Regulating The Gut Microbiota By Intrinsic And Extrinsic Metabolites
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Regulating The Gut Microbiota By Intrinsic And Extrinsic Metabolites
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Author : Salam Habib
language : en
Publisher:
Release Date : 2021
Regulating The Gut Microbiota By Intrinsic And Extrinsic Metabolites written by Salam Habib and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with categories.
"Factors from inside the host (intrinsic factors) or outside the host (extrinsic factors) interact with the gut microbiota and alter the microbiome. Studying these factors provides knowledge on strategies of controlling gut microbiota to improve host health status or prevent disease. In this thesis, the hypothesis that intrinsic metabolites (such as bile acids) and extrinsic metabolites (such as polyphenolic-rich potato extract, PRPE) individually and cooperatively modify gut microbial diversity and composition, and impact the host metabolic status in distinct ways, was tested. Males and females of three mouse genotypes were used in studies: wild-type, Fabp6-/- (model of bile acid malabsorption), and Fabp6-/-;Fabp2-/- (model of bile acid and fat malabsorption). In addition, a new in vitro gut model was developed to facilitate the study of the gut microbiota in the absence of the host-inherent variables. The elevated concentrations of bile acids in the intestinal lumen of Fabp6-/- mice reduced the gut microbial diversity and enriched bile acid tolerant bacteria. On the Western-style diet (WSD; high in saturated fats and refined sugars), Fabp6-/- mice displayed sex dimorphic gut microbial dysbiosis, which was associated with a differential predicted enrichment of gut microbial saccharolysis pathways by the two sexes. PRPE supplementation of WSD prevented adiposity, dysbiosis of gut microbiota, and colonocyte endoplasmic reticulum stress that were induced by WSD in wild-type mice. Similarly, feeding PRPE-supplemented WSD to Fabp6-/- mice mitigated features of WSD-induced gut microbial dysbiosis, but resulted in greater similarity in the phylum composition of the gut microbiota between male female mice. The combined loss of both Fabp2 and Fabp6 on WSD reduced body weight gain in mice and resulted in a sex dimorphic gut microbial response, enhanced glucose tolerance, and attenuated colonocyte endoplasmic reticulum stress. Together, these results demonstrate the ability of intrinsic and extrinsic metabolites to modify the composition of gut microbiota and alter the metabolic status of the host. In addition, intestinal fatty acid binding proteins appear to be indirectly involved in mediating the sex dimorphic response of the gut microbiota to WSD. This work provides new clues on the importance of gut microbial regulation and emphasizes the need for sex-specific nutritional approaches and guidelines. The knowledge generated by this work will facilitate strategies for controlling the gut microbial composition for effective control of health and disease"--
Impact Of Microbiome On Gut Mucosal Immunity In Health And Disease
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Author : Oscar Gilberto Gomez-Duarte
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-07
Impact Of Microbiome On Gut Mucosal Immunity In Health And Disease written by Oscar Gilberto Gomez-Duarte and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-07 with Medical categories.
Microbiota Brain Axis
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Author : Jane Foster
language : en
Publisher: Academic Press
Release Date : 2024-03-01
Microbiota Brain Axis written by Jane Foster and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-01 with Medical categories.
Microbiota Brain Axis: A Neuroscience Primer provides neuroscience researchers with a comprehensive guide on how to conduct effective microbiota-brain research, understand the appropriate methodologies, and collect and analyze microbiota data. The book begins with an introduction to the importance of the microbiota-brain communication in development and how microbiota impact neurodevelopmental disorders, mental health and neurodegeneration. In addition, the book discusses advances in microbiota analysis tools and techniques for neuroscience related research. Reviews the many approaches to manipulating the microbiota in animal studies - including the use of germ-free animals, antibiotics and diet - and covers the strengths and limitations of each Outlines available microbiota research tools, such as 16S sequencing and shot-gun metagenomics Provides a comprehensive guide to analyzing microbiota-related data and the many choices for bioinformatics
The Enteric Nervous System
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Author : John Barton Furness
language : en
Publisher:
Release Date : 1987
The Enteric Nervous System written by John Barton Furness and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with Medical categories.
Metabolism And Medicine
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Author : Brian Fertig
language : en
Publisher: CRC Press
Release Date : 2022-02-01
Metabolism And Medicine written by Brian Fertig and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-01 with Medical categories.
Chronic disease states of aging should be viewed through the prism of metabolism and biophysical processes at all levels of physiological organization present in the human body. This book connects these insights to what causes them to go awry in the context of unhealthy human behaviors and aging, aiming to buttress scientific creativity. It also provides links between the art and science of medicine that strengthens problem-solving in patient care. New and important discoveries in the area of metabolic health and metabolic diseases are discussed in exquisite detail. Key Features: Broad and up-to-date overview of the field of metabolic aspects of health and chronic disease development, especially connecting the spectrum of topics that range from molecular clocks to stress response to nuclear hormone receptors and the role of microbiota in human health Provides a deeper basic science and interdisciplinary understanding of biological systems that broaden the perspectives and therapeutic problem solving by elaborating on the usefulness of the Physiological Fitness Landscape Describes the importance of insulin resistance in metabolic disease, especially diabetes but also includes links to cancer and Alzheimer’s disease Examines the process of aging from the perspective of metabolic decline illustrating it with the Physiological Fitness Landscape This book, the second volume in a two-volume set, primarily targets an audience of clinical and science students, biomedical researchers and physicians who would benefit from understanding each other’s language.
