Producing Sensing And Responding To Cellular Stress In Immunity
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Producing Sensing And Responding To Cellular Stress In Immunity
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Author : Heitor A. Paula-Neto
language : en
Publisher: Frontiers Media SA
Release Date : 2019-11-28
Producing Sensing And Responding To Cellular Stress In Immunity written by Heitor A. Paula-Neto and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-28 with categories.
Cellular stress, being considered as any disturbance in cellular physiology, is a fundamental aspect of tissue and body capacity to adapt to the ever changing environment. It also surges as a consequence of tissue injury or invasion of the body by pathogens. Since the immune system was developed to sense and respond to these deleterious processes, it is reasonable to consider that immune cells are capable of sensing and responding to signs of cellular stress. Moreover, cells of the immune system undergo cellular stress during an immune response. This Research Topic presents a series of articles focusing on how cellular stress influences the outcome of immune responses, covering not only how cellular stress can be a fundamental process during immune cell activation and function, but also how cells of the immune system are capable of sensing and being influenced by factors produced by stressed cells.
Stress Response And Immunity Links And Trade Offs
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Author : Nadia Danilova
language : en
Publisher: Bentham Science Publishers
Release Date : 2020-02-04
Stress Response And Immunity Links And Trade Offs written by Nadia Danilova and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-04 with Science categories.
When environmental conditions deviate from the optimal range, stress ensues. Stress response is a set of reactions that allow the organism to adjust and survive adverse conditions. Stress can be physical, such as extreme temperature, radiation, injury, or psychological, caused by perceived danger or deprivation. Every living cell has biochemical mechanisms to cope with physical stress. These mechanisms show a degree of similarity among several types of living organisms. Stress Response and Immunity: Links and Trade Offs explores the functional and evolutionary connections between stress response and immunity. The book introduces the reader to the concept of stress and subsequently examines the connection between stress response and immunity at various evolutionary stages of living organisms - from bacteria to humans. The book also features chapters dedicated to the role of tumor suppressor genes and the immune system of the brain. The information presented in this reference demonstrates the profound effects of physical and psychological stress on human health. Readers with basic knowledge of molecular biology will learn about the interesting facets of stress responses and the evolutionary trade offs observed in different life forms.
The Innate Immune Response To Noninfectious Stressors
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Author : Massimo Amadori
language : en
Publisher: Academic Press
Release Date : 2016-02-23
The Innate Immune Response To Noninfectious Stressors written by Massimo Amadori and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-02-23 with Medical categories.
The Innate Immune Response to Non-infectious Stressors: Human and Animal Models highlights fundamental mechanisms of stress response and important findings on how the immune system is affected, and in turn affects such a response. In addition, this book covers the crucial link between stress response and energy metabolism, prompts a re-appraisal of some crucial issues, and helps to define research priorities in this fascinating, somehow elusive field of investigation. Provides insights into the fundamental homeostatic processes vis-à-vis stressors to help in investigation Illustrates the depicted tenets and how to offset them against established models of response to physical and psychotic stressors in both animals and humans Covers the crucial issue of the immune response to endocrine disruptors Includes immunological parameters as reporter system of environmental adaptation Provides many illustrative examples to foster reader understanding
Microbial Syntrophy Mediated Eco Enterprising
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Author : Raghvendra Pratap Singh
language : en
Publisher: Academic Press
Release Date : 2022-02-09
Microbial Syntrophy Mediated Eco Enterprising written by Raghvendra Pratap Singh and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-09 with Science categories.
Microbial Syntrophy-Mediated Eco-enterprising summarizes and reviews possible microbial applications for eco-industrial sustainability. The book emphasizes a wide spectrum of experimental and theoretical contributions from eminent researchers in the field. In 13 chapters, there is a focus on the microbial intrusions for remediating sites by accumulated pesticides, heavy metals, polyaromatic hydrocarbons, and other industrial effluents. Moreover, the potentiality and key mechanisms used by microorganisms for sustainable environmental management and their prospects are also considered in this new release. The term syntrophy for nutritional interdependence is often used in microbiology to describe the symbiotic relationship between bacterial species. Understanding such interactions can be of considerable interest when we come to manipulate microbes to our own benefit, such as by disrupting pathogenic communities with antibiotics or by promoting efficiency in communities that produce energy or break down waste. Summarizes and reviews possible microbial applications for eco-industrial sustainability Includes a wide spectrum of experimental and theoretical contributions from eminent researchers in the field Focuses on microbial intrusions for remediating sites and other industrial effluents
Free Radicals In Human Health And Disease
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Author : Vibha Rani
language : en
Publisher: Springer
Release Date : 2014-11-14
Free Radicals In Human Health And Disease written by Vibha Rani and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-14 with Science categories.
The role of oxidative stress in human disease has become an area of intense interest. Free radicals, a normal product of metabolism, exist in all aerobic cells in balance with biochemical antioxidants. Environmental stress increases the levels of free radicals drastically, thereby disturbing the equilibrium between free radical production and the antioxidant capability causing oxidative stress. Over the years, ROS has been implicated in the pathologies of various diseases like cancer, neurological disorder, cardiovascular diseases rheumatoid arthritis, diabetes etc. This book provides an in depth critical state-of-art reviews from established investigators on free radicals, ROS associated pathogenesis of human diseases, biomarkers of oxidative damage, antioxidants, phytonutrients and other related health concerns of modern society. The present book is aimed at graduate students, researchers in academia, industry and clinicians with the interest in redox biology. Special attention has been devoted to the topic of ROS signalling, oxidative stress induced human pathologies & antioxidative therapies. The book consists of four parts in specified topics based on the current literatures for the better understanding of the readers with respect to their subject-wise interests. The first section of the book provides an overview about the ROS production and their measuring tools and techniques followed by the mechanisms involved in the oxidative stress in the second section. The third section describes the involvement of oxidative stress in different human diseases and the last section focuses on the different strategies to ameliorate oxidative stress induced stress.
