Progressive Neuroblastoma
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Progressive Neuroblastoma
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Author : H. Christiansen
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2015-09-28
Progressive Neuroblastoma written by H. Christiansen and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-28 with Medical categories.
Neuroblastoma is a tumor derived from the sympathetic nervous system. It is the most common extracranial solid tumor occurring in children and exhibits a marked variability in outcome when the disease is categorized by clinical (e.g. age or stage) and biologic characteristics. This book gives an introduction into the clinical features of progressive neuroblastoma and focuses on molecular-targeted therapies and immunotherapies of this disease. It has become increasingly clear that MYCN (v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog) holds a key position in neuroblastic transformation and gene expression in normal and transformed cells. In the 14 chapters important topics such as genomic alterations in neuroblastoma and strategies for indirect molecular targeting of MYCN are discussed. Two chapters, for example, review apoptotic pathways and proapoptotic molecular targets in neuroblastoma, one focusing on the p53 pathway and the extrinsic and intrinsic pathways of apoptosis. Other chapters cover topics related to immunology in neuroblastoma, such as immune regulation in neuroblastoma, immunotherapy related to passive and active vaccination approaches and additional immunotherapy in the treatment of progressive disease. This volume will be essential reading for all clinicians and basic researchers who are involved in delivering health care to patients with progressive neuroblastoma.
The Neurology Of Neuroblastoma
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Author : Nina Felice Schor
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Neurology Of Neuroblastoma written by Nina Felice Schor and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Neuroblastoma is the single most common solid tumor of childhood. Although children with small primary neuroblastomas alone are almost always cured by surgery, 65% of children with neuroblastoma already have large bulky tumors or metastatic disease by the time of initial diagnosis. For these children, the 5-year survival rate is only somewhere between 5% and 20% with therapies including surgery, radiation, chemotherapy, and bone marrow transplantation. Dr Schor outlines a new approach to these tumors in order to make a difference for these children. There is much information to support the notion that neuroblastomas represent a developmental aberration of the nervous system, rather than a de novo abnormality in a previously normal cell. While the remote, paraneoplastic effects of neuroblastoma are often the purview of the child neurologist, the neoplasm itself has been viewed and approached therapeutically in much the same manner as all other solid tumors, as the purview of the pediatric oncologist. This work takes the view that approaching neuroblastoma rather as a disorder of nervous system development offers new therapeutic possibilities for this common tumor of childhood.
Neuroblastoma
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Author : Sabine Sarnacki
language : en
Publisher: Springer
Release Date : 2019-08-12
Neuroblastoma written by Sabine Sarnacki and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-12 with Medical categories.
This book addresses neuroblastoma, a type of embryonic tumor derived from neural crest cells and one of the most frequent extra-cranial solid tumors in children. However, the term also describes a heterogeneous group of tumors, the prognosis of which can differ greatly according to age, stage and biology. Some forms undergo spontaneous regression, and some are cured by surgery alone or after chemo-reduction, while others exhibit extremely aggressive behavior. Their successful treatment is one of the best examples of tailored medicine, which involves close collaboration between pediatric surgeons, pediatric oncologists, radiologists, nuclear medicine specialists, biologists, oncogeneticists and radiotherapists. The book pursues a unique approach, as it combines most essential insights from all of these fields, together with key information regarding epidemiology, physiopathology and palliative care. The respective chapters were written by the leading international experts on neuroblastoma, and present the latest advances in terms of research, surgical approaches and medical treatments. The book offers an invaluable resource to all pediatric surgeons, pediatricians, oncologists, students, researchers and all others involved in neuroblastoma management who want to benefit from their colleagues’ expertise.
Neuroblastoma
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Author : Nai-Kong V. Cheung
language : en
Publisher: Springer Science & Business Media
Release Date : 2005-10-21
Neuroblastoma written by Nai-Kong V. Cheung and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-10-21 with Medical categories.
Neuroblastoma is a medical enigma. As a childhood neoplasm arising from neural crest cells, it is characterized by diverse clinical behaviors ranging from spontaneous remission to rapid tumor progression and death. Although clinical outcome can be predicted to a large extent by the stage of disease and the age at diagnosis, an in-depth understanding of its clinico-pathological behavior, now greatly aided by sophisticated molecular genetic profiling, will improve diagnostic precision and refine risk-based therapies. Comprehensive international efforts have advanced our understanding of tumor biology and improved the clinical management of children with neuroblastoma. This book reviews our current understanding of the genes and biological pathways that contribute to neuroblastoma pathogenesis, modern risk-based treatment approaches for these patients, and recent advances in biologically based therapy. It provides a concise up-to-date reference for practitioners, students, and researchers.
