Protein Conformational Dynamics
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Protein Conformational Dynamics
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Author : Ke-li Han
language : en
Publisher: Springer Science & Business Media
Release Date : 2014-01-20
Protein Conformational Dynamics written by Ke-li Han and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-01-20 with Medical categories.
This book discusses how biological molecules exert their function and regulate biological processes, with a clear focus on how conformational dynamics of proteins are critical in this respect. In the last decade, the advancements in computational biology, nuclear magnetic resonance including paramagnetic relaxation enhancement, and fluorescence-based ensemble/single-molecule techniques have shown that biological molecules (proteins, DNAs and RNAs) fluctuate under equilibrium conditions. The conformational and energetic spaces that these fluctuations explore likely contain active conformations that are critical for their function. More interestingly, these fluctuations can respond actively to external cues, which introduces layers of tight regulation on the biological processes that they dictate. A growing number of studies have suggested that conformational dynamics of proteins govern their role in regulating biological functions, examples of this regulation can be found in signal transduction, molecular recognition, apoptosis, protein / ion / other molecules translocation and gene expression. On the experimental side, the technical advances have offered deep insights into the conformational motions of a number of proteins. These studies greatly enrich our knowledge of the interplay between structure and function. On the theoretical side, novel approaches and detailed computational simulations have provided powerful tools in the study of enzyme catalysis, protein / drug design, protein / ion / other molecule translocation and protein folding/aggregation, to name but a few. This work contains detailed information, not only on the conformational motions of biological systems, but also on the potential governing forces of conformational dynamics (transient interactions, chemical and physical origins, thermodynamic properties). New developments in computational simulations will greatly enhance our understanding of how these molecules function in various biological events.
Protein Conformation
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Author : Derek J. Chadwick
language : en
Publisher: John Wiley & Sons
Release Date : 2008-04-30
Protein Conformation written by Derek J. Chadwick and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-30 with Science categories.
How the amino acid sequence of a protein determines its three-dimensional structure is a major problem in biology and chemistry. Leading experts in the fields of NMR spectroscopy, X-ray crystallography, protein engineering and molecular modeling offer provocative insights into current views on the protein folding problem and various aspects for future progress.
Collective Langevin Dynamics Of Conformational Motions In Proteins
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Author : Oliver Lange
language : de
Publisher: Cuvillier Verlag
Release Date : 2006
Collective Langevin Dynamics Of Conformational Motions In Proteins written by Oliver Lange and has been published by Cuvillier Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.
Collective Langevin Dynamics Of Conformational Motions In Protein
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Author :
language : en
Publisher: Cuvillier Verlag
Release Date : 2006-01-06
Collective Langevin Dynamics Of Conformational Motions In Protein written by and has been published by Cuvillier Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-01-06 with Science categories.
Lattice Models Of Protein Folding Dynamics And Thermodynamics
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Author : Andrzej Koliński
language : en
Publisher: Landes Bioscience
Release Date : 1996
Lattice Models Of Protein Folding Dynamics And Thermodynamics written by Andrzej Koliński and has been published by Landes Bioscience this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Medical categories.
Computational Approaches To Protein Dynamics
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Author : Monika Fuxreiter
language : en
Publisher: CRC Press
Release Date : 2014-12-24
Computational Approaches To Protein Dynamics written by Monika Fuxreiter and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-24 with Science categories.
The Latest Developments on the Role of Dynamics in Protein FunctionsComputational Approaches to Protein Dynamics: From Quantum to Coarse-Grained Methods presents modern biomolecular computational techniques that address protein flexibility/dynamics at all levels of theory. An international contingent of leading researchers in chemistry, physics, an
Understanding Protein Dynamics Binding And Allostery For Drug Design
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Author : Guang Hu
language : en
Publisher: Frontiers Media SA
Release Date : 2021-06-08
Understanding Protein Dynamics Binding And Allostery For Drug Design written by Guang Hu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-08 with Science categories.
Computational Studies Of The Structure Dynamics Function Relationship
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Author : Dahlia Ruth Weiss
language : en
Publisher:
Release Date : 2008
Computational Studies Of The Structure Dynamics Function Relationship written by Dahlia Ruth Weiss and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.
Dynamics Of Proteins And Nucleic Acids
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Author : J. Andrew McCammon
language : en
Publisher: Cambridge University Press
Release Date : 1988-04-29
Dynamics Of Proteins And Nucleic Acids written by J. Andrew McCammon and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988-04-29 with Science categories.
This book is a self-contained introduction to the theory of atomic motion in proteins and nucleic acids. An understanding of such motion is essential because it plays a crucially important role in biological activity. The authors, both of whom are well known for their work in this field, describe in detail the major theoretical methods that are likely to be useful in the computer-aided design of drugs, enzymes and other molecules. A variety of theoretical and experimental studies is described and these are critically analyzed to provide a comprehensive picture of dynamic aspects of biomolecular structure and function. The book will be of interest to graduate students and research workers in structural biochemistry (X-ray diffraction and NMR), theoretical chemistry (liquids and polymers), biophysics, enzymology, molecular biology, pharmaceutical chemistry, genetic engineering and biotechnology.
Protein Structure Stability And Folding
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Author : Kenneth P. Murphy
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-04
Protein Structure Stability And Folding written by Kenneth P. Murphy and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-04 with Science categories.
In Protein Structure, Stability, and Folding, Kenneth P. Murphy and a panel of internationally recognized investigators describe some of the newest experimental and theoretical methods for investigating these critical events and processes. Among the techniques discussed are the many methods for calculating many of protein stability and dynamics from knowledge of the structure, and for performing molecular dynamics simulations of protein unfolding. New experimental approaches presented include the use of co-solvents, novel applications of hydrogen exchange techniques, temperature-jump methods for looking at folding events, and new strategies for mutagenesis experiments. Unique in its powerful combination of theory and practice, Protein Structure, Stability, and Folding offers protein and biophysical chemists the means to gain a more comprehensive understanding of some of this complex area by detailing many of the major techniques in use today.