Proceedings Of The 4th International Beilstein Symposium On Experimental Standard Conditions Of Enzyme Characterizations
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Proceedings Of The 4th International Beilstein Symposium On Experimental Standard Conditions Of Enzyme Characterizations
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Author : Martin G. Hicks
language : en
Publisher:
Release Date : 2010
Proceedings Of The 4th International Beilstein Symposium On Experimental Standard Conditions Of Enzyme Characterizations written by Martin G. Hicks and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Catalysis categories.
The STRENDA Commission (Standards for Reporting Enzyme Data), founded in 2003, is concerned with the improvement of the quality of reporting functional enzyme data to support, inter alia, enzyme kinetics for application in the in silico investigation of biological systems. The Commission has developed a set of guidelines for the reporting of data in publications. This 4th ESCEC symposium, organized by the Beilstein-Institut together with the STRENDA Commission, provided a platform to discuss the checklists, to consider further suggestions and to improve the existing recommendations. The STRENDA group took also the opportunity to discuss about the presented STRENDA electronic data capturing tool with members from diverse standardizations initiatives and systems biology groups such as MIBBI, YSBN, EFB and SYSMO, editorial board members from journals and all participating experimentalists and theoreticians. The focus of this presentation was to find answers on the questions such as how to organize and store these massive data sets in standard and easily accessible forms, which new experimental tools have to be developed to gather and configure such data into interactive models, which parameters should be measured, what kind of data constitute the minimum required information, and which experimental conditions should be recommended. The Beilstein Symposia address contemporary issues in the chemical and related sciences by employing an interdisciplinary approach. Scientists from a wide range of areas are invited to present aspects of their work for discussion, with the aim of not only advancing science, but also enhancing interdisciplinary communication. Traditionally, the Beilstein Symposia are kept small with up to 40 participants to provide a convivial atmosphere for the both lectures and intense discussions and the ready exchange of thoughts and ideas.
Proceedings Of The 5th International Beilstein Symposium On Experimental Standard Conditions Of Enzyme Characterizations Escec
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Author : Martin G. Hicks
language : en
Publisher:
Release Date : 2013-04-05
Proceedings Of The 5th International Beilstein Symposium On Experimental Standard Conditions Of Enzyme Characterizations Escec written by Martin G. Hicks and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-05 with Catalysis categories.
The multi-disciplinary approaches which are now typical of research in the natural and life sciences use a combination of modern experimental techniques which have led to an increased accuracy in the measurements of enzyme structures and activities. Modern analysis methods often result in the generation of huge amounts of data and large data sets, which are subsequently published in electronic data repositories and in written papers. However, data in both the literature and in databases suffer from the fact that they are often non-comparable due to incomplete and imprecise descriptions of materials and methods. Furthermore, if the experimental conditions are not fully and accurately stated, the values of the functional data of enzyme activities are of little use for, in particular, systems biology applications.Further problems occur even when the data are well reported; they will have often been collected under quite disparate conditions so that researchers are faced with the problem of the range of method-specific enzyme data. This is often an issue when data move between researchers whose data are supplied by laboratories that use different methods, and can, in the worst case, lead to misinterpretation of laboratory findings. The topics of the Proceedings of the 5th Symposium on ESCEC range from describing how the modification of enzyme structures affects the kinetics of enzyme reactions to discussing new results, approaches and methodologies for establishing physiological ties between sequence, structure and kinetics and modeled networks of collaborative enzymes. The overall topic - standard representation of enzyme data - is still considered and discussed in precise detail.
Proceedings Of The 3rd International Beilstein Workshop On Experimental Standard Conditions Of Enzyme Characterizations
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Author : Martin G. Hicks
language : en
Publisher:
Release Date : 2008
Proceedings Of The 3rd International Beilstein Workshop On Experimental Standard Conditions Of Enzyme Characterizations written by Martin G. Hicks and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Enzymes categories.
Proceedings Of The 1st International Beilstein Workshop On Experimental Standard Conditions Of Enzyme Characterizations
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Author : Martin G. Hicks
language : en
Publisher:
Release Date : 2004
Proceedings Of The 1st International Beilstein Workshop On Experimental Standard Conditions Of Enzyme Characterizations written by Martin G. Hicks and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Enzymes categories.
Biocalorimetry
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Author : Margarida Bastos
language : en
Publisher: CRC Press
Release Date : 2016-06-22
Biocalorimetry written by Margarida Bastos and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-06-22 with Medical categories.
Connecting past, present, and future instrument development and use, Biocalorimetry: Foundations and Contemporary Approaches explores biocalorimetry's history, fundamentals, methodologies, and applications. Some of the most prominent calorimeter developers and users share invaluable personal accounts of discovery, discussing innovative techniques a
Kinetics Of Enzyme Modifier Interactions
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Author : Antonio Baici
language : en
Publisher: Springer
Release Date : 2015-06-24
Kinetics Of Enzyme Modifier Interactions written by Antonio Baici and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-06-24 with Science categories.
