Regression Analysis In Medical Research
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Regression Analysis In Medical Research
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Author : Ton J. Cleophas
language : en
Publisher: Springer
Release Date : 2018-01-29
Regression Analysis In Medical Research written by Ton J. Cleophas and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-29 with Science categories.
This edition is a pretty complete textbook and tutorial for medical and health care students, as well as a recollection/update bench, and help desk for professionals. Novel approaches already applied in published clinical research will be addressed: matrix analyses, alpha spending, gate keeping, kriging, interval censored regressions, causality regressions, canonical regressions, quasi-likelihood regressions, novel non-parametric regressions. Each chapter can be studied as a stand-alone, and covers one field in the fast growing world of regression analyses. The authors, as professors in statistics and machine learning at European universities, are worried, that their students find regression-analyses harder than any other methodology in statistics. This is serious, because almost all of the novel methodologies in current data mining and data analysis include elements of regression-analysis. It is the main incentive for writing this 28 chapter edition, consistent of - 28 major fields of regression analysis, - their condensed maths, - their applications in medical and health research as published so far, - step by step analyses for self-assessment, - conclusion and reference sections. Traditional regression analysis is adequate for epidemiology, but lacks the precision required for clinical investigations. However, in the past two decades modern regression methods have proven to be much more precise. And so it is time, that a book described regression analyses for clinicians. The current edition is the first to do so. It is written for a non-mathematical readership. Self-assessment data-files are provided through Springer' s "Extras Online".
Regression Methods For Medical Research
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Author : Bee Choo Tai
language : en
Publisher: John Wiley & Sons
Release Date : 2013-10-09
Regression Methods For Medical Research written by Bee Choo Tai and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-09 with Medical categories.
Regression Methods for Medical Research provides medical researchers with the skills they need to critically read and interpret research using more advanced statistical methods. The statistical requirements of interpreting and publishing in medical journals, together with rapid changes in science and technology, increasingly demands an understanding of more complex and sophisticated analytic procedures. The text explains the application of statistical models to a wide variety of practical medical investigative studies and clinical trials. Regression methods are used to appropriately answer the key design questions posed and in so doing take due account of any effects of potentially influencing co-variables. It begins with a revision of basic statistical concepts, followed by a gentle introduction to the principles of statistical modelling. The various methods of modelling are covered in a non-technical manner so that the principles can be more easily applied in everyday practice. A chapter contrasting regression modelling with a regression tree approach is included. The emphasis is on the understanding and the application of concepts and methods. Data drawn from published studies are used to exemplify statistical concepts throughout. Regression Methods for Medical Research is especially designed for clinicians, public health and environmental health professionals, para-medical research professionals, scientists, laboratory-based researchers and students.
Regression Models As A Tool In Medical Research
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Author : Werner Vach
language : en
Publisher: CRC Press
Release Date : 2012-11-27
Regression Models As A Tool In Medical Research written by Werner Vach and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-27 with Mathematics categories.
While regression models have become standard tools in medical research, understanding how to properly apply the models and interpret the results is often challenging for beginners. Regression Models as a Tool in Medical Research presents the fundamental concepts and important aspects of regression models most commonly used in medical research, including the classical regression model for continuous outcomes, the logistic regression model for binary outcomes, and the Cox proportional hazards model for survival data. The text emphasizes adequate use, correct interpretation of results, appropriate presentation of results, and avoidance of potential pitfalls. After reviewing popular models and basic methods, the book focuses on advanced topics and techniques. It considers the comparison of regression coefficients, the selection of covariates, the modeling of nonlinear and nonadditive effects, and the analysis of clustered and longitudinal data, highlighting the impact of selection mechanisms, measurement error, and incomplete covariate data. The text then covers the use of regression models to construct risk scores and predictors. It also gives an overview of more specific regression models and their applications as well as alternatives to regression modeling. The mathematical details underlying the estimation and inference techniques are provided in the appendices.
Regression Analysis In Medical Research
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Author : Ton J. Cleophas
language : en
Publisher:
Release Date : 2021
Regression Analysis In Medical Research written by Ton J. Cleophas and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with categories.
Regression analysis of cause effect relationships is increasingly the core of medical and health research. This work is a 2nd edition of a 2017 pretty complete textbook and tutorial for students as well as recollection / update bench and help desk for professionals. It came to the authors' attention, that information of history, background, and purposes, of the regression methods addressed were scanty. Lacking information about all of that has now been entirely covered. The editorial art work of the first edition, however pretty, was less appreciated by some readerships, than were the original output sheets from the statistical programs as used. Therefore, the editorial art work has now been systematically replaced with original statistical software tables and graphs for the benefit of an improved usage and understanding of the methods. In the past few years, professionals have been flooded with big data. The Covid-19 pandemic gave cause for statistical software companies to foster novel analytic programs better accounting outliers and skewness. Novel fields of regression analysis adequate for such data, like sparse canonical regressions and quantile regressions, have been included. .
Quantile Regression In Clinical Research
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Author : Ton J. Cleophas
language : en
Publisher: Springer Nature
Release Date : 2022-01-17
Quantile Regression In Clinical Research written by Ton J. Cleophas and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-17 with Medical categories.
