Progestins And The Mammary Gland
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Progestins And The Mammary Gland
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Author : Orla M. Conneely
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-03-27
Progestins And The Mammary Gland written by Orla M. Conneely and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-03-27 with Science categories.
Progestins play a key role in reproductive endocrinology and as pharmaceutical drugs for contraception and in combined hormone therapy. To further our understanding of progestin action in the mammary gland, an international symposium, attended by leading researchers from academia and industry, was held in Berlin, 21–23 March 2007. Genetic mouse models helped to elucidate the role of progestins, both in normal breast development and in disease. Mechanistic molecular studies inspired the design of new progestins with improved tissue selectivity. In addition, the clinical impact of progesterone receptor agonists and antagonists for the prevention and treatment of breast cancer was discussed.
Progestins And The Mammary Gland
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Author : Orla M. Conneely
language : en
Publisher: Springer
Release Date : 2008-04-24
Progestins And The Mammary Gland written by Orla M. Conneely and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-24 with Science categories.
Progestins play a key role in reproductive endocrinology and as pharmaceutical drugs for contraception and in combined hormone therapy. To further our understanding of progestin action in the mammary gland, an international symposium, attended by leading researchers from academia and industry, was held in Berlin, 21–23 March 2007. Genetic mouse models helped to elucidate the role of progestins, both in normal breast development and in disease. Mechanistic molecular studies inspired the design of new progestins with improved tissue selectivity. In addition, the clinical impact of progesterone receptor agonists and antagonists for the prevention and treatment of breast cancer was discussed.
Progestins And The Mammary Gland
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Author : Orla M. Conneely
language : en
Publisher: Springer
Release Date : 2009-09-02
Progestins And The Mammary Gland written by Orla M. Conneely and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-02 with Science categories.
Progestins play a key role in reproductive endocrinology and as pharmaceutical drugs for contraception and in combined hormone therapy. To further our understanding of progestin action in the mammary gland, an international symposium, attended by leading researchers from academia and industry, was held in Berlin, 21–23 March 2007. Genetic mouse models helped to elucidate the role of progestins, both in normal breast development and in disease. Mechanistic molecular studies inspired the design of new progestins with improved tissue selectivity. In addition, the clinical impact of progesterone receptor agonists and antagonists for the prevention and treatment of breast cancer was discussed.
Progesterone And Progestins
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Author : C. Wayne Bardin
language : en
Publisher: Raven Press (ID)
Release Date : 1983
Progesterone And Progestins written by C. Wayne Bardin and has been published by Raven Press (ID) this book supported file pdf, txt, epub, kindle and other format this book has been release on 1983 with Corpus luteum categories.
The Regulation And Function Of Progesterone Receptor Isoforms A And B In The Normal Mouse Mammary Gland
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Author : Mark Douglas Aupperlee
language : en
Publisher:
Release Date : 2008
The Regulation And Function Of Progesterone Receptor Isoforms A And B In The Normal Mouse Mammary Gland written by Mark Douglas Aupperlee and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Breast categories.
Control Of The Mammary Cell Cycle Clock By Estrogen And Progesterone
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Author :
language : en
Publisher:
Release Date : 2001
Control Of The Mammary Cell Cycle Clock By Estrogen And Progesterone written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with categories.
Both the growth and the development of the mammary gland are controlled by the female hormones estrogen, prolactin and progesterone, and by interactions between the epithelial and stromal compartments of the breast. Changes in the regulation of any of these processes may lead to breast cancer. We have investigated the role of progesterone in the process of sidebranching and alveologenesis in the mammary gland using mice lacking the progesterone receptor which are defective in these processes. By reconstituting murine mammary glands in vivo, we have shown that the progesterone receptor is required only in epithelial cells for proper sidebranching and alveologenesis to occur. Our studies indicate that progesterone acts in a paracrine manner and suggest that Wnt-4 is a mediator of the paracrine signals released from progesterone receptor-positive cells. In addition, we have characterized the role of the estrogen receptor (ER) in regulating the proliferation of breast cancer cells. We postulate that the ability of ER to control cyclin Dl expression and proliferation of breast cancer cells may be acquired during breast cancer progression. This is indicated by the fact that ectopic expression of the estrogen receptor in human epithelial cells does not, on its own, enable signaling between the ER and the cyclin D1 gene. Moreover, others have demonstrated that the ER-positive cells in the mammary epithelium are distinguishable from those that are actively mitotic. Finally, our work indicates that the effects of deletion of the prolactin receptor (PrlR) from mammary epithelial cells closely phenocopy the consequences of deleting cyclin Dl from these cells. We suggest that activation of the PrlR by its ligand results in the production of insulin-like growth factor-2 which in turn induces cyclin D1 synthesis in these cells.
