Prions And Prion Diseases
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Prions And Diseases
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Author : Wen-Quan Zou
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-11-08
Prions And Diseases written by Wen-Quan Zou and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-08 with Medical categories.
Volume II features a variety of animal and human prion diseases, including the newly-identified atypical forms of bovine spongiform encephalopathy and scrapie in animals, and variably protease-sensitive prionopathy in humans, prions in the environment, Tau pathology in human prion disease, transmission of the disease by blood transfusion, mammalian and non-mammalian models, conventional and advanced diagnoses, prion-specific antibodies, as well as decontamination of prions and development of therapeutics of prion diseases, such as the application of immunomodulation. This volume provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the highly publicized animal and human prion diseases.
Prions And Diseases
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Author : Wen-Quan Zou
language : en
Publisher: Springer Nature
Release Date : 2023-01-01
Prions And Diseases written by Wen-Quan Zou and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-01 with Medical categories.
Transmissible spongiform encephalopathies (TSE), known as prion diseases, have been recognized for nearly 300 years in animals and almost 100 years in humans. Modern studies, including the protein-misfolding cyclic amplification (PMCA), have greatly advanced our understanding of the pathogenesis of prion diseases and facilitated the identification of new prion diseases in animals and humans. In the second edition of Prions and Diseases, more than 60 leading researchers and clinicians worldwide provide an up-to-date discussion of these unique infectious pathogens and their associated diseases. The book provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the full range of animal and human prion diseases. As a result, the book contains by far the most authoritative views about the past, present, and future of prions and prion diseases. The new second edition covers such important emerging topics such as inherited human prion disease, stem-cell models in prion research, human prion disease surveillance, and gene therapy strategies.
Prions And Prion Diseases
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Author : Glenn C. Telling
language : en
Publisher: Taylor & Francis
Release Date : 2004
Prions And Prion Diseases written by Glenn C. Telling and has been published by Taylor & Francis this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Science categories.
Research into prions and prion diseases has progressed at a rapid pace in recent years, and has shed new light on areas such as transmissible spongiform encephalopathies. Telling (Center on Aging, University of Kentucky) provides an overview of the pathogenesis, molecular biology, biochemistry, cellular biology, animal models, and immunology of prions, for researchers working in microbiology, molecular biology, and biochemistry, and for those in pharmaceutical and biotechnology companies. Specific topics include the prion protein in cell culture, binding and conversion reactions between prion protein isoforms, PrP deletion mutants, and targeting the murine PrP gene. Other subjects are transgenic mouse models of prion diseases, peripheral pathogenesis, and immunological advances in prion diseases.
Prion Diseases Of Humans And Animals
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Author : Stanley B. Prusiner
language : en
Publisher: Prentice Hall
Release Date : 1992
Prion Diseases Of Humans And Animals written by Stanley B. Prusiner and has been published by Prentice Hall this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Medical categories.
Prions And Diseases
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Author : Wen-Quan Zou
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-11-27
Prions And Diseases written by Wen-Quan Zou and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-27 with Medical categories.
Volume I highlights the association of the cellular prion protein (PrPC) with copper and zinc, the potential roles of PrPC in Alzheimer’s disease and cancers, insoluble PrPC, PMCA, molecular and cellular mechanisms of PrPSc formation and clearance, possible co-factors involved in the conversion of PrPC into PrPSc, infectious and pathogenic forms of PrP, cell biology of prions, prion strains and their interference, as well as yeast prions and their inheritable and structural traits. This unique volume will take you through the fascinating chronicle of prions in mammals, yeast, and fungi.
Prions In Humans And Animals
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Author : Beat Hörnlimann
language : en
Publisher: Walter de Gruyter
Release Date : 2009-05-08
Prions In Humans And Animals written by Beat Hörnlimann and has been published by Walter de Gruyter this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-05-08 with Medical categories.
