucleotides, nucleic acids, and polyketides The properties of these natural product classes, including their structures, biosynthesis, and interrelationships, as well as examples of asymmetric syntheses and the practical value of these compounds Asymmetric Synthesis of Natural Products is a comprehensive, authoritative, and up-to-date learning resource on the subject for advanced level undergraduate or early-stage graduate students. It is also useful for specialists already working in synthesis who wish to learn about asymmetric synthesis.
Asymmetric Organo Metal Catalysis
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Author : Liu-Zhu Gong
language : en
Publisher: John Wiley & Sons
Release Date : 2022-03-14
Asymmetric Organo Metal Catalysis written by Liu-Zhu Gong and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-14 with Science categories.
Explore the latest advances involving organo/metal combined catalysts from leading contributors in the field In Asymmetric Organo-Metal Catalysis: Concepts, Principles, and Applications, accomplished chemist Liu-Zhu Gong delivers a comprehensive discussion of how to design efficient organo/metal combined catalyst systems, new cooperatively catalyzed asymmetric reactions, relay catalytic cascades, and multicomponent reactions. The distinguished author covers critical topics, like the combined catalysis of chiral phase transfer catalysts, enamine, iminium, nucleophilic Lewis base, or Bronsted acids with metal complexes, while also covering the cooperative catalysis of photocatalysts and organocatalysts. The book offers readers an exploration of the general concepts and principles of bond activation and reorganization, together with a comprehensive introduction to the historical developments and recent advances in the field. Readers will also benefit from the descriptions of new chemistry and new synthetic methods included within. Asymmetric Organo-Metal Catalysis also provides: Thorough introductions to chiral PTC-metal cooperative catalysis and enamine-metal cooperative catalysis Comprehensive explorations of iminum-metal relay catalysis and cooperative catalysis of bronsted acids and transition metals Practical discussions of metal-bronsted acid relay catalysis and Lewis base–Lewis acid cooperative catalysis In-depth examinations of Lewis base-transition metal cooperative catalysis and photocatalysis combined with organocatalysis Perfect for organic, catalytic, and pharmaceutical chemists, Asymmetric Organo-Metal Catalysis: Concepts, Principles, and Applications is also an invaluable resource for chemists working with or on organometallics.
Asymmetric Synthesis With Chemical And Biological Methods
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Author : Dieter Enders
language : en
Publisher: John Wiley & Sons
Release Date : 2007-06-27
Asymmetric Synthesis With Chemical And Biological Methods written by Dieter Enders and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-06-27 with Science categories.
Edited by two of the leading researchers in the field, this book provides a deep, interdisciplinary insight into stoichiometric and catalytic reactions in this continuously expanding area. A plethora of top German scientists with an international reputation covers various aspects, from classical organic chemistry to process development, and from the theoretical background to biological methods using enzymes. Throughout the focus is on the development of new synthetic methods in asymmetric synthesis, the synthesis of natural and bioactive compounds and the latest developments in both chemical and biological methods of catalysis, as well as the investigation of special technical and biotechnical aspects.
Dynamic Stereochemistry Of Chiral Compounds
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Author : Christian Wolf
language : en
Publisher: Royal Society of Chemistry
Release Date : 2008
Dynamic Stereochemistry Of Chiral Compounds written by Christian Wolf and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Education categories.
A comprehensive overview of fundamental concepts of asymmetric synthesis along with in-depth discussion. Recent developments that address important synthetic challenges are presented and highlighted with hundreds of examples.
Asymmetric Synthesis
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Author : Alan Aitken
language : en
Publisher: CRC Press
Release Date : 1992-12-30
Asymmetric Synthesis written by Alan Aitken and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-12-30 with Science categories.
Asymmetric synthesis is one of the most important areas of research and development in synthetic organic chemistry, and has wide-ranging industrial applications. This introduction to the subject covers chirality, nomenclature and analytical methods of resolution. The main body of the text describes the principal methods available to the organic chemist wishing to synthesize chiral compounds. Case studies are included, and reference sections allow access to the relevant review and research literature. This book is written for organic chemists at postgraduate and advanced undergraduate level.
Handbook Of Asymmetric Heterogeneous Catalysis
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Author : Kuiling Ding
language : en
Publisher: John Wiley & Sons
Release Date : 2008-09-08
Handbook Of Asymmetric Heterogeneous Catalysis written by Kuiling Ding and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-09-08 with Science categories.
In this most up-to-date handbook each chapter contains a general introduction, followed by the principles of the immobilization and, finally, applications. In this way, it covers the most important approaches currently employed for the heterogenization of chiral catalysts, including data tables, applications, reaction types and literature citations. For chemists in both academia and industry as well as those working in the fine chemical and pharmaceutical industry.