Protein And Peptide Drug Delivery
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Peptide And Protein Delivery
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Author : Chris Van Der Walle
language : en
Publisher: Academic Press
Release Date : 2011-05-12
Peptide And Protein Delivery written by Chris Van Der Walle and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-05-12 with Science categories.
The growing area of peptide and protein therapeutics research is of paramount importance to medical application and advancement. A needed reference for entry level researchers and researchers working in interdisciplinary / collaborative projects, Peptide and Protein Delivery addresses the current and emerging routes for delivery of therapeutics. Covering cerebral delivery, pulmonary delivery, transdermal delivery, intestinal delivery, ocular delivery, parenteral delivery, and nasal delivery, this resource offers an overview of the main routes in therapeutics. Researchers across biochemistry, pharmaceutical, molecular biology, cell biology, immunology, chemistry and biotechnology fields will find this publication invaluable for peptide and protein laboratory research. Discusses the most recent data, ideas and concepts Presents case studies and an industrial perspective Details information from the molecular level to bioprocessing Thought provoking, for the novice to the specialist Timely, for today's biopharmaceuticals market
Peptide And Protein Drug Delivery
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Author : Vincent Lee
language : en
Publisher: CRC Press
Release Date : 1990-11-19
Peptide And Protein Drug Delivery written by Vincent Lee and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990-11-19 with Science categories.
This reference/text covers fundamentals of peptide and protein drug delivery, including such considerations as synthesis, physical chemistry and biochemistry, analysis, proteolytic and transport constraints, pharmacokinetics, and pharmacodynamics; bioavailability from routes of administration, detai
Protein And Peptide Drug Delivery
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Author : Nitai Charan Giri
language : en
Publisher:
Release Date : 2020
Protein And Peptide Drug Delivery written by Nitai Charan Giri and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with Medical categories.
Protein and peptide-based drugs have great potential applications as therapeutic agents since they have higher efficacy and lower toxicity than chemical drugs. However, difficulty with their delivery has limited their use. In particular, their oral bioavailability is very low, and the transdermal delivery faces absorption limitations. Therefore, most of the protein and peptide-based drugs are administered by the parenteral route. However, this route also has some problems, such as patient discomfort, especially for pediatric use. Extensive research has been performed over the past few decades to develop protein and peptide delivery systems that circumvent the problems mentioned above. Various strategies that have been employed during this time include nanoparticle carriers, absorption enhancers, enzyme inhibitors, mucoadhesive polymers, and chemical modification of protein or peptide structures. However, most of these strategies are focused on the delivery of proteins or peptides via the oral route since it is the most preferred route considering its high level of patient acceptance, long-term compliance, and simplicity. However, other routes of administration such as transdermal, nasal, pulmonary can also be attractive alternatives for protein and peptide delivery. This chapter will discuss the most effective approaches used to develop protein and peptide drug delivery systems.
Proteins And Peptides
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Author : Randall J. Mrsny
language : en
Publisher: CRC Press
Release Date : 2009-10-19
Proteins And Peptides written by Randall J. Mrsny and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-10-19 with Medical categories.
Addressing the increased use of protein and peptide candidates as treatments for previously untreatable diseases, this comprehensive and progressive source provides the reader with a roadmap to an increased understanding of issues critical for successfully developing a protein or peptide therapeutic candidate. Proteins and Peptides is
Biological Barriers To Protein Delivery
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Author : Kenneth L. Andus
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Biological Barriers To Protein Delivery written by Kenneth L. Andus and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
In response to the tremendous increase in the number of protein and peptide drugs, this treatise critically reviews transport and metabolism mechanisms relating to the delivery of endogenous and recombinant proteins to mammalian organs, tissues, and cells. It will promote fruitful collaboration among academic and industrial scientists in the fields of pharmacology, cell biology, biochemistry, physiology, and immunology.
Delivery Systems For Peptide Drugs
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Author : S.S. Davis
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
Delivery Systems For Peptide Drugs written by S.S. Davis and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Medical categories.
Recent years have seen enormous advances in the field of protein and peptide engineering and a greater understanding in the way in which biological response modifiers function in the body. It is now possible through the use of recombinant DNA techniques, or by solid phase protein synthesis, to produce significant quantities of a wide variety of regulatory agents that are therapeutically applicable. The list of these response modifiers expands almost daily to include interferons, macrophage activation factors, neuropeptides and agents that may have potential in cardiovascular disease, inflammation, contraception etc. Prospects to use some of these materials in medicine have reached the stage where products have either been approved by regulatory authorities or are the subject of applications as investigatory drugs or as new therapeutic agents. In some uses the pertinent agent will be administered on an acute basis in the form of a simple injection, as, for example, the use of a tissue plasminogen activator for the treatment of coronary infarct. In other cases regulatory proteins and peptides are indicated for chronic therapy and here they will need to be administered by an appropriate delivery system. Unfortunately, the research on delivery systems for peptides and proteins has not kept pace with the rapid progress in biotechnology and, consequently, there are presently few systems that are entirely appropriate for the administration of macromolecular drugs according to complex dosage regimens, (eg intermittent and pulsed therapy). Furthermore essential pharmacokinetic and pharmacodynamic data may be missing.
Protein Peptide Drug Delivery 3
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Author :
language : en
Publisher:
Release Date : 2003
Protein Peptide Drug Delivery 3 written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with categories.
Protein Formulation And Delivery
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Author : Eugene J. McNally
language : en
Publisher: CRC Press
Release Date : 2007-10-26
Protein Formulation And Delivery written by Eugene J. McNally and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-10-26 with Medical categories.
This title is intended to assist pharmaceutical scientists in the development of stable protein formulations during the early stages of the product development process, providing a comprehensive review of mechanisms and causes of protein instability in formulation development, coverage of accelerated stability testing methods and relevant analytica
Trends And Future Perspectives In Peptide And Protein Drug Delivery
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Author : Vincent Lee
language : en
Publisher: CRC Press
Release Date : 1995-02-01
Trends And Future Perspectives In Peptide And Protein Drug Delivery written by Vincent Lee and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-02-01 with Medical categories.
First published in 1995. Routledge is an imprint of Taylor & Francis, an informa company.
Delivery Of Protein And Peptide Drugs In Cancer
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Author : Vladimir P Torchilin
language : en
Publisher: World Scientific
Release Date : 2006-04-05
Delivery Of Protein And Peptide Drugs In Cancer written by Vladimir P Torchilin and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-04-05 with Medical categories.
Written by leading scientists in the field of delivery of protein and peptide drugs to tumors for cancer therapy, this important book provides a broad introduction to the field, with discussion by key experts on the physiological barriers for protein and peptide drugs in tumors, and the different approaches to stabilization of these drugs in biological surroundings, as well as their enhanced delivery to tumors and inside cancer cells.This book can be used as an advanced textbook by graduate students and young scientists and clinicians at the early stages of their career. It is also suitable for non-experts from related areas of chemistry, biochemistry, molecular biology, physiology, experimental and clinical oncology and pharmaceutical sciences, who are interested in general problems of drug delivery and drug targeting as well as in a more specialized topics of using protein and peptide drugs for tumor therapy.Prof Torchilin is an expert in Nanomedicine and a recipient of numerous awards including the Lenin Prize in Science & Technology of the former USSR, membership in the European Academy of Sciences, and AAPS Research Achievement Award in Pharmaceutics and Drug Delivery. He served as an Associate Professor of Radiology at Harvard Medical School before joining Northeastern University as the Chairman of the Department of Pharmaceutical Sciences.