Recent Advancements In Biomarkers And Early Detection Of Gastrointestinal Cancers
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Recent Advancements In Biomarkers And Early Detection Of Gastrointestinal Cancers
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Author : Pallaval Veera Bramhachari
language : en
Publisher: Springer Nature
Release Date : 2020-07-21
Recent Advancements In Biomarkers And Early Detection Of Gastrointestinal Cancers written by Pallaval Veera Bramhachari and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-21 with Medical categories.
This book describes various novel biomarkers for the early diagnosis of gastrointestinal (GI) cancers. It also highlights recent advances in understanding the role of molecular markers and biomarkers, such as volatile biomarkers, serum biomarkers, predictive and prognostic molecular markers for the early detection of GI cancers. Further, it discusses novel biomarkers, including circulating microRNAs, serum microRNA and plasma microRNA in GI cancer. The book presents breakthrough technologies like ultra-sensitive nano-chips, nanosensors, nanodevices, biosensors, electrochemical biosensors, optical biosensors, DNA biosensors, synthetic biology devices, and 'omics' technologies for the early diagnosis of gastrointestinal cancer. In addition it examines the potential of genome-wide association studies, big data analytics, computation biology, systems biology, and nanotechnology for early diagnostics and therapeutics for gastrointestinal cancer, with a focus on personalized cancer treatment. The book is a valuable source for researchers and clinicians engaged in detection and diagnosis of gastrointestinal cancers.
Recent Advancements In Biomarkers And Detection Of Gastrointestinal Cancers
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Author : Mikhael Kular
language : en
Publisher: American Medical Publishers
Release Date : 2023-09-19
Recent Advancements In Biomarkers And Detection Of Gastrointestinal Cancers written by Mikhael Kular and has been published by American Medical Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-19 with Health & Fitness categories.
A biomarker is a biological molecule present in the blood, other body fluids or tissues, that indicates normal or abnormal process, condition or a disease. It can act as an alternative tool and is helpful in selecting accurate treatment in various diseases. Gastrointestinal cancer is a malignant condition affecting gastrointestinal tract and organs of the digestive system including the stomach, pancreas, esophagus, small and large intestine, biliary system, rectum and anus. In the case of esophageal cancer, methylation of DNA can be used as a biomarker for early detection because methylation patterns appear in the initial stages. Protein biomarkers are utilized as markers for gastric tumor for effective diagnosis, prognosis and checking for recurrence of cancer after treatment. Various biomarkers that are utilized in case of stomach cancer include antigens like CA12-5 and CA72-4 as well as alpha-fetoprotein. This book provides comprehensive insights on biomarkers. The topics covered herein deal with the core aspects of the detection of gastrointestinal cancers through biomarkers. This book will serve as a reference to a broad spectrum of readers.
Biomarkers Functional Mechanisms And Therapeutic Potentials In Gastrointestinal Cancers
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Author : Zequn Li
language : en
Publisher: Frontiers Media SA
Release Date : 2023-11-17
Biomarkers Functional Mechanisms And Therapeutic Potentials In Gastrointestinal Cancers written by Zequn Li and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-17 with Medical categories.
Significant changes in diet, environment, and population increase gastrointestinal cancer morbidity. A growing number of novel biomarkers and underlying mechanisms are being elucidated, some of which may even conflict with assumptions of past decades. Therefore, collecting recent findings on novel diagnostic/prognostic factors, biomarkers, and/or risk factors in gastrointestinal cancers is a prerequisite for a better understanding of the disease. Despite remarkable progressions in surgical treatments and chemotherapies, the prognosis of gastrointestinal cancer is far from satisfactory due to the high occurrence of drug resistance. Based on the identification of novel biomarkers as well as their underlying mechanisms, targeted drug development will provide significant complementary therapeutic effects to conventional chemoradiotherapies. High-throughput methods such as next-generation sequencing on RNA level and mass spectrometry on protein/lipid/metabolite level serve as efficient strategies for biomarker identification and drug development. This Research Topic aims at presenting recent advances on gastrointestinal cancer biomarkers and their underlying functional mechanisms, providing a better understanding of carcinogenesis, tumor progression, tumor relapse, as well as drug resistance. This will subsequently contribute to the development of novel therapeutic interventions targeting gastrointestinal cancers, thus improving patients' outcomes.
