Producing And Analyzing Macro Connectomes Current State And Challenges
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Producing And Analyzing Macro Connectomes Current State And Challenges
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Author : Mihail Bota
language : en
Publisher: Frontiers Media SA
Release Date : 2016-10-20
Producing And Analyzing Macro Connectomes Current State And Challenges written by Mihail Bota and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-20 with Neurosciences. Biological psychiatry. Neuropsychiatry categories.
Construction of comprehensive and detailed brain regions neuroanatomical connections matrices (macro-connectomes) is necessary to understand how the nervous system is organized and to elucidate how its different parts interact. Macro-connectomes also are the structural foundation of any finer granularity approaches at the neuron classes and types (meso-connectomes) or individual neuron (micro-connectomes) levels. The advent of novel neuroanatomical methods, as well as combinations of classic techniques, form the basis of several large scale projects with the ultimate goal of producing publicly available connectomes at different levels. A parallel approach, that of systematic and comprehensive collation of connectivity data from the published literature and from publicly accessible neuroinformatics platforms, has produced macro-connectomes of different parts of the central nervous system (CNS) in several mammalian species. The emergence of these public platforms that allow for the manipulation of rich connectivity data sets and enable the construction of CNS macro-connectomes in different species may have significant and long lasting implications. Moreover, when these efforts are leveraged by novel statistical methods, they may influence our way of thinking about the brain. Hence, the present brain region-centric paradigm may be challenged by a network-centric one. Ultimately, these projects will provide the information and knowledge for understanding how different neuronal parts communicate and function, developing novel approaches to diseases and disorders, and facilitating translational efforts in neurosciences. With this Research Topic we bring together the current state of macro-connectome related projects including the large scale production of thousands of publicly available neuronatomical experiments, databases with tens of thousands of connectivity records collated from the published literature, and the newest methods for displaying and analyzing this information. This topic also includes a wide range of challenges and how they are addressed - from platforms designed to integrate connectivity data across different sources, species and CNS levels of organization, to languages specifically designed to use these data in models at different scales of resolution, to efforts of 3D reconstruction and data integration, and to approaches for extraction and representation of this knowledge. Finally, we address the present state of different efforts of meso-connectomes construction, and of computational modeling in the context of the information provided by macro-connectomes.
Producing And Analyzing Macro Connectomes Current State And Challenges
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Author :
language : en
Publisher:
Release Date : 2016
Producing And Analyzing Macro Connectomes Current State And Challenges written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.
Construction of comprehensive and detailed brain regions neuroanatomical connections matrices (macro-connectomes) is necessary to understand how the nervous system is organized and to elucidate how its different parts interact. Macro-connectomes also are the structural foundation of any finer granularity approaches at the neuron classes and types (meso-connectomes) or individual neuron (micro-connectomes) levels. The advent of novel neuroanatomical methods, as well as combinations of classic techniques, form the basis of several large scale projects with the ultimate goal of producing publicly available connectomes at different levels. A parallel approach, that of systematic and comprehensive collation of connectivity data from the published literature and from publicly accessible neuroinformatics platforms, has produced macro-connectomes of different parts of the central nervous system (CNS) in several mammalian species. The emergence of these public platforms that allow for the manipulation of rich connectivity data sets and enable the construction of CNS macro-connectomes in different species may have significant and long lasting implications. Moreover, when these efforts are leveraged by novel statistical methods, they may influence our way of thinking about the brain. Hence, the present brain region-centric paradigm may be challenged by a network-centric one. Ultimately, these projects will provide the information and knowledge for understanding how different neuronal parts communicate and function, developing novel approaches to diseases and disorders, and facilitating translational efforts in neurosciences. With this Research Topic we bring together the current state of macro-connectome related projects including the large scale production of thousands of publicly available neuronatomical experiments, databases with tens of thousands of connectivity records collated from the published literature, and the newest methods for displaying and analyzing this information. This topic also includes a wide range of challenges and how they are addressed - from platforms designed to integrate connectivity data across different sources, species and CNS levels of organization, to languages specifically designed to use these data in models at different scales of resolution, to efforts of 3D reconstruction and data integration, and to approaches for extraction and representation of this knowledge. Finally, we address the present state of different efforts of meso-connectomes construction, and of computational modeling in the context of the.
Micro Meso And Macro Connectomics Of The Brain
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Author : Henry Kennedy
language : en
Publisher: Springer
Release Date : 2016-03-10
Micro Meso And Macro Connectomics Of The Brain written by Henry Kennedy and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-03-10 with Medical categories.
