Recollections Of Pioneers In Xenotransplantation Research
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Recollections Of Pioneers In Xenotransplantation Research
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Author : David K. C. Cooper
language : en
Publisher:
Release Date : 2018
Recollections Of Pioneers In Xenotransplantation Research written by David K. C. Cooper and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with MEDICAL categories.
There is a critical and continuing shortage of organs and cells from deceased human donors for the purposes of transplantation into patients with terminal organ failure. The use of organs and cells from pigs i.e., cross-species transplantation, or xenotransplantation could resolve this problem. Recollections of Pioneers in Xenotransplantation Research is a collection of reminiscences by surgeons and scientists who, over the past 50 years, have made major contributions to research into achieving successful transplantation of pig organs and cells into primates. It records the personal work of 22 researchers from North America, Asia, Europe, and Australasia who developed this field, which will have an immense impact on the future medical care of patients with such diverse conditions as heart and kidney failure, diabetes, corneal blindness, and Parkinsons disease. A pig organ transplanted into a human or nonhuman primate is rejected within minutes. To overcome this immunological barrier, pigs have been genetically-engineered to protect their tissues from the primate immune response. Today, life-supporting organs from pigs with up to six genetic modifications have functioned for more than a year in nonhuman primates, and the blood sugar of diabetic monkeys has been controlled for more than two years by the transplantation of insulin-producing pancreatic islet cells from pigs. Clinical trials of pig islet and corneal transplantation have already been undertaken, and trials of organ transplants are currently being planned. The pioneering researchers who contributed to the early development of this field highlight their own roles, and record their personal recollections of the other scientists and surgeons with whom they collaborated. They do not confine themselves to the scientific progress they made, but comment on the roles of industry and academia in moving the field forward. Recollections of Pioneers in Xenotransplantation Research will be of interest to physicians, scientists, and the lay person with an interest in transplantation or in the care of patients with life-threatening diseases, but also to those interested to understand the potential of genetic-engineering in science and medicine. The book provides a historical record of the research that has contributed to an advance in medicine that has been called the next great medical revolution. Within a few years, this new form of therapy is likely to impact every family in the developed world.
Recollections Of Pioneers In Xenotransplantation Research
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Author : David K. C. Cooper
language : en
Publisher:
Release Date :
Recollections Of Pioneers In Xenotransplantation Research written by David K. C. Cooper and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on with Medical categories.
There is a critical and continuing shortage of organs and cells from deceased human donors for the purposes of transplantation into patients with terminal organ failure. The use of organs and cells from pigs - i.e., cross-species transplantation, or xenotransplantation - could resolve this problem. Recollections of Pioneers in Xenotransplantation Research is a collection of reminiscences by surgeons and scientists who, over the past 50 years, have made major contributions to research into achieving successful transplantation of pig organs and cells into primates. It records the personal work of 22 researchers from North America, Asia, Europe, and Australasia who developed this field, which will have an immense impact on the future medical care of patients with such diverse conditions as heart and kidney failure, diabetes, corneal blindness, and Parkinson's disease.A pig organ transplanted into a human or nonhuman primate is rejected within minutes. To overcome this immunological barrier, pigs have been genetically-engineered to protect their tissues from the primate immune response. Today, life-supporting organs from pigs with up to six genetic modifications have functioned for more than a year in nonhuman primates, and the blood sugar of diabetic monkeys has been controlled for more than two years by the transplantation of insulin-producing pancreatic islet cells from pigs. Clinical trials of pig islet and corneal transplantation have already been undertaken, and trials of organ transplants are currently being planned.The pioneering researchers who contributed to the early development of this field highlight their own roles, and record their personal recollections of the other scientists and surgeons with whom they collaborated. They do not confine themselves to the scientific progress they made, but comment on the roles of industry and academia in moving the field forward.Recollections of Pioneers in Xenotransplantation Research will be of interest to physicians, scientists, and the lay person with an interest in transplantation or in the care of patients with life-threatening diseases, but also to those interested to understand the potential of genetic-engineering in science and medicine.The book provides a historical record of the research that has contributed to an advance in medicine that has been called "the next great medical revolution." Within a few years, this new form of therapy is likely to impact every family in the developed world.
Xenotransplantation
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Author : Daniel J. Hurst
language : en
Publisher: Springer Nature
Release Date : 2023-06-21
Xenotransplantation written by Daniel J. Hurst and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-21 with Medical categories.
