Proteins Enzymes Genes
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Proteins Enzymes Genes
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Author :
language : en
Publisher: Yale University Press
Release Date :
Proteins Enzymes Genes written by and has been published by Yale University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on with Biochemistry categories.
In this book a distinguished scientist-historian offers a critical account of how biochemistry and molecular biology emerged as major scientific disciplines from the interplay of chemical and biological ideas and practice. Joseph S. Fruton traces the historical development of these disciplines from antiquity to the present time, examines their institutional settings, and discusses their impact on medical, pharmaceutical, and agricultural practice.
Applications Of Chimeric Genes And Hybrid Proteins Part C Protein Protein Interactions And Genomics
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Author :
language : en
Publisher: Elsevier
Release Date : 2000-10-28
Applications Of Chimeric Genes And Hybrid Proteins Part C Protein Protein Interactions And Genomics written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-10-28 with Science categories.
The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.
Applications Of Chimeric Genes And Hybrid Proteins Part A Gene Expression And Protein Purification
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Author :
language : en
Publisher: Elsevier
Release Date : 2000-10-11
Applications Of Chimeric Genes And Hybrid Proteins Part A Gene Expression And Protein Purification written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-10-11 with Science categories.
The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.
Gene Families
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Author : Guoxiong Xue
language : en
Publisher: World Scientific
Release Date : 2001
Gene Families written by Guoxiong Xue and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Science categories.
This archival volume is an invaluable collection of rigorously reviewed articles by experts in the fields of gene families, DNA, RNA and proteins, to commemorate the passing of a giant of science -- Professor Clement L Market (1917-1999.) In 1959, Clement Market and Freddy Moller developed the concept of the isozyme, which paved the way for extensive studies of enzyme, protein and gene multiplicity across all living organisms. This important scientific discovery has had a profound influence on the biological sciences for more than 40 years, and has provided the basis for regular international meetings to discuss the biological and biomedical implications of enzyme multiplicity. More recently, this concept has been extended to a wide range of gene families of DNA, RNA, proteins and enzymes.
Role Of Protein Protein Interactions In Metabolism Genetics Structure Function 2nd Edition
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Author : Amit V. Pandey
language : en
Publisher: Frontiers Media SA
Release Date : 2018-06-20
Role Of Protein Protein Interactions In Metabolism Genetics Structure Function 2nd Edition written by Amit V. Pandey and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-20 with categories.
Genetic variations may change the structure and function of individual proteins as well as affect their interactions with other proteins and thereby impact metabolic processes dependent on protein-protein interactions. For example, cytochrome P450 proteins, which metabolize a vast array of drugs, steroids and other xenobiotics, are dependent on interactions with redox and allosteric partner proteins for their localization, stability, (catalytic) function and metabolic diversity (reactions). Genetic variations may impact such interactions by changing the splicing and/or amino acid sequence which in turn may impact protein topology, localization, post translational modifications and three dimensional structure. More generally, research on single gene defects and their role in disease, as well as recent large scale sequencing studies suggest that a large number of genetic variations may contribute to disease not only by affecting gene function or expression but also by modulating complex protein interaction networks. The aim of this research topic is to bring together researchers working in the area of drug, steroid and xenobiotic metabolism who are studying protein-protein interactions, to describe their recent advances in the field. We are aiming for a comprehensive analysis of the subject from different approaches including genetics, proteomics, transcriptomics, structural biology, biochemistry and pharmacology. Of particular interest are papers dealing with translational research describing the role of novel genetic variations altering protein-protein interaction. Authors may submit original articles, reviews and opinion or hypothesis papers dealing with the role of protein-protein interactions in health and disease. Potential topics include, but are not limited to: • Role of protein-protein interactions in xenobiotic metabolism by cytochrome P450s and other drug metabolism enzymes. • Role of classical and novel interaction partners for cytochrome P450-dependent metabolism which may include interactions with redox partners, interactions with other P450 enzymes to form P450 dimers/multimers, P450-UGT interactions and proteins involved in posttranslational modification of P450s. • Effect of genetic variations (mutations and polymorphisms) on metabolism affected by protein-protein interactions. • Structural implications of mutations and polymorphisms on protein-protein interactions. • Functional characterization of protein-protein interactions. • Analysis of protein-protein interaction networks in health and disease. • Regulatory mechanisms governing metabolic processes based on protein-protein interactions. • Experimental approaches for identification of new protein-protein interactions including changes caused by mutations and polymorphisms.
Proteins Involved In Dna Replication
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Author : Ulrich Huebscher
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Proteins Involved In Dna Replication written by Ulrich Huebscher and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.
