Principles And Methods For The Assessment Of Risk From Essential Trace Elements

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Principles And Methods For The Assessment Of Risk From Essential Trace Elements
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Author : Inter-Organization Programme for the Sound Management of Chemicals
language : en
Publisher: World Health Organization
Release Date : 2002-02
Principles And Methods For The Assessment Of Risk From Essential Trace Elements written by Inter-Organization Programme for the Sound Management of Chemicals and has been published by World Health Organization this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-02 with Medical categories.
The risk assessment approach described in this monograph applies only to essential trace elements (ETEs) involved in human health and not to non-essential elements. The purpose of this monograph is to provide the scientific principles that support the concept of an acceptable range of oral intake (AROI) which uses a homeostatic model for determining the range of dietary intakes for essential trace elements (ETEs) that meet the nutritional requirements of a healthy population and avoid excess intakes. To facilitate comparisons AROIs are discussed in relation to other risk assessment approaches. Although it includes examples this monograph is not a compendium of assessments on ETEs nor is it a textbook detailing the scientific basis of risk assessment of the derivation of dietary reference intakes. Described in the book is the process of risk assessment which begins with the selection of the database for a particular ETE. A weight-of-evidence approach is then used for hazard identification selecting relevant end-point of deficient and excess exposures. Next the probability of risk and the severity of various effects are quantified and critical effects are selected. The AROI is then established by balancing end-points of comparable health significance. At this time the exposure assessment is conducted. Finally a risk characterization enumerating the strengths and weaknesses of the databases is performed integrating the AROI and exposure assessment. ... The amount of work which is entailed in these volumes is very great and the low cost does not reflect the time of experts travelling nor even the hours expended UN staff in Geneva... This well informed book with its predecessors in the series is essential reading for biologists chemists and medical professionals concerned with essential trace elements. - The International Journal of Environmental Studies
Handbook On The Toxicology Of Metals Volume I General Considerations
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Author : Gunnar F. Nordberg
language : en
Publisher: Academic Press
Release Date : 2021-11-30
Handbook On The Toxicology Of Metals Volume I General Considerations written by Gunnar F. Nordberg and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-30 with Medical categories.
Handbook on the Toxicology of Metals, Fifth Edition, Volume I: General Considerations is the first volume of a two-volume work that gives an overview and covers topics of general importance including reviews of various health effects of trace metals. The book emphasizes toxic effects in humans, along with discussions on the toxic effects of animals and biological systems in vitro when relevant. The book has been systematically updated with the latest studies and advances in technology and contains several new chapters. As a multidisciplinary resource that integrates both human and environmental toxicology, the book is a comprehensive and valuable reference for toxicologists, physicians, pharmacologists, and environmental scientists in the fields of environmental, occupational and public health. - Contains peer-reviewed chapters that deal with the effects of metallic elements and their compounds on biological systems - Includes information on sources, transport and the transformation of metals in the environment - Covers the ecological effects of metals to provide a basis for better understanding of the potential for adverse effects on human health - Provides critical information on the properties, use, biological monitoring, dose-response relationships, diagnosis, treatment and prevention of metallic elements and compounds
Handbook On The Toxicology Of Metals
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Author : Gunnar F. Nordberg
language : en
Publisher: Academic Press
Release Date : 2014-08-07
Handbook On The Toxicology Of Metals written by Gunnar F. Nordberg and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-08-07 with Medical categories.
