Randomized Controlled Trials


Randomized Controlled Trials
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Introduction To Randomized Controlled Clinical Trials


Introduction To Randomized Controlled Clinical Trials
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Author : John N.S. Matthews
language : en
Publisher: CRC Press
Release Date : 2006-06-26

Introduction To Randomized Controlled Clinical Trials written by John N.S. Matthews and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-06-26 with Mathematics categories.


Evidence from randomized controlled clinical trials is widely accepted as the only sound basis for assessing the efficacy of new medical treatments. Statistical methods play a key role in all stages of these trials, including their justification, design, and analysis. This second edition of Introduction to Randomized Controlled Clinical Trials prov



Randomized Controlled Trials


Randomized Controlled Trials
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Author : Alehandro R. Jadad
language : en
Publisher: John Wiley & Sons
Release Date : 2007-07-23

Randomized Controlled Trials written by Alehandro R. Jadad and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-07-23 with Medical categories.


Randomized controlled trials are one of the most powerful and revolutionary tools of research. This book is a convenient and accessible description of the underlying principles and practice of randomized controlled trials and their role in clinical decision-making. Structured in a jargon-free question-and-answer format, each chapter provides concise and understandable information on a different aspect of randomized controlled trials, from the basics of trial design and terminology to the interpretation of results and their use in driving evidence-based medicine. The authors end each chapter with their musings, going beyond the evidence or citations, and sometimes even beyond orthodox correctness to share their thoughts and concerns about different aspects of randomized controlled trials, and their role within the health system. Updated to include insights from the last decade, this second edition challenges over-reliance on randomized controlled trials by debating their strengths and limitations and discussing their optimal use in modern healthcare. It also includes a new and increasingly relevant chapter on the ethics of randomized trials. World renowned writers and thinkers Drs Jadad and Enkin bring you this invaluable book for busy health professionals who wish to understand the theory of randomized controlled trials and their influence on clinical, research or policy decisions.



Analysis Of Data From Randomized Controlled Trials


Analysis Of Data From Randomized Controlled Trials
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Author : Jos W.R. Twisk
language : en
Publisher: Springer Nature
Release Date : 2021-10-15

Analysis Of Data From Randomized Controlled Trials written by Jos W.R. Twisk and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-15 with Mathematics categories.


This book provides a practical guide to the analysis of data from randomized controlled trials (RCT). It gives an answer to the question of how to estimate the intervention effect in an appropriate way. This problem is examined for different RCT designs, such as RCTs with one follow-up measurement, RCTs with more than one follow-up measurement, cluster RCTs, cross-over trials, stepped wedge trials, and N-of-1 trials. The statistical methods are explained in a non-mathematical way and are illustrated by extensive examples. All datasets used in the book are available for download, so readers can reanalyse the examples to gain a better understanding of the methods used. Although most examples are taken from epidemiological and clinical studies, this book is also highly recommended for researchers working in other fields.



Randomized Controlled Trials


Randomized Controlled Trials
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Author : Alehandro R. Jadad
language : en
Publisher: John Wiley & Sons
Release Date : 2008-04-15

Randomized Controlled Trials written by Alehandro R. Jadad and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-15 with Medical categories.


Randomized controlled trials are one of the most powerful and revolutionary tools of research. This book is a convenient and accessible description of the underlying principles and practice of randomized controlled trials and their role in clinical decision-making. Structured in a jargon-free question-and-answer format, each chapter provides concise and understandable information on a different aspect of randomized controlled trials, from the basics of trial design and terminology to the interpretation of results and their use in driving evidence-based medicine. The authors end each chapter with their musings, going beyond the evidence or citations, and sometimes even beyond orthodox correctness to share their thoughts and concerns about different aspects of randomized controlled trials, and their role within the health system. Updated to include insights from the last decade, this second edition challenges over-reliance on randomized controlled trials by debating their strengths and limitations and discussing their optimal use in modern healthcare. It also includes a new and increasingly relevant chapter on the ethics of randomized trials. World renowned writers and thinkers Drs Jadad and Enkin bring you this invaluable book for busy health professionals who wish to understand the theory of randomized controlled trials and their influence on clinical, research or policy decisions.



Taming Randomized Controlled Trials In Education


Taming Randomized Controlled Trials In Education
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Author : Keith Morrison
language : en
Publisher: Routledge
Release Date : 2020-07-07

Taming Randomized Controlled Trials In Education written by Keith Morrison and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-07 with Computers categories.


There is a recent surge in the use of randomized controlled trials (RCTs) within education globally, with disproportionate claims being made about what they show, ‘what works’, and what constitutes the best ‘evidence’. Drawing on up-to-date scholarship from across the world, Taming Randomized Controlled Trials in Education critically addresses the increased use of RCTs in education, exploring their benefits, limits and cautions, and ultimately questioning the prominence given to them. While acknowledging that randomized controlled trials do have some place in education, the book nevertheless argues that this place should be limited. Drawing together all arguments for and against RCTs in a comprehensive and easily accessible single volume, the book also adds new perspectives and insights to the conversation; crucially, the book considers the limits of their usefulness and applicability in education, raising a range of largely unexplored concerns about their use. Chapters include discussions on: The impact of complexity theory and chaos theory. Design issues and sampling in randomized controlled trials. Learning from clinical trials. Data analysis in randomized controlled trials. Reporting, evaluating and generalizing from randomized controlled trials. Considering key issues in understanding and interrogating research evidence, this book is ideal reading for all students on Research Methods modules, as well as those interested in undertaking and reviewing research in the field of education.



Randomized Controlled Trials


Randomized Controlled Trials
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Author : Phyllis Solomon
language : en
Publisher: Oxford University Press
Release Date : 2009-02-02

Randomized Controlled Trials written by Phyllis Solomon and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-02-02 with Social Science categories.


