Protein Secretion In Bacteria
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Protein Secretion In Bacteria
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Author : Maria Sandkvist
language : en
Publisher: John Wiley & Sons
Release Date : 2020-07-02
Protein Secretion In Bacteria written by Maria Sandkvist and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-02 with Science categories.
Protein transport into and across membranes is a fundamental process in bacteria that touches upon and unites many areas of microbiology, including bacterial cell physiology, adhesion and motility, nutrient scavenging, intrabacterial signaling and social behavior, toxin deployment, interbacterial antagonism and collaboration, host invasion and disruption, and immune evasion. A broad repertoire of mechanisms and macromolecular machines are required to deliver protein substrates across bacterial cell membranes for intended effects. Some machines are common to most, if not all bacteria, whereas others are specific to Gram-negative or Gram-positive species or species with unique cell envelope properties such as members of Actinobacteria and Spirochetes. Protein Secretion in Bacteria, authored and edited by an international team of experts, draws together the many distinct functions and mechanisms involved in protein translocation in one concise tome. This comprehensive book presents updated information on all aspects of bacterial protein secretion encompassing: Individual secretory systems–Sec, Tat, and T1SS through the newly discovered T9SS Mechanisms, structures, and functions of bacterial secretion systems Lipoprotein sorting pathways, outer membrane vesicles, and the sortase system Structures and roles of surface organelles, including flagella, pili, and curli Emerging technologies and translational implications Protein Secretion in Bacteria serves as both an introductory guide for students and postdocs and a ready reference for seasoned researchers whose work touches on protein export and secretion. This volume synthesizes the diversity of mechanisms of bacterial secretion across the microbial world into a digestible resource to stimulate new research, inspire continued identification and characterization of novel systems, and bring about new ways to manipulate these systems for biotechnological, preventative, and therapeutic applications.
Protein Secretion Pathways In Bacteria
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Author : B. Oudega
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Protein Secretion Pathways In Bacteria written by B. Oudega and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
For bacteria ..."the times are achanging"... The genomes of over 60 different bacteria have now been sequenced, and we know a lot about the important research organism Escherichia coli, the important industrial organism Bacillus subtilis, and about important plant and human pathogens. It will not take long before we know all the gene products and their functions of a few of these bacteria. Some of us already begin to think about a digital model E. coli or Bacillus cell. For that end we need to know all the physiological activities and metabolic routes of the cell. But in addition we like to know how things work at the molecular level and how protein and membranes as well as other (macromolecular) structures work together to carry out specific cell functions. Protein Secretion Pathways in Bacteria describes all the known folding and targeting routes of inner and outer membrane proteins as well as of proteins that are secreted by several specific export routes. The book gives detailed molecular information about the structures that are important for the different mechanisms involved. This is a valuable contribution to the understanding of how rather simple and yet complex bacterial cells work.
Bacterial Type Iii Protein Secretion Systems
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Author : Samuel Wagner
language : en
Publisher: Springer Nature
Release Date : 2020-08-14
Bacterial Type Iii Protein Secretion Systems written by Samuel Wagner and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-14 with Medical categories.
One of the most exciting developments in the field of bacterial pathogenesis in recent years is the discovery that many pathogens utilize complex nanomachines to deliver bacterially encoded effector proteins into eukaryotic and prokaryotic target cells to modulate a variety of cellular functions for the pathogen’s benefit. These protein-delivery machines include the type III secretion system (T3SS), which is widespread in nature and encoded not only by bacteria pathogenic to vertebrates or plants, but also by bacteria that are symbiotic to plants or insects. Because they are essential virulence factors for many important human pathogens, these systems are emerging as a prime target for the development of new-generation, anti-infective drugs. This book reviews our current understanding of these intriguing injection machines as well as of the closely related T3SS that serves in flagella assembly. Individual chapters focus on regulation, assembly, structure, and function of the type III secretion machine and on the evolution of the secreted effector proteins. Given its scope, this book will appeal to a broad readership, including researchers and teachers in the fields of infectious diseases, host pathogen interactions, plant and animal pathogenesis, and symbiosis.
Bacterial Protein Secretion Systems
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Author : Laure Journet
language : en
Publisher: Humana Press
Release Date : 2017-07-01
Bacterial Protein Secretion Systems written by Laure Journet and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-01 with Science categories.
This volume details protocols that cover the broad arsenal of techniques used to study a secretion system from A to Z. Chapters focus on identifying and localizing the different subunits, defining interactions within subunits, monitoring conformational changes, purifying and imaging of large complexes, defining the assembly pathway by fluorescence microscopy and the role of energy during assembly and/or secretion, identifying secreted effectors as well as reporters to follow effector transport. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Bacterial Protein Secretion Systems: Methods and Protocol aims to provide techniques that are not restricted to the study of secretion systems but are also of specific interest for any researcher interested on multi-protein complexes of the bacterial cell envelope.
