Regulation Of Signal Transduction In Human Cell Research
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Regulation Of Signal Transduction In Human Cell Research
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Author : Nariyoshi Shinomiya
language : en
Publisher: Springer
Release Date : 2018-02-15
Regulation Of Signal Transduction In Human Cell Research written by Nariyoshi Shinomiya and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-15 with Medical categories.
This volume focuses on the relationship between the regulation of signal transduction and disease mechanisms, and discusses how the dysregulation of intracellular signals cause diseases, cell death, carcinogenesis, and other disorders. Growth, survival, transformation, and metabolic activities at the cellular level are regulated by various intracellular signal transduction pathways. Sources that stimulate intracellular signals include intracellular stresses and signal regulators/modulators, as well as extracellular growth factors. Recent studies on signal transduction analysis using animal and human cell lines have revealed how the intracellular signals are regulated and why their dysregulation leads to pathological states such as tumorigenesis, metabolic diseases, cell death, and so on. This book highlights several important key molecules and intracellular signaling pathways such as microRNA, the TGF-beta signaling pathway, the Wnt signaling pathway and MET signaling pathway as topical and highly relevant issues in human cell research related to signal transduction. In addition to assessing the pathogenic role of these signaling pathways, it focuses on the molecular design of small molecule regulators/inhibitors of said pathways, one of the most important approaches in this area. This book offers a valuable guide, helping not only research scientists but also clinicians to understand how the dysregulation of intracellular signals leads to diseases.
Signal Transduction And Human Disease
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Author : Toren Finkel
language : en
Publisher: John Wiley & Sons
Release Date : 2003-07-18
Signal Transduction And Human Disease written by Toren Finkel and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-07-18 with Science categories.
This book uniquely relates the broad impact of signal transduction research on the understanding and treatment of human disease. There have been significant advances in the area of signaling in disease processes, yet no resource presently connects these advances with understanding of disease processes and applications for novel therapeutics. Given the emphasis on translational research and biological relevance in biotechnology, and, conversely, the importance of molecular approaches for clinical research, it is evident that a single resource bridging signaling research and human disease will be invaluable.
Tissue Specific Cell Signaling
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Author : Joana Vieira Silva
language : en
Publisher: Springer Nature
Release Date : 2020-05-29
Tissue Specific Cell Signaling written by Joana Vieira Silva and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-29 with Medical categories.
Signal transduction comprises the intracellular biochemical signals which induce the appropriate cell response to an external stimulus. The players in signal transduction are diverse, from small molecules as first messengers, to proteins, receptors, transcription factors, among many others. The different signaling pathways and the crosstalk between them originates the unique signaling profile of every cell type in the human body. The cell signaling specificity depends on several aspects including protein composition, subcellular localization and complexes and gene promoters. This textbook provides a comprehensive overview of the specific signaling pathways on a variety of human tissues. This information can be of great value for health science researchers, professionals and students to understand key pathways for tissue-specific functions in the plethora of signals, signals receptors, transducers and effectors. Chapter 3 and 15 are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Trends In Signal Transduction Research
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Author : Jennifer N. Meyers
language : en
Publisher: Nova Publishers
Release Date : 2007
Trends In Signal Transduction Research written by Jennifer N. Meyers and has been published by Nova Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Cell interaction categories.
Signal transduction is any process by which a cell converts one kind of signal or stimulus into another. Processes referred to as signal transduction often involve a sequence of biochemical reactions inside the cell, which are carried out by enzymes and linked through second messengers. In many transduction processes, an increasing number of enzymes and other molecules become engaged in the events that proceed from the initial stimulus. Responses of cells to environmental signals, toxins and stressors have profound implications for diverse aspects of human health and disease including development, cystic fibrosis, diabetes, asthma, heart, autoimmune diseases and cancer. The delineation of the signal transduction pathways affected in these and other complex human diseases are likely to present new avenues for therapeutic intervention and understanding of human disease mechanisms.
Signal Transduction
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Author : ljsbrand M. Kramer
language : en
Publisher: Academic Press
Release Date : 2015-10-23
Signal Transduction written by ljsbrand M. Kramer and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-23 with Science categories.
