Quantitative Methods For Precision Medicine
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Quantitative Methods For Precision Medicine
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Author : Rongling Wu
language : en
Publisher: CRC Press
Release Date : 2022-12-26
Quantitative Methods For Precision Medicine written by Rongling Wu and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-26 with Mathematics categories.
Modern medicine is undergoing a paradigm shift from a "one-size-fits-all" strategy to a more precise patient-customized therapy and medication plan. While the success of precision medicine relies on the level of pharmacogenomic knowledge, dissecting the genetic mechanisms of drug response in a sufficient detail requires powerful computational tools. Quantitative Methods for Precision Medicine: Pharmacogenomics in Action presents the advanced statistical methods for mapping pharmacogenetic control by integrating pharmacokinetic and pharmacodynamic principles of drug-body interactions. Beyond traditional reductionist-based statistical genetic approaches, statistical formulization in this book synthesizes elements of multiple disciplines to infer, visualize, and track how pharmacogenes interact together as an intricate but well-coordinated system to mediate patient-specific drug response. Features: Functional and systems mapping models to characterize the genetic architecture of multiple medication processes Statistical methods for analyzing informative missing data in pharmacogenetic association studies Functional graph theory of inferring genetic interaction networks from association data Leveraging the concept of epistasis to capture its bidirectional, signed and weighted properties Modeling gene-induced cell-cell crosstalk and its impact on drug response A graph model of drug-drug interactions in combination therapies Critical methodological issues to improve pharmacogenomic research as the cornerstone of precision medicine This book is suitable for graduate students and researchers in the fields of biology, medicine, bioinformatics and drug design and delivery who are interested in statistical and computational modelling of biological processes and systems. It may also serve as a major reference for applied mathematicians, computer scientists, and statisticians who attempt to develop algorithmic tools for genetic mapping, systems pharmacogenomics and systems biology. It can be used as both a textbook and research reference. Professionals in pharmaceutical sectors who design drugs and clinical doctors who deliver drugs will also find it useful.
Quantitative Methods For Precision Medicine
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Author : Rongling Wu
language : en
Publisher: CRC Press
Release Date : 2022-12-26
Quantitative Methods For Precision Medicine written by Rongling Wu and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-26 with Mathematics categories.
Modern medicine is undergoing a paradigm shift from a "one-size-fits-all" strategy to a more precise patient-customized therapy and medication plan. While the success of precision medicine relies on the level of pharmacogenomic knowledge, dissecting the genetic mechanisms of drug response in a sufficient detail requires powerful computational tools. Quantitative Methods for Precision Medicine: Pharmacogenomics in Action presents the advanced statistical methods for mapping pharmacogenetic control by integrating pharmacokinetic and pharmacodynamic principles of drug-body interactions. Beyond traditional reductionist-based statistical genetic approaches, statistical formulization in this book synthesizes elements of multiple disciplines to infer, visualize, and track how pharmacogenes interact together as an intricate but well-coordinated system to mediate patient-specific drug response. Features: Functional and systems mapping models to characterize the genetic architecture of multiple medication processes Statistical methods for analyzing informative missing data in pharmacogenetic association studies Functional graph theory of inferring genetic interaction networks from association data Leveraging the concept of epistasis to capture its bidirectional, signed and weighted properties Modeling gene-induced cell-cell crosstalk and its impact on drug response A graph model of drug-drug interactions in combination therapies Critical methodological issues to improve pharmacogenomic research as the cornerstone of precision medicine This book is suitable for graduate students and researchers in the fields of biology, medicine, bioinformatics and drug design and delivery who are interested in statistical and computational modelling of biological processes and systems. It may also serve as a major reference for applied mathematicians, computer scientists, and statisticians who attempt to develop algorithmic tools for genetic mapping, systems pharmacogenomics and systems biology. It can be used as both a textbook and research reference. Professionals in pharmaceutical sectors who design drugs and clinical doctors who deliver drugs will also find it useful.