Handbook on the Toxicology of Metals, Fourth Edition bridges the gap between established knowledgebase and new advances in metal toxicology to provide one essential reference for all those involved in the field. This book provides comprehensive coverage of basic toxicological data, emphasizing toxic effects primarily in humans, but also those of animals and biological systems in vitro. The fourth edition also contains several new chapters on important topics such as nanotoxicology, metals in prosthetics and dental implants, gene-environment interaction, neurotoxicology, metals in food, renal, cardiovascular, and diabetes effects of metal exposures and more. Volume I covers “General Considerations and Volume II is devoted to “Specific Metals. A multidisciplinary resource with contributions from internationally-recognized experts, the fourth edition of the Handbook on the Toxicology of Metals is a prominent and indispensable reference for toxicologists, physicians, pharmacologists, engineers, and all those involved in the toxicity of metals. Contains 61 peer reviewed chapters dealing with the effects of metallic elements and their compounds on biological systems Includes information on sources, transport and transformation of metals in the environment and on certain aspects of the ecological effects of metals to provide a basis for better understanding of the potential for adverse effects on human health Covers the toxicology of metallic nanomaterials in a new comprehensive chapter Metal toxicology in developing countries is dealt with in another new chapter emphasizing the adverse effects on human health by the inadequate handling of "ewaste Other new chapters in the 4th edition include: Toxic metals in food; Toxicity of metals released from medical devices; Gene-environment interactions; Neurotoxicology of metals; Cardiovascular disease; Renal effects of exposure to metals; Gold and gold mining; Iridium; Lanthanum; Lithium and Rhodium
Cmbebih 2021
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Author : Almir Badnjevic
language : en
Publisher: Springer Nature
Release Date : 2021-05-31
Cmbebih 2021 written by Almir Badnjevic and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-31 with Technology & Engineering categories.
This book presents cutting-edge research and developments in the field of medical and biological engineering. It gathers the proceedings of the International Conference on Medical and Biological Engineering, CMBEBIH 2021, held partly virtually, partly physically, on April 21–24, 2021, from and in Mostar, Bosnia and Herzegovina. Focusing on the goal to ‘Stay Focused’, contributions report on both basic and applied research in a wide range of related fields, such as biomedical signal processing, medical physics and imaging, biosensors and micro/nanotechnologies, biomaterials, biomechanics and robotics, cardiorespiratory, endocrine and neural systems engineering. Novel models, methods and technologies for bio- and health informatics, as well as applications of machine learning and AI in health care, and advances in genetic engineering are also highlighted. All in all, this book provides academics and professionals with novel, practical solutions to solve the current problems in biomedical research and applications, and a source of inspiration for improving medicine and health care in the future.
Soil Quality Standards For Trace Elements
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Author : Graham Merrington
language : en
Publisher: CRC Press
Release Date : 2016-04-19
Soil Quality Standards For Trace Elements written by Graham Merrington and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-19 with Science categories.
A comprehensive and practical overview of the state of the science, Soil Quality Standards for Trace Elements: Derivation, Implementation, and Interpretation addresses the derivation of soil quality standards for trace elements and the implementation of these standards within regulatory and risk assessment frameworks. Forty experts from 11 countrie
Risk Assessment For Human Metal Exposures
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Author : Gunnar F. Nordberg
language : en
Publisher: Academic Press
Release Date : 2018-08-21
Risk Assessment For Human Metal Exposures written by Gunnar F. Nordberg and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-21 with Medical categories.
Risk Assessment for Human Metal Exposures: Mode of Action and Kinetic Approaches examines the current principles of risk assessment in human metal exposures, with a focus on Mode of Action(MOA), Toxicokinetic and Toxicodynamic (TKTD) considerations, and computer models. Derived from the highly respected Handbook on the Toxicology of Metals, Fourth Edition (2014), the book summarizes principles and methods and provides examples of how MOA –TKTD can be used. In addition, it presents tactics on how information generated by such methods can be confirmed by epidemiological data. Furthermore, it demonstrates how epidemiological data can be confirmed and evaluated by the examined models and considerations. This resource uniquely integrates several important topics, such as risk assessment, characterization, management and communication—the classic risk assessment paradigm—with mode of action, TKTD, and epidemiology, all topics related to human exposure. Written by pioneers in the field, this book is an essential reference for researchers, students and technicians in toxicology and risk assessment. Covers fundamental risk assessment concerns for the effects of metals on human health Provides an easy-to-use structure to quickly locate specific methods Uses case studies to illustrate the methods and theories described Written to be understood by students, researchers and industry workers who need to conduct risk assessment in metals and human health
The Development Of Dris 1994 2004
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2008-03-12
The Development Of Dris 1994 2004 written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-03-12 with Medical categories.
