Purine Metabolism In Man Biochemistry And Pharmacology Of Uric Acid Metabolism
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Purine Metabolism In Man
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Author : Oded Sperling
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
Purine Metabolism In Man written by Oded Sperling and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Science categories.
Gout and urie acid lithiasis are known to have affected mankind for thousands of years. It is only recently, however, that great progress has been made in the understanding of the processes involved in purine metabolism and its disorders in man. The key enzymes active in the various pathways of purine synthesis and degradation have become known and their properties are the subject of intensive study. Major contributions to the knowledge of normal purine metabolism in man have derived from the study of inborn errors in patients with purine disorders, specifically complete and partial hypoxanthine-guanine phosphoribosyltransferase deficiency. Mutations of other enzymes involved in purine metabolism are being discovered. A great step forward has been made in the treatment of gout with the introduction of uricosuric drugs and more recently of the hypoxanthine analogue allopurinol, a synthetic xanthine oxidase inhibitor. Furthermore, the complex nature of the renal handling of urie acid excretion, although still posing difficult problems, appears to approach clari fication.
Purine Metabolism In Man
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Author : Oded Sperling
language : en
Publisher: Springer
Release Date : 1974-03
Purine Metabolism In Man written by Oded Sperling and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1974-03 with Medical categories.
Gout and urie acid lithiasis are known to have affected mankind for thousands of years. It is only recently, however, that great progress has been made in the understanding of the processes involved in purine metabolism and its disorders in man. The key enzymes active in the various pathways of purine synthesis and degradation have become known and their properties are the subject of intensive study. Major contributions to the knowledge of normal purine metabolism in man have derived from the study of inborn errors in patients with purine disorders, specifically complete and partial hypoxanthine-guanine phosphoribosyltransferase deficiency. Mutations of other enzymes involved in purine metabolism are being discovered. A great step forward has been made in the treatment of gout with the introduction of uricosuric drugs and more recently of the hypoxanthine analogue allopurinol, a synthetic xanthine oxidase inhibitor. Furthermore, the complex nature of the renal handling of urie acid excretion, although still posing difficult problems, appears to approach clari fication.
Purine Metabolism In Man Biochemistry And Pharmacology Of Uric Acid Metabolism
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Author :
language : en
Publisher:
Release Date : 1974
Purine Metabolism In Man Biochemistry And Pharmacology Of Uric Acid Metabolism written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1974 with categories.
Purine Metabolism In Man Ii
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Author : Mathias M. Muller
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Purine Metabolism In Man Ii written by Mathias M. Muller and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The study of gouty arthritis has provided a common meeting ground for the research interests of both the basic scientist and the clinician. The interest of the chemist in gout began 1776 with the isolation of uric acid from a concretion of the urinary tract by the Swedish chemist SCHEELE. The same substance was subsequently extracted from a gouty tophus by the British chemist WOLLASTONE in 1797 and a half century later the cause of the deposits of sodium urate In such tophi was traced to a hyperuricemia in the serum of gouty patients by the British physician Alfred Baring GARROD who had also received training in the chemical laboratory and was therefore a fore-runner of many of today's clinician-investigators. The recent surge of progress in understanding of some of the causes of gout in terms of specific enzyme defects marks the entrance of the biochemist into this field of investigation. The identification of the first primary defect of purine metabolism associated with over-production of uric acid, a severe or partial deficiency of the enzyme hypoxanthine-guanine phospho ribosyl transferase was achieved less than a decade ago. The knowledge of the mechanism of purine over-production that it generated led shortly to the identification of families carrying a dominantly (possibly X-linked) inherited increase in the activity of the enzyme phosphoribosylpyrophosphate synthetase as a cause of purine over-production. Yet this is only a start as these two types of enzyme defects account for less than five per cent of gouty patients.
Purine Metabolism In Man
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Author : Oded Sperling
language : en
Publisher:
Release Date : 1974
Purine Metabolism In Man written by Oded Sperling and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1974 with categories.
Purine Metabolism In Man
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Author : Oded Sperling
language : en
Publisher:
Release Date : 1974
Purine Metabolism In Man written by Oded Sperling and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1974 with categories.
Purine Metabolism In Man
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Author : Oded Sperling
language : en
Publisher:
Release Date : 1974
Purine Metabolism In Man written by Oded Sperling and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1974 with categories.
Purine And Pyrimidine Metabolism In Man Ix
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Author : Andrea Griesmacher
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Purine And Pyrimidine Metabolism In Man Ix written by Andrea Griesmacher and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
th th This volume comprizes articles presented at the joint IX International and 6 Euro pean Symposium on Purine and Pyrimidine Metabolism in Man held in Gmunden, Austria, June 1 through 7, 1997. Since the first of this series of meetings was held in Israel in 1973, conventions were organized every three years in different parts of the world including the USA, Japan, and Europe. The different aspects of purine and pyrimidine metabolism bring together re searchers working in molecular genetics, biochemical pharmacology, biochemistry, devel opmental biology, immunology, epidemiology and the clinics. Oriented research in the field has been seminal for the development of potent anticancer and antiviral drugs. As the number of genes which are cloned, grows, the understanding of metabolism is increas ingly enlarged and might provide leads to further improve therapeutic concepts and to bet ter understand mechanisms responsible for the development of resistance against these drugs. In certain diseases purine and pyrimidine analogs represent not only the drugs of choice but in fact are the sole therapeutic alternative at present. The field has also taken an early lead in attempting to correct inborn errors of purine and pyrimidine metabolism by gene therapy. The organization of this meeting involved a large number of people who dedicated their time in an effort to make this symposium a success. We thank the Abstract Review Committee, the International Advisory Board and in particular the Symposium Secretariat for doing a wonderful job.
Purine Metabolism In Man Ii
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Author : Mathias M Muller
language : en
Publisher: Springer
Release Date : 2014-01-15
Purine Metabolism In Man Ii written by Mathias M Muller and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-01-15 with categories.
Purine Metabolism In Man Iii
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Author : A. Rapado
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Purine Metabolism In Man Iii written by A. Rapado and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.