Precision Medicine
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Author : Hans-Peter Deigner
language : en
Publisher: Academic Press
Release Date : 2018-02-15
Precision Medicine written by Hans-Peter Deigner and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-15 with Medical categories.
Precision Medicine: Tools and Quantitative Approaches discusses precision and personalized medicine, two relevant topics that are revolutionizing diagnostics and treatment, while also providing a shift toward prevention. The book covers the most relevant features and explanations underlying developments in the field. A timely review on prerequisites, causes and consequences is given. Unique to this book is a combined view on technical and data analysis aspects that is mandatory for obtaining and interpreting results. This book is a valuable source for researchers in medical and life sciences, physicians and students with an interest in this emerging field of precision medicine. - Provides technological aspects in precision medicine with aspects of modern statistical and bioinformatics models and methods - Brings timely reviews on status and chances in precision medicine and associated aspects of data analysis, statistics and data interpretation - Encompasses easy access to relevant approaches, interactions and original literature
Precision Medicine In Cancer Therapy
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Author : Daniel D. Von Hoff
language : en
Publisher: Springer
Release Date : 2019-06-17
Precision Medicine In Cancer Therapy written by Daniel D. Von Hoff and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-17 with Medical categories.
This book presents the latest advances in precision medicine in some of the most common cancer types, including hematological, lung and breast malignancies. It also discusses emerging technologies that are making a significant impact on precision medicine in cancer therapy. In addition to describing specific approaches that have already entered clinical practice, the book explores new concepts and tools that are being developed. Precision medicine aims to deliver personalized healthcare tailored to a patient’s genetics, lifestyle and environment, and cancer therapy is one of the areas in which it has flourished in recent years. Documenting the latest advances, this book is of interest to physicians and clinical fellows in the front line of the war on cancer, as well as to basic scientists working in the fields of cancer biology, drug development, biomarker discovery, and biomedical engineering. The contributing authors include translational physicians withfirst-hand experience in precision patient care.
Dynamic Treatment Regimes
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Author : Anastasios A. Tsiatis
language : en
Publisher: CRC Press
Release Date : 2019-12-19
Dynamic Treatment Regimes written by Anastasios A. Tsiatis and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-19 with Mathematics categories.
Dynamic Treatment Regimes: Statistical Methods for Precision Medicine provides a comprehensive introduction to statistical methodology for the evaluation and discovery of dynamic treatment regimes from data. Researchers and graduate students in statistics, data science, and related quantitative disciplines with a background in probability and statistical inference and popular statistical modeling techniques will be prepared for further study of this rapidly evolving field. A dynamic treatment regime is a set of sequential decision rules, each corresponding to a key decision point in a disease or disorder process, where each rule takes as input patient information and returns the treatment option he or she should receive. Thus, a treatment regime formalizes how a clinician synthesizes patient information and selects treatments in practice. Treatment regimes are of obvious relevance to precision medicine, which involves tailoring treatment selection to patient characteristics in an evidence-based way. Of critical importance to precision medicine is estimation of an optimal treatment regime, one that, if used to select treatments for the patient population, would lead to the most beneficial outcome on average. Key methods for estimation of an optimal treatment regime from data are motivated and described in detail. A dedicated companion website presents full accounts of application of the methods using a comprehensive R package developed by the authors. The authors’ website www.dtr-book.com includes updates, corrections, new papers, and links to useful websites.
Progress And Challenges In Precision Medicine
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Author : Mukesh Verma
language : en
Publisher: Academic Press
Release Date : 2016-12-22
Progress And Challenges In Precision Medicine written by Mukesh Verma and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-22 with Science categories.