Neuroblastoma
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Author : Shahab Asgharzadeh
language : en
Publisher: Springer Nature
Release Date :
Neuroblastoma written by Shahab Asgharzadeh and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Neuroblastoma
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Author : Chandrika Gowda
language : en
Publisher: BoD – Books on Demand
Release Date : 2017-10-25
Neuroblastoma written by Chandrika Gowda and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-25 with Medical categories.
Neuroblastoma (NBL) is the most common extracranial solid tumor of childhood, with about 700 new cases of neuroblastoma seen each year in the United States. The 5-year survival rate for children with high-risk NBL is only 50-60%, and this survival rate has not improved over the last 10 years. High-risk patients receive multimodality treatment, including chemotherapy, surgery, radiation therapy, biologic therapy and immunotherapy, all of which are associated with significant morbidity. Recent years have seen many advances in treatment of neuroblastoma, including therapeutic MIBG, immunotherapy, and personalized targeted therapy based on the genetic alterations seen in the tumor. The primary objective of this book is to provide the readers with a comprehensive review of neuroblastoma, from clinical aspects and the currently available treatment to recent advancements and future directions in the field of NBL treatment. The topics and chapters have been compiled keeping in mind a diverse group of readers in different areas of specialty such as pediatric oncology, surgery, radiation oncology, and immunology, as well as physician scientists and basic researchers working in the field of neuroblastoma.
Neuroblastoma
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Author : Carl E. Pochedly
language : en
Publisher: CRC Press
Release Date : 1990-06-21
Neuroblastoma written by Carl E. Pochedly and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990-06-21 with Medical categories.
The purpose of this book is to provide a comprehensive review of current knowledge and to give a thoughtful assessment of the many complex issues involved in the diagnosis and treatment of this common malignant solid tumor found in children. This up-to-date publication also reviews new concepts in histogenesis and histopathology of neuroblastoma. Divided into three main sections, this work focuses on tumor biology, clinical management, and prognosis and future perspectives. This fascinating work includes in-depth discussions on neuroblastoma in infancy and the manifestations of this tumor as it affects various organs and various parts of the body. It also provides guidelines for treatment with surgery, radiotherapy and chemotherapy. This ideal resource is loaded with information for all those who care for children with cancer, including pediatric oncologists, medical oncologists, pathologists, radiotherapists, pediatric nurse oncologists and pediatricians.
Neuroblastoma
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Author : Carl Pochedly
language : en
Publisher: North-Holland
Release Date : 1982
Neuroblastoma written by Carl Pochedly and has been published by North-Holland this book supported file pdf, txt, epub, kindle and other format this book has been release on 1982 with Medical categories.
Neuroblastoma
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Author : Judy S.E. Moyes
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Neuroblastoma written by Judy S.E. Moyes and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The use of metaiodobenzylguanidine as a radiopharmaceutical offers exciting new possibilities, and well-known authorities share their experience in this volume. It is designed as a practical aid for those who are starting to employ the relatively new method of mIGB in the diagnosis and treatment of neuroblastoma. Profusely illustrated case histories demonstrate the normal and pathological uptake of mIGB and assist the beginner to correctly interpret the scintigrams. Details of the techniques for assessing the radiation dose to the tumors undergoing targetted radiotherapy are given, and the practical details required for its safe use in the pediatric environment are discussed.
Neuroblastoma
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Author : Shahab Asgharzadeh
language : en
Publisher: Springer
Release Date : 2024-04-29
Neuroblastoma written by Shahab Asgharzadeh and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04-29 with Medical categories.
This book provides a state-of-the-art review of the biology, treatment, and other critical aspects of neuroblastoma, reflecting the dramatic advances that have been achieved in understanding and management. Topics are arranged according to the book’s dominant themes of the “seed” (tumor genomics, epigenetics, metabolism, and stem cells) and the “soil” (tumor microenvironment, adaptive and innate immunity, and exosomes) and how both of these influences can serve as rich targets for intervention, whether by targeted molecular therapy or immunotherapy. Therapeutic strategies that are currently in use or under consideration for the future are discussed in detail, with the focus on precision medicine. Further individual chapters are devoted to the biology and genetics of relapsed/refractory neuroblastoma and emerging methods of evaluating tumor burden. Finally, in keeping with the, albeit modest, increase in cure rates in high-risk disease, immune and cellular therapies are reviewed. This coverage of what is becoming a not-so-enigmatic tumor will appeal to a broad readership including both experimental oncologists and clinicians who care for patients with neuroblastoma.