Recent Developments In The Pharmacology Of Inflammatory Mediators
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Recent Developments In The Pharmacology Of Inflammatory Mediators
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Author : Iwan L. Bonta
language : en
Publisher:
Release Date : 1977
Recent Developments In The Pharmacology Of Inflammatory Mediators written by Iwan L. Bonta and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1977 with categories.
Recent Developments In The Pharmacology Of Inflammatory Mediators
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Author : Iwan L. Bonta
language : en
Publisher: Agents and Actions Supplements
Release Date : 1977
Recent Developments In The Pharmacology Of Inflammatory Mediators written by Iwan L. Bonta and has been published by Agents and Actions Supplements this book supported file pdf, txt, epub, kindle and other format this book has been release on 1977 with Juvenile Nonfiction categories.
In previous studies (1,2) we demonstrated the occurrence of a foetal protein after injury in the rat. This protein, behaving as an acute phase protein, proved to be already known as slow a2 glo bulin (3), or reproduction associated protein (4). Furthermore it is identical to aM foetoprotein (also known as a2FP or aMFP (5) ). This protein is quite different to the well-known a-foetoprotein (aFP), occurring in man and other species during liver carcinoge nesis and some other tumours. aMfoetoprotein (aMFP) is a glycoprotein with a mol.w. of 800.000. It is produced in the liver (6,2) and in the normal adult rat the plasma concentrations are rather low, about 0 - 40 ~g/ml. During fetal development the plasma level in the fetus is much higher (about 6000 ~g/ml), diminishing rapidly after birth to adult levels. But after injury (laparotomy, deep incision, partial hepatectomy followed by regeneration, BaS04 or CdS04 intraperitoneally), plasma levels increase fastly, reaching peak values of 1000 - 8000 ~g/ml after 24 - 48 hrs, declining thereafter gradually. Also very small lesions, as orbital punction, venasection, cannulations, small infections and so on, cause moderate rises of plasma levels up to 80 - 120 ~g/ml. During fetal stage the inflammatory reaction often lacks some of its characteristic features: oedema and infiltration of leucocytes are often rather scanty (7). Also is known that in exudates proteins occur, inhibiting experimen tal inflammations (8,9).
Recent Developments In The Pharmacology Of Inflammatory Mediators
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Author : Iwan L. Bonta
language : en
Publisher:
Release Date : 1977
Recent Developments In The Pharmacology Of Inflammatory Mediators written by Iwan L. Bonta and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1977 with categories.
Recent Developments In The Pharmacology Of Inflammatory Mediators
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Author : Birkhauser Boston Inc
language : en
Publisher: Birkhauser
Release Date : 1980-01-01
Recent Developments In The Pharmacology Of Inflammatory Mediators written by Birkhauser Boston Inc and has been published by Birkhauser this book supported file pdf, txt, epub, kindle and other format this book has been release on 1980-01-01 with categories.
Recent Developments In Anti Inflammatory Therapy
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Author : Parteek Prasher
language : en
Publisher: Academic Press
Release Date : 2023-02-17
Recent Developments In Anti Inflammatory Therapy written by Parteek Prasher and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-02-17 with Medical categories.
Advances in Anti-inflammatory Therapy explores the cutting-edge in anti-inflammation therapy in clear and concise language, with insights from academia and industry. Sections cover key regulatory pathways that mediate acute and chronic inflammation and disease onset. Further chapters are devoted to advanced anti-inflammatory pharmaceuticals, including chemical moieties, pharmacophores, APIs, natural products, herbal therapies, molecular nanomedicine and advanced drug delivery vectors. Systematically planned chapters and illustrations enable potential readers to gain essential insights on the most recent advancements in the field. Arranged with systematic chapters covering a broad range of inflammatory diseases, discussions on past, current and future therapeutics and advanced anti-inflammatory pharmaceuticals, this book will be useful to a wide range of researchers, especially medicinal chemists, drug design experts, and biological and translational researchers working in the field of inflammation. Identifies recent developments and current trends in anti-inflammation therapy Discusses advanced chemotherapeutics, SAR analysis of novel pharmacophores and natural products Outlines the pathophysiology of inflammatory pathways in the pathogenesis of disease onset, including strategies to counter these intricacies Contains a blend of editors from both academia and industry
10 Years Of Inflammation Pharmacology
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Author : Paola Patrignani
language : en
Publisher: Frontiers Media SA
Release Date : 2020-07-07
10 Years Of Inflammation Pharmacology written by Paola Patrignani and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-07 with categories.
