Prolactin Physiology And Clinical Significance
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Prolactin Physiology And Clinical Significance
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Author : D.F. Horrobin
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Prolactin Physiology And Clinical Significance written by D.F. Horrobin and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
I first became interested in prolactin a little over two years ago. I was then working in Nairobi and I knew nothing about the hormone apart from its role in lactation. Professor Mohammed Hyder of the Department of Zoology in the University of Nairobi was interested in the endocrine mechanisms which enable Tilapia fish to adapt to water with a very high electrolyte content. He invited me to a seminar given by Professor Howard Bern which was largely concerned with the role prolactin plays in fluid and electrolyte balance in sub-mammalian vertebrates. This inspired me to begin a programme of research into the roles prolactin plays in man and other animals. Very few physiologists or clinicians seem aware of the multifarious effects of prolactin in mammals. This book therefore aims to give a comprehensive account of the mammalian physiology of prolactin and to make suggestions about its possible role in diseases ranging from cancer to mental illness. The two subjects which have been previously widely covered, the roles of prolactin in lactation and in rat mammary cancer, are presented relatively briefly though with a full list of references. Other subjects are dealt with more extenSively and I hope that many research workers and clinicians may find the book helpful.
Prolactin
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Author :
language : en
Publisher:
Release Date : 1973
Prolactin written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1973 with categories.
Prolactin
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Author : E. Flückiger
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Prolactin written by E. Flückiger and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Lactogenic hormone activity was first observed in bovine pituitary extracts by Stricker and Griiter in 1928, working in Bouin's laboratory in Strasbourg. Since that time prolactin has been shown to exist in anterior pituitary extracts of almost all vertebrate species investigated. Although its biology was extensively studied in many mammalian species, the existence of prolactin in the human was generally doubted, despite the positive evidence produced by such researchers as Pasteels. This can partly be explained by the fact that human growth hormone isolated in 1961, is itself a potent lactogen, in contrast to nonprimate growth hormones, and is present in the normal human pituitary in much greater amounts than prolactin. As a result there was a lag of nearly 10 years until prolactin was unanimously accepted as a hormone of the human pituitary, separate from human growth hormone. In 1970 new bioassay techniques permitted the demonstration of prolactin bioactivity in the serum of postpartum women and galactorrhea patients, and chromatographic methods led to the isolation and purification of human prolactin allowing the establishment of a specific radioimmunoassay for this hormone. This opened the road to the understanding of prolactin physiology and pathophysiology in the human, which has revolutionized clinical neuroendocrinology and reproductive endocrinology. Particularly hyperprolactinemia has turned out to be one of the most common endocrine syndromes.
Prolactin Disorders
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Author : Nicholas A. Tritos
language : en
Publisher: Springer
Release Date : 2019-05-06
Prolactin Disorders written by Nicholas A. Tritos and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-06 with Medical categories.
This unique book will serve as a valuable resource for clinicians and researchers interested in prolactin physiology and pathophysiology and those who are involved in the care of patients with related disorders, including hyperprolactinemia and prolactin-secreting pituitary adenomas. Timely and up-to-date, it opens with a review of the historical aspects of prolactin research and a discussion of pituitary anatomy and physiology. Several chapters examine basic and translational aspects of prolactin physiology, focusing on recent developments and future directions. The main portion of the book is comprised of chapters presenting the clinical aspects of prolactin excess or deficiency, with particular emphasis placed on prolactin-secreting pituitary adenomas and co-secreting tumors. Concluding chapters address prolactin-secreting pituitary adenomas in special populations – women in the preconception period or during pregnancy, children and adolescents, and men – as well as plurihormonal and aggressive adenomas and carcinomas. Written and edited by experts in the field, Prolactin Disorders will be a ready reference for a diverse array of professionals, from basic scientists to clinical investigators and clinicians from several specialties, including specialists in endocrinology, neurosurgery, radiation oncology and neuro-oncology.
Prolactin
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Author : Nelson D. Horseman
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Prolactin written by Nelson D. Horseman and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
It is an authentic privilege to have the opportunity to assemble and edit a new volume on "Prolactin," the first in several decades to be devoted to this fascinating hormone in all its aspects. The obvious clinical rationale for understanding prolactin (PRL) is the frequent occurrence of prolactinomas, the most common type of pituitary tumor. Fortunately, medical management of prolactinomas can be based on our under standing of the physiology of hypothalamic control of the lactotroph. Armed with this knowledge, therapies for proiactinomas are highly successful and well tolerated. Be cause of the historical and practical importance of knowledge regarding the hypothala mus-Iactotroph axis, the first chapters of this volume are dedicated to reviewing the physiology, development, and cell biology of lactotroph regulation. Chapters focusing on prolactinomas and related clinical issues follow these. PRL is the primary hormone that is responsible for "parental care" in many verte brate species. This reproductive strategy is not unique to mammals, but it has devel oped through evolution to be the central distinguishing feature of the mammalian life cycle. Among the mammals, mice have become the most effective research species in recent years. This can be traced to the development of a wide range of methods for manipulating mouse genetics, and thereby influencing development, physiology and behavior. Mice also provide a profound illustration of the physiological challenges faced in maternity. Female mice undergo a post-partum estrous, and often are both pregnant and lactating simultaneously.
