Proton Therapy
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Proton Beam Therapy
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Author : Santosh Yajnik
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-10-17
Proton Beam Therapy written by Santosh Yajnik and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-17 with Medical categories.
Proton beam therapy is an emerging technology with promise of revolutionizing the treatment of cancer. While nearly half of all patients diagnosed with cancer in the US receive radiation therapy, the majority is delivered via electron accelerators, where photons are used to irradiate cancerous tissue. Because of the physical properties of photon beams, photons may deposit energy along their entire path length through the body. On the other hand, a proton beam directed at a tumor travels in a straight trajectory towards its target, gives off most of its energy at a defined depth called the Bragg peak, and then stops. While photons often deposit more energy within the healthy tissues of the body than within the cancer itself, protons can deposit most of their cancer-killing energy within the area of the tumor. As a result, in the properly selected patients, proton beam therapy has the ability to improve cure rates by increasing the dose delivered to the tumor and simultaneously reduce side-effects by decreasing the dose to surrounding tissue. The benefits of proton beam therapy in delivering a lethal hit to the target while sparing surrounding normal tissues from radiation are becoming applicable to an increasing number of patients and a growing list of conditions. In this book, the author will guide the reader through existing evidence supporting proton beam therapy for pediatric cancer, prostate cancer, lung cancer, brain tumors, spinal tumors, and several other conditions. The book will discuss which conditions are suitable for treatment with proton beam therapy, how the treatment is delivered, and the current data supporting its use.
Proton Therapy
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Author : Thomas J. FitzGerald
language : en
Publisher: BoD – Books on Demand
Release Date : 2021-08-18
Proton Therapy written by Thomas J. FitzGerald and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-18 with Science categories.
Over the past twenty-five years, proton therapy has become more prominent worldwide. It is an important component of clinical radiation therapy for both adult and pediatric clinical care. Due to the inherent ability of protons to spare normal tissue, protons will continue to develop and become increasingly important in radiation oncology. As such, Proton Therapy - Current Status and Future Directions reviews many aspects of proton care including the application of protons in modern clinical trials. It also reviews problems associated with the migration of proton care worldwide and examines the future direction of proton care. This project was created by colleagues at IntechOpen and was carefully managed by Romina Rovan. It has been a privilege to help coordinate the text and chapters designed to acknowledge the history, footprint, and growing interest of proton care worldwide. Proton management is now embedded in the clinical trials process. In pediatric care, proton delivery is embedded with photons for the management of pediatric malignancies and adult groups have initiated proton-specific clinical trials. A proton registry has been established and outcomes are under evaluation. Due to the inherent ability of protons to spare normal tissue, protons will continue to develop and become increasingly important in radiation oncology.
Proton Therapy
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Author : Steven J Frank
language : en
Publisher: Elsevier Health Sciences
Release Date : 2020-05-18
Proton Therapy written by Steven J Frank and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-18 with Medical categories.
As proton therapy treatment centers become smaller and more cost-effective, education and training for today’s multi-disciplinary oncology teams are more important than ever before. This state-of-the-art reference brings you fully up to date with all aspects of proton therapy, with guidance you can trust from MD Anderson Cancer Center, the largest and most experienced proton therapy center in the world. Led by Drs. Steven J. Frank and W. Ronald Zhu, Proton Therapy provides a unique opportunity to benefit from the unsurpassed knowledge and expertise of an esteemed team of leaders in the field. Covers all cancers for which proton therapy is used most often, including prostate, head and neck, pediatrics, central nervous system, gastrointestinal, sarcomas, lungs, breast, lymphomas, and gynecologic cancers. Provides up-to-date information on radiobiology, treatment planning and quality assurance, indications for proton therapy, management approaches, and outcomes after proton therapy by disease site. Discusses technologic advances such as spot scanning and treatment planning systems for the management of solid tumors; radiobiology of proton therapy, including DNA damage and repair mechanisms and acute and late effects on normal tissues; and multifield optimized intensity-modulated proton therapy (MFO-IMPT) for optimizing the distribution of linear energy transfer (LET) of proton beams within target volumes and away from critical normal structures. Includes a special section on head and neck cases in the e-book that photographically illustrates the full cycle of proton therapy care.