Colon
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Author : Luis Bustos-Fernandez
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
Colon written by Luis Bustos-Fernandez and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Medical categories.
The functional and organic alterations of the colon constitute one of the leading reasons why patients consult gastroenterologists. The irritable colon is one of the most com mon causes of discomfort in human beings. The organic pathology of the large bowel (malignancy and chronic inflammatory disease) contributes, particularly among Occi dental peoples, to discouragingly high levels of morbidity and mortality. One realizes the importance of having a thorough physiologic knowledge of the colon in order to scientifically plan the functional treatment of organic colonic dis eases. If we consider the large amount of material published on the physiology of the esophagus, stomach, small bowel, pancreas, and liver, we realize that the colon has been relatively neglected. The chapters in this book have been written by people who have done their utmost to alter this imbalance. I want to thank all the contributors for their generous collaboration that allows me to present in one volume virtually all the information known about the structure and function of the colon, and to record my deep graditude to Dr. Howard Spiro for his willingness to include this volume in his series. I would also like to express my sincere appreciation to Plenum Publishing Corporation for making this book possible. A spe cial thanks goes to Dr.
Microbial Endocrinology The Microbiota Gut Brain Axis In Health And Disease
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Author : Mark Lyte
language : en
Publisher: Springer
Release Date : 2014-07-05
Microbial Endocrinology The Microbiota Gut Brain Axis In Health And Disease written by Mark Lyte and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-05 with Science categories.
The field of microbial endocrinology is expressly devoted to understanding the mechanisms by which the microbiota (bacteria within the microbiome) interact with the host (“us”). This interaction is a two-way street and the driving force that governs these interactions are the neuroendocrine products of both the host and the microbiota. Chapters include neuroendocrine hormone-induced changes in gene expression and microbial endocrinology and probiotics. This is the first in a series of books dedicated to understanding how bi-directional communication between host and bacteria represents the cutting edge of translational medical research, and hopefully identifies new ways to understand the mechanisms that determine health and disease.
Bacterial Signaling
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Author : Reinhard Krämer
language : en
Publisher: John Wiley & Sons
Release Date : 2009-12-09
Bacterial Signaling written by Reinhard Krämer and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-12-09 with Science categories.
Providing a comprehensive insight into cellular signaling processes in bacteria with a special focus on biotechnological implications, this is the first book to cover intercellular as well as intracellular signaling and its relevance for biofilm formation, host pathogen interactions, symbiotic relationships, and photo- and chemotaxis. In addition, it deals in detail with principal bacterial signaling mechanisms -- making this a valuable resource for all advanced students in microbiology. Dr. Krämer is a world-renowned expert in intracellular signaling and its implications for biotechnology processes, while Dr. Jung is an expert on intercellular signaling and its relevance for biomedicine and agriculture.
Parasitology And Microbiology Research
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Author : Gilberto Antonio Bastidas Pacheco
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-06-17
Parasitology And Microbiology Research written by Gilberto Antonio Bastidas Pacheco and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-17 with Medical categories.
The study of both unicellular and multicellular living beings and the diseases they produce from a biological point of view requires constant review of their relationship with their host and environment, given their indisputable sanitary importance. In this sense, in parasitology and microbiology, updated and concise information on life cycle, taxonomic classification, clinical manifestations, diagnosis, treatment, epidemiological behavior, and control measures is of vital importance. This is what we pursue with this book. The approach to parasitology and microbiology and the research that is carried out on it is unquestionable because the associations between life forms have been present from the very beginning of life.Research in parasitology and microbiology is necessary and indispensable for controlling diseases that affect much of the world with serious economic and social consequences. The challenge is to promote research to keep these diseases at bay. This book shows what has been done up to now and what can be done in the future to combat infectious diseases.
Microbiome Immunity Digestive Health And Nutrition
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Author : Debasis Bagchi
language : en
Publisher: Academic Press
Release Date : 2022-07-21
Microbiome Immunity Digestive Health And Nutrition written by Debasis Bagchi and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-21 with Technology & Engineering categories.
Microbiome, Immunity, Digestive Health and Nutrition: Epidemiology, Pathophysiology, Prevention and Treatment addresses a wide range of topics related to the role of nutrition in achieving and maintaining a healthy gut microbiome. Written by leading experts in the field, the book outlines the various foods, minerals, vitamins, dietary fibers, prebiotics, probiotics, nutritional supplements, phytochemicals and drugs that improve gut health. It specifically addresses molecular and cellular mechanisms and pathways by which these nutritional components contribute to the physiology and functionality of a healthy gut microbiome and gut health. Intended for nutrition researchers and practitioners, food experts, gastroenterologists, nurses, general practitioners, public health officials and health professionals, this book is sure to be a welcomed resource. Outlines the nutritional guidelines and healthy lifestyle that is important to boost gut health Demonstrates the effects of diverse environmental stressors in the disruption of the gastrointestinal ecology Discusses the molecular and immunological mechanisms associated with healthy gut microbiome functions Addresses how to boost healthy gut microflora and microbiome Suggests areas for future research of microbiome-based nutrition and therapies
