Prospects For Antisense Nucleic Acid Therapy Of Cancer And Aids
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Prospects For Antisense Nucleic Acid Therapy Of Cancer And Aids
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Author : Eric Wickstrom
language : en
Publisher: Wiley-Liss
Release Date : 1991-10-18
Prospects For Antisense Nucleic Acid Therapy Of Cancer And Aids written by Eric Wickstrom and has been published by Wiley-Liss this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-10-18 with Medical categories.
A wide range of new technology involving a direct genetic approach to the treatment of disease using nucleic acid therapeutics is the main focus of this absorbing book. Provides in-depth coverage of the rapid progress of this new technology, from its theoretical stage to its current position at the verge of experimental applications, along with provocative discussions of the therapeutic implications.
Anti Aids Drug Development
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Author : Prem Mohan
language : en
Publisher: CRC Press
Release Date : 1995-03-01
Anti Aids Drug Development written by Prem Mohan and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-03-01 with Medical categories.
Curative anti-AIDS drug therapy still remains as an unconquered hurdle to drug research. This book covers significant aspects that are involved in the search, design and development of potential anti-AIDS agents with emphasis on areas related to drug development. These include enzyme inhibitors (reverse transcriptase, protease, glucosidase), inhibitors of gene expression (oligonucleotides), viral-binding inhibitors (anionic compounds and CD4 mimetics) and various plant derived products. A focus of this book is the medicinal chemistry of these classes of compounds. In addition, other areas that are pertinent to drug development are also addressed. These include HIV regulatory proteins, the development of anti-HIV-1 assays and resistance to anti-HIV-1 agents.
Delivery Strategies For Antisense Oligonucleotide Therapeutics
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Author : Saghir Akhtar
language : en
Publisher: CRC Press
Release Date : 2017-07-28
Delivery Strategies For Antisense Oligonucleotide Therapeutics written by Saghir Akhtar and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-28 with Medical categories.
With contributions from leading experts, this book is the first to focus solely on addressing the problems and reviewing the strategies currently being used to improve the delivery of antisense nucleic acids. Important delivery issues, such as improving biological stability, improving cell-specific targeting and cellular uptake, manipulating subcellular distribution and producing liposomal delivery systems for antisense agents are comprehensively covered in this volume. This book links review-type articles with contributions that contain exciting never-before-published data on the cellular delivery of oligonucleotides. It stimulates reading for both established researchers and newcomers to the antisense field.
Antisense Research And Applications
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Author : Stanley T. Crooke
language : en
Publisher: CRC Press
Release Date : 1993-05-27
Antisense Research And Applications written by Stanley T. Crooke and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-05-27 with Medical categories.
Antisense Research and Applications is a comprehensive review of oligonucleotide research covering molecular biological advances in this field, the current status of antisense drug research, and strategies for future research and therapeutic applications. In bringing together the latest research from an array of authoritative scientists, Antisense Research and Applications provides an integrated conceptual basis for considering oligonucleotide therapeutics. Topics covered in the 32 chapters of this book include nucleic acid structure and function, antisense RNA, medicinal chemistry of oligonucleotides, analogs, pharmacokinetics and toxicology, and activities of current antisense drugs. This volume addresses advances in a broad range of disciplines and is an excellent resource for basic researchers and applied investigators in pharmaceutical laboratories and in such fields as biochemistry and molecular biology.
Clinical Trials Of Genetic Therapy With Antisense Dna And Dna Vectors
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Author : Eric Wickstrom
language : en
Publisher: CRC Press
Release Date : 2020-08-13
Clinical Trials Of Genetic Therapy With Antisense Dna And Dna Vectors written by Eric Wickstrom and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-13 with Medical categories.
An important new collection of clinical and preclinical reports on genetic therapy, this book describes illustrative examples of diseases in which gene-based interventions are presently plausible, and presents case studies of current research using both synthetic oligonucleotides and biological vectors. Combining the insights of over 50 contributors, Clinical Trials of Genetic Therapy with Antisense DNA and DNA Vectors furnishes a historical overview of genetic therapy highlights official Food and Drug Administration positions on the preparation of oligonucleotides and vectors offers practical models of agent preparation, animal testing, pharmacokinetics, toxicology, and clinical trials discusses both synthetic DNA and biological vector approaches to cancer, viral, and cardiological indications illustrates for new practitioners how each stage of genetic therapy is developed details genetic treatment of leukemia; lymphoma; cancer of the brain, breast, colon, kidney, and lung; melanoma; HIV; and coronary restenosis includes examples of antisense, ribozyme, tumor suppressor, immunostimulation, and gene replacement therapy and addresses questions of preparation, delivery, toxicity, mechanism, and specificity.
Peptide Nucleic Acids Morpholinos And Related Antisense Biomolecules
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Author : Christopher Janson
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-03-06
Peptide Nucleic Acids Morpholinos And Related Antisense Biomolecules written by Christopher Janson and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-03-06 with Medical categories.
This volume is unique to the existing literature in the Peptide Nucleic Acid field, in that it focuses on comparing and contrasting PNA with other available oligonucleotide homologues and considers areas in which these biomolecules could be profitably applied to clinical and diagnostic applications. Part I of the book addresses comparative strengths and weaknesses of various nucleoside homologues. Part II of the book addresses specific translational or clinical applications for PNA and related antisense biomolecules. The editors have succeeded in presenting a balanced yet broad view of the methods available for gene targeting and modification.
Journal Of The National Cancer Institute
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Author :
language : en
Publisher:
Release Date : 1998
Journal Of The National Cancer Institute written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Cancer categories.
Progress In Nucleic Acid Research And Molecular Biology
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Author :
language : en
Publisher: Academic Press
Release Date : 1996-02-12
Progress In Nucleic Acid Research And Molecular Biology written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-02-12 with Science categories.
Praise for the Serial: "Full of interest not only for the molecular biologist - for whom the numerous references will be invaluable - but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell." --British Medical Journal Provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology Contributions from leaders in their fields Abundant references
Current Cancer Research 1992
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Author : Deutsches Krebsforschungszentrum Heidelberg
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
Current Cancer Research 1992 written by Deutsches Krebsforschungszentrum Heidelberg and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Medical categories.
The Zebrafish Genetics Genomics And Informatics
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Author :
language : en
Publisher: Elsevier
Release Date : 2004-12-30
The Zebrafish Genetics Genomics And Informatics written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-12-30 with Science categories.
This volume of Methods in Cell Biology, the second of two parts on the subject of zebrafish, provides a comprehensive compendia of laboratory protocols and reviews covering all the new methods developed since 1999. This second volume covers advances in forward and reverse genetic techniques, provides an update on the zebrafish genome and gene/mutant mapping technologies, examines the new systems for efficient transgenesis in the zebrafish, provides an in-depth view of informatics and the emerging field of comparative genomics, and considers the extensive infrastructure now available to the zebrafish community. * Details state-of-the art zebrafish protocols, delineating critical steps in the procedures as well as potential pitfalls * Illustrates many techiques in full-color * Summarizes the Zebrafish Genome Project