Zika Virus What Have We Learnt Since The Start Of The Recent Epidemic
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Author : Rubén Bueno-Marí
language : en
Publisher: Frontiers Media SA
Release Date : 2018-04-12
Zika Virus What Have We Learnt Since The Start Of The Recent Epidemic written by Rubén Bueno-Marí and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-04-12 with categories.
The considerable number of viral infectious disease threats that have emerged since the beginning of the 21st century have shown the need to dispose global and coordinated responses to fight properly and efficiently against them. Severe acute respiratory syndrome (2003), avian influenza in humans (2005), A(H1N1) pandemic influenza (2009), Middle East respiratory syndrome coronavirus (MERS-CoV) (2012 onward) and Ebola virus disease (2014-2015) are some of the most important examples. The latest emerging and devastating threat was Zika virus, an arbovirus that provoked more than 500,000 suspicious cases in the Americas in 2016 and notable processes of social and medical alarms due to the evidence of a causal link between Zika virus and several congenital injuries, like microcephaly, as well as due to its association with neurological disorders such as Guillain-Barré syndrome in adults (PAHO, 2017). In the framework of this global response and multistrategic approach, the purpose of this Research Topic is to provide updated information and novel researches about control strategies, encompassing virological, entomological and epidemiological data, in order to reach the triad of protagonists of transmission cycles (virus, mosquitoes and humans).
Outsmarting The Host How Bacterial Pathogens Modulate Immune Responses In The Lung
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Author : Gee W. Lau
language : en
Publisher: Frontiers Media SA
Release Date : 2021-03-22
Outsmarting The Host How Bacterial Pathogens Modulate Immune Responses In The Lung written by Gee W. Lau and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-22 with Medical categories.
Role Of Cd1 And Mr1 Restricted T Cells In Immunity And Disease
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Author : Kazuya Iwabuchi
language : en
Publisher: Frontiers Media SA
Release Date : 2019-10-18
Role Of Cd1 And Mr1 Restricted T Cells In Immunity And Disease written by Kazuya Iwabuchi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-18 with categories.
CD1 and MR1 are major histocompatibility complex (MHC) class I-related proteins that bind and present non-peptide antigens to subsets of T cells with specialized functions. CD1 proteins typically present lipid antigens to CD1-restricted T cells, whereas MR1 presents vitamin B-based ligands and a variety of drugs and drug-like molecules to MR1-restricted T cells. The CD1 family of antigen presenting molecules has been divided into two groups: Group 1 contains CD1a, CD1b and CD1c, and Group 2 contains CD1d. Additionally, CD1e is expressed intracellularly and is involved in the loading of lipid antigens onto Group 1 CD1 proteins. Humans express both Groups 1 and 2 CD1 proteins, whereas mice only express CD1d. Group 1 CD1 proteins present lipid antigens to T cells that generally express diverse T cell receptors (TCRs) and exhibit adaptive-like functions, whereas CD1d presents lipid antigens to subsets of T cells that express either diverse or highly restricted TCRs and exhibit innate-like functions. CD1d-restricted T cells are called natural killer T (NKT) cells, which includes Type I or invariant NKT (iNKT) cells expressing semi-invariant TCRs, and Type II NKT cells expressing more diverse TCRs. CD1-restricted T cells have been implicated in a wide variety of diseases, including cancer, infections, and autoimmune, inflammatory and metabolic diseases. Additionally, NKT cells have been targeted for immunotherapy of disease with ligands such as α-galactosylceramide for iNKT cells, or sulfatide for Type II NKT cells. Like iNKT cells, MR1-restricted T cells express semi-invariant TCRs and display innate-like functions. MR1-restricted T cells, also called mucosal-associated invariant T (MAIT) cells, have been implicated in immune responses against a variety of pathogens such as Mycobacterium tuberculosis, Pseudomonas aeruginosa, Helicobacter pylori, hepatitis C virus and influenza virus. Moreover, these cells contribute to autoimmune and inflammatory diseases, including colitis, rheumatoid arthritis, psoriasis, lupus, and diabetes.
Immunity To Fungal Infections Insights From The Innate Immune Recognition And Antifungal Effector Mechanisms
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Author : Rodrigo Tinoco Figueiredo
language : en
Publisher: Frontiers Media SA
Release Date : 2021-09-15
Immunity To Fungal Infections Insights From The Innate Immune Recognition And Antifungal Effector Mechanisms written by Rodrigo Tinoco Figueiredo and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-15 with Science categories.
Systemic Lupus Erythematosus
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Author : George Tsokos
language : en
Publisher: Academic Press
Release Date : 2020-04-07
Systemic Lupus Erythematosus written by George Tsokos and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-07 with Medical categories.
This completely updated and expanded 2nd edition of Systemic Lupus Erythematosus, A Manual includes topics not covered previously with contributors who are at the forefront of each specific topic and with a global appeal. Each chapter is short and is presented critically with selected references, which should be valuable to a wider audience. This book combines basic with clinical science to help internists and specialists in the diagnosis and management of patients with SLE. It is a quick referral for people in the pharmaceutical industry in their efforts to bring much-needed drugs. It provides all the needed information to basic researchers old and new alike, who wish to enter the field of lupus and systemic autoimmunity in general. Focused state-of-the-art chapters prepared by top-notch experts in the field Latest understanding of cellular, molecular, biochemical aspects of disease pathogenesis Advanced aspects of genetic, microbiome, environmental, hormonal, and immunological contribution to the expression of the disease Current understanding of clinical features of the disease Recent efforts to develop new treatments