The past and future of inflammatory pharmacology research: a hot topic in health and disease Inflammation is a physiological response to a traumatic injury, bacterial, or viral infection. However, if not appropriately controlled, it contributes to a long list of diseases, including asthma, atherosclerosis, multiple sclerosis, arthritis, and cancer. Different are the types of inflammatory responses. Acute inflammation is an immediate body response to the cellular damage induced by pathogens, noxious stimuli, or physical injury – it is a short-term response resulting in healing via time-dependent changes of leukocyte functions. First, a leukocytes infiltration happens within the damaged region with the purpose of eliminating the stimulus and repairing the tissue. Chronic inflammation, by contrast, is a prolonged and dysregulated response where the active inflammation contributes both to tissue destruction and to the development of many chronic human conditions and diseases. In the context of exaggerated inflammation, which occurs as a consequence of severe burns or trauma, the body response called sepsis can be associated with fatal outcome. Increased knowledge of the cellular and molecular mechanisms taking part in the different types of inflammation is a central requirement to develop more effective and safer treatments. This is a necessary step to prevent potential severe consequences, i.e., organ failure associated with tissue fibrosis. The mission of Inflammation Pharmacology (section of Frontiers in Pharmacology) is to publish scientifically sound studies that advance our knowledge on different aspects of inflammation and contribute to the development of more effective and safer anti-inflammatory agents. Within the present eBook are collected the top articles published in the Inflammation Pharmacology section in the last 10 years. Some articles explored the roles played by different lipid mediators generated from arachidonic acid, including leukotrienes and prostanoids [such as prostacylin and prostaglandin(PG)F2a], in inflammatory conditions. Moreover, the protectin (PD) family of specialized pro-resolving mediators biosynthesized from the two omega-3 polyunsaturated fatty acids docosahexaenoic acid (DHA) and n–3 docosapentaenoic acid (n–3 DPA) were described for their biological effects, the G-coupled protein receptors pharmacology, biosynthesis, and medicinal chemistry. Some other articles focused on the development of novel strategies to counteract inflammation or to induce its resolution. The current concepts and controversies on classification, pathogenesis, and clinical management of cutaneous adverse events induced by biologic agents used in the treatment of rheumatologic conditions were discussed in another article. The whole-exome and whole-genome sequencing data identifying new and old loci associated with atherosclerosis will lead to discovering new molecular targets for blocking atherosclerosis even in its early stages. This critical issue was reviewed in another paper. Numerous information on an individual clinical condition is held in their platelet-derived microparticles (MPs); the assessment of their number and size together with their content can represent the signature to acquire diagnostic information and to monitor the efficacy of therapeutic agents. Some other articles discussed the role of fibroblasts in the development of fibrosis and potential therapies under investigation. It was enlightened the role of the activation and transdifferentiation of hepatic stellate cells (HSCs) into contractile, matrix-producing myofibroblasts (MFBs) as central events in hepatic fibrogenesis, and summarized the current strategies for targeted delivery of drugs to pro-fibrogenic liver cells, including the development of therapeutics specifically targeting HSCs. (Continued in eBook)
Inflammation Mediators Advances In Research And Application 2011 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-01-09
Inflammation Mediators Advances In Research And Application 2011 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-09 with Medical categories.
Inflammation Mediators: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Inflammation Mediators in a concise format. The editors have built Inflammation Mediators: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Inflammation Mediators in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Inflammation Mediators: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
The Resolution Of Inflammation
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Author : Adriano Rossi
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-03-17
The Resolution Of Inflammation written by Adriano Rossi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-03-17 with Medical categories.
This book provides readers with an up-to-date and comprehensive view on the resolution of inflammation and on new developments in this area, including pro-resolution mediators, apoptosis, macrophage clearance of apoptotic cells, possible novel drug developments.
Chemical Mediators Of The Acute Inflammatory Reaction
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Author : M. Rocha E Silva
language : en
Publisher: Elsevier
Release Date : 2013-10-22
Chemical Mediators Of The Acute Inflammatory Reaction written by M. Rocha E Silva and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Medical categories.
International Series of Monographs in Pure and Applied Biology, Modern Trends in Physiological Sciences, Volume 37: Chemical Mediators of the Acute Inflammatory Reaction traces the history of investigation into the acute inflammatory reaction from the early observations in invertebrates to the experiments of therapeutic significance for humans. This book focuses on mediators that are accepted as being commonly involved in the inflammatory reaction, such as histamine, kinins, serotonin, prostaglandins, and permeability factors. The topics discussed include the phagocytic system and antibody production; factors which influence phagocytosis; measurement of the acute inflammatory reaction; and combined actions of mediators. The reaction to injury and manifestation of inflammation and biochemical aspects of anti-inflammatory drug reaction are also covered. This volume is beneficial to anatomists, biochemists, physiologists, immunologists, pathologists, pharmacologists, and clinicians interested in acute inflammatory reaction.
Recent Developments In The Pharmacolocy Of Inflammatory Mediators
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Author :
language : en
Publisher:
Release Date : 1977
Recent Developments In The Pharmacolocy Of Inflammatory Mediators written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1977 with categories.