Bacterial Protein Secretion Systems
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Author : Laure Journet
language : en
Publisher: Humana
Release Date : 2018-08-08
Bacterial Protein Secretion Systems written by Laure Journet and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-08 with Science categories.
This volume details protocols that cover the broad arsenal of techniques used to study a secretion system from A to Z. Chapters focus on identifying and localizing the different subunits, defining interactions within subunits, monitoring conformational changes, purifying and imaging of large complexes, defining the assembly pathway by fluorescence microscopy and the role of energy during assembly and/or secretion, identifying secreted effectors as well as reporters to follow effector transport. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Bacterial Protein Secretion Systems: Methods and Protocol aims to provide techniques that are not restricted to the study of secretion systems but are also of specific interest for any researcher interested on multi-protein complexes of the bacterial cell envelope.
Bacterial Protein Secretion Systems
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Author : Abrielle Benton
language : en
Publisher: American Medical Publishers
Release Date : 2023-09-19
Bacterial Protein Secretion Systems written by Abrielle Benton and has been published by American Medical Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-19 with Medical categories.
Secretion refers to the movement of materials from one point to another. In bacterial species, secretion is the transport of effector molecules like toxins, enzymes or proteins from the cytoplasm to exterior of the bacterial cell. It is a crucial mechanism in bacterial functioning and operation for their survival and adaptability in their natural surroundings. Bacterial secretion systems are the protein complexes on the cell membranes of bacteria for secretion of substances. These protein secretion systems play the role of cellular devices utilized by pathogenic bacteria to secrete their virulence factors to attack the host cells. They may be categorized on the basis of their composition, activity and distinct structure. Usually, proteins may be secreted via two distinct processes. In one process, cytoplasm of the bacteria is translocated and delivered directly in the host from cell membrane. Whereas, in the second process, proteins are transported to the inner membrane, deposited on periplasm, and then transmitted to the host by the outer cell membrane. The topics included in this book on bacterial protein secretion systems are of utmost significance and bound to provide incredible insights to readers. With state-of-the-art inputs by acclaimed experts of this field, it targets medical students and professionals.
Protein Secretion And Export In Bacteria
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Author : Henry C. Wu
language : en
Publisher: Springer
Release Date : 2012-02-14
Protein Secretion And Export In Bacteria written by Henry C. Wu and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-02-14 with Medical categories.
The last decade has witnessed rapid progress in our under standing of the mechanisms of protein export and secretion in both prokaryotic and eukaryotic cells. Studies of protein secretion across the membranes of the rough endoplasmic reticulum have led to the formulation of the now-classic signal hypothesis, which has stimulated many discussions and new ideas, and the identification of the signal recogni tion particle as an organelle in the initiation of the export process. However, more recent work pertaining to intrage nic information related to targeting specific proteins for either secretion or membrane localization, the energetics of protein secretion, the timing of synthesis versus the initia tion of export, structural requirements for the processing of precursor proteins, and the identification of the proces sing enzymes (signal peptidases), has been the result of a combined biochemical and genetic approach to the study of protein localization in bacteria. While reviews on the biochemistry and genetics of pro tein secretion have appeared frequently in recent years, this book attempts to summarize the current status and the future perspectives of this rapidly moving field in a single volume. Topics covered in this book include the genetics of protein secretion in E. coli, biochemical analysis of pro tein export in vitro, signal peptidases, excretion of colicins and hemolysin in E. coli, protein secretion in Bacillus, and protein secretion cloning vectors.
Protein Export And Secretion Among Bacterial Pathogens
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Author : Sophie Bleves
language : en
Publisher: Frontiers Media SA
Release Date : 2020-02-27
Protein Export And Secretion Among Bacterial Pathogens written by Sophie Bleves and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-27 with categories.
Bacterial Secreted Proteins
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Author : Karl Wooldridge
language : en
Publisher: Caister Academic Press Limited
Release Date : 2009
Bacterial Secreted Proteins written by Karl Wooldridge and has been published by Caister Academic Press Limited this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Science categories.
Extensive publication on bacterial secreted proteins, secretory systems and their vital role in bacterial pathogenesis. Immense value to all microbiologists, molecular biologists, public health scientists and other researchers and professionals.
Unusual Secretory Pathways From Bacteria To Man
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Author : Karl Kuchler
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Unusual Secretory Pathways From Bacteria To Man written by Karl Kuchler and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.
This book constitutes the first comprehensive discussion and collection of facts and functions of unconventional secretory pathways, some of which are of importance in human disease and pathology. The function of ABC transporters in these processes is also discussed. This comparison of common aspects and similarities in all living cells - from bacteria to man - is an excellent reference book with "textbook" character.