This book has brought together leading investigators who work in the new arena of brain connectomics. This includes ‘macro-connectome’ efforts to comprehensively chart long-distance pathways and functional networks; ‘micro-connectome’ efforts to identify every neuron, axon, dendrite, synapse, and glial process within restricted brain regions; and ‘meso-connectome’ efforts to systematically map both local and long-distance connections using anatomical tracers. This book highlights cutting-edge methods that can accelerate progress in elucidating static ‘hard-wired’ circuits of the brain as well as dynamic interactions that are vital for brain function. The power of connectomic approaches in characterizing abnormal circuits in the many brain disorders that afflict humankind is considered. Experts in computational neuroscience and network theory provide perspectives needed for synthesizing across different scales in space and time. Altogether, this book provides an integrated view of the challenges and opportunities in deciphering brain circuits in health and disease.
Connectome Analysis
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Author : Markus D. Schirmer
language : en
Publisher: Academic Press
Release Date : 2023-06-30
Connectome Analysis written by Markus D. Schirmer and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-30 with Psychology categories.
Connectome Analysis: Characterization, Methods, and Analysis is a comprehensive companion for the analysis of brain networks, or connectomes. The book provides sources of constituent structural and functional MRI signals, network construction and practices for analysis, cutting-edge methods that address the latest challenges in neuroscience, and the fundamentals of network theory in the context of giving practical methods for building connectomes for analysis. Emphasis is placed on quality control of the individual analysis steps. Subsequent chapters discuss networks in neuroscience in clinical and general populations, including how findings are related to underlying neurophysiology and neuropsychology. This book is aimed at students and early-career researchers in brain connectomics and neuroimaging who have a background in computer science, mathematics and physics, as well as more broadly to neuroscientists and psychologists who want to start incorporating connectomics into their research. Provides practical recommendations on how to construct, assess and analyze brain networks Gives an understanding of all the technical methods for connectome analysis Presents the basic network theoretical principles typically used in neuroscience Covers the latest tools and data repositories that are freely available for the reader to carry out connectomic analyses
Recent Advances In Computer Based Systems Processes And Applications
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Author : Anupama Namburu
language : en
Publisher: CRC Press
Release Date : 2020-06-14
Recent Advances In Computer Based Systems Processes And Applications written by Anupama Namburu and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-14 with Computers categories.
This was the first conference organized by the school of Computer Science Engineering in VIT-AP University campus with the cumulative efforts of all the faculty members. The proceedings discusses recent advancements and novel ideas in areas of interest. It covers topics such as advances in computer based systems, processes and applications
Computational Diffusion Mri
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Author : Suheyla Cetin-Karayumak
language : en
Publisher: Springer Nature
Release Date : 2021-09-25
Computational Diffusion Mri written by Suheyla Cetin-Karayumak and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-25 with Computers categories.
This book constitutes the proceedings of the International Workshop on Computational Diffusion MRI, CDMRI 2021, which was held on October 1, 2021, in conjunction with MICCAI 2021. The conference was planned to take place in Strasbourg, France, but was held virtually due to the COVID-19 pandemic. The 13 full papers included were carefully reviewed and selected for inclusion in the book. The proceedings also contain a paper about the design and scope of the MICCAI Diffusion-Simulated Connectivity Challenge (DiSCo) which was held at CDMRI 2021. The papers were organized in topical sections as follows: acquisition; microstructure modelling; tractography and connectivity; applications and visualization; DiSCo challenge – invited contribution.
Predictive Intelligence In Medicine
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Author : Islem Rekik
language : en
Publisher: Springer Nature
Release Date : 2020-10-01
Predictive Intelligence In Medicine written by Islem Rekik and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-01 with Computers categories.
This book constitutes the proceedings of the Third International Workshop on Predictive Intelligence in Medicine, PRIME 2020, held in conjunction with MICCAI 2020, in Lima, Peru, in October 2020. The workshop was held virtually due to the COVID-19 pandemic. The 17 full and 2 short papers presented in this volume were carefully reviewed and selected for inclusion in this book. The contributions describe new cutting-edge predictive models and methods that solve challenging problems in the medical field for a high-precision predictive medicine.
Connectomic Deep Brain Stimulation
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Author : Andreas Horn
language : en
Publisher: Academic Press
Release Date : 2021-09-10
Connectomic Deep Brain Stimulation written by Andreas Horn and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-10 with Medical categories.