Proton Therapy In Cancer Treatments Clinical Evidence And Controversies
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Author : Jérôme Doyen
language : en
Publisher: Frontiers Media SA
Release Date : 2022-02-22
Proton Therapy In Cancer Treatments Clinical Evidence And Controversies written by Jérôme Doyen and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-22 with Medical categories.
Physics Against Cancer
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Author : Damien Weber
language : en
Publisher: vdf Hochschulverlag AG
Release Date : 2023-02-06
Physics Against Cancer written by Damien Weber and has been published by vdf Hochschulverlag AG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-02-06 with Medical categories.
Cancer Treatment, Radiation Oncology, PSI, Pencil Beam Scanning, History of Medicine Modern proton therapy is saving the lives of more and more children and adults with difficult-to-treat cancers. The spectacular rise of proton therapy might never have happened if it were not for the pioneering work of the Paul Scherrer Institute – a Swiss centre founded to explore physics and the nature of matter, but which turned its understanding of basic science into applications that would benefit mankind. This is the place that pioneered a technique of delivering protons to tumours called pencil beam scanning (also known as spot scanning) – now used in nearly every proton therapy centre in the world. It also developed techniques to more accurately deliver the correct proton dose to every part of a tumour – again, now used globally. This book is for anyone with an interest in scientists’ continual quest to find out more. It tells the remarkable story, spanning half a century, of the men and women at the Paul Scherrer Institute’s Center for Proton Therapy who had the knowledge, imagination and perseverance to bring their ideas to fruition. It demonstrates, perhaps most of all, just what can be achieved from close collaboration between physicians and scientists – bringing all the powers of physics to bear in the fight against cancer. "For a field to grow, and for the community of patients to be best served, it’s necessary to learn, grow, improve and share, the way it has been done at PSI. This book provides a look at that extremely important perspective. I, for one, read it with great pleasure." (Jay Flanz, Project Director and Technical Director of the Burr Proton Therapy Center, Massachusetts General Hospital)
Proton Therapy And Radiosurgery
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Author : Hans Breuer
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-04-17
Proton Therapy And Radiosurgery written by Hans Breuer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-17 with Medical categories.
The book is divided into two parts: Part I deals with the relevant physics and planning algorithms of protons (H Breuer) and Part II with the radiobiology, radiopathology and clinical outcomes of proton therapy and a comparison of proton therapy versus photon therapy (BJ Smit). Protons can be used for radiosurgery and general radio therapy. Since proton therapy was first proposed in 1946 by Wilson, about sixteen facilities have been built globally. Only a very few of these have isocentric beam delivery systems so that proton therapy is really only now in a position to be compared directly by means of randomised clinical trials, with modern photon radiotherapy therapy sys tems, both for radiosurgery and for general fractionated radiotherapy. Three-dimensional proton planning computer systems with image fusion (image of computerised tomography (CT), magnetic resonance registration) capabilities imaging (MRI), stereotactic angiograms and perhaps positron emission tomography (PET) are essential for accurate proton therapy planning. New planning systems for spot scanning are under development. Many of the older comparisons of the advantageous dose distributions for protons were made with parallel opposing or multiple co-planar field arrangements, which are now largely obsolete. New comparative plans are necessary once more because of the very rapid progress in 3-D conformal planning with photons. New cost-benefit analy ses may be needed. Low energy (about 70 MeV) proton therapy is eminently suitable for the treatment of eye tumours and has firmly established itself as very useful in this regard.
Proton Therapy Physics Second Edition
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Author : Harald Paganetti
language : en
Publisher: CRC Press
Release Date : 2018-11-19
Proton Therapy Physics Second Edition written by Harald Paganetti and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-19 with Science categories.
