Radiobiological Modelling In Radiation Oncology
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Radiobiological Modelling In Radiation Oncology
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Author : Roger G. Dale
language : en
Publisher: British Inst of Radiology
Release Date : 2007
Radiobiological Modelling In Radiation Oncology written by Roger G. Dale and has been published by British Inst of Radiology this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Medical categories.
The move towards individually-optimised treatments, using knowledge of normal tissue and tumour radiosensitivity, proliferation rates, etc, in combination with three-dimensional planning, will need mathematical modelling to achieve its full potential. This modelling process will also be capable of helping develop a rational and cost-effective use of resources.Amongst radiation oncologists and medical physicists there is a need for a greater understanding of the scope, applications and limitations of radiobiological modelling, particularly in complex situations that include multiple treatment variables, the respective influence of which are difficult to separate out by randomised trials without using radiobiologically-based analysis.In future there will be increasing use of modelling in practical situations, including treatment gap corrections, normal tissue tolerance predictions, optimisation of therapy determined by predictive assays, multi-modality schedule design, the simulation of clinical trials, testing contemporaneous medico-legal problems and teaching general principals of radiotherapy.
Radiotherapy Treatment Planning
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Author : J. Donald Chapman
language : en
Publisher: CRC Press
Release Date : 2016-04-21
Radiotherapy Treatment Planning written by J. Donald Chapman and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-21 with Science categories.
Understand Quantitative Radiobiology from a Radiation Biophysics Perspective In the field of radiobiology, the linear-quadratic (LQ) equation has become the standard for defining radiation-induced cell killing. Radiotherapy Treatment Planning: Linear-Quadratic Radiobiology describes tumor cell inactivation from a radiation physics perspective and offers appropriate LQ parameters for modeling tumor and normal tissue responses. Explore the Latest Cell Killing Numbers for Defining Iso-Effective Cancer Treatments The book compiles radiation mechanism information from biophysical publications of the past 50 years, addressing how ionizing radiation produces the killing of stem cells in human tumors. It presents several physical and chemical parameters that can modulate the radiation response of clonogenic cells in tumors. The authors describe the use of the LQ model in basic radiation mechanism studies with cells of relatively homogeneous radiation response and then extend the model to the fitting of survival data generated with heterogeneous cell populations (tumors). They briefly discuss how to use the LQ model for predicting tumor (local) control probability (TCP) and normal tissue complication probability (NTCP). The book also examines potential molecular targets related to alpha- and beta-inactivation and gives suggestions for further molecular characterizations of these two independent processes. Develop Efficacious, Patient-Friendly Treatments at Reduced Costs Focusing on quantitative radiobiology in LQ formulation, this book assists medical physicists and radiation oncologists in identifying improved cancer treatments. It also encourages investigators to translate potentially improved radiotherapy schedules based on TCP and NTCP modeling into actual patient benefit.
Practical Radiobiology For Proton Therapy Planning
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Author : Bleddyn Jones
language : en
Publisher:
Release Date : 2018-01-24
Practical Radiobiology For Proton Therapy Planning written by Bleddyn Jones and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-24 with Medical categories.
Practical Radiobiology for Proton Therapy Planning covers the principles, advantages and potential pitfalls that occur in proton therapy, especially its radiobiological modelling applications. This book is intended to educate, inform and to stimulate further research questions. Additionally, it will help proton therapy centres when designing new treatments or when unintended errors or delays occur. The clear descriptions of useful equations for high LET particle beam applications, worked examples of many important clinical situations, and discussion of how proton therapy may be optimized are all important features of the text. This important book blends the relevant physics, biology and medical aspects of this multidisciplinary subject.
Biomedical Physics In Radiotherapy For Cancer
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Author : Loredana Marcu
language : en
Publisher: CSIRO PUBLISHING
Release Date : 2012
Biomedical Physics In Radiotherapy For Cancer written by Loredana Marcu and has been published by CSIRO PUBLISHING this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Medical categories.
The scientific and clinical foundations of Radiation Therapy are cross-disciplinary. This book endeavours to bring together the physics, the radiobiology, the main clinical aspects as well as available clinical evidence behind Radiation Therapy, presenting mutual relationships between these disciplines and their role in the advancements of radiation oncology.
Modelling Radiotherapy Side Effects
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Author : Tiziana Rancati
language : en
Publisher: CRC Press
Release Date : 2019-06-11
Modelling Radiotherapy Side Effects written by Tiziana Rancati and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-11 with Science categories.
The treatment of a patient with radiation therapy is planned to find the optimal way to treat a tumour while minimizing the dose received by the surrounding normal tissues. In order to better exploit the possibilities of this process, the availability of accurate and quantitative knowledge of the peculiar responses of the different tissues is of paramount importance. This book provides an invaluable tutorial for radiation oncologists, medical physicists, and dosimetrists involved in the planning optimization phase of treatment. It presents a practical, accessible, and comprehensive summary of the field’s current research and knowledge regarding the response of normal tissues to radiation. This is the first comprehensive attempt to do so since the publication of the QUANTEC guidelines in 2010. Features: Addresses the lack of systemization in the field, providing educational materials on predictive models, including methods, tools, and the evaluation of uncertainties Collects the combined effects of features, other than dose, in predicting the risk of toxicity in radiation therapy Edited by two leading experts in the field
Basic Clinical Radiobiology Fourth Edition
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Author : Michael C. Joiner
language : en
Publisher: CRC Press
Release Date : 2009-03-27
Basic Clinical Radiobiology Fourth Edition written by Michael C. Joiner and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-03-27 with Medical categories.
