Producing Sensing And Responding To Cellular Stress In Immunity

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Producing Sensing And Responding To Cellular Stress In Immunity

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Author : Heitor A. Paula-Neto
language : en
Publisher: Frontiers Media SA
Release Date : 2019-11-28

Producing Sensing And Responding To Cellular Stress In Immunity written by Heitor A. Paula-Neto and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-28 with categories.

Cellular stress, being considered as any disturbance in cellular physiology, is a fundamental aspect of tissue and body capacity to adapt to the ever changing environment. It also surges as a consequence of tissue injury or invasion of the body by pathogens. Since the immune system was developed to sense and respond to these deleterious processes, it is reasonable to consider that immune cells are capable of sensing and responding to signs of cellular stress. Moreover, cells of the immune system undergo cellular stress during an immune response. This Research Topic presents a series of articles focusing on how cellular stress influences the outcome of immune responses, covering not only how cellular stress can be a fundamental process during immune cell activation and function, but also how cells of the immune system are capable of sensing and being influenced by factors produced by stressed cells.

Microbial Syntrophy Mediated Eco Enterprising

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Author : Raghvendra Pratap Singh
language : en
Publisher: Academic Press
Release Date : 2022-02-09

Microbial Syntrophy Mediated Eco Enterprising written by Raghvendra Pratap Singh and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-09 with Science categories.

Microbial Syntrophy-Mediated Eco-enterprising summarizes and reviews possible microbial applications for eco-industrial sustainability. The book emphasizes a wide spectrum of experimental and theoretical contributions from eminent researchers in the field. In 13 chapters, there is a focus on the microbial intrusions for remediating sites by accumulated pesticides, heavy metals, polyaromatic hydrocarbons, and other industrial effluents. Moreover, the potentiality and key mechanisms used by microorganisms for sustainable environmental management and their prospects are also considered in this new release. The term syntrophy for nutritional interdependence is often used in microbiology to describe the symbiotic relationship between bacterial species. Understanding such interactions can be of considerable interest when we come to manipulate microbes to our own benefit, such as by disrupting pathogenic communities with antibiotics or by promoting efficiency in communities that produce energy or break down waste. - Summarizes and reviews possible microbial applications for eco-industrial sustainability - Includes a wide spectrum of experimental and theoretical contributions from eminent researchers in the field - Focuses on microbial intrusions for remediating sites and other industrial effluents

Role Of Cd1 And Mr1 Restricted T Cells In Immunity And Disease

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Author : Kazuya Iwabuchi
language : en
Publisher: Frontiers Media SA
Release Date : 2019-10-18

Role Of Cd1 And Mr1 Restricted T Cells In Immunity And Disease written by Kazuya Iwabuchi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-18 with categories.

CD1 and MR1 are major histocompatibility complex (MHC) class I-related proteins that bind and present non-peptide antigens to subsets of T cells with specialized functions. CD1 proteins typically present lipid antigens to CD1-restricted T cells, whereas MR1 presents vitamin B-based ligands and a variety of drugs and drug-like molecules to MR1-restricted T cells. The CD1 family of antigen presenting molecules has been divided into two groups: Group 1 contains CD1a, CD1b and CD1c, and Group 2 contains CD1d. Additionally, CD1e is expressed intracellularly and is involved in the loading of lipid antigens onto Group 1 CD1 proteins. Humans express both Groups 1 and 2 CD1 proteins, whereas mice only express CD1d. Group 1 CD1 proteins present lipid antigens to T cells that generally express diverse T cell receptors (TCRs) and exhibit adaptive-like functions, whereas CD1d presents lipid antigens to subsets of T cells that express either diverse or highly restricted TCRs and exhibit innate-like functions. CD1d-restricted T cells are called natural killer T (NKT) cells, which includes Type I or invariant NKT (iNKT) cells expressing semi-invariant TCRs, and Type II NKT cells expressing more diverse TCRs. CD1-restricted T cells have been implicated in a wide variety of diseases, including cancer, infections, and autoimmune, inflammatory and metabolic diseases. Additionally, NKT cells have been targeted for immunotherapy of disease with ligands such as α-galactosylceramide for iNKT cells, or sulfatide for Type II NKT cells. Like iNKT cells, MR1-restricted T cells express semi-invariant TCRs and display innate-like functions. MR1-restricted T cells, also called mucosal-associated invariant T (MAIT) cells, have been implicated in immune responses against a variety of pathogens such as Mycobacterium tuberculosis, Pseudomonas aeruginosa, Helicobacter pylori, hepatitis C virus and influenza virus. Moreover, these cells contribute to autoimmune and inflammatory diseases, including colitis, rheumatoid arthritis, psoriasis, lupus, and diabetes.

Janeway S Immunobiology

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Author : Kenneth Murphy
language : en
Publisher: Garland Science
Release Date : 2016-03-01

Janeway S Immunobiology written by Kenneth Murphy and has been published by Garland Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-03-01 with Medical categories.

Janeway's Immunobiology is a textbook for students studying immunology at the undergraduate, graduate, and medical school levels. As an introductory text, all students will appreciate the book's clear writing and informative illustrations, and advanced students and working immunologists will appreciate its comprehensive scope and depth. Janeway's I

Outsmarting The Host How Bacterial Pathogens Modulate Immune Responses In The Lung

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Author : Gee W. Lau
language : en
Publisher: Frontiers Media SA
Release Date : 2021-03-22

Outsmarting The Host How Bacterial Pathogens Modulate Immune Responses In The Lung written by Gee W. Lau and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-22 with Medical categories.

