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Producing And Analyzing Macro Connectomes Current State And Challenges


Producing And Analyzing Macro Connectomes Current State And Challenges
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Producing And Analyzing Macro Connectomes Current State And Challenges


Producing And Analyzing Macro Connectomes Current State And Challenges
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Author : Mihail Bota
language : en
Publisher: Frontiers Media SA
Release Date : 2016-10-20

Producing And Analyzing Macro Connectomes Current State And Challenges written by Mihail Bota and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-20 with Neurosciences. Biological psychiatry. Neuropsychiatry categories.


Construction of comprehensive and detailed brain regions neuroanatomical connections matrices (macro-connectomes) is necessary to understand how the nervous system is organized and to elucidate how its different parts interact. Macro-connectomes also are the structural foundation of any finer granularity approaches at the neuron classes and types (meso-connectomes) or individual neuron (micro-connectomes) levels. The advent of novel neuroanatomical methods, as well as combinations of classic techniques, form the basis of several large scale projects with the ultimate goal of producing publicly available connectomes at different levels. A parallel approach, that of systematic and comprehensive collation of connectivity data from the published literature and from publicly accessible neuroinformatics platforms, has produced macro-connectomes of different parts of the central nervous system (CNS) in several mammalian species. The emergence of these public platforms that allow for the manipulation of rich connectivity data sets and enable the construction of CNS macro-connectomes in different species may have significant and long lasting implications. Moreover, when these efforts are leveraged by novel statistical methods, they may influence our way of thinking about the brain. Hence, the present brain region-centric paradigm may be challenged by a network-centric one. Ultimately, these projects will provide the information and knowledge for understanding how different neuronal parts communicate and function, developing novel approaches to diseases and disorders, and facilitating translational efforts in neurosciences. With this Research Topic we bring together the current state of macro-connectome related projects including the large scale production of thousands of publicly available neuronatomical experiments, databases with tens of thousands of connectivity records collated from the published literature, and the newest methods for displaying and analyzing this information. This topic also includes a wide range of challenges and how they are addressed - from platforms designed to integrate connectivity data across different sources, species and CNS levels of organization, to languages specifically designed to use these data in models at different scales of resolution, to efforts of 3D reconstruction and data integration, and to approaches for extraction and representation of this knowledge. Finally, we address the present state of different efforts of meso-connectomes construction, and of computational modeling in the context of the information provided by macro-connectomes.



Producing And Analyzing Macro Connectomes Current State And Challenges


Producing And Analyzing Macro Connectomes Current State And Challenges
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Author :
language : en
Publisher:
Release Date : 2016

Producing And Analyzing Macro Connectomes Current State And Challenges written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.


Construction of comprehensive and detailed brain regions neuroanatomical connections matrices (macro-connectomes) is necessary to understand how the nervous system is organized and to elucidate how its different parts interact. Macro-connectomes also are the structural foundation of any finer granularity approaches at the neuron classes and types (meso-connectomes) or individual neuron (micro-connectomes) levels. The advent of novel neuroanatomical methods, as well as combinations of classic techniques, form the basis of several large scale projects with the ultimate goal of producing publicly available connectomes at different levels. A parallel approach, that of systematic and comprehensive collation of connectivity data from the published literature and from publicly accessible neuroinformatics platforms, has produced macro-connectomes of different parts of the central nervous system (CNS) in several mammalian species. The emergence of these public platforms that allow for the manipulation of rich connectivity data sets and enable the construction of CNS macro-connectomes in different species may have significant and long lasting implications. Moreover, when these efforts are leveraged by novel statistical methods, they may influence our way of thinking about the brain. Hence, the present brain region-centric paradigm may be challenged by a network-centric one. Ultimately, these projects will provide the information and knowledge for understanding how different neuronal parts communicate and function, developing novel approaches to diseases and disorders, and facilitating translational efforts in neurosciences. With this Research Topic we bring together the current state of macro-connectome related projects including the large scale production of thousands of publicly available neuronatomical experiments, databases with tens of thousands of connectivity records collated from the published literature, and the newest methods for displaying and analyzing this information. This topic also includes a wide range of challenges and how they are addressed - from platforms designed to integrate connectivity data across different sources, species and CNS levels of organization, to languages specifically designed to use these data in models at different scales of resolution, to efforts of 3D reconstruction and data integration, and to approaches for extraction and representation of this knowledge. Finally, we address the present state of different efforts of meso-connectomes construction, and of computational modeling in the context of the.



Connectome Analysis


Connectome Analysis
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Author : Markus D. Schirmer
language : en
Publisher: Academic Press
Release Date : 2023-06-30

Connectome Analysis written by Markus D. Schirmer and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-30 with Psychology categories.


