Principles For Evaluating Health Risks To Reproduction Associated With Exposure To Chemicals
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Principles For Evaluating Health Risks To Reproduction Associated With Exposure To Chemicals
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Author : P. Foster
language : en
Publisher: World Health Organization
Release Date : 2001
Principles For Evaluating Health Risks To Reproduction Associated With Exposure To Chemicals written by P. Foster and has been published by World Health Organization this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Medical categories.
Intended as a tool for use by public health officials, research and regulatory scientists and risk managers, this publication seeks to provide a scientific framework for the use and interpretation of reproductive toxicity data from human and animal studies. It also discusses emerging methodology and testing strategy in reproductive toxicity. The text focuses on approaches to assessing reproductive toxicity in males and females, including sexual dysfunction and infertility, and many aspects of developmental toxicity (following both prenatal and postnatal exposure), from conception to sexual maturation. It is an overview of the major scientific principles underlying hazard identification, testing methods and risk assessment strategies in human reproductive toxicity. It also discusses the evaluation of reproductive toxicity data in the context of the extensive risk assessment methodology that has emerged over the past 10-15 years.
Principles For Evaluating Health Risks To Reproduction Associated With Exposure To Chemicals
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Author : [Anonymus AC06052079]
language : en
Publisher:
Release Date : 2006
Principles For Evaluating Health Risks To Reproduction Associated With Exposure To Chemicals written by [Anonymus AC06052079] and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.
Principles For Evaluating Health Risks To Progeny Associated With Exposure To Chemicals During Pregnancy
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Author : World Health Organization
language : en
Publisher:
Release Date : 1984
Principles For Evaluating Health Risks To Progeny Associated With Exposure To Chemicals During Pregnancy written by World Health Organization and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1984 with Abnormalities, Human categories.
Published under the International Programme for Chemical Safety (IPCS), a joint venture of UNEP, ILO and the WHO
Evaluating Chemical And Other Agent Exposures For Reproductive And Developmental Toxicity
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2001-04-13
Evaluating Chemical And Other Agent Exposures For Reproductive And Developmental Toxicity written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-04-13 with Nature categories.
The United States Navy has been concerned for some time with protecting its military and civilian personnel from reproductive and developmental hazards in the workplace. As part of its efforts to reduce or eliminate exposure of Naval personnel and their families to reproductive and developmental toxicants, the Navy requested that the National Research Council (NRC) recommend an approach that can be used to evaluate chemicals and physical agents for their potential to cause reproductive and developmental toxicity. The NRC assigned this project to the Committee on Toxicology, which convened the Subcommittee on Reproductive and Developmental Toxicology, to prepare this report. In this report, the subcommittee recommends an approach for evaluating agents for potential reproductive and developmental toxicity and demonstrates how that approach can be used by the Navy. This report has been reviewed in draft form by individuals chosen for their diverse perspectives and technical expertise, in accordance with procedures approved by the NRC's Report Review Committee. The purpose of this independent review is to provide candid and critical comments that will assist the institution in making its published report as sound as possible and to ensure that the report meets institutional standards for objectivity, evidence, and responsiveness to the study charge. The review comments and draft manuscript remain confidential to protect the integrity of the deliberative process. We wish to thank the following individuals for their review of this report: James Chen (National Center for Toxicological Research), George Daston (Procter and Gamble Company), Jerry Heindel (National Institute of Environmental Health Sciences), Grace Lemasters (University of Cincinnati), and John Young (National Center for Toxicological Research).
Principles For Evaluating Health Risks In Children Associated With Exposure To Chemicals
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Author : Germaine Buck Louis
language : en
Publisher: World Health Organization
Release Date : 2006
Principles For Evaluating Health Risks In Children Associated With Exposure To Chemicals written by Germaine Buck Louis and has been published by World Health Organization this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Medical categories.
Conclusions, and recommendations -- Introduction and background -- Unique biological characteristics of children -- Developmental stage-specific susceptibilities and outcomes in children -- Exposure assessment of children -- Methodologies to assess health outcomes in children -- Implications and strategies for risk assessment for children.