This is the first volume to comprehensively discuss the ethical, regulatory, and social aspects of xenotransplantation research. Organized into four parts, Xenotransplantation begins by examining ethical issues around informed consent of the potential xenograft recipient, the major ethical issues encountered when doing this research on pigs, and allocation issues. Part two examines regulatory aspects from a global perspective, specifically from three major regions of the world doing xenotransplantation research currently, of which include the United States, Western Europe, and Asia. Following this, part three describes religious aspects of xenotransplantation amongst the major world religions, including Christianity, Islam, Judaism, and Hinduism. The book closes with an analysis of quantitative and qualitative studies conducted by the editors that assess the public’s perception of xenotransplantation. Featuring original data collected by the editors, this book is an instrumental resource for all clinicians involved in the research and practice of xenotransplantation.
Ferroic Materials Based Technologies
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Author : Inamuddin
language : en
Publisher: John Wiley & Sons
Release Date : 2024-07-03
Ferroic Materials Based Technologies written by Inamuddin and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-03 with Technology & Engineering categories.
FERROIC MATERIALS-BASED TECHNOLOGIES The book addresses the prospective, relevant, and original research developments in the ferroelectric, magnetic, and multiferroic fields. Ferroic materials have sparked widespread attention because they represent a broad spectrum of elementary physics and are employed in a plethora of fields, including flexible memory, enormous energy harvesting/storage, spintronic functionalities, spin caloritronics, and a large range of other multi-functional devices. With the application of new ferroic materials, strong room-temperature ferroelectricity with high saturation polarization may be established in ferroelectric materials, and magnetism with significant magnetization can be accomplished in magnetic materials. Furthermore, magnetoelectric interaction between ferroelectric and magnetic orderings is high in multiferroic materials, which could enable a wide range of innovative devices. Magnetic, ferroelectric, and multiferroic 2D materials with ultrathin characteristics above ambient temperature are often expected to enable future miniaturization of electronics beyond Moore’s law for energy-efficient nanodevices. This book addresses the prospective, relevant, and original research developments in the ferroelectric, magnetic, and multiferroic fields. Audience The book will interest materials scientists, physicists, and engineers working in ferroic and multiferroic materials.
Clinical Xenotransplantation
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Author : David K. C. Cooper
language : en
Publisher: Springer Nature
Release Date : 2020-09-08
Clinical Xenotransplantation written by David K. C. Cooper and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-08 with Medical categories.
This title provides an illuminating examination of the current state of xenotransplantation – grafting or transplanting organs or tissues between members of different species – and how it might move forward into the clinic. To be sure, this is a critical topic, as a major problem that remains worldwide is an inadequate supply of organs from deceased human donors, severely limiting the number of organ transplants that can be performed each year. Based on presentations given at a major conference on xenotransplantation, this title includes important views from many leading experts who were invited to present their data and opinions on how xenotransplantation can advance into the clinic. Attention was concentrated on pig kidney and heart transplantation as it is in regard to these organs that most progress has been made. Collectively, these chapters effectively highlight the many advantages of xenotransplantation to patients with end-stage organ failure, thereby encouraging the mapping of a concrete pathway to clinical xenotransplantation. The book is organized across 22 chapters, beginning with background information on clinical and experimental xenotransplantation. Following this are discussions addressing how pigs can be genetically engineered for their organs to be resistant to the human immune response through deletion of pig xenoantigens, and the insertion of ‘protective’ human transgenes. Subsequent chapters analyze complications that arise in practice, comparing allotransplant and xenotransplant rejection. The selection of the ideal patients for the first clinical trials is discussed. Finally, the book concludes with an analysis on the regulatory, economic, and social aspects of this research, including FDA perspectives and the sensitive, psychosocial factors regarding allotransplantation and xenotransplantation. A major and timely addition to the literature, Clinical Xenotransplantation will be of great interest to all researchers, physicians, and academics from other disciplines with an interest in xenotransplantation.
Rangeland Ecology Management And Conservation Benefits
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Author : Victor R. Squires
language : en
Publisher:
Release Date : 2015
Rangeland Ecology Management And Conservation Benefits written by Victor R. Squires and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with NATURE categories.
Rangelands are a type of land that include vast grasslands, shrublands, woodland, wetlands and deserts, grazed by domestic livestock or wild animals. They comprise almost one-half of all the lands in the world. This book analyzes the sustainability of beef cattle systems of the Spanish Rangelands known as Dehesas. These systems are considered as outstanding High Nature Value (HNV) farming systems and the most agroforestry systems in Europe. Additionally, on a global scale, China has around one-eighth of the rangelands (the second largest area of land in any country other than Australia). These rangelands are mostly inhabited by peoples of various ethnic minorities. This book provides an overview of the environment and current development trends in the pastoral regions including a glimpse of the people affected most by any conservation or development effort and provide a framework for future integrated conservation and development work in the pastoral regions of north and north-west China. Furthermore, land degradation and biodiversity loss are the most critical issues of ecological environmenti n the West of China and they are the main causes for poverty and constraints for economic development. This book examines rangeland degradation in China as well as rangeland management and livestock production in an effort to arrest and reverse rangeland degradation. In other chapters, changes in vegetation related with grazing are reviewed, the benefits of reintegrating burrowing bettongs as a part of rangeland restoration programs, and integrating national feral camel management plans that are being implemented across the camel range in Australia, aiming to control the damage caused by camels (there are around 750,000 feral camels in arid and semi-arid rangelands in Australia).
