Proteins At Solid Liquid Interfaces

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Proteins At Solid Liquid Interfaces

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Author : Philippe Déjardin
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-09-28

Proteins At Solid Liquid Interfaces written by Philippe Déjardin and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-09-28 with Science categories.

This book opens with a description of fundamental aspects of protein adsorption to surfaces, a phenomenon that plays a key role in biotechnological applications, especially at solid-liquid interfaces. Presented here are methods for studying adsorption kinetics and conformational changes such as optical waveguide lightmode spectroscopy (OWLS). Also described are sensitive bench techniques for measuring the orientation and structure of proteins at solid-liquid interfaces, including total internal reflection ellipsometry (TIRE), dual polarisation interferometry (DPI) and time of flight - secondary ion mass spectrometry (TOF–SIMS). A model study of fibronectin at polymer surfaces is included, as are studies using microporous membranes and textiles with immobilized enzymes for large-scale applications. Biocompatibility, anti-fouling properties and surface modification to modulate the adsorption and activity of biomolecules are among the other topics addressed in this invaluable book.

The Behavior Of Proteins At Solid Liquid Interfaces

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Author : Adam Till Garland
language : en
Publisher:
Release Date : 2014

The Behavior Of Proteins At Solid Liquid Interfaces written by Adam Till Garland and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.

The behavior of a protein molecule at the solid-liquid interface is a worthy scientific problem for at least three reasons. The main driving force for studying this problem is a practical one, as many areas of bio-related technologies, such as medical implants, biosensing, and drug delivery, require the understanding of protein-surface interactions. In this dissertation, the nature of the precursive weakly adsorbed state of proteins during binding is reviewed. From this perspective, the adsorption and binding of proteins to a solid block copolymer thin film was achieved with regular spacing. Further efforts produced a monolayer of green fluorescent protein (GFP) covalently bound with regular spacing and orientation to a diblock copolymer thin film. This protein could be folded and refolded by changing solvent characteristics. We also explored the binding of DC-SIGN to mannose and mannotriose bearing lipid membranes. While no binding was observed, the usefulness of the lipid-based glycan microarray was proven using the well-studied CTB-GM1 binding motif.

Surface Chemistry In Biomedical And Environmental Science

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Author : Jonathan P. Blitz
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-09-09

Surface Chemistry In Biomedical And Environmental Science written by Jonathan P. Blitz and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-09-09 with Science categories.

This volume holds a special niche in describing the current state of the art in the fundamentals and applications of a variety of nanomaterials. A common theme throughout much of this volume involves adsorption and interfacial behavior of nanomaterials. The book provides a useful mixture of reviews and primary research from leading laboratories and offers a unique blend of East European and Western contributors.

Proteins At Solid Liquid Interfaces

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Author : Ananthakrishnan G. Sethuraman
language : en
Publisher:
Release Date : 2004

Proteins At Solid Liquid Interfaces written by Ananthakrishnan G. Sethuraman and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.

Bioseparations Of Proteins

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Author : Ajit Sadana
language : en
Publisher: Elsevier
Release Date : 1997-11-27

Bioseparations Of Proteins written by Ajit Sadana and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-11-27 with Science categories.

This book covers the fundamentals of protein inactivation during bioseparation and the effect on protein processing. Bioseparation of Proteins is unique because it provides a background of the bioseparation processes, and it is the first book available to emphasize the influence of the different bioseparation processes on protein inactivation.Bioseparation of Proteins covers the extent, mechanisms of, and control of protein inactivation during these processes along with the subsequent and essential validation of these processes. The book focuses on the avoidance of protein (biologicalproduct) inactivation at each step in a bioprocess. It compares protein inactivation exhibited during the different bioseparation processes by different workers and provides a valuable framework for workers in different areas interested in bioseparations.Topics include separation and detection methods; estimates of protein inactivation and an analysis of this problem for different separation processes; strategies for avoiding inactivation; the molecular basis of surface activity and protein adsorption,process monitoring, and product validation techniques; and the economics of various bioseparation processes and quality control procedures.Key Features* Protein inactivation and other aspects of biological stability are critical to an effective bioseparation process; This book is a detailed and critical review of the available literature in an area that is essential to the effectiveness, validation, and economics of bioseparation processes for drugs and other biological products; Conveniently assembled under one cover, the survey of the literature and resulting perspective will greatly assist engineers and chemists in designingand improving their own processes; Key features of the text include:* detailed data on biological stability under various bioseparation conditions* extensive case studies from the literature on separation processes, validation, and economics* simplified analysis of protein refolding and inactivation mechanisms* consideration of adsorption theories and the effect of heterogeneity* coverage of both classical and novel bioseparation techniques, including chromatographic procedures

Protein Instability At Interfaces During Drug Product Development

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Author : Jinjiang Li
language : en
Publisher: Springer Nature
Release Date : 2021-02-12

Protein Instability At Interfaces During Drug Product Development written by Jinjiang Li and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-12 with Medical categories.