Randomized controlled trials (RCTs) are considered by many researchers and providers to be the gold standard of health and social service effectiveness research. However, there exist scant resources that deal with the complex nature of designing and implementing RCTs in community-based settings. This clearly written pocket guide provides researchers and social service practitioners insight into each step of an RCT. The goal of this text is to enable readers to understand, design, and implement a community-based RCT. From the initial stage of planning the RCT and developing its conceptual foundations through implementation, the authors provide a wealth of detail and case studies from social work practice research that assist readers to comprehend the detailed information provided. Accessible, concrete advice is woven throughout the text and tackles the many design and implementation challenges that arise in community practice settings. The importance of utilizing a mix of qualitative and quantitative methods is encouraged due to the intricate nature of RCT research in community-based environments. Through utilizing practical case examples, this pocket guide reviews the essentials of RCTs in a manner that will appeal to researchers, practitioners and students alike who are seeking the necessary tools to build the empirical knowledge base for community-based psychosocial interventions for social work.



A Practical Guide To Using Qualitative Research With Randomized Controlled Trials


A Practical Guide To Using Qualitative Research With Randomized Controlled Trials
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Author : Alicia O'Cathain
language : en
Publisher: Oxford University Press
Release Date : 2018

A Practical Guide To Using Qualitative Research With Randomized Controlled Trials written by Alicia O'Cathain and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with Clinical trials categories.


Researchers measure the effectiveness of new interventions using randomized controlled trials (RCTs). They are increasingly using qualitative research with these RCTs to explain the results of RCTs or facilitate the viability and efficiency of RCTs. A Practical Guide to Using Qualitative Research with Randomized Controlled Trials is a "how-to" book about the use of qualitative research with RCTs. Divided into three parts, this book covers the process of using qualitative research with RCTs from start to finish. Section one outlines overarching issues such as the many contributions qualitative research can make to generating evidence of effectiveness, section two provides practical guidance from writing a proposal through to publishing qualitative research undertaken with RCTs, and the final section guides the reader on how to engage with relevant stakeholders. Each chapter focuses on the key steps of undertaking qualitative research in RCTs, giving examples of how to write a proposal, select research questions, integrate qualitative and quantitative components, and much more. A Practical Guide to Using Qualitative Research with Randomized Controlled Trials is ideal for researchers who are leading, undertaking, or planning to use qualitative research with RCTs. With its detailed explanations and inspiring examples, this book is also useful for postgraduate students wishing to conduct qualitative research in the context of an RCT.



Randomised Controlled Clinical Trials


Randomised Controlled Clinical Trials
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Author : Christopher J. Bulpitt
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-04-17

Randomised Controlled Clinical Trials written by Christopher J. Bulpitt and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-17 with Medical categories.


Bradford Hill has defined a clinical trial as "A carefully and ethically designed experiment with the aim of answering some precisely framed question" [1]. This definition specifies a careful design and requires the provision of adequate controls. Random allocation of treatments to subjects is important to ensure is entitled that the treated and control groups are similar. Therefore this book Randomised Controlled Clinical Trials. We can define a randomised controlled trial by rewriting Bradford Hill's definition as follows, "A carefully and ethi cally designed experiment which includes the provision of adequate and ap propriate controls by a process of randomisation, so that precisely framed questions can be answered. " I am a firm advocate ofRandomised Controlled Clinical Trials but intend to give a balanced view of the advantages and disadvantages of these ethical experiments. This book is directed primarily at the medical research worker, although certain chapters may find a wider application. When discussing a randomised controlled trial, it is neither practicable nor desirable to divorce theory from practice, however the first ten chapters con centrate mainly on theory, and the remainder focus on practice. The segment on trial design is followed by sections on writing the protocol, designing the forms, conducting the trial, and analysing the results. This book is meant to serve both as a reference manual and a practical guide to the design and performance of a trial.



Essential Concepts In Clinical Research


Essential Concepts In Clinical Research
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Author : Kenneth Schulz
language : en
Publisher: Elsevier Health Sciences
Release Date : 2018-07-19

Essential Concepts In Clinical Research written by Kenneth Schulz and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-19 with Medical categories.


This practical guide speaks to two audiences: those who read and those who conduct research. Clinicians are medical detectives by training. For each patient, they assemble clinical clues to establish causes of signs and symptoms. The task involves both clinical acumen and knowledge of medical research. This book helps guide clinicians through this detective work, by enabling them to make sense of research and to review medical literature critically. It will also be invaluable to researchers who conduct clinical research, particularly randomized controlled trials. Building on previously published, peer-reviewed articles from The Lancet, this handbook is essential for busy clinicians and active researchers interested in research methods. Written by leaders in the field of clinical research who have published extensively with authorship of hundreds of articles in medical journals. The authorship includes one of the three authors of the CONSORT guidelines for the reporting of randomized controlled trials. The book presents the essential concepts to a wide array of topics including randomized control trials, descriptive studies, cohort studies, case-control studies, bias, and screening tests. The book utilises a readable and humorous prose style, lightening what can be a difficult area for clinical readers. Derived from decades of teaching clinical research in seminar settings the book will empower clinicians to make sense of, and critically appraise, current medical research and will enable researchers to enrich the quality of their work. The updated new edition includes six new chapters: Surrogate endpoints Limitations of observational epidemiology Participant recruitment Practicalities of double-blinding Randomized trials in the context of a prospective meta-analysis Reporting studies in medical journals: CONSORT



Randomized Controlled Trials In Evidence Based Dentistry


Randomized Controlled Trials In Evidence Based Dentistry
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Author : Richie Kohli
language : en
Publisher: Springer Nature
Release Date :

Randomized Controlled Trials In Evidence Based Dentistry written by Richie Kohli and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.