Rediscovering Cancer From Mechanism To Therapy
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Rediscovering Cancer From Mechanism To Therapy
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Author : Sayali Mukherjee
language : en
Publisher: CRC Press
Release Date : 2018-09-04
Rediscovering Cancer From Mechanism To Therapy written by Sayali Mukherjee and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-04 with Medical categories.
This volume presents a snapshot of some of the most important ongoing research in cancer. With cancer as the second leading cause of death worldwide, extensive research is going on globally to decipher the molecular mechanism underlying cancer that will help in finding better targets for drug therapy. The book brings together new research on molecular mechanism and cancer therapeutics in one place. With chapters from experts in their respective fields, chapters cover molecular mechanisms, etiology, prognosis, detection, and treatment of cancer. Emphasis has been given to the intricate mechanism behind the deregulation of cell division, disruption of cell cycle check points, mutation in oncogenes and tumor suppressor genes, apoptosis, and erratic cell signaling. The book discusses in detail topics such as angiogenesis and tumor microenvironment, which are increasingly receiving attention, especially in the field of neoplastic vascularization and metastasis. The book also includes chapters detailing the current understanding and the future perspective of cancer stem cells.
Antiangiogenic Agents In Cancer Therapy
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Author : Beverly A. Teicher
language : en
Publisher: Springer Science & Business Media
Release Date : 1998-12-28
Antiangiogenic Agents In Cancer Therapy written by Beverly A. Teicher and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-12-28 with Medical categories.
Beverly Teicher and a panel of distinguished investigators survey the state-of-the-art of antiangiogenesis research from the lab bench to clinical trials. Timely and authoritative, the contributors summarize our current understanding of tumor growth and its dependence on vascular development, as well as the present status of antiangiogenic agents in preclinical and clinical development. In addition, the book also examines what is known about the mechanisms by which these therapeutic agents interfere with tumor vasculature and grapples with the problem of establishing criteria by which to assess their clinical efficacy. Antiangiogenic Agents in Cancer Therapy offers a unique cutting-edge compendium of antiangiogenic research, taking stock of what has been accomplished , where the experimental therapeutics of antiangiogenic agents is going, and the continuing evolution of their role in cancer treatment and novel drug development.
Fusion Genes And Cancer
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Author : Kunnumakkara Ajaikumar B
language : en
Publisher: World Scientific
Release Date : 2017-04-07
Fusion Genes And Cancer written by Kunnumakkara Ajaikumar B and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-07 with Medical categories.
Development of cancer, a dreadful disease of mankind, is a multi-stage process involving numerous molecular alterations at both genomic and proteomic levels. Immense research for the past several decades in the field of cancer identified many such mutations and their role in carcinogenesis. Concept of 'fusion genes' seeded way back in 20th century has now grown into a new field of cancer research. However, there is a lack of knowledge among scientists about these fusion genes and their importance in cancer, which can be mainly attributed to unavailability of a comprehensive book on this topic. Therefore, this book is first of its kind and aims at giving a detailed idea on the formation of gene fusions and their importance in the development and progression of cancer; techniques to identify novel gene fusions; and therapeutics available to target various fusion proteins and their impact in cancer therapy by compiling the information from the literature available till date. Contents:Cancer — An Overview and Molecular Alterations in Cancer (Nand K Roy, Devivasha Bordoloi, Javadi Monisha, Anand Anip, Ganesan Padmavathi and Ajaikumar B Kunnumakkara)Basic Concepts of Fusion Genes and Their Classification (Ganesan Padmavathi, Nand K Roy, Devivasha Bordoloi, Javadi Monisha and Ajaikumar B Kunnumakkara)Techniques to Identify Novel Fusion Genes and to Detect Known Fusion Genes (Nand K Roy, Ganesan Padmavathi, Devivasha Bordoloi and Ajaikumar B Kunnumakkara)The Receptor Tyrosine Kinase ALK — Its Fusion Partners and Their Implication in Various Cancers(Ganesan Padmavathi, Krishan Kumar Thakur, Anand Anip, Devivasha Bordoloi and Ajaikumar B Kunnumakkara)Role of BCR-ABL Fusion Kinase in the Development of Leukemia (Ganesan Padmavathi, Kishore Banik, Nand K Roy, Javadi Monisha and Ajaikumar B Kunnumakkara)BRD4-NUT Fusion Oncoprotein and Its Significance in the Initiation and Progression of NUT Midline Carcinoma (Ganesan Padmavathi, Devivasha Bordoloi, Kishore Banik and Ajaikumar B Kunnumakkara)Importance of CBFB-MYH11 — A Chimeric Transcriptional Regulator in Leukemia (Ganesan Padmavathi, Choudhary Harsha, Devivasha Bordoloi, Krishan Kumar Thakur and Ajaikumar B