Biomarkers In Cancer Screening And Early Detection
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Author : Sudhir Srivastava
language : en
Publisher: John Wiley & Sons
Release Date : 2017-06-07
Biomarkers In Cancer Screening And Early Detection written by Sudhir Srivastava and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-07 with Medical categories.
Prepared by world leaders on this topic, Biomarkers in Cancer Screening and Early Detection offers a comprehensive, state-of-the-art perspective on the various research and clinical aspects of cancer biomarkers, from their discovery and development to their validation, clinical utility, and use in developing personalized cancer treatment. Offers a comprehensive, state-of-the-art perspective on the various research and clinical aspects of cancer biomarkers Provides immediately actionable information – and hopefully also inspiration – to move discovery and clinical application forward Offers vital knowledge to help develop personalized cancer treatment for individual patients with specific cancers
Early Gastrointestinal Cancers
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Author : Florian Otto
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-11-05
Early Gastrointestinal Cancers written by Florian Otto and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-05 with Medical categories.
This Recent Results in Cancer Research volume contains the majority of the invited expert contributions from the First St. Gallen EORTC Gastrointestinal Cancer Conference, held on 22-24 March 2012 in St. Gallen, Switzerland. Written by some of the world’s leading experts in the field, the volume constitutes a comprehensive update on recent developments in the imaging, molecular biology, pathology, and multidisciplinary management of early cancer of the gastrointestinal tract. The latest recommendations regarding diagnosis and treatment are provided, and areas of consensus and controversy, identified. While the principal focus is on esophageal and gastric cancer, advances in the treatment of colorectal and pancreatic cancer are also discussed in some detail. This book will be of interest to every clinician involved in the care of patients with gastrointestinal malignancies.
Inherited Gastrointestinal Cancers Identification Management And The Role Of Genetic Evaluation And Testing An Issue Of Gastrointestinal Endoscopy Clinics E Book
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Author : Fay Kastrinos
language : en
Publisher: Elsevier Health Sciences
Release Date : 2021-11-26
Inherited Gastrointestinal Cancers Identification Management And The Role Of Genetic Evaluation And Testing An Issue Of Gastrointestinal Endoscopy Clinics E Book written by Fay Kastrinos and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.
This issue of Gastrointestinal Endoscopy Clinics provides a multidisciplinary approach to the evaluation and care of individuals with inherited gastrointestinal cancer conditions. With the many recent advances made in genomic medicine and the potential impact on medical management, the articles in this issue disseminate new knowledge on the identification and management of individuals and families with a genetic susceptibility to the development of gastrointestinal cancers, including the genetic basis and cancer risks associated with inherited cancer syndromes and integrated familial cancer risk assessment; genetic testing approaches; and incorporating genetic risk counseling into routine medical care. The goal is to improve detection of GI cancer syndromes, understand related cancer risks, and optimize strategies for the prevention and early detection of cancers to minimize morbidity and mortality. Integrating genetic assessment into gastrointestinal cancer care is highly relevant across the cancer care spectrum and gastroenterologists will come away with the most current evidence to enhance and improve their clinical practice. Provides in-depth, clinical reviews on Inherited GI Cancers: Identification, Management and the Role of Genetic Evaluation and Testing, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews. Contains 11 relevant, practice-oriented topics including Defining High-Risk Individuals for Pancreatic Cancer and the Role of Genetic Testing; Endoscopic Management and Surgical Consideration for FAP-Related Polyposis; Genetic Syndromes Associated with Gastric Cancer; Screening and Surgical Considerations in Hereditary Diffuse Gastric Cancer; and more.