This comprehensive work, aimed at both students and researchers alike, systematically covers all aspects of prion diseases (transmissible spongiform encephalopathies), from their history, microbiology and pathology to their transmissibility and prevention. The book describes diseases such as Creutzfeldt-Jakob disease, kuru, mad cow disease (BSE), chronic wasting disease and scrapie, highlighting their biochemical, molecular biological, genetic, and clinical aspects. A detailed presentation of the impact of prion diseases in fields such as pharmaceutics, blood products, disinfection, surgical instruments and epidemiology concludes with a discussion of preventive measures. A renowned editorial team, representing the fields of medicine, veterinary medicine and molecular biology, brought together 80 internationally respected authors for this translation and new edition of the successful German publication, not only from relevant research fields, but also from industry and public health institutions. The book includes chapters by, among many other notable scientists, William J. Hadlow, who discovered the relationship between the human and animal forms of prion diseases and Michael P. Alpers, with 45 years of experience in Papua New Guinea investigating the first known human epidemic form, kuru, transmitted by endocannibalism. Further contributions from Gerald A. H. Wells, a veterinary pathologist who described BSE and recognised its similarity to scrapie, thus recording the first cases in 1986 of the most important animal epidemic of modern times, and Robert G. Will, a medical neurologist and epidemiologist who discovered the emergence of the variant form of Creutzfeldt-Jakob disease in 1996, underscore the strength of this author team. Carefully edited with numerous illustrations, this work offers a systematic approach committed to a clear presentation of the current knowledge of prion diseases. It aims to inspire and stimulate interdisciplinary cooperation, innovative research ideas and effective prevention.
Prions And Prion Diseases
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Author : Jean-Michel Verdier
language : en
Publisher: Nova Science Publishers
Release Date : 2012
Prions And Prion Diseases written by Jean-Michel Verdier and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Medical categories.
Prions, probably the most fascinating proteins ever studied, have been in the spotlight for the last 30 years. However, their history is much older. Indeed, the symptoms of what are now known as prion diseases were first described in Europe in sheep in 1730 and called "scrapie" in England, "vertige" in France and "Traberkrankheit" in Germany. This book discusses the development of prions and their various diseases.
Prion Diseases
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Author : Martin H. Groschup
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Prion Diseases written by Martin H. Groschup and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The overwhelming interest and the participation of more than 500 scientists from 26 countries made this symposium the largest meeting ever held in the field. In this book twenty-six invited speakers comprehensively present their data on the pathogenesis of prion diseases in humans and animals, on molecular mechanisms involved in the transmissibility across species barriers, on animal and in-vitro models currently available for the detection and quantification of infectivity and on the characterization of prion strains.
Prions
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Author : Akikazu Sakudo
language : en
Publisher: Caister Academic Press Limited
Release Date : 2013
Prions written by Akikazu Sakudo and has been published by Caister Academic Press Limited this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Science categories.
Prions are infectious, self-propagating proteinaceous agents that cause fatal neurodegenerative diseases, including Creutzfeldt-Jakob Disease (CJD) in humans, scrapie in sheep and goats, and bovine spongiform encephalopathy (BSE) in cattle. In recent years, great strides have been made in the understanding of the mechanism of prion propagation and neurotoxicity, however much remains to be discovered. A better understanding of the cell biology of the prion protein is essential for this, allowing for the development of novel anti-prion strategies. In this book, renowned prion experts review the most recent advances to provide a timely and up-to-date overview of the field. The topics covered include: prion proteins (PrP) and their family members * PrP function * molecular mechanisms of prions diseases * immunological strategies for the prevention and treatment of prion disease * microglial inflammation and prion diseases * methods for prion inactivation * clinical aspects of CJD * the BSE and scrapie prions * chronic wasting disease * future strategies for the prevention and treatment of prion diseases. The book closes with a look to the future of prion research. It will be essential reading for everyone with an interest in prions and prion diseases, and it is recommended for all biology, veterinary, and medical libraries.
Human Prion Diseases
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Author :
language : en
Publisher: Elsevier
Release Date : 2018-06-07
Human Prion Diseases written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-07 with Medical categories.
Human Prion Diseases, Volume 153 is designed to update the reader on the latest advances and clinical aspects of prion diseases. The book is organized into five sections, including the pathophysiology of prions and a description of animal and human diseases. This is followed by detailed reports on recent advances in diagnosis strategies for the development of novel anti-prion molecules and possible designs of clinical trials in such a rare disease. An introductory chapter gives an extensive historical background of prion research, with a final chapter highlighting recent progress, and more importantly, unsolved problems. Offers an authoritative overview of prion diseases in humans, detailing the pathogenesis of the disease, clinical investigations, and the diagnosis of both the genetic and acquired forms Provides clarity and context by presenting prion diseases in relation to other neurodegenerative diseases in humans Emphasizes the unique properties of prion diseases and consequent problems they can cause, both clinically and in public health terms
