Protein Post Translational Modifications In The Nervous System From Development To Disease And Ageing
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Protein Post Translational Modifications In The Nervous System From Development To Disease And Ageing
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Author : Beatriz Alvarez
language : en
Publisher: Frontiers Media SA
Release Date : 2024-10-30
Protein Post Translational Modifications In The Nervous System From Development To Disease And Ageing written by Beatriz Alvarez and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-30 with Science categories.
Post-translational modifications (PTMs) increase the functional diversity of the proteome by reversibly or irreversibly modifying proteins during or after their synthesis. Thereby, they contribute to the structural and functional variety of proteins, conveying a complexity to the proteome that is significantly higher than the coding capacity of the genome. Moreover, providing another level of epigenetic regulation, PTMs of histone proteins in particular contribute to the modulation of gene accessibility and specific cell expression profiles. PTMs include enzymatically controlled modifications such as phosphorylation, glycosylation, acetylation, methylation, ubiquitination, or proteolysis as well as non-enzymatic reactions such as nitrosation, oxidation, or glycation. They can occur at the same amino acid sites, interfering with each other in hierarchical orders and thereby adding another level of complexity. In this way, PTMs influence protein function, turnover, secretion, localization, and interactions with other cellular molecules such as proteins, nucleic acids, lipids, and cofactors. Thus, they influence almost all aspects of cell biology and pathogenesis as well as represent a basis for maintaining cellular homeostasis. In this regard, PTMs regulate several processes during neurodevelopment involving genes important for brain formation, the cytoskeleton and cytoskeleton-associating proteins as well as regulation of cell migration and axonal guidance.
Novel Molecular Mechanisms And Innovative Therapeutic Approaches For Age Associated Diseases
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Author : Leming Sun
language : en
Publisher: Frontiers Media SA
Release Date : 2022-06-03
Novel Molecular Mechanisms And Innovative Therapeutic Approaches For Age Associated Diseases written by Leming Sun and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-03 with Science categories.
Insights In Neurocognitive Aging And Behavior 2021
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Author : Kristy A. Nielson
language : en
Publisher: Frontiers Media SA
Release Date : 2023-03-13
Insights In Neurocognitive Aging And Behavior 2021 written by Kristy A. Nielson and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-13 with Science categories.
Nih Almanac
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Author : National Institutes of Health (U.S.). Division of Public Information
language : en
Publisher:
Release Date : 1992
Nih Almanac written by National Institutes of Health (U.S.). Division of Public Information and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Federal aid to medical care research categories.
Understanding Ptms In Neurodegenerative Diseases
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Author : Victor Corasolla Carregari
language : en
Publisher: Springer Nature
Release Date : 2022-08-27
Understanding Ptms In Neurodegenerative Diseases written by Victor Corasolla Carregari and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-27 with Science categories.
This new volume, a part of the Proteomics, Metabolomics, Interactomics and Systems Biology series, will explain how proteomic studies of post-translational modifications (PTMs) can be applied to neurodegenerative diseases and relevant studies. The goal of the book is to increase awareness among researchers about how PTMs may be helpful in understanding mechanisms in various neurodegenerative diseases through proteomic studies. This book will serve as a tool for those who want to begin work in the proteomics field and explore how to implement PTMs studies into their work. Chapter authors will describe different PTMs enrichment methods developed by experts in the field so that researchers may learn to apply these methods and techniques to new studies. Divided into three sections, chapters will cover sample preparation, data quality, enrichment techniques, guidelines on how to analyze PTMs, and explain the role of PTMs and different brain diseases. Among those topics includes will be brain cancer, SLA disease, Parkinsons disease, muscular dystrophies, and schizophrenia. This volume will be useful for researchers and students studying brain and neurodegenerative diseases who are interested in delving into work with proteomic studies and PTMs.
Neuroproteomics
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Author : Oscar Alzate
language : en
Publisher: CRC Press
Release Date : 2009-10-26
Neuroproteomics written by Oscar Alzate and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-10-26 with Medical categories.
