Quantitative Fundamentals Of Molecular And Cellular Bioengineering
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Quantitative Fundamentals Of Molecular And Cellular Bioengineering
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Author : K. Dane Wittrup
language : en
Publisher: MIT Press
Release Date : 2020-01-07
Quantitative Fundamentals Of Molecular And Cellular Bioengineering written by K. Dane Wittrup and has been published by MIT Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-07 with Science categories.
A comprehensive presentation of essential topics for biological engineers, focusing on the development and application of dynamic models of biomolecular and cellular phenomena. This book describes the fundamental molecular and cellular events responsible for biological function, develops models to study biomolecular and cellular phenomena, and shows, with examples, how models are applied in the design and interpretation of experiments on biological systems. Integrating molecular cell biology with quantitative engineering analysis and design, it is the first textbook to offer a comprehensive presentation of these essential topics for chemical and biological engineering. The book systematically develops the concepts necessary to understand and study complex biological phenomena, moving from the simplest elements at the smallest scale and progressively adding complexity at the cellular organizational level, focusing on experimental testing of mechanistic hypotheses. After introducing the motivations for formulation of mathematical rate process models in biology, the text goes on to cover such topics as noncovalent binding interactions; quantitative descriptions of the transient, steady state, and equilibrium interactions of proteins and their ligands; enzyme kinetics; gene expression and protein trafficking; network dynamics; quantitative descriptions of growth dynamics; coupled transport and reaction; and discrete stochastic processes. The textbook is intended for advanced undergraduate and graduate courses in chemical engineering and bioengineering, and has been developed by the authors for classes they teach at MIT and the University of Minnesota.
Algorithms In Structural Molecular Biology
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Author : Bruce R. Donald
language : en
Publisher: MIT Press
Release Date : 2023-08-15
Algorithms In Structural Molecular Biology written by Bruce R. Donald and has been published by MIT Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-08-15 with Science categories.
An overview of algorithms important to computational structural biology that addresses such topics as NMR and design and analysis of proteins.Using the tools of information technology to understand the molecular machinery of the cell offers both challenges and opportunities to computational scientists. Over the past decade, novel algorithms have been developed both for analyzing biological data and for synthetic biology problems such as protein engineering. This book explains the algorithmic foundations and computational approaches underlying areas of structural biology including NMR (nuclear magnetic resonance); X-ray crystallography; and the design and analysis of proteins, peptides, and small molecules. Each chapter offers a concise overview of important concepts, focusing on a key topic in the field. Four chapters offer a short course in algorithmic and computational issues related to NMR structural biology, giving the reader a useful toolkit with which to approach the fascinating yet thorny computational problems in this area. A recurrent theme is understanding the interplay between biophysical experiments and computational algorithms. The text emphasizes the mathematical foundations of structural biology while maintaining a balance between algorithms and a nuanced understanding of experimental data. Three emerging areas, particularly fertile ground for research students, are highlighted: NMR methodology, design of proteins and other molecules, and the modeling of protein flexibility. The next generation of computational structural biologists will need training in geometric algorithms, provably good approximation algorithms, scientific computation, and an array of techniques for handling noise and uncertainty in combinatorial geometry and computational biophysics. This book is an essential guide for young scientists on their way to research success in this exciting field.
Foundations Of Cellular Neurophysiology
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Author : Daniel Johnston
language : en
Publisher: MIT Press
Release Date : 1994-11-02
Foundations Of Cellular Neurophysiology written by Daniel Johnston and has been published by MIT Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-11-02 with Medical categories.
with simulations and illustrations by Richard Gray Problem solving is an indispensable part of learning a quantitative science such as neurophysiology. This text for graduate and advanced undergraduate students in neuroscience, physiology, biophysics, and computational neuroscience provides comprehensive, mathematically sophisticated descriptions of modern principles of cellular neurophysiology. It is the only neurophysiology text that gives detailed derivations of equations, worked examples, and homework problem sets (with complete answers). Developed from notes for the course that the authors have taught since 1983, Foundations of Cellular Neurophysiology covers cellular neurophysiology (also some material at the molecular and systems levels) from its physical and mathematical foundations in a way that is far more rigorous than other commonly used texts in this area.
Mathematical Modeling In Systems Biology
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Author : Brian P. Ingalls
language : en
Publisher: MIT Press
Release Date : 2022-06-07
Mathematical Modeling In Systems Biology written by Brian P. Ingalls and has been published by MIT Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-07 with Science categories.
An introduction to the mathematical concepts and techniques needed for the construction and analysis of models in molecular systems biology. Systems techniques are integral to current research in molecular cell biology, and system-level investigations are often accompanied by mathematical models. These models serve as working hypotheses: they help us to understand and predict the behavior of complex systems. This book offers an introduction to mathematical concepts and techniques needed for the construction and interpretation of models in molecular systems biology. It is accessible to upper-level undergraduate or graduate students in life science or engineering who have some familiarity with calculus, and will be a useful reference for researchers at all levels. The first four chapters cover the basics of mathematical modeling in molecular systems biology. The last four chapters address specific biological domains, treating modeling of metabolic networks, of signal transduction pathways, of gene regulatory networks, and of electrophysiology and neuronal action potentials. Chapters 3–8 end with optional sections that address more specialized modeling topics. Exercises, solvable with pen-and-paper calculations, appear throughout the text to encourage interaction with the mathematical techniques. More involved end-of-chapter problem sets require computational software. Appendixes provide a review of basic concepts of molecular biology, additional mathematical background material, and tutorials for two computational software packages (XPPAUT and MATLAB) that can be used for model simulation and analysis.
