R Loops

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R Loops

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Author : Andrés Aguilera
language : en
Publisher: Springer Nature
Release Date : 2022-06-15

R Loops written by Andrés Aguilera and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-15 with Science categories.

This detailed book compiles a series of laboratory protocols covering the most important aspects of R-loop biology. Beginning with a range of methods allowing for the detection of DNA-RNA hybrids, as well as their purification and visualization by electron microscopy, the volume continues with methods based on the use of RNase H-derived tools to detect DNA-RNA hybrids in vitro and in vivo. Several protocols permit studying non-canonical RNA nucleotides in the R-loop context, as well as a number of specific protocols devoted to the investigation of R-loop topology and their functional roles in the biology of mitochondria and telomeres. Finally, a large block of chapters is dedicated to different methods allowing genome-wide mapping of DNA-RNA hybrids in various organisms. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, R-Loops: Methods and Protocols serves as an ideal resource for those working on R-loop homeostasis but also to scientists studying such areas of molecular and cell biology as genome integrity, DNA replication and repair, chromatin remodeling, transcription, RNA processing, modification and export, as well as for researchers elucidating the molecular mechanisms of cancer and genetic diseases.

Dna Replication

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Author : Arthur Kornberg
language : en
Publisher: University Science Books
Release Date : 2005-06-24

Dna Replication written by Arthur Kornberg and has been published by University Science Books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-06-24 with Science categories.

DNA Replication, second edition, a classic of modernscience, is now back in print in a paperback edition. Kornberg and Baker'sinsightful coverage of DNA replication and related cellular processes have madethis the standard reference in the field.

Study Of Two Kinds Of Quasi Ag Neutrosophic Extended Triplet Loops

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Author : Xiaogang An
language : en
Publisher: Infinite Study
Release Date :

Study Of Two Kinds Of Quasi Ag Neutrosophic Extended Triplet Loops written by Xiaogang An and has been published by Infinite Study this book supported file pdf, txt, epub, kindle and other format this book has been release on with Mathematics categories.

Abel-Grassmann’s groupoid and neutrosophic extended triplet loop are two important algebraic structures that describe two kinds of generalized symmetries. In this paper, we investigate quasi AG-neutrosophic extended triplet loop, which is a fusion structure of the two kinds of algebraic structures mentioned above.

Dna Repair Part B

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Author :
language : en
Publisher: Elsevier
Release Date : 2011-09-21

Dna Repair Part B written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-21 with Science categories.

This volume emphasizes the intracellular consequences of DNA damage, describing procedures for analysis of checkpoint responses, DNA repair in vivo, replication fork encounter of DNA damage, as well as biological methods for analysis of mutation production and chromosome rearrangements. It also describes molecular methods for analysis of a number of genome maintenance activities including DNA ligases, helicases, and single-strand binding proteins.*Part B of a 2-part series*Addresses DNA maintenance enzymes*Discusses damage signaling*Presents In vivo analysis of DNA repair*Covers mutation and chromosome rearrangements

Fundamental Immunology

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Author : William E. Paul
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 2008

Fundamental Immunology written by William E. Paul and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Medical categories.

Now thoroughly revised and updated, this comprehensive, up-to-date text is ideal for graduate students, post-doctoral fellows, microbiologists, infectious disease physicians, and any physician who treats diseases in which immunologic mechanisms play a role.

Base Excision Repair Pathway

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Author : Kishor K. Bhakat
language : en
Publisher: Springer Nature
Release Date : 2023-09-14

Base Excision Repair Pathway written by Kishor K. Bhakat and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-14 with Science categories.

This detailed volume provides a comprehensive set of experimental protocols and useful strategies to examine the repair of damaged bases via the Base Excision Repair (BER) pathway in vitro and in cells. Beginning with multiple molecular and cellular techniques to examine the excision of damaged bases from double-stranded DNA or DNA wrapped in a nucleosome, the book continues with sections covering procedures to detect and quantify the damaged bases, protein DNA crosslinks, and double-strand breaks, experimental procedures to identify DNA repair protein interactome by conventional tandem affinity purification followed by mass spectroscopy analysis, as well as the analysis of genome-wide binding of DNA repair proteins and copy number variations of the DNA damage response gene in tumors. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Base Excision Repair Pathway: Methods and Protocols serves as a valuable resource for novices and experts trying to examine the repair of various types of DNA lesions in vitro and in cell by the distinct set of proteins in the BER pathway.

Gene Expression

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Author : Fumiaki Uchiumi
language : en
Publisher: BoD – Books on Demand
Release Date : 2022-10-05

Gene Expression written by Fumiaki Uchiumi and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-05 with Medical categories.

Gene expression is dependent on multiple steps, including transcription, RNA processing, and translation. Importantly, recent studies revealed that gene expression is regulated by chromatin structures and non-coding RNA profiles. Elucidating the molecular mechanisms may contribute to the development of novel therapeutics for aging-related diseases, including cancer and neurodegenerative diseases. This book provides a comprehensive overview of gene expression and its role in human disease. It consists of nine chapters organized into two sections on molecular mechanisms in controlling gene expression and the relationships between transcriptional control and human disease.

Decoding Aging And Neurodegeneration

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Author : Jan Barciszewski
language : en
Publisher: Springer Nature
Release Date : 2025-07-14

Decoding Aging And Neurodegeneration written by Jan Barciszewski and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-07-14 with Science categories.

This book focuses on the close relationship between aging and neurodegeneration. By highlighting the reversible nature of epigenetic changes, it provides a comprehensive overview of how these modifications can regulate gene expression without altering the DNA sequence, offering promising solutions for clinical intervention. Aging induces a gradual decline in cerebral function, leading to cognitive impairment, memory loss, motor dysfunction, and eventually functional decline and death. It is accompanied by the decline of organismal functions induced by whole genome alterations leading to neurodegeneration. Epigenetic modifications, including chromatin modifications, DNA methylation, and changes in regulatory RNAs, have a major impact on neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. The chapters in this book address critical issues such as the contribution of epigenetic mechanisms to aging, the interaction between genetic and environmental factors in neurodegeneration, and the potential for epigenetic therapies to delay aging and mitigate disease progression. This volume, part of the RNA Technologies book series, is an invaluable resource for researchers and advanced students in genetics and neuroscience. It provides a deep understanding of the molecular basis of neurodegenerative diseases and offers innovative strategies to address the challenges of aging and neurodegeneration.

Protecting The Code Dna Double Strand Break Repair Pathway Choice

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Author : David Maranon
language : en
Publisher: Frontiers Media SA
Release Date : 2023-03-31

Protecting The Code Dna Double Strand Break Repair Pathway Choice written by David Maranon and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-31 with Science categories.

Nuclear Genome Stability Dna Replication Telomere Maintenance And Dna Repair

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Author : Maria Isabel Nogueira Cano
language : en
Publisher: Frontiers Media SA
Release Date : 2022-03-09

Nuclear Genome Stability Dna Replication Telomere Maintenance And Dna Repair written by Maria Isabel Nogueira Cano and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-09 with Science categories.