Protein Geometry Classification Topology And Symmetry
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Protein Geometry Classification Topology And Symmetry
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Author : William R. Taylor
language : en
Publisher: CRC Press
Release Date : 2004-10-01
Protein Geometry Classification Topology And Symmetry written by William R. Taylor and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-10-01 with Science categories.
From a geometric perspective, this book reviews and analyzes the structural principals of proteins with the goal of revealing the underlying regularities in their construction. It also reviews computer methods for structure analysis and the automatic comparison and classification of these structures with an analysis of the statistical significance of comparing different shapes. Following an analysis of the current state of the protein classification, the authors explore more abstract geometric and topological representations, including the occurrence of knotted topologies. The book concludes with a consideration of the origin of higher-level symmetries in protein structure.
Fractal Symmetry Of Protein Interior
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Author : Anirban Banerji
language : en
Publisher: Springer Science & Business Media
Release Date : 2014-07-08
Fractal Symmetry Of Protein Interior written by Anirban Banerji and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-08 with Science categories.
The essential question that fractal dimensions attempt to answer is about the scales in Nature. For a system as non-idealistic and complex as a protein, studying scale-invariance becomes particularly important. Fractal Symmetry of Protein Interior investigates the diverse facets of the various scales at which we describe protein biophysical and biochemical phenomena. Following a thorough introduction to fractal dimensions, fractal-dimension-based approaches, that have been employed to study protein interior biophysical properties, are described. The focus is on the question “which scales are scale-invariant?” Investigations related to scaling of biophysical and biochemical behaviors may one day help us to formulate a fundamental theory about protein biophysics; which, in turn, may help us to understand fundamental principles of proteins.
Introduction To Molecular Biology Genomics And Proteomics For Biomedical Engineers
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Author : Robert B. Northrop
language : en
Publisher: CRC Press
Release Date : 2008-10-28
Introduction To Molecular Biology Genomics And Proteomics For Biomedical Engineers written by Robert B. Northrop and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-10-28 with Medical categories.
Illustrates the Complex Biochemical Relations that Permit Life to ExistIt can be argued that the dawn of the 21st century has emerged as the age focused on molecular biology, which includes all the regulatory mechanisms that make cellular biochemical reaction pathways stable and life possible. For biomedical engineers, this concept is essential to
Biomedical Materials
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Author : Roger Narayan
language : en
Publisher: Springer Nature
Release Date : 2020-12-09
Biomedical Materials written by Roger Narayan and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-09 with Technology & Engineering categories.
This second edition provides a comprehensive discussion of contemporary materials used in biomedical research and development. The pedagogical writing style and structure provides students with an understanding of the fundamental concepts necessary to pursue research and industrial work in this growing area of biomedical science, including characteristics of biomaterials, biological processes, biocompatibility, and applications of materials in implants and medical instruments. Written by leading researchers in the field, this volume highlights important topics associated with biomedical engineering, medicine and surgery. The revised text contains updates that reflect recent technological advances in biomedical materials. It contains information on new characterization methods and applications for biomedical materials and incorporates suggestions that were offered by readers and educators using the first edition over the years. This textbook takes the reader to the forefront of biomedical materials development, providing graduate students with a taste of how the field is changing, while also serving as a useful reference to physicians and engineers.
Innovations In Biomolecular Modeling And Simulations
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Author : Tamar Schlick
language : en
Publisher: Royal Society of Chemistry
Release Date : 2012-05-24
Innovations In Biomolecular Modeling And Simulations written by Tamar Schlick and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-05-24 with Science categories.
The chemical and biological sciences face unprecedented opportunities in the 21st century. A confluence of factors from parallel universes - advances in experimental techniques in biomolecular structure determination, progress in theoretical modeling and simulation for large biological systems, and breakthroughs in computer technology - has opened new avenues of opportunity as never before. Now, experimental data can be interpreted and further analysed by modeling, and predictions from any approach can be tested and advanced through companion methodologies and technologies. This two volume set describes innovations in biomolecular modeling and simulation, in both the algorithmic and application fronts. With contributions from experts in the field, the books describe progress and innovation in areas including: simulation algorithms for dynamics and enhanced configurational sampling, force field development, implicit solvation models, coarse-grained models, quantum-mechanical simulations, protein folding, DNA polymerase mechanisms, nucleic acid complexes and simulations, RNA structure analysis and design and other important topics in structural biology modeling. The books are aimed at graduate students and experts in structural biology and chemistry and the emphasis is on reporting innovative new approaches rather than providing comprehensive reviews on each subject.
Protein Protein Interactions
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Author : Krishna Mohan Poluri
language : en
Publisher: Springer Nature
Release Date : 2021-05-19
Protein Protein Interactions written by Krishna Mohan Poluri and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-19 with Science categories.
