Systems Biology For Signaling Networks

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Systems Biology For Signaling Networks

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Author : Sangdun Choi
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-08-09

Systems Biology For Signaling Networks written by Sangdun Choi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-08-09 with Science categories.

System Biology encompasses the knowledge from diverse fields such as Molecular Biology, Immunology, Genetics, Computational Biology, Mathematical Biology, etc. not only to address key questions that are not answerable by individual fields alone, but also to help in our understanding of the complexities of biological systems. Whole genome expression studies have provided us the means of studying the expression of thousands of genes under a particular condition and this technique had been widely used to find out the role of key macromolecules that are involved in biological signaling pathways. However, making sense of the underlying complexity is only possible if we interconnect various signaling pathways into human and computer readable network maps. These maps can then be used to classify and study individual components involved in a particular phenomenon. Apart from transcriptomics, several individual gene studies have resulted in adding to our knowledge of key components that are involved in a signaling pathway. It therefore becomes imperative to take into account of these studies also, while constructing our network maps to highlight the interconnectedness of the entire signaling pathways and the role of that particular individual protein in the pathway. This collection of articles will contain a collection of pioneering work done by scientists working in regulatory signaling networks and the use of large scale gene expression and omics data. The distinctive features of this book would be: Act a single source of information to understand the various components of different signaling network (roadmap of biochemical pathways, the nature of a molecule of interest in a particular pathway, etc.), Serve as a platform to highlight the key findings in this highly volatile and evolving field, and Provide answers to various techniques both related to microarray and cell signaling to the readers.

Systems Biology Of Metabolic And Signaling Networks

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Author : Miguel A. Aon
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-10-22

Systems Biology Of Metabolic And Signaling Networks written by Miguel A. Aon and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Science categories.

Systems Biology represents a new paradigm aiming at a whole-organism-level understanding of biological phenomena, emphasizing interconnections and functional interrelationships rather than component parts. The study of network properties, and how they control and regulate behavior from the cellular to organism level, constitutes a main focus of Systems Biology. This book addresses from a novel perspective a major unsolved biological problem: understanding how a cell works and what goes wrong in pathology. The task undertaken by the authors is in equal parts conceptual and methodological, integrative and analytical, experimental and theoretical, qualitative and quantitative, didactic and comprehensive. Essentially, they unravel the spatio-temporal unfolding of interacting mass-energy and information networks at the cellular and organ levels, as well as its modulation through activation or repression by signaling networks to produce a certain phenotype or (patho)physiological response. Starting with the historical roots, in thirteen chapters this work explores the Systems Biology of signaling networks, cellular structures and fluxes, organ and microorganism functions. In doing so, it establishes the basis of a 21st century approach to biological complexity.

Systems Biology

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Author : Lilia Alberghina
language : en
Publisher: Springer Science & Business Media
Release Date : 2005-09-22

Systems Biology written by Lilia Alberghina and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-09-22 with Computers categories.

Annotation. The wealth of genomic and post-genomic data needs to be structured so that the understanding of complex cellular processes can be achieved by creating computational models able to describe and predict phenotypes at the cell or organism level in health and disease. This book provides a detailed presentation of systems biology studies that are paving the way towards the above-mentioned goal and discusses the most efficient experimental and computational strategies for this purpose. The potential benefits for bioindustry, in particular the discovery of new drugs and better management, are also presented.

Systems Biology

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Author : Bernhard Ø. Palsson
language : en
Publisher: Cambridge University Press
Release Date : 2006-01-16

Systems Biology written by Bernhard Ø. Palsson and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-01-16 with Science categories.

Genome sequences are now available that enable us to determine the biological components that make up a cell or an organism. The discipline of systems biology examines how these components interact and form networks, and how the networks generate whole cell functions corresponding to observable phenotypes. This textbook, devoted to systems biology, describes how to model networks, how to determine their properties, and how to relate these to phenotypic functions. The prerequisites are some knowledge of linear algebra and biochemistry. Though the links between the mathematical ideas and biological processes are made clear, the book reflects the irreversible trend of increasing mathematical content in biology education. Therefore to assist both teacher and student, in an associated website Palsson provides problem sets, projects and Powerpoint slides, and keeps the presentation in the book concrete with illustrative material and experimental results.

Egfr Signaling Networks In Cancer Therapy

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Author : John D. Haley
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-03-01

Egfr Signaling Networks In Cancer Therapy written by John D. Haley and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-03-01 with Medical categories.

