Prion Phenomena In Neurodegenerative Diseases
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Prion Phenomena In Neurodegenerative Diseases
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Author : Giuseppe Legname
language : en
Publisher:
Release Date : 2015
Prion Phenomena In Neurodegenerative Diseases written by Giuseppe Legname and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Nervous system categories.
The most fascinating and unique feature of prion diseases is that they are caused almost exclusively by a proteinaceous and infectious particle termed prions by the Nobel Prize laureate S B Prusiner, who discovered this class of pathogens. In the latter part of the 1990s, mad-cow disease, a disease caused by prions acquired through foodborne transmission, raised unprecedented public concern due to the concrete possibility that prions in animals could be transmitted to humans through the food chain. For roughly two decades, prions were under intense scrutiny and many studies were undertaken worldwide. These investigations have led our community to a better risk assessment and management of prion diseases in humans and in animals, substantially limiting the possibility of new prion epidemics. Nowadays, prions have been brought once again to the foreground after the discovery that a variety of neurodegenerative diseases, in particular Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis, share fundamental features with prions, including protein misfolding and aggregation in the brain, cell-to-cell transmission and in vivo infectivity. Therefore, studying prions might help to understand the pathological mechanism of these disorders. The Prion Phenomena In Neurodegenerative Diseases: New Frontiers in Neuroscience is a book that benefits from the contribution of leading scientists in different fields of neuroscience, including Gianluigi Zanusso, Holger Wille, Fabrizio Tagliavini, Andrew F Hill, Jerson L Silva, Vladimir N Uversky, Henrike Heise, David W Colby, Neil R Cashman and the Nobel Prize laureate Eric R Kandel. This chapter collection discusses the development of prions and their various diseases, and provides a detailed overview about the state of the art of the novel prion phenomena observed in other fatally damaging protein misfolding disorders. This book represents an up-to-date review of different protein-misfolding diseases, serving as an invaluable tool for both specialized researchers working in the field of neurodegeneration and for a broad spectrum of academic readers that wish to learn more about the prion phenomena.
Prions And Neurodegenerative Diseases
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Author :
language : en
Publisher: Academic Press
Release Date : 2020-09-19
Prions And Neurodegenerative Diseases written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-19 with Science categories.
Prions and Neurodegenerative Diseases, Volume 172, in the Progress in Molecular Biology and Translational Science series, provides the most topical, informative and exciting monographs available on a wide variety of research topics. The series includes in-depth knowledge on the molecular biological aspects of organismal physiology, with this release including chapters on Cell-free amplification of prions: where do we stand? Transgenic mouse models for the study of prion diseases and much more. Includes comprehensive coverage of molecular biology Presents ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided Contains contributions from renowned experts in the field Includes comprehensive coverage of molecular biology Presents ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided Contains contributions from renowned experts in the field
Human Prion Diseases
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Author :
language : en
Publisher: Elsevier
Release Date : 2018-06-07
Human Prion Diseases written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-07 with Medical categories.
Human Prion Diseases, Volume 153 is designed to update the reader on the latest advances and clinical aspects of prion diseases. The book is organized into five sections, including the pathophysiology of prions and a description of animal and human diseases. This is followed by detailed reports on recent advances in diagnosis strategies for the development of novel anti-prion molecules and possible designs of clinical trials in such a rare disease. An introductory chapter gives an extensive historical background of prion research, with a final chapter highlighting recent progress, and more importantly, unsolved problems. Offers an authoritative overview of prion diseases in humans, detailing the pathogenesis of the disease, clinical investigations, and the diagnosis of both the genetic and acquired forms Provides clarity and context by presenting prion diseases in relation to other neurodegenerative diseases in humans Emphasizes the unique properties of prion diseases and consequent problems they can cause, both clinically and in public health terms
Prions Neurodegenerative Disease
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Author : Gregg Books
language : en
Publisher:
Release Date : 2020-10-17
Prions Neurodegenerative Disease written by Gregg Books and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-17 with categories.
Prions provides a unique perspective of the recenetly identified infectious agent. Prions are proven to be the cause of many different diseases both in humans and animals. The topic is a hot topic in modern-day science. Scientists seemingly cannot agree whether or not prions cause other very common neurodegenerative diseases such as Alzheimer's, ALS, Parkinson's, and countless others. Excluding the controversy, other topics found inside the book include: ★ History of Prion Diseases ★ Cause of Prion Diseases ★ Genetics (Risk-Factors) Associated w/ Prion Diseases ★ Symptoms of Prion Diseases ★ Potential ways to prevent Prion Diseases ★ Treatment options available for Prion Diseases The idiosyncrasy of the material is the inclusion of prestigious researcher opinions on prions and their potential role in the cause of individual neurodegenerative disease. Prions are self-infectious proteins proven to be the agent responsible for causing prion diseases. The recent discovery of prions in 1982 has sparked controversy inside the research field of neurodegenerative disease.
