Regulatory Protein Modification
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Regulatory Protein Modification
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Author : Hugh C. Hemmings
language : en
Publisher: Humana Press
Release Date : 2010-10-28
Regulatory Protein Modification written by Hugh C. Hemmings and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-28 with Medical categories.
Distinguished international experts offer critical reviews of the major categories of posttranslational protein modification in neurons, as well as a comprehensive collection of state-of-the-art techniques for their analysis. They provide detailed and specific methods for studying protein phosphorylation/dephospohorylation, methylation, long chain fatty acylation, ADP-ribosylation, glycosylation, and glycosylphosphatidylinositol anchors. Using both conventional analytical and novel molecular biological approaches, these experts present important techniques and reagents and cite numerous examples from the neuroscience literature in a way that allows investigators to determine the best experimental approaches for their own systems. The book offers the most complete review of protein kinase and phosphatase inhibitor applications available.
Protein Modificomics
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Author : Tanveer Ali Dar
language : en
Publisher: Academic Press
Release Date : 2019-05-21
Protein Modificomics written by Tanveer Ali Dar and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-21 with Science categories.
Protein Modificomics: From Modifications to Clinical Perspectives comprehensively deals with all of the most recent aspects of post-translational modification (PTM) of proteins, including discussions on diseases involving PTMs, such as Alzheimer's, Huntington's, X-linked spinal muscular atrophy-2, aneurysmal bone cyst, angelman syndrome and OFC10. The book also discusses the role PTMs play in plant physiology and the production of medicinally important primary and secondary metabolites. The understanding of PTMs in plants helps us enhance the production of these metabolites without greatly altering the genome, providing robust eukaryotic systems for the production and isolation of desired products without considerable downstream and isolation processes.
Protein Modificomics
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Author : Tanveer Ali Dar
language : en
Publisher: Academic Press
Release Date : 2019-05-18
Protein Modificomics written by Tanveer Ali Dar and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-18 with Science categories.
Protein Modificomics: From Modifications to Clinical Perspectives comprehensively deals with all of the most recent aspects of post-translational modification (PTM) of proteins, including discussions on diseases involving PTMs, such as Alzheimer’s, Huntington’s, X-linked spinal muscular atrophy-2, aneurysmal bone cyst, angelman syndrome and OFC10. The book also discusses the role PTMs play in plant physiology and the production of medicinally important primary and secondary metabolites. The understanding of PTMs in plants helps us enhance the production of these metabolites without greatly altering the genome, providing robust eukaryotic systems for the production and isolation of desired products without considerable downstream and isolation processes. Provides thorough insights into the post translational modifications (PTMs) of proteins in both the plant and animal kingdom Presents diagrammatic representations of various protein modification and estimation mechanisms in four-color Includes coverage of diseases involving post translational modifications
Post Translational Modifications In Health And Disease
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Author : Cecilio J. Vidal
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-10-13
Post Translational Modifications In Health And Disease written by Cecilio J. Vidal and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-13 with Science categories.
Post-translational modifications serve many different purposes in several cellular processes such as gene expression, protein folding and transport to appropriate cell compartment, protein-lipid and protein-protein interactions, enzyme regulation, signal transduction, cell proliferation and differentiation, protein stability, recycling and degradation. Although several-hundred different modifications are known, the significance of many of them remains unknown. The enormous versatility of the modifications which frequently alter the physico-chemical properties of the respective proteins represents an extraordinary challenge in understanding their physiological role. Since essential cellular functions are regulated by protein modifications, an improvement of current understanding of their meaning might allow new avenues to prevent and/or alleviate human and animal diseases.
Posttranslational Modification Of Proteins
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Author : Christopher Walsh
language : en
Publisher: Roberts and Company Publishers
Release Date : 2006
Posttranslational Modification Of Proteins written by Christopher Walsh and has been published by Roberts and Company Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Science categories.
Covering the major classes of posttranslational modifications, Posttranslational Modification of Proteins is the first comprehensive treatment of this burgeoning area of proteome diversification.
Protein Modifications In Pathogenic Dysregulation Of Signaling
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Author : Jun-ichiro Inoue
language : en
Publisher: Springer
Release Date : 2015-09-02
Protein Modifications In Pathogenic Dysregulation Of Signaling written by Jun-ichiro Inoue and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-02 with Science categories.
This book is devoted to recent advances in analysis of the molecular basis and dynamics of post-translational modifications (PTMs) of proteins for a comprehensive understanding of their key roles in cell signaling networks and diverse biological processes, and their perturbation in a variety of life-threatening diseases such as cancer and inflammatory diseases. The book includes research regarding PTMs and methods of their investigation derived from interdisciplinary collaborations between leading scientists in the fields of molecular, medical, proteomic, structural, and mathematical biology. This book consists of four sections. The first part focuses on recent advances in procedures for analysis of PTMs and cell signaling. The second part is devoted to mathematical simulation of signal transduction pathways and of the formation of protein complexes in living cells. The third part deals with structural and functional analyses of proteins involved in the regulation of PTMs and cell signaling. The fourth part describes cutting-edge findings regarding critical signal transduction pathways and their dysregulation in human diseases. This book is aimed at both established scientists and students in various fields of biology including molecular, cellular, structural, proteomic, and mathematical biology. Readers can access cutting-edge research and methodologies in their own field as well as interdisciplinary research that impacts on their field. The book can function as a reference for pharmaceutical scientists, biomedical researchers, and clinicians for the development of molecular-targeted therapy of human diseases.