A reference on cellular signaling processes, the third edition of Signal Transduction continues in the tradition of previous editions, in providing a historical overview of how the concept of stimulus-response coupling arose in the early twentieth century and shaped our current understanding of the action of hormones, cytokines, neurotransmitters, growth factors and adhesion molecules. In a new chapter, an introduction to signal transduction, the book provides a concise overview of receptor mechanisms, from receptor – ligand interactions to post-translational modifications operational in the process of bringing about cellular changes. The phosphorylation process, from bacteria to men, is discussed in detail. Signal transduction third edition further elaborates on diverse signaling cascades within particular contexts such as muscle contraction, innate and adaptive immunity, glucose metabolism, regulation of appetite, oncogenic transformation and cell fate decision during development or in stem cell niches. The subjects have been enriched with descriptions of the relevant anatomical, histological, physiological or pathological condition. In-depth insight into a subject central to cell biology and fundamental to biomedicine, including the search for novel therapeutic interventions Essential signaling events embedded in rich physiological and pathological contexts Extensive conceptual colour artwork to assist with comprehension of key topics Special emphasis on how molecular structure determines protein function and subcellular localization Employment of unambiguous protein names (symbols) in agreement with leading protein- and gene databases, allowing the learner to extend his/her exploration on the web
Signal Transduction Pathways Mechanisms And Diseases
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Author : Ari Sitaramayya
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-12-02
Signal Transduction Pathways Mechanisms And Diseases written by Ari Sitaramayya and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-12-02 with Science categories.
Providing an overview of recent developments in the field of signal transduction, this volume emphasizes direct clinical significance. As such, topics like nuclear receptors, apoptosis, growth factors, cell cycles and cancer are examined.
Cellular Signal Transduction In Toxicology And Pharmacology
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Author : Jonathan W. Boyd
language : en
Publisher: John Wiley & Sons
Release Date : 2019-04-16
Cellular Signal Transduction In Toxicology And Pharmacology written by Jonathan W. Boyd and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-16 with Science categories.
Covering a key topic due to growing research into the role of signaling mechanisms in toxicology, this book focuses on practical approaches for informatics, big data, and complex data sets. Combines fundamentals / basics with experimental applications that can help those involved in preclinical drug studies and translational research Includes detailed presentations of study methodology and data collection, analysis, and interpretation Discusses tools like experimental design, sample handling, analytical measurement techniques
Signal Transduction
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Author : Bastien D. Gomperts
language : en
Publisher: Gulf Professional Publishing
Release Date : 2002-03-08
Signal Transduction written by Bastien D. Gomperts and has been published by Gulf Professional Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-03-08 with Science categories.
Signal Transduction is a well-illustrated, coherent look at cellular signaling processes. Beginning with the basics, it explains how cells respond to external cues, hormones, growth factors, cytokines, cell surfaces, etc., and then shows how these inputs are integrated and coordinated. The extensive color artwork provides the reader with a clearer comprehension of key topics, and margin notes are incorporated to highlight milestones in the evolution of signal transduction. This book serves as an invaluable resource for advanced undergraduates, graduate researchers, and established scientists working in cell biology, pharmacology, immunology, and related fields. Coherent, precise text providing insight in depth to a subject that is central to cell biology and fundamental to many areas of biomedicine Extensive conceptual colour artwork assists with the comprehension of key topics Extensive referencing provides an invaluable link to the core and historical literature Margin notes highlighting milestones in the evolution of our understanding of signalling mechanisms
Molecular Targeting And Signal Transduction
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Author : Rakesh Kumar
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-04-18
Molecular Targeting And Signal Transduction written by Rakesh Kumar and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-04-18 with Medical categories.
Our limited understanding of cellular regulatory signal-transduction-networks has been a barrier to progress in improving the overall cure-rate of human cancers. Delineation of the physiologic roles of the specific regulatory signaling components, with known association with metastatic phenotypes, is a highly promising area which will likely provide the next generation of targeted strategies in the future of molecular cancer medicine. These signaling components are likely to be used in diagnosis, prognosis, and as novel targets for therapeutic development. This book brings together up-to-date summaries by leading cancer researchers on the major principles of cancer cell biology: survival, apoptosis, adhesion, and cell cycle deregulation. It is directed at clinicians and scientists working in the areas of experimental and molecular therapeutics, molecular medicine, translational cancer research, and bio-medical sciences in general.
Signal Transduction
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Author : Carl-Henrik Heldin
language : en
Publisher: Garland Science
Release Date : 1996
Signal Transduction written by Carl-Henrik Heldin and has been published by Garland Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Cell physiology categories.
Signal Transduction was published in association with The International Union of Biochemistry and Molecular Biology. In a series of twenty-three short chapters, leading researchers provide cutting-edge reviews of signal transduction, and form cell membrane receptors through to gene regulation. Written for those with a basic understanding of molecular and cell biology, the book will be of particular interest to graduate students and researchers who need to grasp the principles of signal transduction.