Regulation Of The Eukaryotic Cell Cycle
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Regulation Of The Eukaryotic Cell Cycle
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Author : Joan Marsh
language : en
Publisher: John Wiley & Sons
Release Date : 2008-04-30
Regulation Of The Eukaryotic Cell Cycle written by Joan Marsh and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-30 with Science categories.
Comprised of the latest developments in cell cycle research, it analyzes the principles underlying the control of cell division. Offers a framework for future investigation, especially that aimed toward understanding and treatment of cancer.
Cell Cycle Control
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Author : Tim Humphrey
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-04
Cell Cycle Control written by Tim Humphrey and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-04 with Science categories.
The fundamental question of how cells grow and divide has perplexed biologists since the development of the cell theory in the mid-19th century, when it was recognized by Virchow and others that “all cells come from cells.” In recent years, considerable effort has been applied to the identification of the basic molecules and mechanisms that regulate the cell cycle in a number of different organisms. Such studies have led to the elucidation of the central paradigms that underpin eukaryotic cell cycle control, for which Lee Hartwell, Tim Hunt, and Paul Nurse were jointly awarded the Nobel Prize for Medicine and Physiology in 2001 in recognition of their seminal contributions to this field. The importance of understanding the fundamental mechanisms that modulate cell division has been reiterated by relatively recent discoveries of links between cell cycle control and DNA repair, growth, cellular metabolism, development, and cell death. This new phase of integrated cell cycle research provides further challenges and opportunities to the biological and medical worlds in applying these basic concepts to understanding the etiology of cancer and other proliferative diseases.
Transcriptional Regulation In The Eukaryotic Cell Cycle
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Author : John D. McKinney
language : en
Publisher:
Release Date : 1991
Transcriptional Regulation In The Eukaryotic Cell Cycle written by John D. McKinney and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with categories.
Reproduction Of Eukaryotic Cells
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Author : David M. Prescott
language : en
Publisher: Elsevier
Release Date : 2012-12-02
Reproduction Of Eukaryotic Cells written by David M. Prescott and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
Reproduction of Eukaryotic Cells organizes in a single source the principal facts and observations on the cell life cycle and reproduction of eukaryotic cells. The aim is to increase the overall understanding of how these cells reproduce themselves and how this reproduction is regulated. The book begins with a discussion of the sections of the cell cycle and regulation of cell reproduction. Separate chapters on cell growth, cell synchrony, the G1 period, S period, and G2 period follow. Subsequent chapters are devoted to activities during cell division; cell cycle changes in surface morphology; the role of cyclic AMP (cAMP) and cyclic GMP (cGMP) in regulation of cell reproduction; and changes in nuclear proteins, RNA synthesis, and enzyme activities during the cell cycle. The final chapter covers the genetic analysis of the cell cycle.
Eukaryotic Gene Regulation
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Author : Gerald M. Kolodny
language : en
Publisher: CRC Press
Release Date : 2018-01-18
Eukaryotic Gene Regulation written by Gerald M. Kolodny and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-18 with Medical categories.
The cause of cancer and its many manifestations is at present unknown. Since many of its manifestations, including is control of cell division, appear to represent abnormal patterns of gene expression, studies of the regulation of gene expression nwill provide important insights in the understanding and treatment of cancer. This volume attempts to present some of the recent work on regulation of gene expression in eukaryotic cells.
Cell Cycle Control
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Author : Michele Pagano
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Cell Cycle Control written by Michele Pagano and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.
Addressing the regulation of the eukaryotic cell cycle, this book brings together experts to cover all aspects of the field, clearly and unambiguously, delineating what is commonly accepted in the field from the problems that remain unsolved. It will thus appeal to a large audience: basic and clinical scientists involved in the study of cell growth, differentiation, senescence, apoptosis, and cancer, as well as graduates and postgraduates.