This book provides a comprehensive overview of the fundamental aspects of protein-protein interactions (PPI), including a detailed account of the energetics and thermodynamics involved in these interactions. It also discusses a number of computational and experimental approaches for the prediction of PPI interactions and reviews their principles, advantages, drawbacks, and the recent developments. Further, it offers structural and mechanistic insights into the formation of protein-protein complexes and maps different PPIs into networks to delineate various pathways that operate at the cellular level. Lastly, it describes computational protein-protein docking techniques and discusses their implications for further experimental research. Given its scope, this book is a valuable resource for students, researchers, scientists, entrepreneurs, and medical/healthcare professionals.
Protein Interactions
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Author : Volkhard Helms
language : en
Publisher: John Wiley & Sons
Release Date : 2023-02-06
Protein Interactions written by Volkhard Helms and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-02-06 with Science categories.
A fundamental guide to the burgeoning field of protein interactions From enzymes to transcription factors to cell membrane receptors, proteins are at the heart of biological cell function. Virtually all cellular processes are governed by their interactions, with one another, with cell bodies, with DNA, or with small molecules. The systematic study of these interactions is called Interactomics, and research within this new field promises to shape the future of molecular cell biology. Protein Interactions goes beyond any existing guide to protein interactions, presenting the first truly comprehensive overview of the field. Edited by two leading scholars in the field of protein bioinformatics, this book covers all known categories of protein interaction, stable as well as transient, as well as the effect of mutations and post-translational modifications on the interaction behavior. Protein Interactions readers will also find: Introductory chapters on protein structure, conformational dynamics, and protein-protein binding interfaces A data-driven approach incorporating machine learning and integrating experimental data into computational models An outlook on the current challenges in the field and suggestions for future research Protein Interactions will serve as a fundamental resource for novice researchers who want a systematic introduction to interactomics, as well as for experienced cell biologists and bioinformaticians who want to gain an edge in this exciting new field.
Fractal Symmetry Of Protein Exterior
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Author : Anirban Banerji
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-04-18
Fractal Symmetry Of Protein Exterior written by Anirban Banerji and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-18 with Science categories.
The essential question that fractal dimensions attempt to answer is about the scales in Nature. For a system as non-idealistic and complex as a protein, studying scale-invariance becomes particularly important. Fractal Symmetry of Protein Exterior investigates the diverse facets of the various scales at which we describe protein biophysical and biochemical phenomena. Although these ideas are entirely mathematical, mathematical expositions have been avoided, unless the use of some expressions becomes absolutely obligatory. A first chapter introduce into fractal dimensions, protein exteriors and to methods to study the roughness of surfaces. The main topics covered in the following chapters include: protein-protein interaction interfaces; protein surface-roughness and local shape as well as adhesion on protein and other rough biomolecular surfaces.
Book Review Index
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Author :
language : en
Publisher:
Release Date : 2006
Book Review Index written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Books categories.
Every 3rd issue is a quarterly cumulation.
Structural Insights Into Unnatural Proteins From Symmetry And Pseudosymmetry
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Author : Dale Franklin Kreitler
language : en
Publisher:
Release Date : 2017
Structural Insights Into Unnatural Proteins From Symmetry And Pseudosymmetry written by Dale Franklin Kreitler and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
The work herein describes fundamental insights into the conformations adopted by polypeptide chains, comprised of both natural and unnatural amino acids, obtained primarily through X-ray crystallography. In Chapter 1, I discuss the propensity of racemic and quasiracemic mixtures of molecules to crystallize in centrosymmetric space groups. In Chapter 2, I employ quasiracemic crystallization to explore the structural consequences of polyamide backbone modifications within a mini-protein structure, and I also evaluate the impact these modifications have on the thermodynamic stability of the mini-protein. I use deviations from crystallographic inversion symmetry in each of the quasiracemic structures, in combination with the thermodynamic data, to identify the positions of backbone modification that are the most important for mini-protein stability. In Chapter 3, I demonstrate that the impact of a cyclic backbone constraint that varies in charge and polarity has a sequence-positional dependence on thermodynamic stability of the mini-protein system described in Chapter 2. The thermodynamic data presented in Chapters 2 and 3, combined with the quasiracemic structural data from Chapter 2, show that the modification position that is most tolerant in terms of stability also displays the smallest deviation from inversion symmetry. In Chapter 4, I describe a relationship between pseudo-inversion symmetry and the probability distributions of diffracted X-ray reflection intensities. I also discuss a method for quantifying pseudo-inversion symmetry in addition to the potential impact pseudo-inversion symmetry has on macromolecular crystal structure refinement and global quality indicators. Finally, in Chapter 5 I report three atomic resolution crystal structures showing interactions between enantiomorphic peptide [alpha]-helices of opposite sense. I discuss the geometrical restraints of amino acid residues at the heterochiral interface in addition to a method for parameterizing such assemblies in which extracted model parameters are employed to corroborate these restraints.