Purinergic And Pyrimidinergic Signalling Ii
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Purinergic And Pyrimidinergic Signalling Ii
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Author : Maria P. Abracchio
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Purinergic And Pyrimidinergic Signalling Ii written by Maria P. Abracchio and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Physiological, pharmacological and molecular biological data generated over the past three decades have demonstrated the existence of two major families of extracellular receptors, the P1, a family of four G-protein coupled receptors and the P2, a family of at least 12 receptors responsive to purine (ATP, ADP) and pyrimidine (UTP) nucleotides through which adenosine and ATP can function as extracellular messengers. The present two-part volume represents an integrated compendium of invited chapters by leading researchers in the area focusing on advances in the understanding of purinergic and pyrimidinergic signaling systems, their role(s) in tissue function and pathophysiology and advances in developing potential new medications based on the modulation of P1 and P2 receptor signaling processes. The volumes will thus provide the reader with a topical, comprehensive and integrated overview of this important area.
Purinergic And Pyrimidinergic Signalling
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Author : Maria P. Abracchio
language : en
Publisher: Springer Science & Business Media
Release Date : 2001-02-12
Purinergic And Pyrimidinergic Signalling written by Maria P. Abracchio and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-02-12 with Medical categories.
Physiological, pharmacological and molecular biological data generated over the past three decades have demonstrated the existence of two major families of extracellular receptors, the P1, a family of four G-protein coupled receptors and the P2, a family of at least 12 receptors responsive to purine (ATP, ADP) and pyrimidine (UTP) nucleotides through which adenosine and ATP can function as extracellular messengers. The present two-part volume represents an integrated compendium of invited chapters by leading researchers in the area focusing on advances in the understanding of purinergic and pyrimidinergic signaling systems, their role(s) in tissue function and pathophysiology and advances in developing potential new medications based on the modulation of P1 and P2 receptor signaling processes. The volumes will thus provide the reader with a topical, comprehensive and integrated overview of this important area.
Extracellular Nucleotides And Nucleosides Release Receptors And Physiological Pathophysiological Effects
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Author :
language : en
Publisher: Elsevier
Release Date : 2003-09-10
Extracellular Nucleotides And Nucleosides Release Receptors And Physiological Pathophysiological Effects written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-09-10 with Science categories.
Purinergic receptors are proteins that bind ATP as their extracellular ligand. Once thought only as an intracellular molecule that provides energy, ATP is also now considered an essential autocrine/paracrine agonist that acts extracellularly within tissues and tissue microenvironments. Receptors for ATP and its metabolites, so-called "purinergic receptors," are essential membrane receptors that transduce the extracellular signal carried by ATP. Many cell types or tissues express multiple types of these receptors, often on the same cell. This volume will cover the history and overall impact of extracellular ATP signaling, methods to detect ATP release and signaling, the molecular and cell biology of purinergic receptors, the pharmacology of purinergic receptors, the ion channel biophysics and biochemistry of P2X purinergic receptor channels, and the physiology and pathophysiology of purinergic receptors.Key Features* Organized and written by world-renowned experts* Covers state-of-the-art experimental methods* Has broad appeal to basic and clinical scientists, the biotch industry and pharmaceutical research companies
The Enteric Nervous System
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Author : Stuart Brierley
language : en
Publisher: Springer
Release Date : 2016-07-05
The Enteric Nervous System written by Stuart Brierley and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-05 with Medical categories.