The kinetic mechanisms by which enzymes interact with inhibitors and activators, collectively called modifiers, are scrutinized and ranked taxonomically into autonomous species in a way similar to that used in the biological classification of plants and animals. The systematization of the mechanisms is based on two fundamental characters: the allosteric linkage between substrate and modifier and the factor by which a modifier affects the catalytic constant of the enzyme. Combinations of the physically significant states of these two characters in an ancestor-descendant-like fashion reveal the existence of seventeen modes of interaction that cover the needs of total, partial and fine-tuning modulation of enzyme activity. These interactions comprise five linear and five hyperbolic inhibition mechanisms, five nonessential activation mechanisms and two hybrid species that manifest either hyperbolic inhibition or nonessential activation characteristics depending on substrate concentration. Five essential activation mechanisms, which are taxonomically independent of the mentioned basic species, complete the inventory of enzyme modifiers. Often masked under conventional umbrella terms or treated as anomalous cases, all seventeen basic inhibition and nonessential activation mechanisms are represented in the biochemical and pharmacological literature of this and the past century, either in the form of rapid or slow-onset reversible interactions, or as irreversible modification processes. The full potential of enzyme inhibitors and activators can only be appreciated after elucidating the details of their kinetic mechanisms of action exploring the entire range of physiologically significant reactant concentrations. This book highlights the wide spectrum of allosteric enzyme modification in physiological occurrences as well as in pharmacological and biotechnological applications that embrace simple and multiple enzyme-modifier interactions. The reader is guided in the journey through this still partly uncharted territory with the aid of mechanistically-oriented criteria aimed at showing the logical way towards the identification of a particular mechanism.
Experimental Standard Conditions Of Enzyme Characterizations
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Author : Martin G. Hicks
language : en
Publisher:
Release Date : 2007
Experimental Standard Conditions Of Enzyme Characterizations written by Martin G. Hicks and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Enzymes categories.
Protein Folding And Drug Design
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Author : Luis Serrano Romero
language : en
Publisher: IOS Press
Release Date : 2007
Protein Folding And Drug Design written by Luis Serrano Romero and has been published by IOS Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Mathematics categories.
One of the great unsolved problems of science and also of physics is the prediction of the three dimensional structure of a protein from its amino acid sequence. It may be stated that the deep connection existing between physics and protein folding is not so much, or in any case not only, through physical methods, but through physical concepts.
Systems Biology For Signaling Networks
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Author : Sangdun Choi
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-08-09
Systems Biology For Signaling Networks written by Sangdun Choi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-08-09 with Science categories.
System Biology encompasses the knowledge from diverse fields such as Molecular Biology, Immunology, Genetics, Computational Biology, Mathematical Biology, etc. not only to address key questions that are not answerable by individual fields alone, but also to help in our understanding of the complexities of biological systems. Whole genome expression studies have provided us the means of studying the expression of thousands of genes under a particular condition and this technique had been widely used to find out the role of key macromolecules that are involved in biological signaling pathways. However, making sense of the underlying complexity is only possible if we interconnect various signaling pathways into human and computer readable network maps. These maps can then be used to classify and study individual components involved in a particular phenomenon. Apart from transcriptomics, several individual gene studies have resulted in adding to our knowledge of key components that are involved in a signaling pathway. It therefore becomes imperative to take into account of these studies also, while constructing our network maps to highlight the interconnectedness of the entire signaling pathways and the role of that particular individual protein in the pathway. This collection of articles will contain a collection of pioneering work done by scientists working in regulatory signaling networks and the use of large scale gene expression and omics data. The distinctive features of this book would be: Act a single source of information to understand the various components of different signaling network (roadmap of biochemical pathways, the nature of a molecule of interest in a particular pathway, etc.), Serve as a platform to highlight the key findings in this highly volatile and evolving field, and Provide answers to various techniques both related to microarray and cell signaling to the readers.
Modelling Methodology For Physiology And Medicine
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Author : Ewart Carson
language : en
Publisher: Newnes
Release Date : 2013-12-05
Modelling Methodology For Physiology And Medicine written by Ewart Carson and has been published by Newnes this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-05 with Technology & Engineering categories.
Modelling Methodology for Physiology and Medicine, Second Edition, offers a unique approach and an unprecedented range of coverage of the state-of-the-art, advanced modeling methodology that is widely applicable to physiology and medicine. The second edition, which is completely updated and expanded, opens with a clear and integrated treatment of advanced methodology for developing mathematical models of physiology and medical systems. Readers are then shown how to apply this methodology beneficially to real-world problems in physiology and medicine, such as circulation and respiration. The focus of Modelling Methodology for Physiology and Medicine, Second Edition, is the methodology that underpins good modeling practice. It builds upon the idea of an integrated methodology for the development and testing of mathematical models. It covers many specific areas of methodology in which important advances have taken place over recent years and illustrates the application of good methodological practice in key areas of physiology and medicine. It builds on work that the editors have carried out over the past 30 years, working in cooperation with leading practitioners in the field. Builds upon and enhances the reader's existing knowledge of modeling methodology and practice Editors are internationally renowned leaders in their respective fields Provides an understanding of modeling methodologies that can address real problems in physiology and medicine and achieve results that are beneficial either in advancing research or in providing solutions to clinical problems