Immunity To Fungal Infections Insights From The Innate Immune Recognition And Antifungal Effector Mechanisms

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Author : Rodrigo Tinoco Figueiredo
language : en
Publisher: Frontiers Media SA
Release Date : 2021-09-15

Immunity To Fungal Infections Insights From The Innate Immune Recognition And Antifungal Effector Mechanisms written by Rodrigo Tinoco Figueiredo and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-15 with Science categories.

The Innate Immune Response To Noninfectious Stressors

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Author : Massimo Amadori
language : en
Publisher: Academic Press
Release Date : 2016-02-23

The Innate Immune Response To Noninfectious Stressors written by Massimo Amadori and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-02-23 with Medical categories.

The Innate Immune Response to Non-infectious Stressors: Human and Animal Models highlights fundamental mechanisms of stress response and important findings on how the immune system is affected, and in turn affects such a response. In addition, this book covers the crucial link between stress response and energy metabolism, prompts a re-appraisal of some crucial issues, and helps to define research priorities in this fascinating, somehow elusive field of investigation. - Provides insights into the fundamental homeostatic processes vis-à-vis stressors to help in investigation - Illustrates the depicted tenets and how to offset them against established models of response to physical and psychotic stressors in both animals and humans - Covers the crucial issue of the immune response to endocrine disruptors - Includes immunological parameters as reporter system of environmental adaptation - Provides many illustrative examples to foster reader understanding

Cellular And Molecular Immunology E Book

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Author : Abul K. Abbas
language : en
Publisher: Elsevier Health Sciences
Release Date : 2021-02-19

Cellular And Molecular Immunology E Book written by Abul K. Abbas and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-19 with Medical categories.

Well-written, readable, and superbly illustrated, Cellular and Molecular Immunology, 10th Edition, continues the tradition of excellence established through multiple editions of this bestselling text. Offering an unparalleled introduction to this complex field, it retains a practical, clinical focus while updating and revising all content to ensure clarity and comprehension, bringing readers fully up to date with new and emerging information in this challenging area. It's an ideal resource for medical, graduate, and undergraduate students, as well as a trusted reference for physicians and scientists. - Highlights the implications of immunologic science for the management of human disease, emphasizing clinical relevance throughout. - Employs a highly accessible writing style that makes difficult concepts easier to understand, and provides clear implications of immunologic science to the management of human disease and clinical practice. - Features updates from cover to cover, including new information on intracellular sensors of innate immunity, therapeutic use of monoclonal antibodies, regulation of migration events during T cell-B cell interactions, regulatory and transcriptional events in germinal center formation, immunology of infectious diseases including coronaviruses, human immunodeficiency disorders, and immunology of HIV. - Provides a highly visual, full-color description of the key immunologic and molecular processes with a fully updated, comprehensive, and consistent art program, including many new and extensively revised illustrations. - Helps readers grasp the details of experimental observations that form the basis for the science of immunology at the molecular, cellular, and whole-organism levels and draw the appropriate conclusions. - Includes summary boxes that assist with rapid review and mastery of key material. - Evolve Instructor site with an image and test bank is available to instructors through their Elsevier sales rep or via request at https://evolve.elsevier.com.

Viral Evasion Mechanisms Of The Host Response

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Author : Ricardo Martín Gómez
language : en
Publisher: Frontiers Media SA
Release Date : 2020-04-06

Viral Evasion Mechanisms Of The Host Response written by Ricardo Martín Gómez and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-06 with categories.

Sirtuin Biology In Medicine

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Author : Kenneth Maiese
language : en
Publisher: Academic Press
Release Date : 2021-03-04

Sirtuin Biology In Medicine written by Kenneth Maiese and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-04 with Medical categories.

Sirtuin Biology in Medicine: Targeting New Avenues of Care in Development, Aging, and Disease provides a fascinating and in-depth analysis of sirtuins in the body during normal physiology as well during disease highlighting the targeting of sirtuin-controlled pathways for the development of innovative, efficacious, and safe therapeutic strategies for multiple disorders in the body that ultimately can affect lifespan extension. Sirtuins are expressed throughout the body, have broad biological effects, and can significantly impact both cellular survival and longevity during acute and long-term illnesses. These histone deacetylases play an intricate role in the pathology, progression, and treatment of several disease entities ranging from neurodegenerative disorders, cardiovascular disease, immune system dysfunction, reproductive dysfunction, endocrine disorders, gastrointestinal disease, drug dependency, and aging-related disorders. Implementing a translational medicine format, this unique reference highlights novel signaling pathways for sirtuins that promote stem cell proliferation, enhance cellular protection, modulate pathways of apoptosis and autophagy, and extend life span. Each chapter is presented with insightful detail that will be of interest and a comprehensive resource to audiences that include scientists, physicians, pharmaceutical industry experts, nutritionists, and students. - Chapters are authored by internationally recognized experts who discuss the broad role of sirtuins in health and disease - Details the basic and clinical role of sirtuins for the development of new clinical treatments - Summarizes the multidiscipline views and publications for the compelling discipline of sirtuins by covering systems throughout the body - Serves as an important resource for a broad audience of healthcare providers, scientists, drug developers, and students in both clinical and research settings