Connectome Analysis: Characterization, Methods, and Analysis is a comprehensive companion for the analysis of brain networks, or connectomes. The book provides sources of constituent structural and functional MRI signals, network construction and practices for analysis, cutting-edge methods that address the latest challenges in neuroscience, and the fundamentals of network theory in the context of giving practical methods for building connectomes for analysis. Emphasis is placed on quality control of the individual analysis steps. Subsequent chapters discuss networks in neuroscience in clinical and general populations, including how findings are related to underlying neurophysiology and neuropsychology. This book is aimed at students and early-career researchers in brain connectomics and neuroimaging who have a background in computer science, mathematics and physics, as well as more broadly to neuroscientists and psychologists who want to start incorporating connectomics into their research. - Provides practical recommendations on how to construct, assess and analyze brain networks - Gives an understanding of all the technical methods for connectome analysis - Presents the basic network theoretical principles typically used in neuroscience - Covers the latest tools and data repositories that are freely available for the reader to carry out connectomic analyses



Recent Advances In Diagnosis And Treatment Of Brain Tumors From Pediatrics To Adults


Recent Advances In Diagnosis And Treatment Of Brain Tumors From Pediatrics To Adults
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Author : John Bianco
language : en
Publisher: Frontiers Media SA
Release Date : 2025-06-12

Recent Advances In Diagnosis And Treatment Of Brain Tumors From Pediatrics To Adults written by John Bianco and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-12 with Medical categories.


In the last few years, an impressive development has been achieved in the arena of new diagnostic and therapeutic approaches for brain tumors, both in children and adults. This has in turn led to the recognition of new tumour entities as well as to better categorization of the existing ones. The recent WHO classification of the CNS tumors (2021) has been entirely revised and the term “integrated diagnosis” has been since then applied, which refers to a combination of the classical histopathological diagnosis with the accompanying molecular results of some of the most common tumors. In addition, a lot of progress has been made in the field of imaging, with the invention of more accurate methods and the improvement of previously established diagnostic modalities. As a result of the aforementioned achievements in the diagnosis of brain tumors, new treatment options have been introduced, which respond more successfully to the handling of the several tumor entities. Due to the immense progress not only in the field of diagnosis but also in the treatment of brain tumors, it is of utmost importance to present the newly identified biomarkers and innovative techniques, which allow on the one hand a more accurate diagnosis and on the other hand a more precise therapeutic intervention. Since a lot of research is conducted at present with this regard, the result of these investigations should be shared with the broader research community, in order to improve thereafter both the available diagnostic methods in the fields of histopathology and imaging and the therapeutic techniques in the areas of neurosurgery and chemo-/radiotherapy. Undoubtfully, this will contribute substantially in the accomplishment of the target of “personalized medicine” in the public. The current Research Topic aims to bring together new discoveries in the diagnosis and therapy of pediatric and adult brain tumors. In this context there is an open invitation to all the researchers and clinicians who are involved in this area, to participate actively by contributing their valuable results and experiences with research focused on primary brain tumors. Moving towards our actual goal as medical society, which is not other than the implementation of “personalized medicine”, our actual topic could be of particular value in the accomplishment of some of its fundamentals, namely i. precise diagnosis, ii. personalized intervention, iii. patient’s participation, iv. prediction and prevention of the disease and v. supportive care/ neurorehabilitation. Manuscripts that are primarily in silico/bioinformatics based, including prognostic algorithms using large databases, and do not have sufficient validation in an independent cohort of patients from one or more institutions (rather than using another database) and/or functional validation in at least two acceptable tumor cell lines in vitro/in vivo, will not be considered



Micro Meso And Macro Connectomics Of The Brain


Micro Meso And Macro Connectomics Of The Brain
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Author : Henry Kennedy
language : en
Publisher: Springer
Release Date : 2016-03-10

Micro Meso And Macro Connectomics Of The Brain written by Henry Kennedy and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-03-10 with Medical categories.


This book has brought together leading investigators who work in the new arena of brain connectomics. This includes ‘macro-connectome’ efforts to comprehensively chart long-distance pathways and functional networks; ‘micro-connectome’ efforts to identify every neuron, axon, dendrite, synapse, and glial process within restricted brain regions; and ‘meso-connectome’ efforts to systematically map both local and long-distance connections using anatomical tracers. This book highlights cutting-edge methods that can accelerate progress in elucidating static ‘hard-wired’ circuits of the brain as well as dynamic interactions that are vital for brain function. The power of connectomic approaches in characterizing abnormal circuits in the many brain disorders that afflict humankind is considered. Experts in computational neuroscience and network theory provide perspectives needed for synthesizing across different scales in space and time. Altogether, this book provides an integrated view of the challenges and opportunities in deciphering brain circuits in health and disease.



Recent Advances In Computer Based Systems Processes And Applications


Recent Advances In Computer Based Systems Processes And Applications
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Author : Anupama Namburu
language : en
Publisher: CRC Press
Release Date : 2020-06-14

Recent Advances In Computer Based Systems Processes And Applications written by Anupama Namburu and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-14 with Computers categories.


