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Principles Of Toxicology Testing

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Principles Of Toxicology Testing

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Author : Frank A. Barile
language : en
Publisher: CRC Press
Release Date : 2007-07-23

Principles Of Toxicology Testing written by Frank A. Barile and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-07-23 with Medical categories.

The evolution of toxicology testing finds its impetus in the continuing growth of the chemical and pharmaceutical industries, as well as the awareness of public health initiatives, needs, and responses that demand faster, more accurate, more economical methods for screening potential toxicity. Concurrent advances in biotechnology enable viable in v

Principles Of Toxicology Testing

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Author : Frank A Barile
language : en
Publisher: CRC Press
Release Date : 2013-04-02

Principles Of Toxicology Testing written by Frank A Barile and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-02 with Medical categories.

Principles Of Toxicology Testing Second Edition

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Author : Frank A Barile
language : en
Publisher: CRC Press
Release Date : 2013-04-02

Principles Of Toxicology Testing Second Edition written by Frank A Barile and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-02 with Medical categories.

Nationally, toxicology programs have evolved from a traditional exploration of the chemistry and applied toxicity of chemicals and drugs to a more comprehensive study of toxicology and toxicology testing as independent entities. Consequently, the second edition of Principles of Toxicology Testing starts with basic toxicological principles, including absorption, distribution, metabolism, and elimination of toxins, including chemicals and drugs. The book then continues with animal (in vivo) and in vitro toxicology testing methods associated with toxicological analysis and preclinical drug development. As in the first edition, the book begins with an introduction into the fundamentals of toxicology (Section I) to prepare readers for the subsequent topics and continues through with a discussion of toxicokinetics and human risk assessment. This introductory material is useful in understanding the applications of toxicology testing. Section II describes the fundamental principles of toxicology testing in animals in greater detail. This section describes acute toxicity studies as well as subchronic and chronic studies performed on animals. Special emphasis is placed on study design and determination of classical indicators for acute and chronic testing, such as the LD50. The book examines other short- and long-term animal toxicity testing methodologies, including dermal, ocular, and reproductive toxicity testing. In addition, mutagenicity and carcinogenicity studies are also discussed in separate chapters. Section III introduces and discusses in vitro alternatives to animal toxicology tests. This section emphasizes cell culture methodology and cellular methods for acute systemic toxicity, target organ toxicity, and local toxicity. The contributors present the advantages and disadvantages of alternative methods. They also describe the use of high-throughput screening and its applications, the concepts of standardization and validation of in vitro techniques (especially large, organized validation efforts currently supported by US and EU regulatory agencies), and the theories supporting the development of in vitro methodologies. This second edition is a must-read for undergraduate and graduate toxicology students. Industrial and academic research centers will also find the text useful for establishing a toxicology testing laboratory.

Principles Of Toxicology Second Edition

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Author : Stine Karen
language : en
Publisher: CRC Press
Release Date : 2006-01-24

Principles Of Toxicology Second Edition written by Stine Karen and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-01-24 with Medical categories.

Written by two experienced toxicology lecturers, Principles of Toxicology provides a broad-based yet in-depth introduction to this diverse subject. Comprehensive and easy-to-read, the book covers this broad and interdisciplinary field from the viewpoint of three different functional levels: molecular and cellular; physiological; and ecological and environmental. This revised second edition expands the coverage of the book while keeping the organizational format that made the first edition a bestseller. It also includes a series of brief case studies illustrating the application of toxicological principles to current issues of interest. Each and every chapter has been revised, several have been significantly rewritten, and three are entirely new. This new edition retains the extensive cross-referencing system that links all sections and enhances the integration of material. It also includes an appendix of selected toxicants that describes chemical structure and category of use. These features combine to make finding specific information quick and easy. The highly readable format and uniform, consistent presentation of information will make this the most used reference on your shelf. See what's new in the second edition:

Principles Of Forensic Toxicology

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Author : Barry Levine
language : en
Publisher: Amer. Assoc. for Clinical Chemistry
Release Date : 2003

Principles Of Forensic Toxicology written by Barry Levine and has been published by Amer. Assoc. for Clinical Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Law categories.

Principles Of Toxicology

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Author : Stine Karen
language : en
Publisher: CRC Press
Release Date : 2006-01-24

Principles Of Toxicology written by Stine Karen and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-01-24 with Medical categories.

Practical Toxicology

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Author : David Woolley
language : en
Publisher: CRC Press
Release Date : 2017-03-16

Practical Toxicology written by David Woolley and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-16 with Medical categories.