Posttranslational Covalent Modifications Of Proteins
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Author : B. Connor Johnson
language : en
Publisher: Elsevier
Release Date : 2012-12-02
Posttranslational Covalent Modifications Of Proteins written by B. Connor Johnson and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Nature categories.
Posttranslational Covalent Modifications of Proteins focuses on the processes involved in the regulation of protein functions. Partitioned into 21 chapters, the book starts with discussions on the perspectives and prospectives of posttranslational protein modifications; protein phosphorylation and neural and hormonal control of enzymes; and research on the Rous sarcoma virus. The text also looks at studies on phosphorylation, protein kinases, and protein acetylation. The studies show the different reactions of proteins when combined under varying conditions and controlled environments. Schematic representations are presented to validate the processes involved. The book also presents experiments done on Vitamin K-dependent carboxylase from rat liver and cow. Lengthy discussions and diagrams are presented to give credence to the methodologies and results obtained. The text also focuses on studies on enzymatic activities in bacterial toxins and animals tissues. The book is a vital source of data for readers interested in the processes, techniques, and methodologies involved in the modification of proteins.
Posttranslational Protein Modifications In The Reproductive System
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Author : Peter Sutovsky
language : en
Publisher: Springer
Release Date : 2014-07-16
Posttranslational Protein Modifications In The Reproductive System written by Peter Sutovsky and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-16 with Health & Fitness categories.
This book's aim is to increase the awareness of a great variety of posttranslational modifications in the male and female reproductive system. Some of the most intriguing reproductive strategies, mechanisms, and pathways involving PTM are discussed, with an added angle of evolutionary conservation and diversity. The book also chapters on sperm-egg binding, as well as on histone modification in both the embryo and sperm. Chapters are also devoted to protein ubiquitination, the regulation of sperm function during fertilization in mammals and tubulin modifications in gametes and embryos. There are no other current books on posttranslational protein modifications as they relate to reproduction, making this contribution unique in the field. It is useful for both researchers and graduate students alike.
Regulatory Potential Of Post Translational Modifications In Bacteria
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Author : Ivan Mijakovic
language : en
Publisher: Frontiers Media SA
Release Date : 2015-07-22
Regulatory Potential Of Post Translational Modifications In Bacteria written by Ivan Mijakovic and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-22 with Microbiology categories.
Post-translational modifications (PTMs) are widely employed by all living organisms to control the enzymatic activity, localization or stability of proteins on a much shorter time scale than the transcriptional control. In eukarya, global analyses consistently reveal that proteins are very extensively phosphorylated, acetylated and ubiquitylated. Glycosylation and methylation are also very common, and myriad other PTMs, most with a proven regulatory potential, are being discovered continuously. The emergent picture is that PTM sites on a single protein are not independent; modification of one residue often affects (positively or negatively) modification of other sites on the same protein. The best example of this complex behavior is the histone “bar-code” with very extensive cross-talk between phosphorylation, acetylation and methylation sites. Traditionally it was believed that large networks of PTMs exist only in complex eukaryal cells, which exploit them for coordination and fine-tuning of various cellular functions. PTMs have also been detected in bacteria, but the early examples focused on a few important regulatory events, based mainly on protein phosphorylation. The global importance (and abundance) of PTMs in bacterial physiology was systematically underestimated. In recent years, global studies have reported large datasets of phosphorylated, acetylated and glycosylated proteins in bacteria. Other modifications of bacterial proteins have been recently described: pupylation, methylation, sirtuin acetylation, lipidation, carboxylation and bacillithiolation. As the landscape of PTMs in bacterial cells is rapidly expanding, primarily due to advances of detection methods in mass spectrometry, our research field is adapting to comprehend the potential impact of these modifications on the cellular physiology. The field of protein phosphorylation, especially of the Ser/Thr/Tyr type, has been profoundly transformed. We have become aware that bacterial kinases phosphorylate many protein substrates and thus constitute regulatory nodes with potential for signal integration. They also engage in cross-talk and eukaryal-like mutual activation cascades. The regulatory potential of protein acetylation and glycosylation in bacteria is also rapidly emerging, and the cross-talk between acetylation and phosphorylation has been documented. This topic deals with the complexity of the PTM landscape in bacteria, and focus in particular on the physiological roles that PTMs play and methods to study them. The topic is associated to the 1st International Conference on Post-Translational Modifications in Bacteria (September 9-10, 2014, Göttingen, Germany).
Cellular Regulation By Protein Phosphorylation
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Author : L.M.G. Jr. Heilmeyer
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Cellular Regulation By Protein Phosphorylation written by L.M.G. Jr. Heilmeyer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.
Proceedings of the NATO Advanced Study Institute on Cellular Regulation by Protein Phosphorylation held at Chateau La Londe les Maures (France), September 5-15, 1990