Proteins are exposed to various interfacial stresses during drug product development. They are subjected to air-liquid, liquid-solid, and, sometimes, liquid-liquid interfaces throughout the development cycle-from manufacturing of drug substances to storage and drug delivery. Unlike small molecule drugs, proteins are typically unstable at interfaces where, on adsorption, they often denature and form aggregates, resulting in loss of efficacy and potential immunogenicity. This book covers both the fundamental aspects of proteins at interfaces and the quantification of interfacial behaviors of proteins. Importantly, this book introduces the industrial aspects of protein instabilities at interfaces, including the processes that introduce new interfaces, evaluation of interfacial instabilities, and mitigation strategies. The audience that this book targets encompasses scientists in the pharmaceutical and biotech industry, as well as faculty and students from academia in the surface science, pharmaceutical, and medicinal chemistry areas.

Adsorption From Solution At The Solid Liquid Interface

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Author : G. D. Parfitt
language : en
Publisher:
Release Date : 1983

Adsorption From Solution At The Solid Liquid Interface written by G. D. Parfitt and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1983 with Science categories.

Non-electrolytes. Adsorption of small molecules. Adsorption from mixtures of miscible liquids. Adsorption of nonionic surfactants. Adsorption of polymers. Electrolytes. Adsorption of small ions. Adsorption of ionic surfactants. Adsorption of dyes. Adsorption of polyelectrolytes from dilute solution.

Foams Physics Chemistry And Structure

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Author : Ashley J. Wilson
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11

Foams Physics Chemistry And Structure written by Ashley J. Wilson and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Technology & Engineering categories.

Foams and froths are an important feature of everyday life; one only has to think of shaving foam, foam upholstery, fire fighting foam, bread, bear head, and ice cream. Less obvious but equally important are the foams and foaming processes which are being exploited in ever more complex and imaginative ways in industry. However, the unusual nature of foams, the fact that they are neither solids or liquids, and their very fragility has prevented scientists from obtaining a thorough understanding of even the basic principles of foam formation and stability. This volume presents papers on the physics, chemistry, structure and ultrastructure of foams by contributors from a wide range of backgrounds and research disciplines. The aim of the book is to present a unique multi-disciplinary cross section of work currently being undertaken on the subject of foams.

Machine Learning And Artificial Intelligence In Chemical And Biological Sensing

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Author : Jeong-Yeol Yoon
language : en
Publisher: Elsevier
Release Date : 2024-07-07

Machine Learning And Artificial Intelligence In Chemical And Biological Sensing written by Jeong-Yeol Yoon and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-07 with Science categories.

Machine learning (ML) has recently become popular in chemical and biological sensing applications. ML is a subset of artificial intelligence (AI) and other AI techniques have been used in various chemical and biological sensing. Machine Learning and Artificial Intelligence in Chemical and Biological Sensing covers the theoretical background and practical applications of various ML/AI methods toward chemical and biological sensing. No comprehensive reference text has been available previously to cover the wide breadth of this topic. The Editors have written the first three chapters to firmly introduce the reader to fundamental ML theories that can be used for chemical/biosensing. The subsequent chapters then cover the practical applications with contributions by various experts in the field. They show how ML and AI-based techniques can provide solutions for: 1) identifying and quantifying target molecules when specific receptors are unavailable 2) analyzing complex mixtures of target molecules, such as gut microbiome and soil microbiome3) analyzing high-throughput and high-dimensional data, such as drug screening, molecular interaction, and environmental toxicant analysis, 4) analyzing complex data sets where fingerprinting approach is needed This book is written primarily for upper undergraduate students, graduate students, research staff, and faculty members at teaching and research universities and colleges who are working on chemical sensing, biosensing, analytical chemistry, analytical biochemistry, biomedical imaging, medical diagnostics, environmental monitoring, and agricultural applications. - Presents the first comprehensive reference text on the use of ML and AI for chemical and biological sensing - Provides a firm grounding in the fundamental theories on ML and AI before covering the practical applications with contributions by various experts in the field - Includes a wide array of practical applications covered, including: E-nose, Raman, SERS, lens-free imaging, multi/hyperspectral imaging, NIR/optical imaging, receptor-free biosensing, paper microfluidics, single molecule analysis in biomedicine, in situ protein characterization, microbial population dynamics, and all-in-one sensor systems

Artificial Protein And Peptide Nanofibers

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Author : Gang Wei
language : en
Publisher: Woodhead Publishing
Release Date : 2020-07-28

Artificial Protein And Peptide Nanofibers written by Gang Wei and has been published by Woodhead Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-28 with Technology & Engineering categories.

Artificial Protein and Peptide Nanofibers: Design, Fabrication, Characterization, and Applications provides comprehensive knowledge of the preparation, modification and applications of protein and peptide nanofibers. The book reviews the synthesis and strategies necessary to create protein and peptide nanofibers, such as self-assembly (including supramolecular assembly), electrospinning, template synthesis, and enzymatic synthesis. Then, the key chemical modification and molecular design methods are highlighted that can be utilized to improve the bio-functions of these synthetic fibers. Finally, fabrication methods for key applications, such as sensing, drug delivery, imaging, tissue engineering and electronic devices are reviewed. This book will be an ideal resource for those working in materials science, polymer science, chemical engineering, nanotechnology and biomedicine. - Reviews key chemical modification and molecular design methods to improve the bio-functions of synthetic peptide and protein nanofibers - Discusses the most important synthesis strategies, including supramolecular assembly, electrospinning, template synthesis and enzymatic synthesis - Provides information on fabrication of nanofibers for key applications such as sensing, imaging, drug delivery and tissue engineering