Nearly 30 years ago, a number of scientists working on the Enteric Nervous System (ENS) gathered at Flinders University, in Adelaide, Australia to discuss the advances and future of their research. It was a friendly and stimulating meeting, attended by most of the major players, in what was to become the discipline of ‘Neurogastroenterology'. In 2014, the main Australasian Neuroscience Society meeting was held in Adelaide, Australia, providing the perfect opportunity to recreate a follow-up ENS meeting. As such, the ‘ENS II 2014 meeting’ aimed to identify how far the field of enteric neuroscience had developed, where the future was heading, and what technological advances had been made to address current and future unresolved questions. 30 speakers from around the world were invited to give talks and revisit the original expectations, the advances made since, and the future directions of ENS research. These discussions included three generations of investigators from 7 different countries. This publication represents the majority of proceedings from the ‘The Enteric Nervous System II 2014’ conference, which was held on February 1st - 2nd 2014 at the National Wine Centre of Australia, Adelaide. This meeting was an Official satellite meeting of the 34th Annual Meeting of Australasian Neuroscience Society, which was also held in Adelaide. The 20 contributions contained within this submission are from international researchers in the field of the ENS, who reviewed the advances made since the first meeting in the early 1980s and summarizes the present and future perspectives of neuro-gastroenterology. Some colleagues could not attend but did send greetings and their messages are included in these proceedings.
Autonomic Nervous System
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Author : Geoffrey Burnstock
language : en
Publisher: Elsevier Inc. Chapters
Release Date : 2013-11-11
Autonomic Nervous System written by Geoffrey Burnstock and has been published by Elsevier Inc. Chapters this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Medical categories.
After some early hints, cotransmission was proposed in 1976 and then “chemical coding” later established for sympathetic nerves (noradrenaline/norepinephrine, adenosine 5′-triphosphate (ATP), and neuropeptide Y), parasympathetic nerves (acetylcholine, ATP, and vasoactive intestinal polypeptide (VIP)), enteric nonadrenergic, noncholinergic inhibitory nerves (ATP, nitric oxide, and VIP), and sensory-motor nerves (calcitonin gene-related peptide, substance P, and ATP). ATP is a primitive signaling molecule that has been retained as a cotransmitter in most, if not all, nerve types in both the peripheral and central nervous systems. Neuropeptides coreleased with small molecule neurotransmitters in autonomic nerves do not usually act as cotransmitters but rather as prejunctional neuromodulators or trophic factors. Autonomic cotransmission offers subtle, local variation in physiological control mechanisms, rather than the dominance of inflexible central control mechanisms envisaged earlier. The variety of information imparted by a single neuron then greatly increases the sophistication and complexity of local control mechanisms. Cotransmitter composition shows considerable plasticity in development and aging, in pathophysiological conditions and following trauma or surgery. For example, ATP appears to become a more prominent cotransmitter in inflammatory and stress conditions.
Biomechanics At Micro And Nanoscale Levels
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Author : Hiroshi Wada
language : en
Publisher: World Scientific
Release Date : 2006
Biomechanics At Micro And Nanoscale Levels written by Hiroshi Wada and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Science categories.
This volume contains the proceedings of the 8th Epioptics Workshop, held at the Ettore Majorana Foundation and Centre for Scientific Culture, Erice, Sicily. The book assesses the capabilities of state-of-the-art optical techniques in elucidating the fundamental electronic and structural properties of semiconductor and metal surfaces, interfaces, thin layers, and layer structures. The contributions consider the usefulness of these techniques for optimization of high quality multilayer samples through feedback control during materials growth and processing. Particular emphasis is placed on the theory of non-linear optics and on dynamical processes through the use of pump-probe techniques together with the search for new optical sources. Some new applications of Scanning Near-field Optical Microscopy to material science and biological samples, dried and in vivo, with the use of different laser sources are also included.
Pharmacological Mechanisms And The Modulation Of Pain
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Author :
language : en
Publisher: Academic Press
Release Date : 2016-02-23
Pharmacological Mechanisms And The Modulation Of Pain written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-02-23 with Medical categories.
Pharmacological Mechanisms and the Modulation of Pain, the newest volume in the Advances in Pharmacology series, presents the pharmacological mechanisms and the modulation of pain. With a variety of chapters and the best authors in the field, this volume is an essential resource for pharmacologists, immunologists, and biochemists alike. - Contains contributions from the best authors in the field of pharmacology that focus on the pharmacological mechanisms and modulation of pain - Provides an essential resource for pharmacologists, immunologists, and biochemists
Autonomic Nervous System
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Author : Ruud M. Buijs
language : en
Publisher: Newnes
Release Date : 2013-11-11
Autonomic Nervous System written by Ruud M. Buijs and has been published by Newnes this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Medical categories.