This book collects the Proceedings of a workshop sponsored by the European Molecular Biology Organization (EMBO) entitled "Pro teins Involved in DNA Replication" which was held September 19 to 23,1983 at Vitznau, near Lucerne, in Switzerland. The aim of this workshop was to review and discuss the status of our knowledge on the intricate array of enzymes and proteins that allow the replication of the DNA. Since the first discovery of a DNA polymerase in Escherichia coli by Arthur Kornberg twenty eight years ago, a great number of enzymes and other proteins were des cribed that are essential for this process: different DNA poly merases, DNA primases, DNA dependent ATPases, helicases, DNA liga ses, DNA topoisomerases, exo- and endonucleases, DNA binding pro teins and others. They are required for the initiation of a round of synthesis at each replication origin, for the progress of the growing fork, for the disentanglement of the replication product, or for assuring the fidelity of the replication process. The number, variety and ways in which these proteins inter act with DNA and with each other to the achievement of replication and to the maintenance of the physiological structure of the chromo somes is the subject of the contributions collected in this volume. The presentations and discussions during this workshop reinforced the view that DNA replication in vivo can only be achieved through the cooperation of a high number of enzymes, proteins and other cofactors.
Directed Enzyme Evolution
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Author : Frances H. Arnold
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-02
Directed Enzyme Evolution written by Frances H. Arnold and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-02 with Science categories.
Directed evolution comprises two distinct steps that are typically applied in an iterative fashion: (1) generating molecular diversity and (2) finding among the ensemble of mutant sequences those proteins that perform the desired fu- tion according to the specified criteria. In many ways, the second step is the most challenging. No matter how cleverly designed or diverse the starting library, without an effective screening strategy the ability to isolate useful clones is severely diminished. The best screens are (1) high throughput, to increase the likelihood that useful clones will be found; (2) sufficiently sen- tive (i. e. , good signal to noise) to allow the isolation of lower activity clones early in evolution; (3) sufficiently reproducible to allow one to find small improvements; (4) robust, which means that the signal afforded by active clones is not dependent on difficult-to-control environmental variables; and, most importantly, (5) sensitive to the desired function. Regarding this last point, almost anyone who has attempted a directed evolution experiment has learned firsthand the truth of the dictum “you get what you screen for. ” The protocols in Directed Enzyme Evolution describe a series of detailed p- cedures of proven utility for directed evolution purposes. The volume begins with several selection strategies for enzyme evolution and continues with assay methods that can be used to screen enzyme libraries. Genetic selections offer the advantage that functional proteins can be isolated from very large libraries s- ply by growing a population of cells under selective conditions.
Multifunctional Proteins
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Author : Hans Bisswanger
language : en
Publisher: John Wiley & Sons
Release Date : 1980
Multifunctional Proteins written by Hans Bisswanger and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 1980 with Science categories.
Genetically Engineered Proteins And Enzymes From Yeasts
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Author : Alan Wiseman
language : en
Publisher: Prentice Hall
Release Date : 1991
Genetically Engineered Proteins And Enzymes From Yeasts written by Alan Wiseman and has been published by Prentice Hall this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Science categories.
Presents the important concepts and advances on how to successfully use genetic engineering techniques to obtain human proteins and enzymes - an area of vital importance for the production of human proteins for medical purposes.
Gene Enzyme Systems In Drosophila
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Author : W. J. Dickinson
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Gene Enzyme Systems In Drosophila written by W. J. Dickinson and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.
There was a period in the history of modern biology when proteins were thought to be "gene products" in a rather direct sense. An account of their appearance and disappearance in the course of development and differentiation thus seemed an appropriate means of describing "gene regulation". When RNA was found to be the immediate product of genetic activity, the study of proteins as gene products lost some of its original attraction. Indeed, the development of the powerful method of nucleic acid hybridization aroused the hope that a large array of specific messenger-RNA molecules synthesized during cell differentiation could be individually assayed. The difficulties in the way of such ambitious projects were described in Volume 3 of this series: Nucleic Acid Hybridization in the Study of Cell Differentiation (ed. H. URSPRUNG, 1972). Enzymes are in large measure responsible for cell function. Clearly, their synthesis must be under genetic control. We are convinced that the study of enzyme behavior during development merits much attention, particularly if the work is carried out on a eukaryote that lends itself to genetic and developmental analysis. An impressive amount of genetic information is available on the insect Drosophila, and much has been learnt about its development. The giant chromosomes present in several tissues of this insect might well be useful in a continuing analysis of the appearance of specific enzymes and the transcription of the cognate genetic loci.