Practical Toxicology: Evaluation, Prediction, and Risk, Third Edition shows how to conduct a program of safety evaluation and testing and then to interpret and apply the resulting data and information in the real world, beginning with the basic concepts in toxicology and progressing to the interpretation of the resulting data. Revised and updated chapters on risk assessment guide the reader to setting the foundations necessary for submission to regulatory authorities. In addition, a new chapter in the book reviews the errors in toxicology, mistakes, misuse, mismanagement, and misunderstanding with a view to avoiding these in the future. New Chapters in the Third Edition: Toxicology in silico Errors in Toxicology Safety Assessment of Extractables and Leachables. This new edition follows a practical sequence from introducing the basics of toxicology (including the vital concept of normality in controls) to describing a test program and then interpreting the data and translating that to risk assessment that can be used in a number of real world situations where safety and secure risk assessment are essential. Although written primarily from the perspective of pharmaceutical development, the test designs and toxicological problems encountered in that field are entirely relevant to those with other classes of chemicals, the only difference being the regulatory context. Toxicology is an international discipline and the book has been written to take into account some of the differences in regulatory nuance between the main regions of the world. Completely revised and written in an easily accessible style, the text address several audiences—from students and post-graduates coming to the subject for the first time to established professionals who find themselves needing to learn about toxicology, toxicity testing, interpretation of the results, and risk assessment. It is intended primarily as a textbook, with case studies and information on where to go to ask questions, but can also be used as a practical reference book. It covers all the basics of toxicology and the main aspects of safety evaluation testing and risk assessment while reviewing critically the current state of the discipline. It also provides a foundation for those seeking registration or certification.

Principles Of Toxicology

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Author : Karen E. Stine
language : en
Publisher: CRC Press
Release Date : 2015-04-17

Principles Of Toxicology written by Karen E. Stine and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-17 with Medical categories.

Reflecting the broad and interdisciplinary nature of toxicology, this third edition of Principles of Toxicology explores the biochemical, physiological, and environmental aspects of the subject.This new edition is updated and revised to include reference to several major new directions in the science of toxicology, including significant changes in

Principles Of Environmental Toxicology

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Author : I. Shaw
language : en
Publisher: CRC Press
Release Date : 1998-04-08

Principles Of Environmental Toxicology written by I. Shaw and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-04-08 with Science categories.

Environmental toxicology is the study of the action of chemicals upon ecosystems. Understanding the effects of exogenous chemicals upon the inhabitants of an ecosystem may enable us to predict and possibly prevent their deleterious effects. This textbook provides a good general introduction to all the major areas of environmental toxicology, including the fate of chemicals in the environment, environmental toxicity testing, risk assessment, radioactivity in the environment, legislation, environmental monitoring and the future impact of industrial development on the environment. It is written in an informal, accessible style with many examples of environmental issues taken from the author's personal experience and will provide students and other interested individuals with a broad overview of the science of environmental toxicology.

Fundamentals Of Analytical Toxicology

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Author : Robert J. Flanagan
language : en
Publisher: John Wiley & Sons
Release Date : 2008-03-03

Fundamentals Of Analytical Toxicology written by Robert J. Flanagan and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-03-03 with Science categories.

The analytical toxicologist may be required to detect, identify, and in many cases measure a wide variety of compounds in samples from almost any part of the body or in related materials such as residues in syringes or in soil. This book gives principles and practical information on the analysis of drugs and poisons in biological specimens, particularly clinical and forensic specimens. After providing some background information the book covers aspects of sample collection, transport, storage and disposal, and sample preparation. Analytical techniques - colour tests and spectrophotometry, chromatography and electrophoresis, mass spectrometry, and immunoassay – are covered in depth, and a chapter is devoted to the analysis of trace elements and toxic metals. General aspects of method implementation/validation and laboratory operation are detailed, as is the role of the toxicology laboratory in validating and monitoring the performance of point of care testing (POCT) devices. The book concludes with reviews of xenobiotic absorption, distribution and metabolism, pharmacokinetics, and general aspects of the interpretation of analytical toxicology results. A clearly written, practical, integrated approach to the basics of analytical toxicology. Focuses on analytical, statistical and pharmacokinetic principles rather than detailed applications. Assumes only a basic knowledge of analytical chemistry. An accompanying website provides additional material and links to related sites. Written by an experienced team of authors,Fundamentals of Analytical Toxicology is an invaluable resource for those starting out in a career in analytical toxicology across a wide range of disciplines including clinical and forensic science, food safety, and pharmaceutical development. Praise from the reviews: “This is an ambitious effort to describe in detail the many and varied aspects of the science of toxicological analysis. The 17 chapters cover every foreseeable aspect, from specimen collection through analytical techniques and quality control to pharmacological principles and interpretation of results. The authors bring together a great deal of experience in the field and have succeeded admirably in achieving their goal: "to give principles and practical information on the analysis of drugs, poisons and other relevant analytes in biological specimens...". The book is very readable and quite up-to-date, and contains many illustrative figures, charts and tables. Both the student and the practicing professional would do well to study this material carefully, as there is something here for every conceivable level of interest.” Review from Randall Baselt "This text comes highly recommended for any analytical toxicology trainee." The Bulletin of the Royal College of Pathologists “Overall, this book provides a comprehensive, thorough, clear, up to date and practical treatment of analytical toxicology at a high standard. Understanding of the text is enhanced by the use of many illustrations. Specifications, guidelines, and methods are highlighted in grey background “Boxes”. The many and up to date literature references in each chapter demonstrate the authors’ thorough work and permit easy access to deeper information. Therefore this book can be highly recommended as a valuable source of knowledge in analytical toxicology both as an introduction and for the advanced reader.” GTFCh Bulletin “Toxichem + Krimtech”, May 2008 (translated, original review in German) “Many toxicologists will add this important reference to their libraries because it competently fills a need ...” International Journal of Toxicology “The book is very well illustrated, easy to understand and pleasant to read, and contains a wealth of dedicated information.” International Journal of Environmental Analytical Chemistry

Principles Of Toxicology Testing

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