Autonomic Nervous System provides an introduction to the latest science and detailed chapters on advances in the clinical diagnosis and treatment of autonomic system disorders. The autonomic nervous system controls all involuntary actions within the human nervous system. Core body functions regulated by the autonomic system include breathing, heartbeat, blood pressure, body temperature, perspiration, and bowel, bladder and sexual function. Our understanding of the neurotransmitters associated with the autonomic nervous system has expanded over the past 15 years associated with current research efforts and are now impacting the diagnosis and treatment of autonomic nervous system disorders by clinical neurologists. This volume is a valuable companion for neuroscience and clinical neurology researchers and practitioners. - A volume in the Handbook of Clinical Neurology series, which has an unparalleled reputation as the world's most comprehensive source of information in neurology - International list of contributors, including the leading workers in the field - Describes the advances that have occurred in clinical neurology and the neurosciences and their impact on the understanding of neurological disorders and on patient care
The Pulmonary Neuroepithelial Body Microenvironment
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Author : Inge Brouns
language : en
Publisher: Springer Nature
Release Date : 2021-05-05
The Pulmonary Neuroepithelial Body Microenvironment written by Inge Brouns and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-05 with Medical categories.
This monograph sheds new light on pulmonary sensory receptors. Diving into the pulmonary microenvironment, the book focuses on the role of pulmonary neuroepithelial bodies (NEBs) as potential receptors and effectors, able to store and release neurotransmitters. It explores NEBs as potential stem cell niche and highlights the multidisciplinary approach taken to identify and study NEBs, including functional morphological investigation, live cell imaging, genetic models, and laser microdissection combined with gene expression analysis. Complexly organized NEBs are an integral part of the intrapulmonary airway epithelium of all air-breathing vertebrates. For decades a quest has been going on to unravel the functional significance of these intriguing structures that appear to be modified in the course of many pulmonary diseases. The NEB microenvironment (ME) is composed of organoid clusters of pulmonary neuroendocrine cells (PNECs) that are able to store and release neurotransmitters and are closely contacted by extensive nerve terminals, emphasizing a potential receptor/effector role and probable signalling to the central nervous system. PNECs are largely shielded from the airway lumen by a special type of Clara cells, the Clara-like cells, with potential stem cell characteristics. So far, functional studies of the pulmonary NEB ME revealed that PNECs can be activated by various mechanical and chemical stimuli, resulting in a calcium-mediated release of neurotransmitters. In the past decades, a number of publications have exposed NEBs as potential hypoxia sensors. Recent experimental evidence unveiled that the NEB ME is a quiescent stem cell niche in healthy postnatal lungs, and silencing may involve bone morphogenetic protein signalling mediated by vagal afferents. Only an integrated approach that takes all current information into account will be able to explain the full role of the pulmonary NEB ME in health and disease. This highly informative and carefully presented book, provides insights for researchers, PhD students with an interest in (bio)medical and veterinary science, especially in the field of the autonomic innervation of the lung, chemo-and mechanoreceptors
Cardiovascular Hormone Systems
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Author : Michael Bader
language : en
Publisher: John Wiley & Sons
Release Date : 2008-10-20
Cardiovascular Hormone Systems written by Michael Bader and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-10-20 with Science categories.
Edited by a renowned scientist in the field with more than 200 high profile scientific publications to his name, this is the first book to provide a comprehensive overview of all cardiovascular hormone systems. Clearly structured, the text covers steroid and peptide hormones, amines, and arachidonic acid metabolites, as well as such others as nucleotides, nitric oxide, and acetylcholine. An essential reference for researchers working on the cardiovascular system and related diseases.