Metal Ions And Neurodegenerative Disorders
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Author : Paolo Zatta
language : en
Publisher: World Scientific
Release Date : 2003
Metal Ions And Neurodegenerative Disorders written by Paolo Zatta and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Medical categories.
Numerous studies have established a clear connection between neuronal oxidative stress and several neurodegenerative diseases, with consequential damages to lipids, proteins, nucleic acids, etc. In addition, several modifications indicative of oxidative stress have been described in association with neurons, neurofibrillary tangles and senile plaques in Alzheimer''s disease, including advanced glycation end products and free carbonyl oxidation. Oxidative damage and antioxidant responses are now well characterized, but sources of damaging free radicals are yet to be fully understood. Evidences of alteration in metal ions metabolism have been reported in various diseases like Alzheimer''s, Wilson, Menkes, Prion, Pick, Huntington disease, epilepsy and other pathological events. Thus, metal ions play a pivotal role in neurodegenerative phenomena. Chelation therapy is still in the early days of its development, but research in this area could lead to new products that could revolutionize treatment. Two international conferences on OC Metals and the Brain: From Neurochemistry to NeurodegenerationOCO (Padova, Italy, 2000 and Fez, Morocco, 2002) were recently held to discuss the role of metal ions in neurophysiopathology. A third will be held in 2005 in Johannesburg, South Africa. This book follows the same train of thought as those conferences, in order to highlight the unquestionable importance of metal ions in the research on the neurophysiopathology of neurodegenerative diseases. The excellent reputation of the scientists who have contributed to this project ensures the quality of the chapters presented here, and hopefully this will help spur new research initiatives in the field, which is still in its infancy. Contents: Metal-Catalyzed Redox Activity in Neurodegenerative Disease (M A Taddeo et al.); Aluminum and Central Nervous System Morphology in Hemodialysis (E Reusche); Transition Metals, Oxidation, Lipoproteins, and Amyloid-: Major Players in Alzheimer''s Disease (A Kontush); Molecular Basis of Copper Transport: Cellular and Physiological Functions of Menkes and Wilson Disease Proteins (ATP7A and ATP7B) (D R Kramer et al.); Copper-Zinc Superoxide Dismutase and Familial Amyotrophic Lateral Sclerosis (M B Yim et al.); Copper and Prion Disease (J Sasson & D Brown); Metallothioneins in Neurodegeneration (M Aschner et al.); Iron and Neurodegeneration (S L Grab & J R Connor); Iron, Neuromelanin, and -Synuclein in Neuropathogenesis of Parkinson''s Disease (K L Double et al.); Iron and Epilepsy (W-Y Ong et al.); Role of Iron Metabolism in Multiple Sclerosis (M J Kotze et al.); Neuroprotective Effects of Lithium (S Ermidiou-Pollet & S Pollet); and other articles. Readership: Academics, graduate students and researchers in neurology, psychiatry, neuroscience and environmental health."
Prion Diseases
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Author : Stanley B. Prusiner
language : en
Publisher:
Release Date : 2017
Prion Diseases written by Stanley B. Prusiner and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with MEDICAL categories.
Diseases such as Creutzfeldt-Jakob disease and kuru develop when PrP proteins form prions by misfolding, clumping together, and spreading from cell to cell. Over the past decade, a number of proteins have been reported to possess the characteristics of PrP prions. A growing collection of disorders has been found to be caused by prions; some of these prion diseases include such devastating illnesses as Alzheimer's and Parkinson's and possibly type 2 diabetes. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers the progress that has recently been made in our understanding of the pathophysiology of prion diseases, as well as ongoing efforts to develop effective therapeutics. The contributors discuss how proteins such as tau, islet amyloid polypeptide, and alpha-synuclein adopt alternative shapes that lead them to aggregate, resulting in cellular degeneration. Therapies for human and animal diseases caused by prions are also covered. This volume is therefore useful for all biomedical scientists and physicians wishing to understand and treat this expanding group of devastating disorders.
Proteopathic Seeds And Neurodegenerative Diseases
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Author : Mathias Jucker
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-27
Proteopathic Seeds And Neurodegenerative Diseases written by Mathias Jucker and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-27 with Medical categories.