Prolactin Secretion A Multidisciplinary Approach
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Author : Flavio Mena
language : en
Publisher: Academic Press
Release Date : 2012-12-02
Prolactin Secretion A Multidisciplinary Approach written by Flavio Mena and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
Prolactin Secretion: A Multidisciplinary Approach covers the proceedings of the 1982 symposium on the frontiers and perspective of prolactin secretion through a multidisciplinary approach, convened in Nabor Carrillo Hall of the Natural University of Mexico. The symposium represents a genuine interdisciplinary effort to provide insights into the complexities of prolactin. Separating 24 manuscripts into chapters, this book first discusses studies on the molecular evolution of prolactin (PRL) and the related growth hormones and placental lactogens and the relevance of these studies for biological research on PRL, with particular emphasis on PRL secretion. Significant topics on the physiology, biochemistry, synthesis regulation, structure, function, glycoconjugates, gene expression control, regulatory, and control mechanisms of PRL and its secretion are considered in the subsequent chapters. This book also examines the action(s) of dopamine on the PRL-producing cells, the effects of his-pro diketopiperazine on PRL secretion, and the role of cellular phospholipids and the Ca2+-calmodulin system as modulators of PRL release. The effect of the suckling stimulus on the induction of PRL release in different reproductive states and the role of PRL in parental behavior in selected species of mammals and birds are also considered. The concluding chapters describe the morphologic features of abnormal lactotrophs, the in vivo and in vitro secretory activity exhibited by different types of pituitary adenomas and hyperprolactinemia. This book serves as an important reference for a wide range of investigators and advanced medical students who are engaged in the study of basic and clinical prolactin physiology.
Prolactin
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Author : E. Flückiger
language : en
Publisher: Springer
Release Date : 1981-12-01
Prolactin written by E. Flückiger and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1981-12-01 with Medical categories.
Lactogenic hormone activity was first observed in bovine pituitary extracts by Stricker and Griiter in 1928, working in Bouin's laboratory in Strasbourg. Since that time prolactin has been shown to exist in anterior pituitary extracts of almost all vertebrate species investigated. Although its biology was extensively studied in many mammalian species, the existence of prolactin in the human was generally doubted, despite the positive evidence produced by such researchers as Pasteels. This can partly be explained by the fact that human growth hormone isolated in 1961, is itself a potent lactogen, in contrast to nonprimate growth hormones, and is present in the normal human pituitary in much greater amounts than prolactin. As a result there was a lag of nearly 10 years until prolactin was unanimously accepted as a hormone of the human pituitary, separate from human growth hormone. In 1970 new bioassay techniques permitted the demonstration of prolactin bioactivity in the serum of postpartum women and galactorrhea patients, and chromatographic methods led to the isolation and purification of human prolactin allowing the establishment of a specific radioimmunoassay for this hormone. This opened the road to the understanding of prolactin physiology and pathophysiology in the human, which has revolutionized clinical neuroendocrinology and reproductive endocrinology. Particularly hyperprolactinemia has turned out to be one of the most common endocrine syndromes.
Lactogenesis
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Author : Monica Reynolds
language : en
Publisher: University of Pennsylvania Press
Release Date : 2016-11-11
Lactogenesis written by Monica Reynolds and has been published by University of Pennsylvania Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-11 with Medical categories.
Proceedings of a symposium, satellite to the 24th International Congress of Physiological Sciences, University of Pennsylvania.
Clinical Neuroendocrinology
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Author : Michael Wilkinson
language : en
Publisher: Cambridge University Press
Release Date : 2019-01-03
Clinical Neuroendocrinology written by Michael Wilkinson and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-03 with Medical categories.
A concise and innovative account of clinical neuroendocrine disorders and the key principles underlying their diagnosis and management.
Prolactin And Prolactinomas
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Author : George Tolis
language : en
Publisher:
Release Date : 1983
Prolactin And Prolactinomas written by George Tolis and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1983 with Medical categories.