Kunnumakkara)Rearrangements Involving ETS Family of Genes and Their Role in Different Cancers (Ganesan Padmavathi, Javadi Monisha, Kishore Banik, Choudhary Harsha, Devivasha Bordoloi and Ajaikumar B Kunnumakkara)Translocation of FET Family Members with Various Partner Genes and Their Role in Cancer Development (Ganesan Padmavathi, Devivasha Bordoloi, Anand Anip, Krishan Kumar Thakur and Ajaikumar B Kunnumakkara)Translocations of FGF and FGFR Proteins and Their Effect in Cancer (Ganesan Padmavathi, Javadi Monisha, Choudhary Harsha and Ajaikumar B Kunnumakkara)IG/MYC and Its Implication in Cancer (Ganesan Padmavathi, Kishore Banik, Krishan Kumar Thakur and Ajaikumar B Kunnumakkara)Chimeric RAF Kinases in the Development of Cancer (Ganesan Padmavathi, Kishore Banik, Devivasha Bordoloi, Choudhary Harsha and Ajaikumar B Kunnumakkara)Mucoepidermoid Carcinoma (MEC) and Associated MAML2 Fusion Genes (Ganesan Padmavathi, Choudhary Harsha, Devivasha Bordoloi, Kishore Banik and Ajaikumar B Kunnumakkara)Mixed Lineage Leukemia/AF9 Fusion and Associated Leukemia (Ganesan Padmavathi, Choudhary Harsha and Ajaikumar B Kunnumakkara)MYB-NFIB Fusion Gene — Hallmark of Adenoid Cystic Carcinoma (ACC) (Ganesan Padmavathi, Krishan Kumar Thakur and Ajaikumar B Kunnumakkara)Translocations Involving PAX Family Genes and Their Effect in Cancer (Ganesan Padmavathi, Krishan Kumar Thakur and Ajaikumar B Kunnumakkara)Retinoic Acid Receptor Alpha (RARα) Fusion Genes in Leukemia (Ganesan Padmavathi, Javadi Monisha, Anand Anip, Krishan Kumar Thakur and Ajaikumar B Kunnumakkara)RET/PTC Translocations and Thyroid Malignancies (Ganesan Padmavathi, Devivasha Bordoloi, Anand Anip, Choudhary Harsha and Ajaikumar B Kunnumakkara)RUNX1 or AML1 Fusion Genes in Leukemia and Other Cancers (Ganesan Padmavathi, Javadi Monisha, Kishore Banik, Choudhary Harsha, Devivasha Bordoloi and Ajaikumar B Kunnumakkara)Recently Discovered Fusion Genes and Their Implications in Cancer (Ganesan Padmavathi, Devivasha Bordoloi, Javadi Monisha, Nand K Roy, Choudhary Harsha and Ajaikumar B Kunnumakkara)Targeting Fusion Genes for Cancer Therapy (Nand K Roy, Devivasha Bordoloi, Ganesan Padmavathi and Ajaikumar B Kunnumakkara) Readership: Scientists working in the field of cancer biology, cancer genomics and proteomics. Also specialists and researchers in diverse fields of disease pathogenesis as it provides collective information about fusion genes and cancer from the basics to the targeted therapies.
Drug Repurposing In Cancer Therapy
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Author : Kenneth K.W. To
language : en
Publisher: Academic Press
Release Date : 2020-07-29
Drug Repurposing In Cancer Therapy written by Kenneth K.W. To and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-29 with Science categories.
Drug Repurposing in Cancer Therapy: Approaches and Applications provides comprehensive and updated information from experts in basic science research and clinical practice on how existing drugs can be repurposed for cancer treatment. The book summarizes successful stories that may assist researchers in the field to better design their studies for new repurposing projects. Sections discuss specific topics such as in silico prediction and high throughput screening of repurposed drugs, drug repurposing for overcoming chemoresistance and eradicating cancer stem cells, and clinical investigation on combination of repurposed drug and anticancer therapy. Cancer researchers, oncologists, pharmacologists and several members of biomedical field who are interested in learning more about the use of existing drugs for different purposes in cancer therapy will find this to be a valuable resource. Presents a systematic and up-to-date collection of the research underpinning the various drug repurposing approaches for a quick, but in-depth understanding on current trends in drug repurposing research Brings better understanding of the drug repurposing process in a holistic way, combining both basic and clinical sciences Encompasses a collection of successful stories of drug repurposing for cancer therapy in different cancer types
Cancer Chemotherapy And Biotherapy
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Author : Bruce A. Chabner
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 2011-12-07
Cancer Chemotherapy And Biotherapy written by Bruce A. Chabner and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-12-07 with Medical categories.
Updated to include the newest drugs and those currently in development, this Fifth Edition is a comprehensive reference on the preclinical and clinical pharmacology of anticancer agents. Organized by drug class, the book provides the latest information on all drugs and biological agents—their mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance. The authors explain the rationale for use of drugs in specific schedules and combinations and offer guidelines for dose adjustment in particular situations. This edition's introduction includes timely information on general strategies for drug usage, the science of drug discovery and development, economic and regulatory aspects of cancer drug development, and principles of pharmacokinetics. Eight new chapters have been added and more than twenty have been significantly revised. A companion website includes the fully searchable text and an image bank.
