Protein Kinase C
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Protein Kinase C Protocols
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Author : Alexandra C. Newton
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-03
Protein Kinase C Protocols written by Alexandra C. Newton and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-03 with Science categories.
Since the discovery that protein kinase C (PKC) transduces the ab- dance of signals that result in phospholipid hydrolysis, this enzyme has been at the forefront of research in signal transduction. Protein Kinase C Protocols covers fundamental methods for studying the structure, function, regulation, subcellular localization, and macromolecular interactions of PKC. Protein Kinase C Protocols is divided into 11 sections representing the major aspects of PKC regulation and function. Part I contains an introduction and a historical perspective on the discovery of PKC by Drs. Yasutomi Nishizuka and Ushio Kikkawa. Part II describes methods to purify PKC. Part III describes the standard methods for measuring PKC activity: its enzymatic activity and its stimulus-dependent translocation from the cytosol to the membrane. Part IV describes methods for measuring the membrane interaction of PKC in vivo and in vitro. Part V provides methodologies and techniques for measuring the ph- phorylation state of PKC, including a protocol for measuring the activity of PKC’s upstream kinase, PDK-1. Novel methods for identifying substrates are described in Part VI. Part VII presents protocols for expressing and analyzing the membrane targeting domains of PKC. Part VIII provides a comprehensive c- pilation of methods used to identify binding partners for PKC. Part IX describes pharmacological probes used to study PKC. The book ends with a presentation of genetic approaches to study PKC (Part X) and a discussion of approaches used to study PKC in disease (Part XI).
Protein Kinase C
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Author : Jyh-Fa Kuo
language : en
Publisher: Oxford University Press, USA
Release Date : 1994
Protein Kinase C written by Jyh-Fa Kuo and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Medical categories.
Protein kinase plays a major role in cellular function and regulation, controlling many cellular processes. In addition to its involvement in cellular processes, the molecular and regulatory properties of the enzyme are discussed in this volume.
Protein Kinase C
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Author : Peter J. Parker
language : en
Publisher: Landes Bioscience
Release Date : 1997
Protein Kinase C written by Peter J. Parker and has been published by Landes Bioscience this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Medical categories.
Advances In Protein Kinase C Research And Application 2011 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-01-09
Advances In Protein Kinase C Research And Application 2011 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-09 with Medical categories.
Advances in Protein Kinase C Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Protein Kinase C in a concise format. The editors have built Advances in Protein Kinase C Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Protein Kinase C in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Protein Kinase C Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Protein Kinase C
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Author : David Simon Lester
language : en
Publisher: Prentice Hall
Release Date : 1992
Protein Kinase C written by David Simon Lester and has been published by Prentice Hall this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Science categories.
Attempts to provide a detailed study of a protein which plays an important role in the regulation of numerous cellular processes. The volume contains reviews of current research in the field and provides a background to the techniques and concepts necessary for future developments.
Protein Kinase C In Cancer Signaling And Therapy
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Author : Marcelo G. Kazanietz
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-06-10
Protein Kinase C In Cancer Signaling And Therapy written by Marcelo G. Kazanietz and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-06-10 with Medical categories.
Protein kinase C (PKC), a family of serine-threonine kinases, rocketed to the forefront of the cancer research field in the early 1980’s with its identification as an effector of phorbol esters, natural products with tumor promoting activity. Phorbol esters had long been of interest to the cancer research field due to early studies in the mouse skin carcinogenesis model, which showed that prolonged topical application of phorbol esters promoted the formation of skin tumors on mice previously treated with mutagenic agents. Research in the last years has established key roles for PKC isozymes in the control of cell proliferation, migration, adhesion, and malignant transformation. In addition, there is a large body of evidence linking PKC to invasion and cancer cell metastasis. Moreover, it is now well established that the expression of PKC isozymes is altered in various types of cancers. More importantly, small molecule inhibitors have been developed with significant anti-cancer activity. The relevance of PKC isozymes in cancer signaling is therefore remarkable. This book will have 4 sections. There will be 23 chapters. Each section will have a brief introduction by an expert in the field (~ 1-2 pages).
Mechanisms Of Protein Kinase C Activation And Substrate Phosphorylation
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Author : Phillip S. Leventhal
language : en
Publisher:
Release Date : 1993
Mechanisms Of Protein Kinase C Activation And Substrate Phosphorylation written by Phillip S. Leventhal and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with categories.
Advances In Protein Kinase C Research And Application 2012 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-12-26
Advances In Protein Kinase C Research And Application 2012 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-26 with Medical categories.
Advances in Protein Kinase C Research and Application / 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Protein Kinase C in a concise format. The editors have built Advances in Protein Kinase C Research and Application / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Protein Kinase C in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Protein Kinase C Research and Application / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Protein Kinase C
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Author : Dean J. Pierce
language : en
Publisher:
Release Date : 2018
Protein Kinase C written by Dean J. Pierce and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with SCIENCE categories.
Protein Kinase C In Cancer Signaling And Therapy
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Author : Marcelo G. Kazanietz
language : en
Publisher: Humana Press
Release Date : 2011-07-21
Protein Kinase C In Cancer Signaling And Therapy written by Marcelo G. Kazanietz and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-07-21 with Medical categories.
Protein kinase C (PKC), a family of serine-threonine kinases, rocketed to the forefront of the cancer research field in the early 1980’s with its identification as an effector of phorbol esters, natural products with tumor promoting activity. Phorbol esters had long been of interest to the cancer research field due to early studies in the mouse skin carcinogenesis model, which showed that prolonged topical application of phorbol esters promoted the formation of skin tumors on mice previously treated with mutagenic agents. Research in the last years has established key roles for PKC isozymes in the control of cell proliferation, migration, adhesion, and malignant transformation. In addition, there is a large body of evidence linking PKC to invasion and cancer cell metastasis. Moreover, it is now well established that the expression of PKC isozymes is altered in various types of cancers. More importantly, small molecule inhibitors have been developed with significant anti-cancer activity. The relevance of PKC isozymes in cancer signaling is therefore remarkable. This book will have 4 sections. There will be 23 chapters. Each section will have a brief introduction by an expert in the field (~ 1-2 pages).