Regulation Of Cytokine Gene Expression In Immunity And Diseases
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Regulation Of Cytokine Gene Expression In Immunity And Diseases
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Author : Xiaojing Ma
language : en
Publisher: Springer
Release Date : 2016-10-12
Regulation Of Cytokine Gene Expression In Immunity And Diseases written by Xiaojing Ma and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-12 with Medical categories.
This book explores the major cytokines, such as IL-1 and IFN-γ, with respect to the regulation of their gene expression and protein production in specific immune cell types. It discusses both healthy physiological settings and in pathological situations in which the expression of some cytokines could be dysregulated, resulting in either immunodeficiency or exacerbated inflammatory sequelae in animal models as well as in human patients. Cytokines are important regulators of immune responses that require the highly coordinated participation and communication of multiple cell types. The expression of cytokines by various producer cell types is therefore carefully regulated in response to environmental cues at multiple levels: transcription, translation and posttranslational modification. Presenting cutting-edge advances in our understanding of the regulation of cytokine expression, this book is a valuable resource for anyone involved or interested in immune regulation.
Cytokine Frontiers
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Author : Takayuki Yoshimoto
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-10-28
Cytokine Frontiers written by Takayuki Yoshimoto and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-28 with Medical categories.
This book guides the reader through the latest research on the cytokine network, covering signaling pathways, control of the immune response, and potential therapeutics. Different cytokines stimulate diverse responses in various phases of inflammation and immunity, including the innate immune response, the generation of effector T cells, and the development of antibodies by the humoral immune system. It is now clear that the pathophysiology of many infectious, autoimmune, allergic, and malignant diseases can be largely explained by which cytokines are induced and subsequently regulate the cellular responses. In clinical medicine, cytokines are involved in a wide spectrum of diseases. This book describes in three parts the properties and roles of 15 key cytokines under physiological and pathological conditions. Part I presents nine cytokines associated with inflammatory disorders, pro-inflammatory cytokines, and the recently identified new helper T (Th) subset: Th17 cells. Part II gives details of three cytokines associated with allergic disorders, including Th2 responses and recently identified types of innate cells. Part III describes three cytokines that are associated with immunological tolerance and anti-inflammation, including regulatory T (Treg) cells, IL-10-producing Treg (Tr1) cells, and inducible IL-35-producing Treg (iTr35) cells. Cytokines are considered to be important as therapeutic targets for specific agonists or antagonists in numerous immune and inflammatory diseases. The ultimate goal of this book is to facilitate the development of therapeutic treatments for such diseases which has been limited by an insufficient understanding of the biology of cytokines and the complicated network that they create.
The Cytokine Handbook Two Volume Set
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Author : Angus W. Thomson
language : en
Publisher: Elsevier
Release Date : 2003-04-22
The Cytokine Handbook Two Volume Set written by Angus W. Thomson and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-04-22 with Medical categories.
The fourth edition of The Cytokine Handbook provides an encyclopedic coverage of the molecules that induce and regulate immune responses. Now expanded to two volumes, co-edited by Michael T Lotze, and written by over 120 international experts, the scope of the book has been broadened to include a major emphasis on the clinical applications of cytokines. The early chapters discuss individual cytokines, chemokines and receptors. Additional chapters discuss the clinical implications and applications of cytokines, including cytokine gene transfer, antisense therapy and assay systems. This book is essential for researchers and clinicians interested in cytokines, including anyone working in cancer biology, transplantation, infectious diseases, autoimmunity or bioinformatics. Key Features* Covers all main cytokines and chemokines * Written by experts* Up-to-date- includes detailed referencing accessing current, modern literature and reflects the newest findings from the human genome * The new edition has been thoroughly revised and extended (now 2 volumes) as compared to the last edition, including new co-editor (MTL), new authors, new hot topics and new chapters* Includes major emphasis on clinical applications* Extensively illustrated with tables and figures
Cytokine Regulation Of Humoral Immunity
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Author : Clifford M. Snapper
language : en
Publisher: John Wiley & Sons
Release Date : 1996-08-06
Cytokine Regulation Of Humoral Immunity written by Clifford M. Snapper and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-08-06 with Medical categories.
This work focuses on the impact of the cytokine network on the humoral immune response, as well as on its implications for the evolving field of cytokine-based medical therapeutics. Scientists interested in how cytokines regulate the production of antibody, and the selective expression of distinct antibody classes in response to microbial and other antigenic challenges now have a single, comprehensive and timely volume covering this complex field.
The Cytokines Of The Immune System
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Author : Zlatko Dembic
language : en
Publisher: Academic Press
Release Date : 2015-05-23
The Cytokines Of The Immune System written by Zlatko Dembic and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-05-23 with Medical categories.