The misfolding and aggregation of specific proteins is an early and obligatory event in many of the age-related neurodegenerative diseases of humans. The initial cause of this pathogenic cascade and the means whereby disease spreads through the nervous system, remain uncertain. A recent surge of research, first instigated by pathologic similarities between prion disease and Alzheimer’s disease, increasingly implicates the conversion of disease-specific proteins into an aggregate-prone b-sheet-rich state as the prime mover of the neurodegenerative process. This prion-like corruptive protein templating or seeding now characterizes such clinically and etiologically diverse neurological disorders as Alzheimer ́s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and frontotemporal lobar degeneration. Understanding the misfolding, aggregation, trafficking and pathogenicity of the affected proteins could therefore reveal universal pathomechanistic principles for some of the most devastating and intractable human brain disorders. It is time to accept that the prion concept is no longer confined to prionoses but is a promising concept for the understanding and treatment of a remarkable variety of diseases that afflict primarily our aging society.
Metal Ions And Neurodengenerative Disorders
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Author : Paolo Zatta
language : en
Publisher: World Scientific
Release Date : 2003-11-03
Metal Ions And Neurodengenerative Disorders written by Paolo Zatta and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-11-03 with Medical categories.
Numerous studies have established a clear connection between neuronal oxidative stress and several neurodegenerative diseases, with consequential damages to lipids, proteins, nucleic acids, etc. In addition, several modifications indicative of oxidative stress have been described in association with neurons, neurofibrillary tangles and senile plaques in Alzheimer's disease, including advanced glycation end products and free carbonyl oxidation.Oxidative damage and antioxidant responses are now well characterized, but sources of damaging free radicals are yet to be fully understood. Evidences of alteration in metal ions metabolism have been reported in various diseases like Alzheimer's, Wilson, Menkes, Prion, Pick, Huntington disease, epilepsy and other pathological events. Thus, metal ions play a pivotal role in neurodegenerative phenomena.Chelation therapy is still in the early days of its development, but research in this area could lead to new products that could revolutionize treatment. Two international conferences on “Metals and the Brain: From Neurochemistry to Neurodegeneration” (Padova, Italy, 2000 and Fez, Morocco, 2002) were recently held to discuss the role of metal ions in neurophysiopathology. A third will be held in 2005 in Johannesburg, South Africa.This book follows the same train of thought as those conferences, in order to highlight the unquestionable importance of metal ions in the research on the neurophysiopathology of neurodegenerative diseases. The excellent reputation of the scientists who have contributed to this project ensures the quality of the chapters presented here, and hopefully this will help spur new research initiatives in the field, which is still in its infancy.
Prions
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Author : Ivo Nikolaev Sirakov
language : en
Publisher: BoD – Books on Demand
Release Date : 2019-01-30
Prions written by Ivo Nikolaev Sirakov and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-30 with Medical categories.
The cellular prion protein (PrPC) is expressed as a cell surface protein mainly in the central and peripheral nervous system. The discovery that prions are infectious agents changed the concept of protein synthesis in modern biology and built a bridge between the genesis of infectious and genetic diseases. This book discusses the normal function of the PrPC and its modulatory role in synaptic mechanisms. It describes the pathophysiological processes that accompany TSE - neurotoxicity, loss of anti-inflammatory protective function, neuronal death including prion-induced autophagy and apoptosis, and accumulation of PrPSc in the cytoplasm of neurons. Another aspect outlined here is that some prion diseases show strain variations that determine their development, demonstrating their key role in the development and progression of TSE.
Advanced Understanding Of Neurodegenerative Diseases
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Author : Raymond Chuen-Chung Chang
language : en
Publisher: BoD – Books on Demand
Release Date : 2011-12-16
Advanced Understanding Of Neurodegenerative Diseases written by Raymond Chuen-Chung Chang and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-12-16 with Medical categories.
Advanced Understanding of Neurodegenerative Diseases focuses on different types of diseases, including Alzheimer's disease, frontotemporal dementia, different tauopathies, Parkinson's disease, prion disease, motor neuron diseases such as multiple sclerosis and spinal muscular atrophy. This book provides a clear explanation of different neurodegenerative diseases with new concepts of understand the etiology, pathological mechanisms, drug screening methodology and new therapeutic interventions. Other chapters discuss how hormones and health food supplements affect disease progression of neurodegenerative diseases. From a more technical point of view, some chapters deal with the aggregation of prion proteins in prion diseases. An additional chapter to discuss application of stem cells. This book is suitable for different readers: college students can use it as a textbook; researchers in academic institutions and pharmaceutical companies can take it as updated research information; health care professionals can take it as a reference book, even patients' families, relatives and friends can take it as a good basis to understand neurodegenerative diseases.