Who Human Health Risk Assessment Toolkit
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Author : World Health Organization
language : en
Publisher: World Health Organization
Release Date : 2021-09-30
Who Human Health Risk Assessment Toolkit written by World Health Organization and has been published by World Health Organization this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-30 with History categories.
Toxicological Risk Assessment Of Chemicals
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Author : Elsa Nielsen
language : en
Publisher: CRC Press
Release Date : 2008-02-21
Toxicological Risk Assessment Of Chemicals written by Elsa Nielsen and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-21 with Medical categories.
Unlike many existing books on toxicology that cover either toxicity of a particular substance or toxicity of chemicals on particular organ systems, Toxicological Risk Assessment of Chemicals: A Practical Guide lays out the principle activities of conducting a toxicological risk assessment, including international approaches and methods for the risk
Drinking Water And Health
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 1986-02-01
Drinking Water And Health written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986-02-01 with Nature categories.
The most recent volume in the Drinking Water and Health series contains the results of a two-part study on the toxicity of drinking water contaminants. The first part examines current practices in risk assessment, identifies new noncancerous toxic responses to chemicals found in drinking water, and discusses the use of pharmacokinetic data to estimate the delivered dose and response. The second part of the book provides risk assessments for 14 specific compounds, 9 presented here for the first time.
Review Of The Environmental Protection Agency S Draft Iris Assessment Of Formaldehyde
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2011-05-31
Review Of The Environmental Protection Agency S Draft Iris Assessment Of Formaldehyde written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-05-31 with Science categories.
Formaldehyde is ubiquitous in indoor and outdoor air, and everyone is exposed to formaldehyde at some concentration daily. Formaldehyde is used to produce a wide array of products, particularly building materials; it is emitted from many sources, including power plants, cars, gas and wood stoves, and cigarettes; it is a natural product in come foods; and it is naturally present in the human body as a metabolic intermediate. Much research has been conducted on the health effects of exposure to formaldehyde, including effects on the upper airway, where formaldehyde is deposited when inhaled, and effects on tissues distant from the site of initial contact. The U.S. Environmental Protection Agency (EPA) released noncancer and cancer assessments of formaldehyde for its Intergated Risk Information System (IRIS) in 1990 and 1991, respectively. The agency began reassessing formaldehyde in 1998 and released a draft IRIS assessment in June 2010. Given the complexity of the issues and the knowledge that the assessment will be used as the basis of regulatory decisions, EPA asked the National Research Council (NRC) to conduct an independent scientific review of the draft IRIS assessment. In this report, the Committee to Review EPA's Draft IRIS Assessment of Formaldehyde first addresses some general issues associated with the draft IRIS assessment. The committee next focuses on questions concerning specific aspects of the draft assessment, including derivation of the reference concentrations and the cancer unit risk estimates for formaldehyde. The committee closes with recommendations for improving the IRIS assessment of formaldehyde and provides some general comments on the IRIS development process.
Application Of Systematic Review Methods In An Overall Strategy For Evaluating Low Dose Toxicity From Endocrine Active Chemicals
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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2017-08-14
Application Of Systematic Review Methods In An Overall Strategy For Evaluating Low Dose Toxicity From Endocrine Active Chemicals written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-14 with Science categories.
To safeguard public health, the US Environmental Protection Agency (EPA) must keep abreast of new scientific information and emerging technologies so that it can apply them to regulatory decision-making. For decades the agency has dealt with questions about what animal-testing data to use to make predictions about human health hazards, how to perform dose-response extrapolations, how to identify and protect susceptible subpopulations, and how to address uncertainties. As alternatives to traditional toxicity testing have emerged, the agency has been faced with additional questions about how to incorporate data from such tests into its chemical assessments and whether such tests can replace some traditional testing methods. Endocrine active chemicals (EACs) have raised concerns that traditional toxicity-testing protocols might be inadequate to identify all potential hazards to human health because they have the ability to modulate normal hormone function, and small alterations in hormone concentrations, particularly during sensitive life stages, can have lasting and significant effects. To address concerns about potential human health effects from EACs at low doses, this report develops a strategy to evaluate the evidence for such low-dose effects.