The epidermal gro wth factor (EGF ) receptor and its downstream signal transduction networks have been implicated in the ontology and maintenance of tumor tissues, which has motivated the discovery and development of molecularly targeted anti-EGF receptor therapies. Over decades of study, the EGF receptor structure, its ligand binding domains, the physical biochemistry underlying its intrinsic tyrosine kinase catalytic function and the modular interactions with SH2, PTB, and SH3 domain containing signaling adaptor p- teins required for signal transduction, have been extensively dissected. Not only is the EGF receptor the nexus of many streams of information, but it also forms one part of a calcul- ing device by forming dimers and oligomers with the other three receptors in its family in response to at least eleven ligands (some of which are expressed in multiple forms with overlapping or quite distinct functions). This phenomenon, while recruiting to the inner surface of the cell membrane and activating multiple second messenger proteins, also allows the possibility of cross talk between these systems, permitting a further layer of information to be exchanged. Less well described are the cross re gulation of the EGF receptor and other anti-apoptotic, mitogenic and metabolic signaling systems. The study of these systems has yielded new surprises. One hurdle in these efforts has been that signal transduction pathways have frequently been defined in the generic absence of their tissue-specific or cell-interaction specific context.

Systems Biology Of Cell Signaling

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Author : Zhike Zi
language : en
Publisher: Frontiers Media SA
Release Date : 2022-02-17

Systems Biology Of Cell Signaling written by Zhike Zi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-17 with Science categories.

Topic Editor Prof. Xing is in collaboration with ATCC (https://www.atcc.org/) on testing some of their cell lines in research. All other Topic Editors declare no competing interests with regards to the Research Topic subject.

Systems Biology Of Cancer

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Author : Sam Thiagalingam
language : en
Publisher: Cambridge University Press
Release Date : 2015-04-09

Systems Biology Of Cancer written by Sam Thiagalingam and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-09 with Mathematics categories.

An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.

Handbook Of Systems Biology

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Author : Marian Walhout
language : en
Publisher: Academic Press
Release Date : 2012-12-31

Handbook Of Systems Biology written by Marian Walhout and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-31 with Science categories.

This book provides an entry point into Systems Biology for researchers in genetics, molecular biology, cell biology, microbiology and biomedical science to understand the key concepts to expanding their work. Chapters organized around broader themes of Organelles and Organisms, Systems Properties of Biological Processes, Cellular Networks, and Systems Biology and Disease discuss the development of concepts, the current applications, and the future prospects. Emphasis is placed on concepts and insights into the multi-disciplinary nature of the field as well as the importance of systems biology in human biological research. Technology, being an extremely important aspect of scientific progress overall, and in the creation of new fields in particular, is discussed in 'boxes' within each chapter to relate to appropriate topics. - 2013 Honorable Mention for Single Volume Reference in Science from the Association of American Publishers' PROSE Awards - Emphasizes the interdisciplinary nature of systems biology with contributions from leaders in a variety of disciplines - Includes the latest research developments in human and animal models to assist with translational research - Presents biological and computational aspects of the science side-by-side to facilitate collaboration between computational and biological researchers

Computational Modeling Of Signaling Networks

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Author : Lan K. Nguyen
language : en
Publisher: Springer Nature
Release Date : 2023-04-19

Computational Modeling Of Signaling Networks written by Lan K. Nguyen and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-19 with Science categories.

This volume focuses on the computational modeling of cell signaling networks and the application of these models and model-based analysis to systems and personalized medicine. Chapters guide readers through various modeling approaches for signaling networks, new methods and techniques that facilitate model development and analysis, and new applications of signaling network modeling towards systems and personalized treatment of cancer. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and methods, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Computational Modeling of Signaling Networks aims to benefit a wide spectrum of readers including researchers from the biological as well as computational systems biology communities.

Systems Biology And In Depth Applications For Unlocking Diseases

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Author : Babak Sokouti
language : en
Publisher: Elsevier
Release Date : 2024-11-05

Systems Biology And In Depth Applications For Unlocking Diseases written by Babak Sokouti and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-05 with Science categories.

Systems Biology and In-Depth Applications for Unlocking Diseases provides the essence of systems biology approaches in a practical manner illustrating the basic principles essential to develop and model in real life science applications. Methodologies covered show how to interrogate biological data, with the purpose of obtaining insight about disease diagnosis, prognosis, and treatment.Systematically written in 4 parts, this book first provides an introduction and history of systems biology; second, it provides the tools and resources needed for the structure and function of biological systems; next, it provides the evidence of systems biology in action to better understand disease connections; and finally, it provides the extensions of systems biology in various scientific fields including pharmacology, immunology, vaccinology, neuroscience, virology, and medicine. Examples include big data techniques, scale networks, mathematical model development, and much more.This is the perfect reference to provide the fundamental base of knowledge needed for systems biologists, professionals in systems medicine, computational biologists, and bioinformaticians, whether needed for immediate application or for building a comprehensive understanding of the field. - Provides detailed and comprehensive coverage of the field of systems biology - Delivers instruction on how to interrogate biological data, with the purpose of obtaining insight about disease diagnosis, prognosis, and treatment - Makes effective steps towards personalized medicine in the treatment of disease - Explains effective disease treatment strategies at early diagnosis stages