In this, the post-genomic age, our knowledge of biological systems continues to expand and progress. As the research becomes more focused, so too does the data. Genomic research progresses to proteomics and brings us to a deeper understanding of the behavior and function of protein clusters. And now proteomics gives way to neuroproteomics as we beg
Cumulated Index Medicus
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Author :
language : en
Publisher:
Release Date : 1979
Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1979 with Medicine categories.
Biomedical Index To Phs Supported Research
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Author :
language : en
Publisher:
Release Date : 1991
Biomedical Index To Phs Supported Research written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Medicine categories.
Gene Therapy Of The Central Nervous System From Bench To Bedside
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Author : Michael G. Kaplitt
language : en
Publisher: Gulf Professional Publishing
Release Date : 2006
Gene Therapy Of The Central Nervous System From Bench To Bedside written by Michael G. Kaplitt and has been published by Gulf Professional Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Medical categories.
Few areas of biomedical research provide greater opportunities to capitalize upon the revolution in genomics and molecular biology than gene therapy. This is particularly true for the brain and nervous system, where gene transfer has become a key technology for basic research and has recently been translated to human therapy in several landmark clinical trials. Gene Therapy in the Brain: From Bench to Bedside represents the definitive volume on this subject. Edited by two pioneers of neurological gene therapy, this volume contains contributions by leaders who helped to create the field as well as those who are expanding the promise of gene therapy for the future of basic and clinical neuroscience. Drawing upon this extensive collective experience, this book provides clear and informative reviews on a variety of subjects which would be of interest to anyone who is currently using or contemplating exploring gene therapy for neurobiological applications. Basic gene transfer technologies are discussed, with particular emphases upon novel vehicles, immunological issues and the role of gene therapy in stem cells. Numerous research applications are reviewed, particularly in complex fields such as behavioral neurobiology. Several preclinical areas are also covered which are likely to translate into clinical studies in the near future, including epilepsy, pain and amyotrophic lateral sclerosis. Among the most exciting advances in recent years has been the use of neurological gene therapy in human clinical trials, including Parkinson's disease, Canavan disease and Batten disease. Finally, readers will find "insider" information on technological and regulatory issues which can often limit effective translation of even the most promising idea into clinical use. This work provides up-to-date information and key insights into those gene therapy issues which are important to both scientists and clinicians focusing upon the brain and central nervous system.
Clinical Genetics And Genomics Of Aging
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Author : Juan Carlos Gomez-Verjan
language : en
Publisher: Springer Nature
Release Date : 2020-04-13
Clinical Genetics And Genomics Of Aging written by Juan Carlos Gomez-Verjan and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-13 with Medical categories.
The world population is rapidly aging—it is estimated that by 1950, around 17% of the population will be elderly. In this context, aging involves several physiological, psychological and highly complex social processes that vary from one person to another. For a long time, medical care for older adults has focused on treating chronic, age-related diseases and their associated consequences. Recently, biomedical research brings a novel point of view to develop more effective interventions by targeting the aging process itself rather than separate conditions. There is a growing number of reports indicating that aging is driven by several interconnected mechanisms and biological components referred to as the molecular pillars of aging. Interfering with these mechanisms could help to treat, prevent, and understand the development of age-related diseases and associated syndromes. This book provides a clinical perspective and general update on biomedical and genetic research in aging, moving from an update in the molecular pillars of aging to a perspective of the most recent pharmacological, clinical, and diagnostic applications using genomic approaches and techniques. While this book focuses on the specifics of genetics and genomics, it also adopts a clinical perspective of geroscience, which seeks to understand the genetic, molecular and cellular mechanisms that make aging an important risk factor and, sometimes, a determining factor in the diseases and common chronic conditions of older people. Additionally, Clinical Genetics and Genomics of Aging is a significant contribution to support aging research, as it shows that collaboration across disciplines is relevant to progress in the field. As more and more people benefit from increased longevity, clinician and researchers will be empowered by this knowledge to contribute to the progress of aging research.