The Effects Of Estrogen Progesterone And Prolactin On The Oxytocin Receptors In The Rat Mammary Gland
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Author : Annabeth Ruberti
language : en
Publisher:
Release Date : 1982
The Effects Of Estrogen Progesterone And Prolactin On The Oxytocin Receptors In The Rat Mammary Gland written by Annabeth Ruberti and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1982 with Lactation categories.
Hormonal Regulation Of Mammary Tumors
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Author : Benjamin S. Leung
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Hormonal Regulation Of Mammary Tumors written by Benjamin S. Leung and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The concept that hormones influence tumor growth originated in 1889 with the proposal of Albert Schinzinger who suggested that breast cancer is related to the ovaries. Several years later, Sir George Beatson observed that remission of disseminated breast cancer could be achieved in premenopausal patients by performing bilateral oophorectomy. As a result of the contri butions of Hedley Atkins, Charles Huggins and others, additive and ablative hormonal therapies have been widely used for the treatment of advanced breast cancers for several decades. Model systems to study the effects of hormones on growth and regression of breast tumors have been available for many years; however, the complexities of the hormonal environment have rendered in vivo studies difficult in man and experimental animals. Recently, the availability of long-term cultures of breast cancer cells has stimulated many investigators to use these cell lines to unravel the mechanisms of hormone action. Because of the extreme diversity and complexity of advances regarding the endocrinology of the breast and breast cancers, a multi-authored review was deemed necessary. It has been gratifying to receive contributions from many noted scholars. In Volume I of this monograph, the influence of steroid hormones and their antagonists upon normal and neoplastic tissues of the mammary gland are presented. In Volume II, the effects of peptide and other hormones are reviewed.
Is The Regenerative Capacity Of The Mammary Gland Contained With Those Mammary Cells That Express The Progesterone Receptor Implications For Breast Cancer
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Author :
language : en
Publisher:
Release Date : 2001
Is The Regenerative Capacity Of The Mammary Gland Contained With Those Mammary Cells That Express The Progesterone Receptor Implications For Breast Cancer written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with categories.
Recent transgenic studies have demonstrated that targeted overexpression of the A and B isoforms of the progesterone receptor (PR) to the mammary gland results in excessive ductal branching and alveolar growth respectively. Based on the above, we hypothesized that mammary-specific stem cells are present as a subgroup within those epithelial cells that express PR. To determine whether a stem cell population is contained within the PR expressing cell population (PR(+)), a PR-lacZ knockin mouse in combination with fluorescent-activated cell sorting (FACS) was utilized to separate PR(+) from PR( - ) mammary cells; both cell populations would then be evaluated for their regenerative capacity by transplantation into the cleared mammary fat pad of a host animal. FACS analysis applied to the PR-lacZ mammary gland provided a significantly enriched (70%) PR(+) mammary epithelial cell population that maintained lacZ expression in culture. Although, PR(+) and PR( - ) enriched mammary epithelial cell populations were transplanted into mammary fat pads, these host animals were lost to Tropical Storm 'Allison'; estimation of the regenerative potential of the above mammary epithelial cell populations will have to await the expansion of the PR-lacZ colony.
Hormones And Breast Cancer In Post Menopausal Women
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Author : Sandra Z. Haslam
language : en
Publisher: IOS Press
Release Date : 2006
Hormones And Breast Cancer In Post Menopausal Women written by Sandra Z. Haslam and has been published by IOS Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Breast categories.
Focuses on the challenges of determining the mechanistic basis for the role of hormones in the etiology of postmenopausal breast cancer. This book intends to bring attention to the advancements and challenges facing effective prevention and treatment of this disease.