Protocols For Gene Transfer In Neuroscience
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Protocols For Gene Transfer In Neuroscience
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Author : P. R. Lowenstein
language : en
Publisher:
Release Date : 1996-07-25
Protocols For Gene Transfer In Neuroscience written by P. R. Lowenstein and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-07-25 with Medical categories.
Protocols for Gene Transfer in Neuroscience Towards Gene Therapy of Neurological Disorders Edited by P. R. Lowenstein University of Manchester, UK and L. W. Enquist Princeton University, USA The brain and the cells that compose it have always presented unique barriers to any kind of outside interventions, including drug delivery, surgical procedures and the genetic manipulation of cells. However, these barriers are now being bypassed by the new technology of gene delivery. Protocols for Gene Transfer in Neuroscience is the first practical guide to gene delivery, providing over 150 easy to follow, step-by-step protocols, together with troubleshooting hints and the theoretical background needed for neuroscientists to understand, adapt and expand the technology as needed. Written by a team of international expert neuroscientists, geneticists, molecular biologists and biochemists, Protocols for Gene Transfer in Neuroscience describes the latest techniques from the top gene-delivery labs, ranging from physical transfection techniques, through the use of a wide range of viral vectors, to retrovirally transduced cell and bone marrow transplantation. Several variations of a single protocol are given, thus demonstrating how different labs have solved a common problem in different ways. The protocols are also indexed and cross-referenced so that an investigator can find all the details required for a particular problem.
Handbook Of Neurochemistry And Molecular Neurobiology
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Author : Abel Lajtha
language : en
Publisher: Springer Science & Business Media
Release Date : 2008
Handbook Of Neurochemistry And Molecular Neurobiology written by Abel Lajtha and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Medical categories.
This volume features data on multiple immunomodulators, many of which are also the products of hypothalamic brain cell neurosecretion.
Gene Therapy Methods
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Author : M. Ian Phillips
language : en
Publisher: Academic Press
Release Date : 2002-02-22
Gene Therapy Methods written by M. Ian Phillips and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-02-22 with Medical categories.
This volume in the prestigious Methods in Enzymology series discusses methods currently used in preclinical and clinical gene therapy. Subjects covered in this book, such as the use of adeno-associated virus delivery for treatment of Parkinson's disease, are topical and are presented in the methods-oriented style popularized by this series. Discusses methods currently used in preclinical and clinical gene therapy Covers the use of adeno-associated virus delivery for treatment of Parkinson's disease
Gene Therapy For Neurological Disorders
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Author : Pedro R. Lowenstein
language : en
Publisher: CRC Press
Release Date : 2016-04-19
Gene Therapy For Neurological Disorders written by Pedro R. Lowenstein and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-19 with Medical categories.
Coedited by internationally recognized leaders in gene therapy research, this guide supplies the most recent advances, studies, and expert opinion on gene therapy for neurological disorders. Spanning conditions such as Parkinsons's and Alzheimer's disease, multiple sclerosis, brain tumors, stroke, epilepsy, and brain and spinal cord trauma, this reference presents the basic science and applications of recombinant gene products, immune and stem cell-mediated therapeutic strategies, and brain tumor gene therapy.
Genetics Manual Current Theory Concepts Terms
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Author : George P Redei
language : en
Publisher: World Scientific
Release Date : 1998-03-31
Genetics Manual Current Theory Concepts Terms written by George P Redei and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-03-31 with Science categories.
The 1,150 pages contain more information than any other comparable book. It is not a glossary or dictionary or review because all concepts are explained, not just defined or mentioned.Covers the latest developments, usually missed in textbooks and monographs.The broad range of modern genetics, of cell and molecular biology, biometry, etc. are included without glossing over the classical foundations.The hundreds of simple and clear illustrations are vey useful for classroom purposes because they can be drawn on the blackboard or projected on a screen without taking much time to make the crucial points.The cross-references among the entries tie the contents into an extremely useful comprehensive textbook.The concise style leads the reader to the point without verbiage.The etymology of the terms is explained.The text is not intimidating and it is very easy to read because all the terms are explained within the book. Most of the biometrical procedures are presented by worked-out examples in a plain form, rarely or not found at all in other books.It effectively reaches out to non-geneticists without compromising high scientific standards. Usually the most essential features of a concept are presented at the beginning of the entry, and the reader can go as far as she/he feels needed about the logic.The WEB and e-mail addresses of databases and other sources of detailed information are very helpful.A well selected list of about 1000 references, published mainly in the last couple of years, completes the volume.The moderate price makes it a best buy, and an excellent choice to own for students, teachers, scientists, physicians, lawyers and all educated persons who cannot afford an entire library yet wish to be well informed.
Gene Therapy
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Author : David Cooper
language : en
Publisher: Garland Science
Release Date : 2020-09-10
Gene Therapy written by David Cooper and has been published by Garland Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-10 with Science categories.
Gene Therapy describes the delivery systems now available to target a given tissue with specific gene or oligonucleotide sequences, and explores the utility of animal modules as test systems. In the context of selected disease states, it summarises in vitro and in vivo studies and clinical trials performed to date.
