Protein Targeting With Small Molecules
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Protein Targeting With Small Molecules
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Author : Hiroyuki Osada
language : en
Publisher: John Wiley & Sons
Release Date : 2009-07-31
Protein Targeting With Small Molecules written by Hiroyuki Osada and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-07-31 with Science categories.
Discover the link between the latest chemical biology approaches and novel drug therapies! Protein Targeting with Small Molecules: Chemical Biology Techniques and Applications takes readers beyond the use of chemical biology in basic research, providing a highly relevant look at techniques that can address the challenges of biology and drug design and development. This indispensable bench companion features up-to-date coverage of advances in chemistry and assesses their impact on developing new therapeutics, making it ideal for chemical biologists and medicinal chemists who are developing small molecule drugs to target proteins and treat diseases. In addition, the book examines the full range of complex biological systems and their interrelationship with chemistry, from the interaction of biological response modifiers with proteins to the chemical biology of cell surface oligosaccharides. Distinguished by an overview of chemical biology that is reinforced and clarified by detailed examples and descriptions of techniques, Protein Targeting with Small Molecules: Chemical Biology Techniques and Applications: Introduces key technologies and methods of chemical biology designed to detect the interactions of small molecules and proteins Facilitates the discovery of small molecules that bind to proteins and describes the molecules' application in the investigation of biological processes Presents timely coverage of the development of fluorescent probes for small molecules, as well as the generation of small molecule ligands and inhibitors Reviews important techniques such as chemical genomics, target profiling, immobilization technology, detection methods, chemical inhibition, and structure-based targeting Offers a compelling synopsis of data that underscores the recent progress made in the area of targeting proteins by small molecules
Cellular Protein Targets Of Small Molecule Inhibitors Of Rapamycin
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Author : Yuguo Lei
language : en
Publisher:
Release Date : 2006
Cellular Protein Targets Of Small Molecule Inhibitors Of Rapamycin written by Yuguo Lei and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.
Protein Protein Interactions As New Drug Targets
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Author : Enno Klussmann
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-05-20
Protein Protein Interactions As New Drug Targets written by Enno Klussmann and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-05-20 with Medical categories.
Disease-relevant intracellular protein-protein interactions occurring at defined cellular sites possess great potential as drug targets. They permit highly specific pharmacological interference with defined cellular functions. Drugs targeting such interactions are likely to act with fewer side effects than conventional medication influencing whole cell functions. This book discusses therapeutically relevant protein-protein interactions with a major focus on scaffolding proteins tethering signal transduction processes to defined cellular compartments by direct protein-protein interactions. Recent advances in the development of pharmacological agents interfering with protein-protein interactions are highlighted.
Protein Targeting Compounds
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Author : Thomas Böldicke
language : en
Publisher: Springer
Release Date : 2016-05-28
Protein Targeting Compounds written by Thomas Böldicke and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-05-28 with Medical categories.
This book presents an overview of the most relevant protein knockdown techniques. Readers will find a description of the generation and use of recombinant human antibodies, ER intrabodies and peptides as well as a description of the working mechanism and potential of the inhibitory action of each of these molecules. The book will also describe the selection and activity of a number of phosphatases, aptamers and allosteric modulators, focusing on A G protein coupled receptors. The book starts with a chapter on the in silico prediction of target-inhibitor interactions. Key aspects of this book are: - Selection strategies for monoclonal and recombinant human antibodies - Selection strategies for ER intrabodies, peptides and aptamers - Examples of the most efficient inhibitors and their applications in protein biochemistry and cell biology - Antibodies for cancer therapy and inhibitors of angiogenesis. The book will be of great interest to scientists and students working in the life sciences on all areas related to protein biology. The variety of methods to modulate the activities of specific proteins which are introduced here will be of great benefit to the reader who is interested in general protein research or to readers who have very specific protein related questions.
Protein Target Identification For Small Molecule Enhancers Of Rapamycin
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Author : Fei Fu
language : en
Publisher:
Release Date : 2008
Protein Target Identification For Small Molecule Enhancers Of Rapamycin written by Fei Fu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.
Protein Targeting With Small Molecules
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Author : Hiroyuki Osada
language : en
Publisher:
Release Date : 2009
Protein Targeting With Small Molecules written by Hiroyuki Osada and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Molecular probes categories.
Discovery Of Small Molecule Modulators Of Protein Rna Interactions For Treating Cancer And Covid 19
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Author : Wan Gi Byun
language : en
Publisher: Springer Nature
Release Date : 2022-12-13
Discovery Of Small Molecule Modulators Of Protein Rna Interactions For Treating Cancer And Covid 19 written by Wan Gi Byun and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-13 with Science categories.
This book describes the development of novel protein–RNA-binding assays and their applications in a high-throughput manner for the identification of small-molecule modulators of protein–RNA interactions to treat cancer and COVID-19. Modulating protein–RNA interactions with small molecules is expected to provide novel biological insights of the interrelation of diseases with the protein–RNA interactome. The modulations may also be exploited therapeutically. For these reasons, the development of a simple, reliable, and sensitive protein–RNA-binding assay is necessary for high-throughput screening to discover new effective chemical entities capable of acting on diverse protein–RNA interactions. This book discusses the discovery of small-molecule modulators targeting protein–RNA interactions that are potentially valuable to treat cancer and COVID-19 by constructing novel high-throughput screening methods. The results of this dissertation provide valuable insights into the regulation of protein–RNA interactions in chemical biology and drug development.
Gene Family Targeted Molecular Design
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Author : Karen Lackey
language : en
Publisher: John Wiley & Sons
Release Date : 2008-12-01
Gene Family Targeted Molecular Design written by Karen Lackey and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-12-01 with Science categories.
As research progresses and information continues to proliferate in the field of molecular design for therapeutic use, there is a need for a reference that brings current theory and proven practice together in a how-to volume. This reference guides scientists new to the field on how to design small molecules that interact with critical protein targets. The chapters condense useful material into a manageable format which is carefully organized and presented. It offers an essential resource for a variety of chemists in academia, and the biotech and pharmaceutical industries, as well as professionals in complementary fields.
Targeted Cancer Therapies From Small Molecules To Antibodies
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Author : Zhe-Sheng Chen
language : en
Publisher: Frontiers Media SA
Release Date : 2020-07-22
Targeted Cancer Therapies From Small Molecules To Antibodies written by Zhe-Sheng Chen and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-22 with categories.
Comparative Genomics And Proteomics In Drug Discovery
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Author : John Parrington
language : en
Publisher: Taylor & Francis
Release Date : 2018-12-07
Comparative Genomics And Proteomics In Drug Discovery written by John Parrington and has been published by Taylor & Francis this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-12-07 with Medical categories.
Comparative Genomics and Proteomics in Drug Discovery gives an overview of how emerging genomic and proteomic technologies are making significant contributions to global drug discovery programs, and in particular the key role that comparative genomics and proteomics play within this strategy. Each chapter is written by respected authorities, with hands-on experience, from both academic and pharmaceutical backgrounds.