Kidney Transplantation Principles And Practice E Book
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Author : Stuart J. Knechtle
language : en
Publisher: Elsevier Health Sciences
Release Date : 2013-10-24
Kidney Transplantation Principles And Practice E Book written by Stuart J. Knechtle and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-24 with Medical categories.
With meticulous updates throughout, Kidney Transplantation remains your definitive medical resource for state-of-the-art answers on every aspect of renal transplantation. A multidisciplinary approach from internationally renowned nephrologists from around the world offers practice-applicable guidance for all members of the transplant team. With coverage encompassing applied science, surgical techniques, immunosuppressive methods, outcomes, risks, and medical considerations related to kidney transplantation, both in adults and children, you’ll have the balanced information you need to achieve the best possible outcomes. Visualize key concepts and discern nuances of renal transplantation techniques through more than 335 superb illustrations.
Christiaan Barnard
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Author : David Cooper
language : en
Publisher: Fonthill Media
Release Date : 2017-12-17
Christiaan Barnard written by David Cooper and has been published by Fonthill Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-17 with Biography & Autobiography categories.
Contemporary Kidney Transplantation
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Author : Carlo Gerardo B. Ramirez
language : en
Publisher: Springer
Release Date : 2018-07-12
Contemporary Kidney Transplantation written by Carlo Gerardo B. Ramirez and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-12 with Medical categories.
This book provides a comprehensive guide to successful kidney transplantation in the highly regulated environment of today. It covers the history of kidney transplant to highlight innovations that have made kidney transplantation so successful as well as the new deceased donor kidney allocation strategy and postulates what types of changes might occur with this new policy. The book highlights special areas of nephrology concern in kidney transplantation, especially diseases likely to recur following transplant. It deals with many of the medications used in kidney transplantation including different commonly used antirejection protocols. It also provides a complete reference on the various operations involved in kidney transplantation. The text includes detailed pictures and surgical technique sections on cadaveric kidney transplantation and living kidney transplantation. It includes information on living kidney donation surgery with a chapter dedicated to the minimally invasive techniques that have been popularized in the last fifteen years. Some coverage on open living kidney donation is presented. Included in this section is discussions of how to handle certain operative challenges like severe atherosclerosis, venous sclerosis and various urinary system aberrancies. Comprehensive coverage of common surgical complications is presented including management of urinary strictures, urinary leaks, lymphoceles, vascular probl ems following transplant, and what steps should be taken when an early kidney transplant biopsy is necessary. It also covers in detail what is required for maintenance of health after kidney transplantation including the major risks for graft loss as well as what disease processes kidney transplant patients are particularly vulnerable to.
The Anticipatory Corpse
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Author : Jeffrey P. Bishop
language : en
Publisher: University of Notre Dame Pess
Release Date : 2011-09-19
The Anticipatory Corpse written by Jeffrey P. Bishop and has been published by University of Notre Dame Pess this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-19 with Religion categories.
In this original and compelling book, Jeffrey P. Bishop, a philosopher, ethicist, and physician, argues that something has gone sadly amiss in the care of the dying by contemporary medicine and in our social and political views of death, as shaped by our scientific successes and ongoing debates about euthanasia and the “right to die”—or to live. The Anticipatory Corpse: Medicine, Power, and the Care of the Dying, informed by Foucault’s genealogy of medicine and power as well as by a thorough grasp of current medical practices and medical ethics, argues that a view of people as machines in motion—people as, in effect, temporarily animated corpses with interchangeable parts—has become epistemologically normative for medicine. The dead body is subtly anticipated in our practices of exercising control over the suffering person, whether through technological mastery in the intensive care unit or through the impersonal, quasi-scientific assessments of psychological and spiritual “medicine.” The result is a kind of nihilistic attitude toward the dying, and troubling contradictions and absurdities in our practices. Wide-ranging in its examples, from organ donation rules in the United States, to ICU medicine, to “spiritual surveys,” to presidential bioethics commissions attempting to define death, and to high-profile cases such as Terri Schiavo’s, The Anticipatory Corpse explores the historical, political, and philosophical underpinnings of our care of the dying and, finally, the possibilities of change. This book is a ground-breaking work in bioethics. It will provoke thought and argument for all those engaged in medicine, philosophy, theology, and health policy.