Neuronal Degeneration And Regeneration From Basic Mechanisms To Prospects For Therapy
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Author : F.W. Van Leeuwen
language : en
Publisher: Elsevier
Release Date : 1998-11-09
Neuronal Degeneration And Regeneration From Basic Mechanisms To Prospects For Therapy written by F.W. Van Leeuwen and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-11-09 with Psychology categories.
This book is the result of the 20th International Summer School in Brain Research, organized in August 1997 in Amsterdam, by the Netherlands Institute for Brain Research at the Royal Netherlands Academy of Sciences. It is the first book that provides a complete overview of the field of neurodegeneration and regeneration including spinal cord injury, neurodegenerative diseases and therapy. Divided into five sections, the first two sections give an overview of fundamental research on nerve cell death, neuronal survival, neurite outgrowth and guidance. Extensive attention is given to the role of neurotrophins, their receptor tyrosine kinases and cell-adhesion molecules in development and regeneration of the nervous system. The third section of the book is devoted to research involving human neurodegenerative diseases and emerging treatment strategies. Section four focusses on recent advances in the understanding of pathophysiological mechanisms underlying neurodegenerative diseases, including Alzheimer's, Parkinson's and Huntington's diseases along with prion diseases. Novel insights into the neuropathological hallmarks of these diseases, as well as into transgenic animal models, the involvement of environmental factors, and genomic and mRNA changes that can cause neurodegeneration. The final section of this volume reveals recent developments in the use of cell and gene therapy to treat neurodegenerative disease and lesion-related deficits. Implantation of genetically modified cells, direct gene transfer with viral vectors and the first clinical trials with encapsulated genetically modified cells in patients suffering from amyotrophic lateral scelerosis are examples of new therapeutic strategies treating neurodegenerative diseases.The book is of particular interest to departments of neuroscience, neurological clinics and departments, the pharmalogical industry and medical libraries.
Cellular And Molecular Methods In Neuroscience Research
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Author : Adalberto Merighi
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-12-14
Cellular And Molecular Methods In Neuroscience Research written by Adalberto Merighi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-12-14 with Medical categories.
There are numerous books on cellular and molecular protocols for general use in cell biology but very few are exclusively devoted to neurobiology. This book fills this gap and explains in a clear and consistent manner, some of the more commonly used protocols in neuroscience research. Each chapter is written by either the person who invented the procedure or an expert in the field. The format is uniform: "Overview," "Background," "Protocols," and "results and discussion." Each protocol begins with the principle of the technique, studies in cell culture, materials and reagents, and, lastly, step-by-step outline of the procedure itself. This highly practical book is also well illustrated (with 17 four color plates) to make the concepts and procedures easy to understand and perform.
Stem Cell Biology And Gene Therapy
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Author : Peter J. Quesenberry
language : en
Publisher: John Wiley & Sons
Release Date : 1998-09-10
Stem Cell Biology And Gene Therapy written by Peter J. Quesenberry and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-09-10 with Science categories.
STEM CELL BIOLOGY AND GENE THERAPY Edited by Peter J. Quesenberry, Gary S. Stein, Bernard Forget, and Sherman Weissman Advances in molecular genetics and recombinant DNA technology have ushered in a new era in medical therapeutic research. New insights into the molecular basis of human disease and the role played by biological regulatory mechanisms have precipitated tremendous drug development efforts backed by intensive research into human gene therapy worldwide. Stem Cell Biology and Gene Therapy is the first book to thoroughly cover major advances in the field and their applications to novel molecular therapies. This self-contained volume integrates biological and clinical components of stem cell biology, examines some of the most difficult aspects of gene therapy, and provides a systematic review of advanced gene modification techniques. Twenty essays by leading researchers address some of the most compelling topics in contemporary medical research, including: * Fundamental regulatory mechanisms that operate in stem cells * Stem cells from a therapeutic perspective, including preparations of stem cells and their therapeutic potential as vehicles for gene therapy * Delivery systems for therapeutic genes, including an overview of the most promising vectors * Clinical applications for gene therapy, covering a broad range of diseases such as hemophilia, cancers, neurological disease, and more Complete with illustrations and real-world examples of a variety of disorders, Stem Cell Biology and Gene Therapy is essential for researchers in gene therapy and members of the biotechnology industry who are developing human molecular therapies for commercial use. It is also an important reference for molecular biologists, cell biologists, immunologists, molecular geneticists, hematologists, cancer researchers, biochemists, and anyone working in internal medicine.
Concepts In Genetic Medicine
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Author : Boro Dropulic
language : en
Publisher: John Wiley & Sons
Release Date : 2008-01-03
Concepts In Genetic Medicine written by Boro Dropulic and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-01-03 with Medical categories.
This book delivers a collection of organized and succinct reviews in the field of therapeutic genetic medicine presented by a carefully selected group of top experts. Each chapter focuses on a single, current topic and explains issues in the development of genetic treatments, critical challenges and strategies for implementing them, and future directions in research and translational applications. The book is complemented with uniformly designed illustrations and a supplementary Web site with a PowerPoint presentation for educators.