Novel Therapeutic Approaches For Gastrointestinal Malignancies
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Author : Ganji Purnachandra Nagaraju
language : en
Publisher: Springer Nature
Release Date : 2020-10-01
Novel Therapeutic Approaches For Gastrointestinal Malignancies written by Ganji Purnachandra Nagaraju and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-01 with Medical categories.
This book provides an up-to-date overview of gastrointestinal malignancies, including prevention, early detection, intervention, and life-extending therapeutics. It also assesses various biomarkers used for diagnostics, prognostics and prediction of response to chemoresistance. Further, it discusses the latest trends in the use of small-molecule targeted therapies and immunotherapies as single agents or combination with other treatments. Since resistance to radiation and chemotherapy contribute to the high recurrence and poor survival rates, improving the outcome for GI malignancies is dependent on the introduction of new biomarkers and therapeutic agents. Lastly, the book systematically investigates novel theranostics approaches using nanotechnology for the detection, diagnosis, and personalized treatment of GI malignancies.
Diagnosis And Treatment Of Gastrointestinal Cancers An Issue Of Gastroenterology Clinics Of North America E Book
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Author : Marta Davila
language : en
Publisher: Elsevier Health Sciences
Release Date : 2022-09-25
Diagnosis And Treatment Of Gastrointestinal Cancers An Issue Of Gastroenterology Clinics Of North America E Book written by Marta Davila and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-25 with Medical categories.
In this issue of Diagnosis and Treatment of Gastrointestinal Cancers, guest editors Drs. Marta Davila and Raquel E. Davila bring their considerable expertise to the topic of Diagnosis and Treatment of Gastrointestinal Cancers. The early detection, diagnosis, and accurate staging of GI cancers, along with enhanced imaging techniques, new therapies, and a greater understanding of GI tumors at the molecular level, has revolutionized the approach to GI cancer patients in recent years. In this issue, distinguished authors recognized internationally as leading authorities in the field provide an exhaustive review of the latest topics in GI cancer. Contains 13 practice-oriented topics including management of Barrett’s esophagus and early esophageal adenocarcinoma; familial pancreatic cancer; colorectal cancer: screening and early detection; the microbiome in gastrointestinal cancers; and more. Provides in-depth clinical reviews on diagnosis and treatment of gastrointestinal cancers, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Cancer Biomarkers And Targets In Digestive Organs
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Author : Nikki P. Lee
language : en
Publisher: MDPI
Release Date : 2019-09-03
Cancer Biomarkers And Targets In Digestive Organs written by Nikki P. Lee and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-03 with Medical categories.
Identification and development of cancer biomarkers and targets have greatly accelerated progress towards precision medicine in oncology. Studies of tumor biology have not only provided insights into the mechanisms underlying carcinogenesis, but also led to discovery of molecules that have been developed into cancer biomarkers and targets. Multi-platforms for molecular characterization of tumors using next-generation genomic sequencing, immunohistochemistry, in situ hybridization, and blood-based biopsies have greatly expanded the portfolio of potential biomarkers and targets. These cancer biomarkers have been developed for diagnosis, early detection, prognosis, and prediction of treatment response. The molecular targets have been exploited for anti-cancer therapy and delivery of therapeutic agents. This Special Issue of Biomedicines focuses on recent advances in the discovery, characterization, translation, and clinical application of cancer biomarkers and targets in malignant diseases of the digestive system. The goal is to stimulate basic and translational research and clinical collaboration in this exciting field with the hope of developing strategies for prevention and early detection/diagnosis of cancer in digestive organs, and improving therapeutic and psychosocial outcomes in patients with these malignant diseases.
The Evolving Landscape Clinical Implications And Future Perspective Of Biomarkers In Gastrointestinal Cancers
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Author : Kenneth K. W. To
language : en
Publisher: Frontiers Media SA
Release Date : 2022-04-11
The Evolving Landscape Clinical Implications And Future Perspective Of Biomarkers In Gastrointestinal Cancers written by Kenneth K. W. To and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-11 with Medical categories.