In what ways can the process for developing Dietary Reference Intakes (DRIs) be enhanced? The workshop entitled "The Development of DRIs 1994-2004: Lessons Learned and New Challenges" offered a valuable window into the issues and challenges inherent in the development of nutrient reference values. The dialogue-carried out under the auspices of the Institute of Medicine (IOM), Food and Nutrition Board (hereafter referred to jointly as the IOM)-was enriched by the 10 years of experience in deriving the expanded set of values known as the DRIs, plus the decades of experience that grounded the earlier Recommended Dietary Allowances for the United States and the Recommended Nutrient Intakes for Canada. The lessons learned and the knowledge gained will guide decisions about the next phase of the DRIs. To paraphrase one participant, we are now asking better questions. In 2006, the IOM, with support from the United States and Canadian governments, undertook an effort to synthesize the research needs identified during the 10 years of DRI development. While the workshop summarized here was predicated on the fact that the development of DRIs is improved by better data, its focus was different. Its goals were to examine the framework and conceptual underpinnings for developing DRIs and to identify issues important for enhancing the process of DRI development. The workshop was designed to use the existing framework for DRI development as a basis for the discussions and to consider the components of the framework in sequence. Consideration of the pros and cons of the current conceptual underpinnings of the framework opened the workshop, followed by the general "road map" for decision making and the needed scientific criteria. Next, the challenges associated with providing guidance for users were explored. The Development of DRIs 1994-2004: Lessons Learned and New Challenges: Workshop Summary explains an array of issues germane to the future process for developing DRIs, including strategies for updating and revising existing DRIs and opportunities for stakeholder input.
Risk Management Of Complex Inorganic Materials
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Author : Violaine Verougstraete
language : en
Publisher: Academic Press
Release Date : 2017-11-21
Risk Management Of Complex Inorganic Materials written by Violaine Verougstraete and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-21 with Medical categories.
Risk Management of Complex Inorganic Materials: A Practical Guide facilitates the risk assessment and management of complex inorganic materials around the world by providing accessible and specific guidance on their assessment. Inorganic complex materials, such as ores and concentrates, metal containing- glasses, ceramic and inorganic pigments, alloys, and UVCBs produced during the manufacturing of metals present specificities not addressed by most guidance documents. This book explains the main characteristics of inorganic complex materials affecting their hazard and risk assessment and management, including their source and main uses, also covering hazard and exposure assessment, risk characterization and risk management. It is an essential reference for regulators involved in risk assessment and risk management, industry experts charged of compliance with chemical management program requirements, consultants preparing chemicals management files for companies and regulators, and academics involved in research on complex inorganic materials. - Focuses on key information required to globally manage the risk of inorganic complex material - Includes user-friendly descriptions of methodologies and tools that facilitate chemicals management of such materials - Provides key messages to assist communication on risk assessment and risk management to audiences like regulators, workers and communities living around industrial sites
Who Human Health Risk Assessment Toolkit
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Author : World Health Organization
language : en
Publisher: World Health Organization
Release Date : 2021-09-30
Who Human Health Risk Assessment Toolkit written by World Health Organization and has been published by World Health Organization this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-30 with History categories.
Heavy Metals In The Environment
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Author : Bibudhendra Sarkar
language : en
Publisher: CRC Press
Release Date : 2002-03-21
Heavy Metals In The Environment written by Bibudhendra Sarkar and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-03-21 with Science categories.
This text presents contemporary analytical techniques for the determination of heavy metals in air particles, water, soil and biological samples. It details experimental studies to reduce the occurance of disease, remediate contaminated sites and establish acceptable range of oral intakes (AROI) guidelines.