Genetic Expression In The Cell Cycle
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Author : G.M. Padilla
language : en
Publisher: Elsevier
Release Date : 2012-12-02
Genetic Expression In The Cell Cycle written by G.M. Padilla and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
Genetic Expression in the Cell Cycle provides an understanding of the molecular mechanisms that govern the expression of genetic information during the cell cycle. The initial five chapters describe the intimate relationships between the supramolecular complexes that form the basic structure of chromatin. Emphasis is placed on the dynamics of cycle-dependent changes in the structural organization of some of these components. Subsequent chapters demonstrate that small nuclear RNAs (SnRNA) are actively involved in gene regulation in eukaryotic cells; discuss the relationship between cell cycle regulation in the yeast Saccharomyces cerevisiae and transcription of ribosomal RNA genes; and describe the use of conditional lethal mutants to study the regulation of the cell cycle of eukaryotic cells. The remaining chapters discuss the concepts and methodologies employed to isolate and study specific cell cycle mutants of S. cerevisiae; the antiproliferative effect of interferon on cultured human fibroblasts; and the role of cell membrane and related subcellular elements in the control of proliferation, differentiation, and cell cycle kinetics.
Cell Cycle Checkpoints
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Author : Willis X. Li
language : en
Publisher: Humana Press
Release Date : 2011-08-30
Cell Cycle Checkpoints written by Willis X. Li and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-08-30 with Science categories.
Cell cycle checkpoints control the fidelity and orderly progression of eukaryotic cell division. By controlling the orderly progression of critical cell cycle events such as DNA replication and chromosome segregation and ensuring proper repair of damaged DNA, cell cycle checkpoints function to ensure genome integrity. Mechanisms of checkpoint controls are not only the research focus of investigators interested in mechanisms that regulate the cell cycle, but are also the interests of researchers studying cancer development as it is increasingly clear that loss of cell cycle checkpoints, which leads to genomic instability as a result, is a hallmark of tumorigenesis. Cell Cycle Checkpoints: Methods and Protocols provides detailed descriptions of methodologies currently employed by researchers in the field, including those commonly used in the mammalian, yeast, C. elegans, Drosophila, and Xenopus model systems. Each chapter describes a specific technique or protocol, such as a method to induce cell cycle checkpoints in a particular model system, to synchronize a population of cells to allow observations of cell cycle progression, to identify genes involved in checkpoint regulation, and to study particular protein components of cell cycle checkpoint pathways. Written in the highly successful Methods in Molecular BiologyTM series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Cell Cycle Checkpoints: Methods and Protocols seeks to serve both professionals and novices with its well-honed methodologies in an effort to further our knowledge of this essential field.
Cell Cycle Control In Eukaryotes
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Author : David H. Beach
language : en
Publisher:
Release Date : 1988
Cell Cycle Control In Eukaryotes written by David H. Beach and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with Science categories.
Cell Cycle Checkpoint Control Protocols
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Author : Howard B. Lieberman
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-02
Cell Cycle Checkpoint Control Protocols written by Howard B. Lieberman and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-02 with Science categories.
The field of cell cycle regulation is based on the observation that the life cycle of a cell progresses through several distinct phases, G1, M, S, and G2, occurring in a well-defined temporal order. Details of the mechanisms involved are rapidly emerging and appear extraordinarily complex. Furthermore, not only is the order of the phases important, but in normal eukaryotic cells one phase will not begin unless the prior phase is completed successfully. Che- point control mechanisms are essentially surveillance systems that monitor the events in each phase, and assure that the cell does not progress prematurely to the next phase. If conditions are such that the cell is not ready to progress—for example, because of incomplete DNA replication in S or DNA damage that may interfere with chromosome segregation in M—a transient delay in cell cycle progression will occur. Once the inducing event is properly handled— for example, DNA replication is no longer blocked or damaged DNA is repaired—cell cycle progression continues. Checkpoint controls have recently been the focus of intense study by investigators interested in mechanisms that regulate the cell cycle. Furthermore, the relationship between checkpoint c- trol and carcinogenesis has additionally enhanced interest in these cell cycle regulatory pathways. It is clear that cancer cells often lack these checkpoints and exhibit genomic instability as a result. Moreover, several tumor suppressor genes participate in checkpoint control, and alterations in these genes are as- ciated with genomic instability as well as the development of cancer.