Prodrugs
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Prodrugs
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Author : Valentino Stella
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-03-12
Prodrugs written by Valentino Stella and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-03-12 with Medical categories.
These volumes represent a comprehensive guide to prodrugs. They guide the reader through the current status of the prodrug concept and its many applications and highlight its many successes in overcoming formulation and delivery of problematic drugs. Replete with examples of approved and marketed prodrugs, these volumes introduce the topic to the novice as well as professional in the design of prodrugs.
Design Of Prodrugs
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Author : Hans Bundgaard
language : en
Publisher: Elsevier Publishing Company
Release Date : 1985
Design Of Prodrugs written by Hans Bundgaard and has been published by Elsevier Publishing Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 1985 with Medical categories.
Prodrugs And Targeted Delivery
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Author : Jarkko Rautio
language : en
Publisher: John Wiley & Sons
Release Date : 2011-01-11
Prodrugs And Targeted Delivery written by Jarkko Rautio and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-01-11 with Medical categories.
This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design. It summarizes current experiences and strategies for the rational design of prodrugs, beginning at the early stages of the development process, as well as discussing organ- and site-selective prodrugs. Every company employing medicinal chemists will be interested in this practice-oriented overview of a key strategy in modern drug discovery and development.
Recent Advancement In Prodrugs
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Author : Kamal Shah
language : en
Publisher: CRC Press
Release Date : 2020-05-13
Recent Advancement In Prodrugs written by Kamal Shah and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-13 with Science categories.
Recent Advancement in Prodrugs Drugs used as medicines have many limitations like low chemical stability, aqueous solubility, or oral absorption/bioavailability, rapid presystemic metabolism, toxicity, inadequate site specificity, or poor patient acceptance/compliance (unwanted adverse effects, unacceptable taste or odor, irritation or pain). Prodrugs design is an approach to overcome these limitations. Key features Covers recent advancements in development of prodrugs Presents balanced synthesis and applications of prodrug chemistry Discusses broad spectrum of prodrug categories and outlines industrial applications Reviews prodrugs in cancer nanomedicine, its therapy and treatment Elucidates mathematical models to study the kinetics of prodrugs This book covers recent advances in the design of prodrugs. It contains all the significant recent examples of prodrug chemistry developments and will aid academics and researchers seeking to generate new projects in the field.
Prodrug Design
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Author : Vivekkumar K Redasani
language : en
Publisher: Academic Press
Release Date : 2015-07-07
Prodrug Design written by Vivekkumar K Redasani and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-07 with Science categories.
Prodrug Design: Perspectives, Approaches and Applications in Medicinal Chemistry provides a focused overview of this critical area of drug discovery, as that continuous process strives not only to discover new drug compounds but also to modify the existing ones. This valuable primer supports this mission of drug development and its goal of reducing undesired effects and improving therapeutic effectiveness of drug compounds. Providing a unique compilation of data, insightful case studies, and review of existing literature in the area, the book will promote innovation in medicinal and pharmaceutical chemistry research, exploring the limitations of existing drugs and their improvement. Prodrug Design reviews marketed compounds, the safety of promoieties, and a detailed classification of prodrugs organized by therapeutic area for easy reference. Offers unique, detailed overview of Prodrug research and literature Provides detailed chemical structures Includes Prodrug listing by therapeutic area
Prodrugs Design
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Author : Rafik Karaman
language : en
Publisher: Nova Science Publishers
Release Date : 2014
Prodrugs Design written by Rafik Karaman and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Prodrugs categories.
The prodrug approach is a promising and well established strategy for the development of new entities that possess superior efficacy, selectivity and reduced toxicity. Hence an optimised therapeutic outcome can be accomplished using this approach. Prodrug design is becoming more elaborate in the development of efficient and selective drug delivery systems. The targeted prodrug approach, in combination with gene delivery and controlled expression of enzymes and carrier proteins, is a promising strategy for precise and efficient drug delivery and enhancement of the therapeutic effect. This book describes in details all prodrug approaches and examples of prodrugs that succeeded to enter the market. There are two major prodrug design approaches that are considered as widely used among all other approaches: the targeted drug design approach by which prodrugs can be designed to target specific enzymes or carriers by considering enzyme-substrate specificity or carrier-substrate specificity in order to overcome various undesirable drug properties. Examples for such approach is the antibody-directed enzyme prodrug therapy (ADEPT), gene-directed enzyme prodrug therapy (GDEPT), virus-directed enzyme prodrug therapy (VDEPT) and GDEPT. In addition, this book describes in details a novel prodrug chemical approach which is based on intramolecular reactions that were utilised to understand how enzymes exert their high catalysis. The information gained from the experimental and theoretical calculations on these enzyme models was used to design efficient chemical moieties to be utilised as prodrug linkers with the potential to release the corresponding parent drugs in a slow or fast release manner. Several prodrugs for commonly used drugs suffer from low bioavailability or/and bitter sensation were designed using quantum mechanics methods (DFT and ab initio) and recently a large number among these prodrugs were synthesised. Examples of such prodrugs are presented in the different chapters of the book.