This concise but comprehensive textbook sets out the essentials of the science and clinical application of radiobiology for those seeking accreditation in radiation oncology, clinical radiation physics and radiation technology. Fully revised and updated to keep abreast of current developments in radiation biology and radiation oncology, the fourth edition continues to present in an interesting way the biological basis of radiation therapy, discussing the basic principles and significant developments that underlie the latest attempts to improve the radiotherapeutic management of cancer. New topics for the fourth edition include chapters on the mechanisms of cell death, biological response modifiers, and biological image guided radiotherapy, with major revisions to sections on the molecular basis of the radiation response, tumour hypoxia and the dose-rate effect. A variety of new authors have contributed to this revision, who, together with the new Editorial team, have used their significant international teaching experience to ensure the content remains clear and comprehensive, and as valuable to the trainee as it is to the established radiation oncologist. With the fourth edition we will see the most radical change so far - as Professor Gordon Steel has retired as Editor and has been replaced by Bert van der Kogel, the current current course director for the above-mentioned course, plus Michael Joiner, who is the head of the Radiation Biology Program at the Wayne State University and is the Associate Editor of the International Journal of Radiation Biology.
Radiobiology In Radiotherapy
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Author : Norman M. Bleehen
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Radiobiology In Radiotherapy written by Norman M. Bleehen and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The ninth annual multidisciplinary symposium on clinical oncology organized by the Royal College of Radiologists was jointly arranged with the International Society for Radiation Oncology. It was held in London in February 1987 and discussed the biological and clinical basis of the effects of radiotherapy. Wherever possible lectures by an experimental scientist were paired with those of a clinical scientist in order to emphasize clinical relevance. It is hoped that this has resulted in a widely balanced view of the subject. The volume presents an updated version of these subjects based on those talks. After surgery, radiotherapy is the main treatment used in the management of patients with cancer. Its empirical success when first introduced is now backed up by a wealth of laboratory, clinical and experimental experience. New techniques for adminis tering the conventional X-ray therapy have been supplemented by methods which can be used to modify the radiation response. These include changes in dose rate or fractionation, and combined modality treatments including sensitization by drugs or heat. Other types of radiation, such as neutrons and other particles, are also now available which have enhanced physical and biological advantages.
Basic Clinical Radiobiology
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Author : Michael C. Joiner
language : en
Publisher: CRC Press
Release Date : 2018-08-28
Basic Clinical Radiobiology written by Michael C. Joiner and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-28 with Medical categories.
Builds on success and reputation of previous editions Draws on the considerable teaching experience of an international author team, most notably the US and European Editors The gold-standard European text for training, adopted by ESTRO as a course book, as a text for the Royal College of Radiologists' radiobiology exam and by courses in the US Highly illustrated with new, 2 colour illustrations Clear and concise style, appropriate for trainees and also practising radiation oncologists requiring a ready reference to the subject Includes new chapters on stem cells, tissue response and the meeting point of meeting point of radiotherapy, radiobiology and physics
Big Data In Radiation Oncology
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Author : Jun Deng
language : en
Publisher: CRC Press
Release Date : 2019-03-07
Big Data In Radiation Oncology written by Jun Deng and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-07 with Science categories.
Big Data in Radiation Oncology gives readers an in-depth look into how big data is having an impact on the clinical care of cancer patients. While basic principles and key analytical and processing techniques are introduced in the early chapters, the rest of the book turns to clinical applications, in particular for cancer registries, informatics, radiomics, radiogenomics, patient safety and quality of care, patient-reported outcomes, comparative effectiveness, treatment planning, and clinical decision-making. More features of the book are: Offers the first focused treatment of the role of big data in the clinic and its impact on radiation therapy. Covers applications in cancer registry, radiomics, patient safety, quality of care, treatment planning, decision making, and other key areas. Discusses the fundamental principles and techniques for processing and analysis of big data. Address the use of big data in cancer prevention, detection, prognosis, and management. Provides practical guidance on implementation for clinicians and other stakeholders. Dr. Jun Deng is a professor at the Department of Therapeutic Radiology of Yale University School of Medicine and an ABR board certified medical physicist at Yale-New Haven Hospital. He has received numerous honors and awards such as Fellow of Institute of Physics in 2004, AAPM Medical Physics Travel Grant in 2008, ASTRO IGRT Symposium Travel Grant in 2009, AAPM-IPEM Medical Physics Travel Grant in 2011, and Fellow of AAPM in 2013. Lei Xing, Ph.D., is the Jacob Haimson Professor of Medical Physics and Director of Medical Physics Division of Radiation Oncology Department at Stanford University. His research has been focused on inverse treatment planning, tomographic image reconstruction, CT, optical and PET imaging instrumentations, image guided interventions, nanomedicine, and applications of molecular imaging in radiation oncology. Dr. Xing is on the editorial boards of a number of journals in radiation physics and medical imaging, and is recipient of numerous awards, including the American Cancer Society Research Scholar Award, The Whitaker Foundation Grant Award, and a Max Planck Institute Fellowship.
Machine Learning With Radiation Oncology Big Data
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Author : Jun Deng
language : en
Publisher: Frontiers Media SA
Release Date : 2019-01-21
Machine Learning With Radiation Oncology Big Data written by Jun Deng and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-21 with categories.