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Radiation Carcinogenesis

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Radiation Carcinogenesis

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Author : Arthur C. Upton
language : en
Publisher: Elsevier Publishing Company
Release Date : 1986

Radiation Carcinogenesis written by Arthur C. Upton and has been published by Elsevier Publishing Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986 with Medical categories.

This book provides the first comprehensive and systematic survey of present knowledge about radiation carcinogenesis. World experts review in detail current information on such topics as the incidence of various forms of cancer in irradiated populations, the carcinogenic effects of ionizing radiation in laboratory animals, theoretical mechanisms of radiation carcinogenesis, and the implications of the data for assessing the risks of human cancer. In view of recent controversy about the carcinogenic hazards of low-level exposure to radiation and other carcinogens, this book is a timely contribution toward our understanding of the carcinogenic risks of low-level radiation.

Radiation Carcinogenesis And Dna Alterations

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Author : Frederic J. Burns
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-13

Radiation Carcinogenesis And Dna Alterations written by Frederic J. Burns and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-13 with Medical categories.

This volume is based on the proceedings of an Advanced Study Institute (ASI) sponsored by the North Atlantic Treaty Organization (NATO) held October 1984 in Corfu, Greece. The meeting received finan cial support from the United States Department of Energy and the United States National Cancer Institute. A plethora of recent developments in the molecular biology of DNA are leading to new ideas concerning how DNA alterations might be involved in the mechanism of radiation carcinogenesis. Evidence is accumulating that genetic sequences, known as oncogenes, are involved in the translation of DNA molecular alterations into phenotypic changes associated with malignant cells. For example, a chromosome break often occurs at or near the loca tion of a specific oncogene in Burkitt's lymphoma. Such breaks could represent initial lesions in a translocation process that activates the oncogene by inserting it at a new location, eg., near an active pro moter. Since breakage of the DNA is one of the principal ways that ion izing radiation affects mammalian cells, these new molecular ideas sug gest ways that radiation-induced DNA breaks might be involved as initial events in carcinogenesis. While the possible involvement of oncogenes in radiation carcino genesis is an exciting new development, a direct sequential connection between early molecular changes in DNA and later tumor development has yet to be established. Accordingly, there is a tremendous need for experimental studies of how DNA alterations might convert normal cells to cancer cells.

Biology Of Radiation Carcinogenesis

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Author : John M. Yuhas
language : en
Publisher:
Release Date : 1976

Biology Of Radiation Carcinogenesis written by John M. Yuhas and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1976 with Medical categories.

Comparative Observations On Radiation Carcinogenesis In Man And Animals

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Author :
language : en
Publisher:
Release Date : 1965

Comparative Observations On Radiation Carcinogenesis In Man And Animals written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1965 with categories.

Icrdb Cancergram

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Author :
language : en
Publisher:
Release Date : 1984

Icrdb Cancergram written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1984 with Alimentary canal categories.

Aging Carcinogenesis And Radiation Biology

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Author : Kendric Smith
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09

Aging Carcinogenesis And Radiation Biology written by Kendric Smith and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Medical categories.

The covalent attachment to deoxyribonucleic acid in vivo of a large number of different types of chemical compounds (both normal cellular constituents such as proteins and amino acids, and also exogenous compounds such as drugs, carcinogens, etc. ) have been shown to exert profound effects upon cells. Four research activi ties, formerly considered to be totally independent, relate to this problem of nucleic acid adducts--(1) normal covalent attachment of DNA to membranes, protein linkers in chromosomes, etc. ; (2) the roles of radiation and chemical enhancement of DNA adduct formation in cell killing and mutagenesis. (A related field is the use of known cross-linking reactions to gain information on structural associations in macromolecular complexes. ); (3) the relevance of DNA adducts to chemical and radiation carcinogenesis; (4) the rele vance of DNA adducts to the cross-linking theory of cellular aging. (1) There are numerous examples of normal linkages between DNA and protein, e. g. , DNA-membrane attachment sites, protein linkers in chromosomes, amino acids covalently linked to DNA as a function of growth conditions, and gene regulation by non-covalently bound proteins. A summary of data on natural adducts to DNA thus serves to introduce the subject of the radiation and chemical enhancement of DNA adduct formation. (2) In the past, radiation biology has been concerned mainly with trying to understand the radiation chemistry of purified DNA, and the biological effects and repair of these radiation-induced alterations when produced in cellular DNA.