Application Of Peptide Based Prodrug Chemistry In Drug Development
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Author : Arnab De
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-08-18
Application Of Peptide Based Prodrug Chemistry In Drug Development written by Arnab De and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-08-18 with Medical categories.
Macromolecular (specifically peptide-based) drugs could potentially be highly effective medicines. However they have a relatively short duration of action and variable therapeutic index. An example of such a peptide is Glucagon-like Peptide I which could potentially be used as a revolutionary drug for diabetes. This is because it stimulates insulin only when the blood glucose level is high thereby reducing the risk of hypoglycemia (a significant disadvantage of using insulin is that an insulin overdose is the single most potent cause of life-threatening hypoglycemia). However it’s short duration of action (half-life of 2 minutes in plasma) precludes its therapeutic use. In this volume, the use of novel therapeutics like GLP1 as an alternative to tradition insulin-based drugs in diabetes is described. Application of Peptide-Based Prodrug Chemistry in Drug Development elucidates the traditional concept of prodrugs as “specialized non-toxic protective groups used in a transient manner to alter or to eliminate certain limiting properties in the parent small molecule” (IUPAC definition). It goes on to provide insight into how prodrugs of peptides (with GLP1 as an example) could be appropriately used to extend the biological half life, broaden the therapeutic index of macromolecules and improve the pharmacodynamics of such drugs. Author explains the logic behind designing peptide prodrugs, synthetic procedures and bioassays to examine the conversion of the prodrug to the drug under therapeutic conditions. The prodrugs described slowly convert to the parent drug at physiological conditions of 37C and pH 7.2 driven by their inherent chemical instability without the need of any enzymatic cleavage. The diketopiperazine and diketomorpholine (DKP and DMP) strategies for prodrug conversion are demonstrated in detail with special emphasis on the chemical flexibility that it offers to develop prodrugs with variable time actions. This book will be of useful to chemists, biochemists, medicinal chemists, biologists and people in the medical profession (doctors). It may be used in undergraduate classes but will certainly help post-graduate students and advanced professionals. The author is grateful to Prof. Richard DiMarchi (Standiford H. Cox Professor of Chemistry and the Linda & Jack Gill Chair in Biomolecular Sciences at Indiana University) for valuable suggestions. The foreword for the book has been written by Prof. Jean Martinez, (Legion d'Honneur awarded by the French Republic; Professor of Chemistry and Medicinal Chemistry of the University of Montpellier, France; and Chairman of European Peptide Society, 2002-2010).
Design Of Biopharmaceutical Properties Through Prodrugs And Analogs
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Author : Edward B. Roche
language : en
Publisher:
Release Date : 1977
Design Of Biopharmaceutical Properties Through Prodrugs And Analogs written by Edward B. Roche and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1977 with Science categories.
Contains papers presented during a symposium sponsored by the Medicinal Chemistry Section of the APhA Academy of Pharmaceutical Sciences and held in Orlando, Fla., Nov. 16-17, 1976.
Prodrugs
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Author : Kenneth B. Sloan
language : en
Publisher: CRC Press
Release Date : 1992-03-17
Prodrugs written by Kenneth B. Sloan and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-03-17 with Medical categories.
Advances In Prodrugs
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Author : Claudiu Trandafir Supuran
language : en
Publisher: Elsevier
Release Date : 2024-07-01
Advances In Prodrugs written by Claudiu Trandafir Supuran and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-01 with Science categories.
Advances in Prodrugs: Design and Therapeutic Applications provides a versatile tool in prodrug design and development as well as a concrete perspective on clinical and preclinical studies currently available on prodrugs. Prodrugs are inactive drug precursors which undergo different chemical transformation by metabolic processes to provide pharmacologically active compounds. Prodrugs include a broad range of structurally diverse molecules employed for the treatment of several diseases. The first part of this book discusses different chemical classes of prodrugs, with particular emphasis on metabolic pathways and mechanisms involved in the activation of their functional groups. The second part of the book covers therapeutic applications of prodrugs against the most discussed diseases, providing detailed discussion on recent achievements in the field. This book offers researchers involved in drug discovery key criteria for the successful development of prodrug-based therapeutic tools. Highlights chemistry and pharmacology-related aspects, offering a versatile tool for the readers involved in prodrug development and study Discusses in depth treatment of several activation mechanisms and applications for disease treatments Covers a range of topics from basic contents, design, mechanisms of actions to current applications in drugs