The Cytokines of the Immune System catalogs cytokines and links them to physiology and pathology, providing a welcome and hugely timely tool for scientists in all related fields. In cataloguing cytokines, it lists their potential for therapeutic use, links them to disease treatments needing further research and development, and shows their utility for learning about the immune system. This book offers a new approach in the study of cytokines by combining detailed guidebook-style cytokine description, disease linking, and presentation of immunologic roles. Supplies new ideas for basic and clinical research Provides cytokine descriptions in a guidebook-style, cataloging the origins, structures, functions, receptors, disease-linkage, and therapeutic potentials Offers a textbook-style view on the immune system with the immunologic role of each cytokine
Cytokine Knockouts
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Author : Scott K. Durum
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-04-17
Cytokine Knockouts written by Scott K. Durum and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-17 with Medical categories.
My personal history in the field of cytokines had an initial period of several years during which my student and then colleague, Werner Muller, tried in vain to attract me to them. My interest always vanished when I was confronted with complex data pointing to func tional redundancy of cytokines in cell culture systems. When gene targeting in the mouse germline became possible, this frustration came to an end. We and others immediately embarked on analyzing the in vivo function of cytokines and the problem of functional redundancy with this powerful new approach. The early cytokine gene knockouts performed by colleagues in Wiirzburg (IL-2) and by ourselves (IL-4 and IL-l 0) seemed to give clear answers and at the same time led to surprises: Each of these cytokines apparently had its own special and irreplaceable function, and this function could be quite distinct from what had been anticipated from functional experiments in vitro. Al though the latter finding is of course a wonderful incentive for fur ther research, the former is pleasing in a general sense since it highlights the value of each of those one hundred thousand genes or so in our genome, cherished by evolution to become respectable mem bers of the community. Even in the present era of "genomics" there will be no way around the careful functional analysis of each gene by itself.
The Cytokine Handbook
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Author : Angus W. Thomson
language : en
Publisher: Gulf Professional Publishing
Release Date : 2003
The Cytokine Handbook written by Angus W. Thomson and has been published by Gulf Professional Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Chemokines categories.
The fourth edition of The Cytokine Handbook provides an encyclopedic coverage of the molecules that induce and regulate immune responses. Expanded to two volumes, the scope of the book has been broadened to include a major emphasis on the clinical applications of cytokines. The early chapters discuss individual cytokines, chemokines and receptors. Additional chapters discuss the clinical implications and applications of cytokines, including cytokine gene transfer, antisense therapy and assay systems.
Analysis Of The Kinetics And Regulation Of Cytokine Gene Expression During The Primary In Vivo Immune Response To Killed Brucella Abortus
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Author : Yichun Jian
language : en
Publisher:
Release Date : 1992
Analysis Of The Kinetics And Regulation Of Cytokine Gene Expression During The Primary In Vivo Immune Response To Killed Brucella Abortus written by Yichun Jian and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with categories.
Immune Response In The Critically Ill
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Author : John C. Marshall
language : en
Publisher: Springer Science & Business Media
Release Date : 2002-01-21
Immune Response In The Critically Ill written by John C. Marshall and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-01-21 with Medical categories.
This book brings together basic scientists or clinicians from a variety of different backgrounds - immunology, infectious diseases or critical care - who share a common interest in understanding the changes that occur in immune responses in sepsis. It provides an up-to-date and unrivalled synthesis of current research in this rapidly developing field.
Regulation Of Cytokine Expression During The Inflammatory Process
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Author : Julia Yung Lee
language : en
Publisher:
Release Date : 2002
Regulation Of Cytokine Expression During The Inflammatory Process written by Julia Yung Lee and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with categories.
Monocytes and macrophages respond to bacterial components as a part of the innate immune response to fight off pathogenic infections. Various biologically active cytokines are produced to mediate the inflammatory process and stimulate a cascade of inflammatory mediators. A microenvironment is maintained to activate cells, clear pathogens, and contain the area of infection. We examine specifically two pro-inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma). The inappropriate or excessive production of these cytokines results in tissue damage and has implications in chronic inflammation and autoimmune diseases. TNF-alpha potently stimulates the production of other cytokines and adhesion molecules. It recruits other inflammatory cells and upregulates the adaptive immune response. We explore how TNF-alpha production is regulated by two mechanisms. We find that chromatin structures in the promoter region of the TNF-alpha gene are altered with maturation. In vitro human monocytic cell lines representing different stages of maturation demonstrate increasing histone H3 acetylation with increasing maturation. Primary human monocytes and macrophages also show similar phenomena. Increasing acetylation of histone H3 is associated with increasing responsiveness to stimulation. Another aspect of TNF-alpha gene regulation is examined from the perspective of signaling pathways initiated by IFN-gamma and lipopolysaccharide (LPS). We investigate how IFN-gamma may be able to potentiate the LPS-inducible TNF-alpha production in monocytes and determine that this occurred at the level of transcription. We also assess the role of IFN-gamma in pathogenesis of the autoimmune disease, systemic lupus erythematosus. Specifically, a dinucleotide repeat polymorphism in the first intron of the human IFN-gamma gene is associated with specific disease manifestations. Understanding how cytokines in the inflammatory process are regulated has important clinical significance. Controlling the aberrant production of these cytokines may be used therapeutically to prevent chronic inflammation and autoimmune conditions.