Cellular Biophysics Volume 2
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Author : Thomas Fischer Weiss
language : en
Publisher: National Geographic Books
Release Date : 1996-03-06
Cellular Biophysics Volume 2 written by Thomas Fischer Weiss and has been published by National Geographic Books this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-03-06 with Science categories.
Cellular Biophysics is a quantitatively oriented basic physiology text for senior undergraduate and graduate students in bioengineering, biophysics, physiology, and neuroscience programs. It will also serve as a major reference work for biophysicists. Developed from the author's notes for a course that he has taught at MIT for many years, these books provide a clear and logical explanation of the foundations of cell biophysics, teaching transport and the electrical properties of cells from a combined biological, physical, and engineering viewpoint. Each volume contains introductory chapters that motivate the material and present it in a broad historical context. Important experimental results and methods are described. Theories are derived almost always from first principles so that students develop an understanding of not only the predictions of the theory but also its limitations. Theoretical results are compared carefully with experimental findings and new results appear throughout. There are many time-tested exercises and problems as well as extensive lists of references. The volume on the electrical properties of cells covers both electrically inexcitable cells as well as electrically excitable cells such as neurons and muscle cells. Included are chapters on lumped-parameter and distributed-parameter models of cells, linear electric properties of cells, the Hodgkin-Huxley model of the giant axon of the squid, saltatory conduction in myelinated nerve fibers, and voltage-gated ion channels.
Biomedical Engineering
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Author : W. Mark Saltzman
language : en
Publisher: Cambridge University Press
Release Date : 2009-06-29
Biomedical Engineering written by W. Mark Saltzman and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-06-29 with Technology & Engineering categories.
This is an ideal text for an introduction to biomedical engineering. The book presents the basic science knowledge used by biomedical engineers at a level accessible to all students and illustrates the first steps in applying this knowledge to solve problems in human medicine. Biomedical engineering encompasses a range of fields of specialization including bioinstrumentation, bioimaging, biomechanics, biomaterials, and biomolecular engineering. This introduction to bioengineering assembles foundational resources from molecular and cellular biology and physiology and relates them to various sub-specialties of biomedical engineering. The first two parts of the book present basic information in molecular/cellular biology and human physiology; quantitative concepts are stressed in these sections. Comprehension of these basic life science principles provides the context in which biomedical engineers interact. The third part of the book introduces sub-specialties in biomedical engineering, and emphasizes - through examples and profiles of people in the field - the types of problems biomedical engineers solve.
The Application Of Plasmas To Chemical Processing
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Author : Raymond F. Baddour
language : en
Publisher: Pergamon
Release Date : 1967
The Application Of Plasmas To Chemical Processing written by Raymond F. Baddour and has been published by Pergamon this book supported file pdf, txt, epub, kindle and other format this book has been release on 1967 with Chemical engineering categories.
Chemical Biophysics
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Author : Daniel A. Beard
language : en
Publisher: Cambridge University Press
Release Date : 2010-11-25
Chemical Biophysics written by Daniel A. Beard and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-25 with Technology & Engineering categories.
Chemical Biophysics provides an engineering-based approach to biochemical system analysis for graduate-level courses on systems biology, computational bioengineering and molecular biophysics. It is the first textbook to apply rigorous physical chemistry principles to mathematical and computational modeling of biochemical systems for an interdisciplinary audience. The book is structured to show the student the basic biophysical concepts before applying this theory to computational modeling and analysis, building up to advanced topics and research. Topics explored include the kinetics of nonequilibrium open biological systems, enzyme mediated reactions, metabolic networks, biological transport processes, large-scale biochemical networks and stochastic processes in biochemical systems. End-of-chapter exercises range from confidence-building calculations to computational simulation projects.
Biomechanics Of Movement
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Author : Thomas K. Uchida
language : en
Publisher: MIT Press
Release Date : 2021-01-12
Biomechanics Of Movement written by Thomas K. Uchida and has been published by MIT Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-12 with Technology & Engineering categories.
An engaging introduction to human and animal movement seen through the lens of mechanics. How do Olympic sprinters run so fast? Why do astronauts adopt a bounding gait on the moon? How do running shoes improve performance while preventing injuries? This engaging and generously illustrated book answers these questions by examining human and animal movement through the lens of mechanics. The authors present simple conceptual models to study walking and running and apply mechanical principles to a range of interesting examples. They explore the biology of how movement is produced, examining the structure of a muscle down to its microscopic force-generating motors. Drawing on their deep expertise, the authors describe how to create simulations that provide insight into muscle coordination during walking and running, suggest treatments to improve function following injury, and help design devices that enhance human performance. Throughout, the book emphasizes established principles that provide a foundation for understanding movement. It also describes innovations in computer simulation, mobile motion monitoring, wearable robotics, and other technologies that build on these fundamentals. The book is suitable for use as a textbook by students and researchers studying human and animal movement. It is equally valuable for clinicians, roboticists, engineers, sports scientists, designers, computer scientists, and others who want to understand the biomechanics of movement.
Textile Fabric Flammability
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Author : G. S. Tesoro
language : en
Publisher: Mit Press
Release Date : 2003-02-01
Textile Fabric Flammability written by G. S. Tesoro and has been published by Mit Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-02-01 with Technology & Engineering categories.
A report on fabric and garment flammability research; a reference for fiber and textile technologists.