Progress and Challenges in Precision Medicine presents an insightful overview to the myriad factors of personalized and precision medicine. The availability of the human genome, large amounts of data on individual genetic variations, environmental interactions, influence of lifestyle, and cutting-edge tools and technologies for big-data analysis have led to the age of personalized and precision medicine. Bringing together a global range of experts on precision medicine, this book collects previously scattered information into one concise volume which covers the most important developments so far in precision medicine and also suggests the most likely avenues for future development. The book includes clinical information, informatics, public policy implications, and information on case studies. It is a useful reference and background work for students, researchers, and clinicians working in the biomedical and medical fields, as well as policymakers in the health sciences. - Provides an overview of the growing field of precision medicine - Contains chapters from geographically diverse experts in their field - Explores important aspects of precision medicine, including applications, ethics, and development
Machine Learning Advanced Dynamic Omics Data Analysis For Precision Medicine
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Author : Tao Zeng
language : en
Publisher: Frontiers Media SA
Release Date : 2020-03-30
Machine Learning Advanced Dynamic Omics Data Analysis For Precision Medicine written by Tao Zeng and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-30 with categories.
Molecular Medicine And Biomedical Research In The Era Of Precision Medicine
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Author : Ranbir Chander Sobti
language : en
Publisher: Elsevier
Release Date : 2025-05-15
Molecular Medicine And Biomedical Research In The Era Of Precision Medicine written by Ranbir Chander Sobti and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-05-15 with Science categories.
Molecular Medicine and Biomedical Research in the Era of Precision Medicine: New Technologies and Personalized Drug Therapies for Patient Care provides researchers with an extensive overview of recent advances in molecular biology impacting the development of targeted therapies. The book delivers insights into the pathobiological and pathogenetic mechanisms of various diseases, providing a detailed study of the latest personalized interventions to be implemented across such conditions. It covers a range of technologies, including RNA-sequencing, AI, Machine Learning, gene therapy, omics and nanotechnology, delving into their clinical applications across various diseases.The book also tackles targeted treatments of different disease types, including acute, chronic, infectious and noncommunicable diseases. Future perspectives are also covered, providing an in-depth study across molecular medicine, drug discovery and delivery, disease diagnosis and prevention, and therapeutic interventions, and acting as an invaluable interdisciplinary reference for researchers across the biomedical sciences. - Investigates the molecular basis and mechanisms of diseases, including cardiovascular, infectious, and neurological diseases - Presents molecular-based therapeutics for personalized treatment and the diagnosis of various conditions - Considers a range of technologies in the field of biomedicine and molecular medicine, including artificial intelligence and nanotechnology
Detection Methods In Precision Medicine
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Author : Mengsu Yang
language : en
Publisher: Royal Society of Chemistry
Release Date : 2020-12-14
Detection Methods In Precision Medicine written by Mengsu Yang and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-14 with Science categories.
This book will be among the first to cover the detection methods for precision medicine that are set to transform health care in the future.
Toward Precision Medicine
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2012-01-16
Toward Precision Medicine written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-16 with Medical categories.
Motivated by the explosion of molecular data on humans-particularly data associated with individual patients-and the sense that there are large, as-yet-untapped opportunities to use this data to improve health outcomes, Toward Precision Medicine explores the feasibility and need for "a new taxonomy of human disease based on molecular biology" and develops a potential framework for creating one. The book says that a new data network that integrates emerging research on the molecular makeup of diseases with clinical data on individual patients could drive the development of a more accurate classification of diseases and ultimately enhance diagnosis and treatment. The "new taxonomy" that emerges would define diseases by their underlying molecular causes and other factors in addition to their traditional physical signs and symptoms. The book adds that the new data network could also improve biomedical research by enabling scientists to access patients' information during treatment while still protecting their rights. This would allow the marriage of molecular research and clinical data at the point of care, as opposed to research information continuing to reside primarily in academia. Toward Precision Medicine notes that moving toward individualized medicine requires that researchers and health care providers have access to very large sets of health- and disease-related data linked to individual patients. These data are also critical for developing the information commons, the knowledge network of disease, and ultimately the new taxonomy.