Connectomic Deep Brain Stimulation (DBS) covers this highly efficacious treatment option for movement disorders such as Parkinson’s Disease, Essential Tremor and Dystonia. The book examines its impact on distributed brain networks that span across the human brain in parallel with modern-day neuroimaging concepts and the connectomics of the brain. It asks several questions, including which cortical areas should DBS electrodes be connected in order to generate the highest possible clinical improvement? Which connections should be avoided? Could these connectomic insights be used to better understand the mechanism of action of DBS? How can they be transferred to individual patients, and more. This book is suitable for neuroscientists, neurologists and functional surgeons studying DBS. It provides practical advice on processing strategies and theoretical background, highlighting and reviewing the current state-of-the-art in connectomic surgery. Written to provide a "hands-on" approach for neuroscience graduate students, as well as medical personnel from the fields of neurology and neurosurgery Includes preprocessing strategies (such as co-registration, normalization, lead localization, VTA estimation and fiber-tracking approaches) Presents references (key articles, books and protocols) for additional detailed study Provides data analysis boxes in each chapter to help with data interpretation
Brain Connectivity In Autism
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Author : Rajesh K. Kana
language : en
Publisher: Frontiers E-books
Release Date : 2014-09-23
Brain Connectivity In Autism written by Rajesh K. Kana and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-23 with Autism categories.
The brain's ability to process information crucially relies on connectivity. Understanding how the brain processes complex information and how such abilities are disrupted in individuals with neuropsychological disorders will require an improved understanding of brain connectivity. Autism is an intriguingly complex neurodevelopmental disorder with multidimensional symptoms and cognitive characteristics. A biological origin for autism spectrum disorders (ASD) had been proposed even in the earliest published accounts (Kanner, 1943; Asperger, 1944). Despite decades of research, a focal neurobiological marker for autism has been elusive. Nevertheless, disruptions in interregional and functional and anatomical connectivity have been a hallmark of neural functioning in ASD. Theoretical accounts of connectivity perceive ASD as a cognitive and neurobiological disorder associated with altered functioning of integrative circuitry. Neuroimaging studies have reported disruptions in functional connectivity (synchronization of activated brain areas) during cognitive tasks and during task-free resting states. While these insights are valuable, they do not address the time-lagged causality and directionality of such correlations. Despite the general promise of the connectivity account of ASD, inconsistencies and methodological differences among studies call for more thorough investigations. A comprehensive neurological account of ASD should incorporate functional, effective, and anatomical connectivity measures and test the diagnostic utility of such measures. In addition, questions pertaining to how cognitive and behavioral intervention can target connection abnormalities in ASD should be addressed. This research topic of the Frontiers in Human Neuroscience addresses “Brain Connectivity in Autism” primarily from cognitive neuroscience and neuroimaging perspectives.
How Best To Go On Prospects For A Modern Synthesis In The Sciences Of Mind
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Author : Kevin Moore
language : en
Publisher: Frontiers Media SA
Release Date : 2016-08-08
How Best To Go On Prospects For A Modern Synthesis In The Sciences Of Mind written by Kevin Moore and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-08 with Psychology categories.
Psychology straddles areas from the biological to the social and cultural. Within that vast range, there have been recent explosions of interest in neuropsychology, genetics and epigenetics, and the evolutionary bases of mindedness. Correspondingly, there have been conceptual innovations and new empirical evidence in relation to the embodied, social and discursive processes supporting mind and personhood. Simultaneously, awareness of developmental processes and their dynamic interweaving of genetic, physiological, neurological, social and cultural elements has also increased. Might such developments help ‘connect the dots’ between diverse aspects of mindedness and the contexts within which it arises? Whilst it seems clear that mind is co-constituted of both biological and socio-cultural processes, how might we bring these disparate realms of knowledge together? In a number of these areas, suggestive integrative possibilities have been explored (e.g., predictive processing, embodied and situated cognition, dynamic developmental systems theory) and insights such as a focus on action, ‘knowledge as skills’, embeddedness and connectivity have been pursued across a range of disciplines. This edited collection of articles bring together such possibilities – and others - in the same forum in order to provide an opportunity to re-visit a recurring discussion within theoretical psychology: The claimed lack of - and potential for - theoretical synthesis and unity. While the chapters range over a number of areas of research, this collection is focused on current prospects for conceptual synthesis within - or convergence of research between - aspects of mind and mindedness. As is clear from the contributions, it highlights integrative conceptual proposals that emphasize action-orientation, process, embeddedness and connectivity – especially between explanatory ‘levels’. Beyond specific proposals for integration, several of the contributions explicitly or implicitly expose broader questions about the purpose of psychological research, the epistemological and ontological commitments required, and the relevant social, political and economic contexts within which such research is performed. This is perhaps inevitable since any aim for synthesis of various understandings of mind will - or should - lead to consideration of the general implications, beyond the ‘science’, that follow from an integrated account of mind and mindedness. Whether or not the contributions in this volume provide insights into profitable paths towards greater theoretical synthesis in the sciences of mind or, alternatively, provide grist for the mill of renewed skepticism over the potential or even desirability of such synthesis is unpredictable. Whichever the outcome, we feel sure that they will help provoke future productive research in, and thinking about, the sciences of mind. Kevin Moore and John Cromby Associate Guest Editors