Expanding on the highly successful first edition, this second edition of Proton Therapy Physics has been completely restructured and updated throughout, and includes several new chapters. Suitable for both newcomers in medical physics and more seasoned specialists in radiation oncology, this book provides an in-depth overview of the physics of this radiation therapy modality, eliminating the need to dig through information scattered across medical physics literature. After tracing the history of proton therapy, the book explores the atomic and nuclear physics background necessary for understanding proton interactions with tissue. The text then covers dosimetry, including beam delivery, shielding aspects, computer simulations, detector systems and measuring techniques for reference dosimetry. Important for daily operations, acceptance testing, commissioning, quality assurance and monitor unit calibrations are outlined. The book moves on to discussions of treatment planning for single- and multiple-field uniform doses, dose calculation concepts and algorithms, and precision and uncertainties for nonmoving and moving targets. Imaging for treatment guidance as well as treatment monitoring is outlined. Finally, the biological implications of using protons from a physics perspective are discussed. This book is an ideal practical guide for physicians, dosimetrists, radiation therapists, and physicists who already have some experience in radiation oncology. It is also an invaluable reference for graduate students in medical physics programs, physicians in their last year of medical school or residency, and those considering a career in medical physics. Features: Updated with the latest technologies and methods in the field, covering all delivery methods of proton therapy, including beam scanning and passive scattering Discusses clinical aspects, such as treatment planning and quality assurance Offers insight on the past, present, and future of proton therapy from a physics perspective
Proton And Carbon Ion Therapy
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Author : C-M Charlie Ma
language : en
Publisher: CRC Press
Release Date : 2012-10-09
Proton And Carbon Ion Therapy written by C-M Charlie Ma and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-09 with Medical categories.
Proton and Carbon Ion Therapy is an up-to-date guide to using proton and carbon ion therapy in modern cancer treatment. The book covers the physics and radiobiology basics of proton and ion beams, dosimetry methods and radiation measurements, and treatment delivery systems. It gives practical guidance on patient setup, target localization, and trea
Proton Therapy
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Author : James M. Metz, MD
language : en
Publisher: Demos Medical
Release Date : 2010-12-16
Proton Therapy written by James M. Metz, MD and has been published by Demos Medical this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-16 with Medical categories.
Proton Therapy: Proton therapy is a promising new technology in radiation medicine. This issue of Radiation Medicine Rounds provides a comprehensive review for practitioners on the current status of proton therapy, its scientific basis and current clinical applications along with reviews of the available clinical evidence, discussions of costs and technology development, and reviews of the issues in establishing a proton therapy center and the future development of proton therapy as a tool in clinical practice, both in academic centers and its future potential in community practice. About the Series: Radiation Medicine Rounds is an invited review publication providing a thorough analysis of new scientific, technologic, and clinical advances in all areas of radiation medicine. There is an emphasis throughout on multidisciplinary approaches to the specialty, as well as on quality and outcomes analysis. Published three times a year Radiation Medicine Rounds provides authoritative, thorough assessments of a wide range of œhot topics” and emerging new data for the entire specialty of radiation medicine. Features of Radiation Medicine Rounds include: Editorial board of nationally recognized experts across the spectrum of radiation medicine In-depth, up-to-date expert reviews and analysis of major new developments in all areas of Radiation Medicine Issues edited by an authority in specific subject area Focuses on major topics in Radiation Medicine with in-depth articles covering advances in radiation science radiation medicine technology, radiation medicine practice, and assessment of recent quality and outcomes studies Emphasizes multidisciplinary approaches to research and practice "
Proton Therapy Physics
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Author : Harald Paganetti
language : en
Publisher: CRC Press
Release Date : 2016-04-19
Proton Therapy Physics written by Harald Paganetti and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-19 with Medical categories.
Proton Therapy Physics goes beyond current books on proton therapy to provide an in-depth overview of the physics aspects of this radiation therapy modality, eliminating the need to dig through information scattered in the medical physics literature. After tracing the history of proton therapy, the book summarizes the atomic and nuclear physics background necessary for understanding proton interactions with tissue. It describes the physics of proton accelerators, the parameters of clinical proton beams, and the mechanisms to generate a conformal dose distribution in a patient. The text then covers detector systems and measuring techniques for reference dosimetry, outlines basic quality assurance and commissioning guidelines, and gives examples of Monte Carlo simulations in proton therapy. The book moves on to discussions of treatment planning for single- and multiple-field uniform doses, dose calculation concepts and algorithms, and precision and uncertainties for nonmoving and moving targets. It also examines computerized treatment plan optimization, methods for in vivo dose or beam range verification, the safety of patients and operating personnel, and the biological implications of using protons from a physics perspective. The final chapter illustrates the use of risk models for common tissue complications in treatment optimization. Along with exploring quality assurance issues and biological considerations, this practical guide collects the latest clinical studies on the use of protons in treatment planning and radiation monitoring. Suitable for both newcomers in medical physics and more seasoned specialists in radiation oncology, the book helps readers understand the uncertainties and limitations of precisely shaped dose distribution.