Immunomodulating Drugs For The Treatment Of Cancer
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Author : Asher A. A. Chanan-Khan
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 2011
Immunomodulating Drugs For The Treatment Of Cancer written by Asher A. A. Chanan-Khan and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Medical categories.
Immunomodulatory (IMiDs) drugs are a new class of anticancer agents that has made a tremendous impact on the treatment of patients with various malignant diseases, including blood cancers and several cancers of the solid organs. Their popularity in prescribing is based on several important characteristics including: (1) oral bioavailability, (2) non-chemotherapeutic, (3) extremely well-tolerated in all age groups, (4) ability to activate patient's own immune response against cancer, (5) ease of combination with other agents such as chemotherapy resulting in higher responses as well as (6) variability of anticancer activity and a number of cancers. While there is a lot of literature published on these agents, there is no textbook that provides a comprehensive resource for clinicians and researchers regarding these agents and their rapidly emerging role in cancer medicine.
Systems Biology In Cancer Research And Drug Discovery
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Author : Asfar S Azmi
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-09-29
Systems Biology In Cancer Research And Drug Discovery written by Asfar S Azmi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-09-29 with Medical categories.
Systems Biology in Cancer Research and Drug Discovery provides a unique collection of chapters, by world-class researchers, describing the use of integrated systems biology and network modeling in the cancer field where traditional tools have failed to deliver expected promise. This book touches four applications/aspects of systems biology (i) in understanding aberrant signaling in cancer (ii) in identifying biomarkers and prognostic markers especially focused on angiogenesis pathways (iii) in unwinding microRNAs complexity and (iv) in anticancer drug discovery and in clinical trial design. This book reviews the state-of-the-art knowledge and touches upon cutting edge newer and improved applications especially in the area of network modeling. It is aimed at an audience ranging from students, academics, basic researcher and clinicians in cancer research. This book is expected to benefit the field of translational cancer medicine by bridging the gap between basic researchers, computational biologists and clinicians who have one ultimate goal and that is to defeat cancer.
Comprehensive Dermatologic Drug Therapy
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Author : Stephen E. Wolverton
language : en
Publisher: Elsevier Health Sciences
Release Date : 2019-12-14
Comprehensive Dermatologic Drug Therapy written by Stephen E. Wolverton and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-14 with Medical categories.
Designed with practical usability in mind, Comprehensive Dermatologic Drug Therapy, 4th Edition, helps you safely and effectively treat the skin disorders you’re likely to see in your practice. Dr. Stephen E. Wolverton and new associate editor Dr. Jashin J. Wu lead a team of global experts to bring you concise, complete guidance on today's full spectrum of topical, intralesional, and systemic drugs. You’ll prescribe with confidence thanks to expert coverage of which drugs to use, when to use them, and adverse effects to monitor. Includes new drug interaction tables, drug risk profiles, and FDA guidelines, as well as two new appendices that summarize chapter questions and summarize highest-risk drug interactions. Covers the best uses for new biologic therapeutics. Contains new chapters covering medical decision-making principles, PDE-4 and JAK inhibitors, interleukin 17 inhibitors, interleukin 23 inhibitors, additional biologic therapeutics, and hedgehog pathway inhibitors. Contains quick-access summaries of indications/contraindications, dosage guidelines, drug interactions, drug monitoring guidelines, adverse effects, and treatment protocols. Features a highly detailed, disease-specific index, as well as purchase information for major drugs. Helps you assess your knowledge and prepare for certification or recertification with about 800 review questions and answers throughout the book.
Cancer Chemotherapy Immunotherapy And Biotherapy
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Author : Bruce A. Chabner
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 2024-06-18
Cancer Chemotherapy Immunotherapy And Biotherapy written by Bruce A. Chabner and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-18 with Medical categories.
Focusing on individual patient needs, Cancer Chemotherapy, Immunotherapy and Biotherapy: Principles and Practice, Seventh Edition, provides thorough, comprehensive information from Drs. Bruce A. Chabner, Dan L. Longo, and an authoritative team of clinicians and scientists working at renowned cancer centers across the globe. It covers fundamental information about mechanism of action, pharmacokinetics, clinical toxicity, and drug interactions, all essential to the safe and effective use of the drug.
Toxicity Mechanisms Exposure Toxicokinetic And Risk Assessment Aspects Of Metals Toxic For Animals And Humans
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Author : Yanzhu Zhu
language : en
Publisher: Frontiers Media SA
Release Date : 2022-03-10
Toxicity Mechanisms Exposure Toxicokinetic And Risk Assessment Aspects Of Metals Toxic For Animals And Humans written by Yanzhu Zhu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-10 with Science categories.