Ras Past Present And Future
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Ras Past Present And Future
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Author :
language : en
Publisher: Academic Press
Release Date : 2022-01-29
Ras Past Present And Future written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-29 with Science categories.
Advances in Cancer Research, volume 153 provides a timely review of the biology, biochemistry, and current approaches to therapeutically target the RAS oncoprotein, the most frequently mutated oncogene family in human cancers. 2021 saw the approval of the first direct RAS inhibitor (sotorasib) for use in treating non-small cell lung cancers harboring KRAS(G12C) mutations. The successful approval and use of this drug highlights that the once “undruggable RAS is indeed pharmacologically tractable. This volume provides an overview of efforts to develop additional approaches to therapeutically target oncogenic RAS. In addition, the reader will find excellent reviews on the history and research efforts to understand the biochemistry and oncogenic activity of RAS in human cancers. Overview of the history and development of efforts to pharmacologically inhibit RAS. Discussion of the biochemistry and biology of different RAS mutant proteins and how this might be effectively leveraged in the development of anti-RAS therapies. Up-to-date reviews of the cutting-edge approaches to develop new anti-RAS pharmacologics.
Ras Drug Discovery
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Author : Adrian Gill
language : en
Publisher: Elsevier
Release Date : 2024-10-01
Ras Drug Discovery written by Adrian Gill and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-01 with Science categories.
KRAS Drug Discovery: Past, Present and Future is a comprehensive overview of the state-of-the-art medicinal chemistry approaches towards targeting the formerly undruggable oncogene, KRAS. It includes Seminal medicinal chemistry case histories of KRASG12C inhibitors such as Sotorosib, the first approved KRASG12C inhibitor for NSCLC, alongside the latest advances towards identification of in vivo tools and development candidates targeting KRAS G12D, KRAS G13C and other mutations. The book also provides the reader with a comprehensive overview of the in vitro assay systems, in vivo pharmacology xenograft models and chemical biology tools available to characterize small molecule inhibitors of KRAS.
The Past The Present And The Future
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Author : Henry Charles Carey
language : en
Publisher: Philadelphia, Carey & Hart
Release Date : 1848
The Past The Present And The Future written by Henry Charles Carey and has been published by Philadelphia, Carey & Hart this book supported file pdf, txt, epub, kindle and other format this book has been release on 1848 with Economics categories.
Renin Angiotensin System
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Author : Anna Tolekova
language : en
Publisher: BoD – Books on Demand
Release Date : 2017-07-12
Renin Angiotensin System written by Anna Tolekova and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-12 with Medical categories.
Exploring the contractile activity of smooth muscle segments isolated from various organs of healthy animals and animals with experimentally induced diabetes, she obtained original data about angiotensin II-induced force and time parameters. For the first time, she established the effect of ghrelin on angiotensin II-provoked contraction of the urinary bladder. Original data on the role of both types of angiotensin receptors for the contractile activity of the various segments of the gastrointestinal tract and bladder were obtained. By applying specific software for force and time parameter analysis, the contribution of different types of angiotensin receptors on muscle contractility has been shown. The new methodology was used to analyze the data obtained during the registration of smooth muscle relaxation activity, which allows the determination of not only the magnitude of the mechanical response but also the parameters related to the time and speed of the contractions. Plasma renin activity models have been developed using mathematical approaches to predict the effect of different drug doses on the behavior of the system.
Past Present Future
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Author : Rachel Lynn Solomon
language : en
Publisher: Simon and Schuster
Release Date : 2024-06-04
Past Present Future written by Rachel Lynn Solomon and has been published by Simon and Schuster this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-04 with Young Adult Fiction categories.
Rowan and Neil, in a committed long-distance relationship while attending different colleges in Boston and New York City, face the challenges of navigating the first months of college life and personal struggles as they strive to make their relationship last.
India S Kathak Dance Past Present Future
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Author : Reginald Massey
language : en
Publisher: Abhinav Publications
Release Date : 1999
India S Kathak Dance Past Present Future written by Reginald Massey and has been published by Abhinav Publications this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Dance categories.
All The Major Dance Styles Of The Indian Subcontinent Share A Common Root System Of Ethical And Aesthetic Values. Hence No Single Style Can Claim To Be Purer Or Older Than Any Other. Kathak- The Style That Grew, Took Shape And Flourished In The Northern Regions Of The Subcontinent-Has Been Misunderstood And Misinterpreted On Account Of Ignorance And Prejudice From Various Quarters. This Book Sets Out, Therefore, To Rectify Incorrect Perceptions By Presenting Historical Facts And Placing Kathak Dance In Its Proper Cultural Context. The Background Of The Dance Is Explained In Detail; The Religious, Social And Political Influences Over The Centuries Are Recounted; Myth, Theory And Reality Are Expounded Upon; Current Trends Are Described And Future Possibilities Examine; And, Not Least, The Sheer Beauty Of Kathak Is Exposed To Both The Eye And The Intellect. This Book Provides Not Only Information On Technique And Training But Also Tells The Dance Lover What To Look For In A Typical Kathak Performance. It Will, Indeed, Assist The Reader Better To Appreciate And Understand A Great Dance Style. The Names And Addresses Of Recognised Dance Schools And Teachers, Both In India And Abroad, Will Prove Useful, As Will The Glossary And Bibliography. India S Kathak Dance: Past, Present, Future Is Essential Reading For All Those Who Wish To Be Acquainted With India S Immense Cultural And Artistic Achievements.
The Past The Present And The Future
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Author : Henry Charles Carey
language : en
Publisher:
Release Date : 1856
The Past The Present And The Future written by Henry Charles Carey and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1856 with categories.
Past Present And Future Engineering In The Royal Navy
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Author :
language : en
Publisher:
Release Date : 1989
Past Present And Future Engineering In The Royal Navy written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Marine engineering categories.
Molecular Pathogenesis Of Colorectal Cancer
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Author : Kevin M. Haigis, Ph.D.
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-10-02
Molecular Pathogenesis Of Colorectal Cancer written by Kevin M. Haigis, Ph.D. and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-02 with Medical categories.
Colorectal cancer has for more than two decades served as the paradigm for the multi-step concept of cancer initiation and progression. Perhaps more than any other organ site, cancer of the colon is extensively characterized at the molecular level. We are now entering a time when molecular classification, rather than histologic classification, of cancer subtypes is driving the development of clinical trials with emerging targeted therapies. The book will focus on the progression from the identification of mutations that drive colorectal cancer initiation and progression to the search for novel therapies to treat the disease.
Mtor Inhibition For Cancer Therapy Past Present And Future
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Author : Monica Mita
language : en
Publisher: Springer
Release Date : 2015-11-18
Mtor Inhibition For Cancer Therapy Past Present And Future written by Monica Mita and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-18 with Medical categories.
This book describes the challenges involved in developing mTOR inhibitors for cancer treatment, starting with an in-depth examination of their molecular mechanism of action, with emphasis on the class side-effects, efficacy and mechanisms of resistance, as well as on promising novel directions for their development, including novel compounds and rational combinations with other anti-neoplastic drugs. Over the last 10 years, inhibitors of mTOR have emerged as a major class of anticancer drugs. Two rapamycin analogs are currently approved for the treatment of renal cell carcinoma, and it is estimated that a variety of other tumor types could benefit from mTOR inhibition, with numerous clinical trials (including pivotal registration trials) already underway. Second-generation small-molecule inhibitors of the pathway have also shown promise in terms of their superior tolerability and efficacy and are undergoing extensive clinical evaluation, with an estimated 30+ compounds currently under evaluation.