Quantile regression is an approach to data at a loss of homogeneity, for example (1) data with outliers, (2) skewed data like corona - deaths data, (3) data with inconstant variability, (4) big data. In clinical research many examples can be given like circadian phenomena, and diseases where spreading may be dependent on subsets with frailty, low weight, low hygiene, and many forms of lack of healthiness. Stratified analyses is the laborious and rather explorative way of analysis, but quantile analysis is a more fruitful, faster and completer alternative for the purpose. Considering all of this, we are on the verge of a revolution in data analysis. The current edition is the first textbook and tutorial of quantile regressions for medical and healthcare students as well as recollection/update bench, and help desk for professionals. Each chapter can be studied as a standalone and covers one of the many fields in the fast growing world of quantile regressions. Step by step analyses of over 20 data files stored at extras.springer.com are included for self-assessment. We should add that the authors are well qualified in their field. Professor Zwinderman is past-president of the International Society of Biostatistics (2012-2015) and Professor Cleophas is past-president of the American College of Angiology(2000-2002). From their expertise they should be able to make adequate selections of modern quantile regression methods for the benefit of physicians, students, and investigators.
Using And Understanding Medical Statistics
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Author : David E. Matthews
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2007-01-01
Using And Understanding Medical Statistics written by David E. Matthews and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-01-01 with Medical categories.
Noteworthy advances have occurred in both the practice of medicine and biostatistical methods since the previous edition of this book was published. For example, physicians' acceptance of the importance of 'evidence-based medicine' is much more widespread now than it was in the mid-1990s. Even a casual reading of the current medical literature reveals that a basic grasp of statistical concepts and a passing appreciation for what statistical analysis can and cannot do is essential in order to understand and critically assess published reports concerning the frontiers of medical research. The fourth revised edition of this highly successful volume represents the most substantial revision of 'Using and Understanding Medical Statistics' since the first edition was published more than 20 years ago. The authors have added five entirely new chapters on Poisson regression, the analysis of variance, meta-analysis, diagnostic tests and the subject of measurement agreement and reliability. In addition, there are sections describing new topics or exploring new examples in the chapters on the Kaplan-Meier estimate, the log-rank test, longitudinal studies, data analysis, clinical trials and epidemiological applications. The end result is an excellent introduction to medical statistics, as well as a valuable reference concerning many of the more complex statistical methods and techniques currently appearing in medical publications.
Medical Statistics From A To Z
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Author : B. S. Everitt
language : en
Publisher: Cambridge University Press
Release Date : 2003-06-26
Medical Statistics From A To Z written by B. S. Everitt and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-06-26 with Mathematics categories.
An accessible non-technical introduction to the terminology of medical statistics.
Using And Understanding Medical Statistics
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Author : D.E. Matthews
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2015-07-02
Using And Understanding Medical Statistics written by D.E. Matthews and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-02 with Language Arts & Disciplines categories.
The fifth revised edition of this highly successful book presents the most extensive enhancement since Using and Understanding Medical Statistics was first published 30 years ago. Without question, the single greatest change has been the inclusion of source code, together with selected output, for the award-winning, open-source, statistical package known as R. This innovation has enabled the authors to de-emphasize formulae and calculations, and let software do all of the ‘heavy lifting’. This edition also introduces readers to several graphical statistical tools, such as Q-Q plots to check normality, residual plots for multiple regression models, funnel plots to detect publication bias in a meta-analysis and Bland-Altman plots for assessing agreement in clinical measurements. New examples that better serve the expository goals have been added to a half-dozen chapters. In addition, there are new sections describing exact confidence bands for the Kaplan-Meier estimator, as well as negative binomial and zero-inflated Poisson regression models for over-dispersed count data. The end result is not only an excellent introduction to medical statistics, but also an invaluable reference for every discerning reader of medical research literature.
Modern Survival Analysis In Clinical Research
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Author : Ton J. Cleophas
language : en
Publisher: Springer Nature
Release Date : 2023-05-29
Modern Survival Analysis In Clinical Research written by Ton J. Cleophas and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-29 with Medical categories.
An important novel menu for Survival Analysis entitled Accelerated Failure Time (AFT) models has been published by IBM (international Businesss Machines) in its SPSS statistical software update of 2023. Unlike the traditional Cox regressions that work with hazards, which are the ratio of deaths and non-deaths in a sample, it works with risk of death, which is the proportion of deaths in the same sample. The latter approach may provide better sensitivity of testing, but has been seldom applied, because with computers risks are tricky and hazards because they are odds are fine. This was underscored in 1997 by Keiding and colleague statisticians from Copenhagen University who showed better-sensitive goodness of fit and null-hypothesis tests with AFT than with Cox survival tests. So far, a controlled study of a representative sample of clinical Kaplan Meier assessments, where the sensitivity of Cox regression is systematically tested against that of AFT modeling, has not been accomplished. This edition is the first textbook and tutorial of AFT modeling both for medical and healthcare students and for professionals. Each chapter can be studied as a standalone, and, using, real as well as hypothesized data, it tests the performance of the novel methodology against traditional Cox regressions. Step by step analyses of over 20 data files stored at Supplementary Files at Springer Interlink are included for self-assessment. We should add that the authors are well qualified in their field. Professor Zwinderman is past-president of the International Society of Biostatistics (2012-2015) and Professor Cleophas is past-president of the American College of Angiology (2000-2002). From their expertise they should be able to make adequate selections of modern data analysis methods for the benefit of physicians, students, and investigators. The authors have been working and publishing together for 25 years and their research can be characterized as a continued effort to demonstrate that clinical data analysis is not mathematics but rather a discipline at the interface of biology and mathematics.
Applied Multilevel Analysis
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Author : Jos W. R. Twisk
language : en
Publisher: Cambridge University Press
Release Date : 2006-04-06
Applied Multilevel Analysis written by Jos W. R. Twisk and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-04-06 with Medical categories.
This is a practical introduction to multilevel analysis, written for non-mathematicians.