This was the first conference organized by the school of Computer Science Engineering in VIT-AP University campus with the cumulative efforts of all the faculty members. The proceedings discusses recent advancements and novel ideas in areas of interest. It covers topics such as advances in computer based systems, processes and applications



Computational Diffusion Mri


Computational Diffusion Mri
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Author : Suheyla Cetin-Karayumak
language : en
Publisher: Springer Nature
Release Date : 2021-09-25

Computational Diffusion Mri written by Suheyla Cetin-Karayumak and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-25 with Computers categories.


This book constitutes the proceedings of the International Workshop on Computational Diffusion MRI, CDMRI 2021, which was held on October 1, 2021, in conjunction with MICCAI 2021. The conference was planned to take place in Strasbourg, France, but was held virtually due to the COVID-19 pandemic. The 13 full papers included were carefully reviewed and selected for inclusion in the book. The proceedings also contain a paper about the design and scope of the MICCAI Diffusion-Simulated Connectivity Challenge (DiSCo) which was held at CDMRI 2021. The papers were organized in topical sections as follows: acquisition; microstructure modelling; tractography and connectivity; applications and visualization; DiSCo challenge – invited contribution.



Principles Of Nuclear Magnetic Resonance Microscopy


Principles Of Nuclear Magnetic Resonance Microscopy
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Author : Paul T. Callaghan
language : en
Publisher:
Release Date : 1993

Principles Of Nuclear Magnetic Resonance Microscopy written by Paul T. Callaghan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Science categories.


This book explores principles and common themes underlying two variants of NMR Microscopy - k-space and q-space - providing many examples of their use. The methods discussed here are of importance in fundamental biological and physical research, as well as having applications in a wide variety of industries, including those concerned with petrochemicals, polymers, biotechnology, food processing, and natural product processing.



Human Behavior In The Social Environment


Human Behavior In The Social Environment
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Author : Anissa Taun Rogers
language : en
Publisher: Routledge
Release Date : 2016-08-05

Human Behavior In The Social Environment written by Anissa Taun Rogers and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-05 with Social Science categories.


In this book and companion custom website you will find: • A comprehensive overview of the issues related to human behavior and the social environment that are important to understand for practice, updated with current and relevant information on important topics in social work. Additional relevant content, contemporary theories, and intervention modalities are incorporated throughout the text to keep students up to date with what is happening in the field. • Careful organization of chapters to first present foundational theoretical perspectives on the human condition, and then provide information on basic facets of human development, encouraging students to use conceptual lenses to inform their practice with individuals at different stages of life. Four final chapters cover theoretical foundations and issues surrounding spirituality, families and groups, organizations, and communities. These chapters offer in-depth information and discussions on mezzo and macro content. The organization of the chapters also helps students better understand how contemporary theories and approaches to issues stem from foundational theories and how they can be used to inform work with clients. • Particular emphasis on the ways in which poverty, diversity, and strengths affect human development and behavior. • The opportunity to see how the concepts fit into social work practice using case examples that open each chapter and are referred to throughout the chapter. • Interactive case studies at www.routledgesw.com/cases: Six easy-to-access fictional cases with dynamic characters and situations that students can easily reach from any computer and that provide a “learning by doing” format unavailable with any other text. Your students will have an advantage unlike any other they will experience in their social work training. • A wealth of instructor-only resources at www.routledgesw.com/hbse that provide full-text readings that link to the concepts presented in each of the chapters; a complete bank of objective and essay-type test items, all linked to current CSWE EPAS (Council on Social Work Education Educational Policy and Accreditation Standards); PowerPoint presentations to help students master key concepts; annotated links to a treasure trove of social work assets on the Internet; and a forum inviting all instructors using books in the series to communicate with each other and share ideas to improve teaching and learning. • Ideal for use in online as well as hybrid course instruction—in addition to traditional “bricks and mortar” classes. This bestseller is ideal for use in either one-semester or year-long generalist human behavior courses. Why? Because the text is concise and easily used in a one-semester course. But the text also comes with a companion set of readings, additional chapters focused on macro social work, and six unique cases that encourage your students to “learn by doing” and to apply their knowledge of human behavior to best practices. Go to www.routledgesw.com/hbse to learn more. These additional resources easily allow you to use the text (and its related resources) in a two-semester sequence.



Psychotic Disorders


Psychotic Disorders
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Author : Carol A. Tamminga
language : en
Publisher:
Release Date : 2020-11-03

Psychotic Disorders written by Carol A. Tamminga and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-03 with Medical categories.


The volume provides a comprehensive review of cutting-edge topics and treatment approaches to one of the most complex and fascinating brain disorders: psychosis. More than 70 leading experts in the field world-wide cover a broad range of topics on clinical, neurobiological, and treatment-related aspects of psychotic disorders. Chapters present a novel approach to psychotic disorders, emphasizing its dimensional nature and complexities of its underlying mechanisms incorporating both biological and psychosocial factors.